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Edited extract from the Contents page of the Neurosim manual, showing the types of pre-designed tutorials which come with the program.
A Initial Note on Technique: voltage clamp and current clamp
Conceptual Summary
Voltage, Current and Conductance in a Spike
Sodium Dependence of a Spike
Spike Threshold
Strength-Duration Characteristics of Threshold Stimulus
Theory of the Voltage Clamp
Separation of Ionic Currents in Voltage Clamp
Voltage-Dependent Sodium Current and Conductance
Voltage-Dependent Potassium Current and Conductance
Chord and Slope Resistance
Tail Currents
Conceptual Summary
Sodium channel
Potassium channel
Voltage-Dependent Channels and Gates, and Patch Clamp Records
Micro and Macro Conductances
Molecular Insights from Macro Events
Activation Variables, Currents and the Action Potential
Patch Records
Refractory Period
Spike Threshold Accommodation
Ramp stimulus
Stimulus Summation
Rebound Excitation
Repetitive Activity
Temperature
Building Equations to Produce an Action Potential
Voltage dependency of gate position
Voltage dependency of channel conductance
Current flow through channels
Equations for the membrane potential
What Hodgkin and Huxley Actually Did
First: deciding the model
Second: quantifying the model
Third: reconstructing the model
Mean Sojourn Duration and Transition Rate Constants
Sojourn Distribution is Exponential
Microscopic and Macroscopic Properties
Open-Time Distribution
Effect of Blocker Concentration
Closed-Time Distribution
A Potential Problem with Normal Histograms
Comparison of Open- and Closed-Time Distributions
What is the Point? A Reminder
Open-Time Distributions
Closed-Time Distribution
Burst Analysis
Bursts with Transmitters
The Acetylcholine Receptor Model
Excitation and Inhibition
Depolarising IPSPs
Voltage-Dependent Synapses
Non-Spiking Synapses
Electrical Synapses
LTP
Associativity (Classical Conditioning)
Extinction and Consolidation
Facilities for Investigating Learning
Network Oscillators
Reciprocal Inhibition
Recurrent Cyclic Inhibition
Discovering which Neurons Participate in Pattern Generation
Fictive Swimming in Xenopus Embryos
Endogenous Bursters and Plateau Potentials
Endogenous bursters
Plateau Potentials
Co-ordination
A Puzzle
Spiking Interactions
Non-Spiking Interactions
Passive and Active Conduction
Spike Propagation and Collision
Saltatory Conduction
Spatial Summation
Compartmental Coupling
Dendritic Computation
Proximal and Distal Inhibition
Directional Sensitivity
Compartmental Caveat
A-Currents
Inking in Aplysia
Endogenous Burster Neurons
A Quick Look at Kinetics
Drugs
Plateau Potentials
Other Burster Mechanisms
A Take Home Message
Basic EPSP Physiology
Summation and Facilitation
Temporal Summation
Spatial Summation
Facilitation
Quantal Statistics
Quantal Size Distribution
Facilitation and Quantal Analysis
Inhibition
Synaptic interactions
Conductance Decrease Synapses
Voltage dependent synapses
NMDA and Glutamate
A Caveat on Drugs
The Basic Equations
Two Equivalent Equation Sets
Empirical Equations for Set 1
Empirical Equations for Set 2
Equations for passive conduction
Why is there attenuation with distance?
Factors effecting the length constant
Physiological significance of space constant
Temporal Summation
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Thank you for your patience in viewing this presentation. There are many more features in the Neurosim programs than I have been able to demonstrate here, but hopefully this presentation, in combination with the demonstration version of the HH program, have given you enough information to decide whether Neurosim is a suitable tool to help you in teaching and understanding neuroscience.
If you want any more information about Neurosim, contact the publisher Biosoft,or the author.
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visits since 2nd September, 1997 |