Dr Victor H. Villar
Research Fellow (Liquid Biopsy/Novel Biomarkers)
Research areas
Metabolism and Biomarkers Lab
Our research is dedicated to identifying specific metabolic alterations in cancer to drive biomarker discovery and develop innovative therapeutic strategies. By utilizing LC-MS-based metabolomics, we explore potential biomarkers and therapeutic targets for Hepatocellular Carcinoma, Soft Tissue Sarcoma, and Esophageal Cancer. Our goal is to advance cancer diagnostics and treatment through a deeper understanding of tumor metabolism.
PhD supervision
- Keira Hughes
- Mark Kelly
Selected publications
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Open access
Breast cancer secretes anti-ferroptotic MUFAs anddepends on selenoprotein synthesis for metastasis
Ackermann , T., Shokry, E., Deshmukh, R., Anand, J., Galbraith, L. C. A., Mitchell, L., Rodriguez-Blanco, G., Villar, V. H., Sterken, B. A., Nixon, C., Zanivan, S., Blyth, K., Sumpton, D. & Tardito, S., 2024, In: Embo Molecular Medicine.Research output: Contribution to journal › Article › peer-review
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Current and Future Cancer Chemoprevention Strategies
Santibanez, J., Villar, V. & Echeverria, C., 19 May 2023. 5 p.Research output: Contribution to conference › Paper › peer-review
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Open access
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer
Villar, V., Allega, M., Deshmukh, R., Ackermann, T., Nakasone, M., Vande Voorde, J., Drake, T., Oetjen, J., Bloom, A., Nixon, C., Müller, M., May, S., Tan, E., Vereecke, L., Jans, M., Blancke, G., Murphy, D., Huang, D., Lewis, D. & Bird, T. & 4 others, , Mar 2023, In: Nature Chemical Biology. 19, 3, p. 292-304 13 p.Research output: Contribution to journal › Article › peer-review
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Transforming growth factor-β1 in cancer immunology: opportunities for immunotherapy
Villar, V. H., Subotički, T., Đikić, D., Mitrović-Ajtić, O., Simon, F. & Santibanez, J. F., 25 Apr 2023, Advances in molecular pathology. Simon, F. & Bernabeu, C. (eds.). Cham: Springer, Cham, p. 309-328 20 p. (Advances in experimental medicine and biology; vol. 1408).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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Open access
Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis
Taurino, G., Deshmukh, R., Villar, V. H., Chiu, M., Shaw, R., Hedley, A., Shokry, E., Sumpton, D., Dander, E., D'Amico, G., Bussolati, O. & Tardito, S., 1 Sept 2022, In: Molecular Metabolism. 63, 10 p., 101532.Research output: Contribution to journal › Article › peer-review
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Open access
The metabolic features of tumor-associated macrophages: opportunities for immunotherapy?
Mojsilovic, S. S., Mojsilovic, S., Villar, V. H. & Santibanez, J. F., 24 Aug 2021, In: Analytical Cellular Pathology. 2021, 12 p., 5523055.Research output: Contribution to journal › Review article › peer-review
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Open access
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Bodineau, C., Tomé, M., Courtois, S., Costa, A. S. H., Sciacovelli, M., Rousseau, B., Richard, E., Vacher, P., Parejo-Pérez, C., Bessede, E., Varon, C., Soubeyran, P., Frezza, C., Murdoch, P. D. S., Villar, V. H. & Durán, R. V., 10 Aug 2021, In: Nature Communications. 12, 13 p., 4814.Research output: Contribution to journal › Article › peer-review
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Open access
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
Hulme, H., Meikle, L. M., Strittmatter, N., van der Hooft, J. J. J., Swales, J., Bragg, R. A., Villar, V. H., Ormsby, M. J., Barnes, S., Brown, S. L., Dexter, A., Kamat, M. T., Komen, J. C., Walker, D., Milling, S., Osterweil, E. K., MacDonald, A. S., Schofield, C. J., Tardito, S. & Bunch, J. & 6 others, , 2020, In: Science Advances. 6, 11, eaax6328.Research output: Contribution to journal › Article › peer-review
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Nilotinib as coadjuvant treatment with doxorubicin in patients with sarcomas: A phase i trial of the Spanish group for research on sarcoma
Alemany, R., Moura, D. S., Redondo, A., Martinez-Trufero, J., Calabuig, S., Saus, C., Obrador-Hevia, A., Ramos, R., Villar, V. H., Valverde, C., Vaz, M. A., Medina, J., Felipe-Abrio, I., Hindi, N., Taron, M. & Martin-Broto, J., 1 Nov 2018, In: Clinical Cancer Research. 24, 21, p. 5239-5249 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
Villar, V. H., Nguyen, T. L., Terés, S., Bodineau, C. & Durán, R. V., 4 May 2017, In: Molecular and Cellular Oncology. 4, 3, e1297284.Research output: Contribution to journal › Article › peer-review