Dr Louise Major
Technical Manager (Research)
Selected publications
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Open access
An eggshell-localised annexin plays a key role in the coordination of the life cycle of a plant-parasitic nematode with its host
Price, J. A., Ali, M. F., Major, L. L., Smith, T. K. & Jones, J. T., 13 Feb 2023, In: PLoS Pathogens. 19, 2, 19 p., e1011147.Research output: Contribution to journal › Article › peer-review
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Open access
Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins
Desai, A. V., Vornholt, S. M., Major, L. L., Ettlinger, R., Jansen, C., Rainer, D., de Rome, R., So, V., Wheatley, P. S., Edward, A. K., Elliott, C., Pramanik, A., Karmakar, A., Armstrong, R., Janiak, C., Smith, T. K. & Morris, R. E., 22 Feb 2023, In: ACS Applied Materials & Interfaces. 15, 7, p. 9058–9065 8 p.Research output: Contribution to journal › Article › peer-review
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Open access
Towards chemical validation of Leishmania infantum ribose 5-phosphate isomerase as a drug target
Dickie, E. A., Ronin, C., Sá, M., Ciesielski, F., Trouche, N., Tavares, J., Santarem, N., Major, L. L., Pemberton, I. K., MacDougall, J., Smith, T. K., Cordeiro-da-Silva, A. & Ciapetti, P., 19 Apr 2021, (E-pub ahead of print) In: Antimicrobial Agents and Chemotherapy. EarlyResearch output: Contribution to journal › Article › peer-review
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Open access
Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues
Nandikolla, A., Srinivasarao, S., Karan Kumar, B., Murugesan, S., Aggarwal, H., Major, L. L., Smith, T. K. & Chandra Sekhar, K. V. G., 19 Oct 2020, In: RSC Advances. 10, 63, p. 38328-38343 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Novel benzothiazole-based ureas as 17β-HSD10 inhibitors, a potential Alzheimer’s disease treatment
Aitken, L., Benek, O., McKelvie, B., Hughes, R. E., Hroch, L., Schmidt, M., Major, L. L., Vinklarova, L., Kuca, K., Smith, T. K., Musilek, K. & Gunn-Moore, F. J., 29 Jul 2019, In: Molecules. 24, 15, 2757.Research output: Contribution to journal › Article › peer-review
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Open access
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease
Gaspar, L., Coron, R. P., Kongthoo Lin, P., Costa, D. M., Perez-Cabezas, B., Tavares, J., Roura-Ferrer, M., Ramos, I., Ronin, C., Major, L. L., Ciesielski, F., Pemberton, I. K., MacDougall, J., Ciapetti, P., Smith, T. K. & Cordeiro-da-Silva, A., 22 Jan 2018, In: PLoS Neglected Tropical Diseases. 12, 1, 30 p., e0006180.Research output: Contribution to journal › Article › peer-review
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Open access
Trypanosoma brucei bloodstream forms depend upon uptake of myo-inositol for Golgi phosphatidylinositol synthesis and normal cell growth
González-Salgado, A., Steinmann, M., Major, L. L., Sigel, E., Reymond, J-L., Smith, T. K. & Bütikofer, P., Jun 2015, In: Eukaryotic Cell. 14, 6, p. 616-624Research output: Contribution to journal › Article › peer-review
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Open access
The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei
Lilley, A. C., Major, L. L., Young, S., Stark, M. J. R. & Smith, T. K., May 2014, In: Molecular Microbiology. 92, 3, p. 453-470 18 p.Research output: Contribution to journal › Article › peer-review
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Open access
Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target.
Major, L. L., Denton, H. & Smith, T. K., 2013, Drug Discovery. El-Shemy, H. (ed.). London: IntechOpen, p. 413-431Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Open access
Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a 1H-NMR method to assess deacetylase activity
Pirrie, L., McCarthy, A. R., Major, L. L., Morkunaite, V., Zubriene, A., Matulis, D., Lain, S., Lebl, T. & Westwood, N. J., Oct 2012, In: Molecules. 17, 10, p. 12206-12224 19 p.Research output: Contribution to journal › Article › peer-review