Dr Will Jowsey

Research Fellow in Pathogen Genomics

Researcher profile

Email

wjj1@st-andrews.ac.uk

Selected publications

• Open access

  Aerobic soil bacteria adapt to hypoxia by hybridizing fermentation with carbon storage

  Gillett, D. L., Koralegedara, T., Hutchinson, T. F., Nguyen-Dinh, T., Watts, T. D., Solari, J., Mudaliyar, M., Jowsey, W. J., Athukorala, N., Wong, W. W., Locop, J. U. S., Hall, N., Jimenez, L., Hanchapola, I., Lee, H.-C., Tanuwidjaya, E., Steele, J. R., Schittenhelm, R. B., Barlow, C. K. & Grinter, R. & 6 others, Cook, G. M., McNeil, M. B., Ghosal, D., Leung, P. M., Cook, P. L. M. & Greening, C., 9 Jun 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 23, p. 1-12 12 p., e2606389123.

  Research output: Contribution to journal › Article › peer-review

• Open access

  ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis

  Barter, I. K., Bedding, M. J., Leodolter, J., Maxwell, J. W. C., Hawkins, P. M. E., Stevens, M. T., McNeil, M. B., Jowsey, W. J., Wang, T., Quan, D., Junker, S., Flórido, M., Hesselson, D., Cook, G. M., Clausen, T., Britton, W. J., Larance, M. & Payne, R. J., 17 Feb 2026, In: Nature Communications. 7, p. 1-17 17 p., 1725.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Dormancy regulon reduction was pivotal to the evolution of Mycobacterium tuberculosis

  Silcocks, M., Lingford, J. P., Cheung, C.-Y., Jowsey, W. J., McCall, R. M., Rae, C. D., Harold, L. K., Edwards, D., Pepper-Tunick, E., Neville, S. L., Maher, M. J., Canalda-Baltrons, A., Chang, X., Thai, P. V. K., Holt, K. E., Baliga, N. S., Cook, G. M., Hawn, T. R., Thuong, N. T. T. & Caws, M. & 5 others, Greening, C., McDevitt, C. A., Cox, J. S., McNeil, M. B. & Dunstan, S. J., 22 Jun 2026, In: Nature Communications. 17, p. 1-18 18 p., 5484 .

  Research output: Contribution to journal › Article › peer-review

• Open access

  Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis

  Wang, X., Jowsey, W. J., Cheung, C.-Y., Dickerhof, N., Champan, C. L., Taka, J. R. H., Hampton, M. B., Bashiri, G., Gardner, P. P., Fineran, P. C., Cook, G. M., Jackson, S. A. & McNeil, M. B., 27 Jul 2026, In: Nature Communications. 17, p. 1-16 16 p., 7380.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis

  Xiong, Z., Yang, X., Wang, S., Smart, C. J., Sisson, H. M., Lin, Z., Hu, T., Ran, Y., Xu, C., Yang, X., Zhao, Y., Jowsey, W. J., Cook, G. M., McNeil, M. B., Guddat, L. W., Rao, Z. & Zhang, B., 29 May 2025, In: Nature Communications. 16, p. 1-11 11 p., 4976.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity

  Fountain, A. J., Waller, N. J. E., Cheung, C.-Y., Jowsey, W., Chrisp, M. T., Troll, M., Edelstein, P. H., Cook, G. M., McNeil, M. B. & Ramakrishnan, L., 22 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 16, p. 1-8 8 p., e2426827122.

  Research output: Contribution to journal › Article › peer-review

• A dual-targeting succinate dehydrogenase and F₁F_o-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis

  Adolph, C., Cheung, C.-Y., McNeil, M. B., Jowsey, W. J., Williams, Z. C., Hards, K., Harold, L. K., Aboelela, A., Bujaroski, R. S., Buckley, B. J., Tyndall, J. D. A., Li, Z., Langer, J. D., Preiss, L., Meier, T., Steyn, A. J. C., Rhee, K. Y., Berney, M., Kelso, M. J. & Cook, G. M., 18 Apr 2024, In: Cell Chemical Biology. 31, 4, p. 683-698.e7 23 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Antibiotic resistance in Mycobacterium tuberculosis alters tolerance to cell wall-targeting inhibitors

  Jowsey, W. J., Cook, G. M. & McNeil, M. B., 4 Jun 2024, In: JAC-Antimicrobial Resistance. 6, 3, p. 1-10 10 p., dlae086.

  Research output: Contribution to journal › Article › peer-review

• Identification of chemical scaffolds that inhibit the Mycobacterium tuberculosis respiratory complex succinate dehydrogenase

  Adolph, C., Hards, K., Williams, Z. C., Cheung, C.-Y., Keighley, L. M., Jowsey, W. J., Kyte, M., Inaoka, D. K., Kita, K., Mackenzie, J. S., Steyn, A. J. C., Li, Z., Yan, M., Tian, G.-B., Zhang, T., Ding, X., Furkert, D. P., Brimble, M. A., Hickey, A. J. R. & McNeil, M. B. & 1 others, Cook, G. M., 13 Sept 2024, In: ACS Infectious Diseases. 10, 10, p. 3496-3515 20 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis

  Wang, X., Jowsey, W. J., Cheung, C.-Y., Smart, C. J., Klaus, H. R., Seeto, N. E. J., Waller, N. J. E., Chrisp, M. T., Peterson, A. L., Ofori-Anyinam, B., Strong, E., Nijagal, B., West, N. P., Yang, J. H., Fineran, P. C., Cook, G. M., Jackson, S. A. & McNeil, M. B., 13 Nov 2024, In: Nature Communications. 15, p. 1-18 18 p., 9791.

  Research output: Contribution to journal › Article › peer-review

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