Research areas
The immune system relies on the ability to detect when cells are virally infected, or potentially tumorigenic, and to specifically eliminate these cells. This is achieved by the actions of Major Histocompatibility Complex (MHC) class I molecules, which bind small peptides from the proteolytic turnover of proteins in the cytoplasm, and present these peptides on the cell surface to T lymphocytes. Detection of viral, or non-self, peptides can stimulate the generation of potent anti-viral cytotoxic T lymphocyte responses.
PhD supervision
- Jason Corbett
- Debra Lennox
Selected publications
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Open access
Characterising the HLA-I Immunopeptidome of plasma-derived extracellular vesicles in patients with melanoma
Boyne, C. M., Coote, A., Synowsky, S. A., Naden, A. B., Shirran, S. L. & Powis, S. J., Mar 2024, In: Journal of Extracellular Biology. 3, 3, 12 p., e146.Research output: Contribution to journal › Article › peer-review
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Open access
EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders
Kuiper, J. J., Prinz, J. C., Stratikos, E., Kuśnierczyk, P., Arakawa, A., Springer, S., Mintoff, D., Padjen, I., Shumnalieva, R., Vural, S., Kötter, I., van de Sande, M. G., Boyvat, A., de Boer, J. H., Bertsias, G., de Vries, N., Krieckaert, C. L., Leal, I., Vidovič Valentinčič, N. & Tugal-Tutkun, I. & 21 others, , 1 Jul 2023, In: Annals of the Rheumatic Diseases. 82, 7, p. 887-896 10 p.Research output: Contribution to journal › Review article › peer-review
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Open access
High throughput hemogram of T cells using digital holographic microscopy and deep learning: Optics Continuum
Gupta, R. K., Hempler, N., Malcolm, G. P. A., Dholakia, K. & Powis, S. J., 9 Mar 2023, In: Optics Continuum. 2, 3, p. 670-682 13 p.Research output: Contribution to journal › Article › peer-review
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Open access
Intrinsic folding properties of the HLA-B27 heavy chain revealed by single chain trimer versions of peptide-loaded class I Major Histocompatibility Complex molecules
Lenart, I., Truong, L.-H., Nguyen, D. D., Rasiukienė, O., Tsao, E., Armstrong, J., Kumar, P., McHugh, K., Pereira, B. I., Maan, B. S., Garstka, M. A., Bowness, P., Blake, N., Powis, S. J., Gould, K., Nesbeth, D. & Antoniou, A. N., 25 Jul 2022, (E-pub ahead of print) In: Frontiers in Immunology. 13, 902135.Research output: Contribution to journal › Article › peer-review
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Open access
Salmonella exhibit altered cellular localization in the presence of HLA-B27 and codistribute with endo-reticular membrane
Kriston-Vizi, J., Lenart, I., Iwawaki, T., Gould, K., Nesbeth, D., Powis, S. J. & Antoniou, A. N., 16 Sept 2022, In: Journal of Immunology Research. 2022, p. 1-9 9 p., 9493019.Research output: Contribution to journal › Article › peer-review
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Open access
Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles
Kumar, P., Boyne, C., Brown, S. E., Qureshi, A., Thorpe, P. J., Synowsky, S. A., Shirran, S. L. & Powis, S. J., 1 Jun 2022, In: Immunology. 166, 2, p. 249-264 15 p., 13471.Research output: Contribution to journal › Article › peer-review
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Open access
Real-time imaging of cellular forces using optical interference
Meek, A. T., Kronenberg, N. M., Morton, A., Liehm, P., Murawski, J., Dalaka, E., Booth, J. H., Powis, S. J. & Gather, M. C., 11 Jun 2021, In: Nature Communications. 12, 11 p., 3552.Research output: Contribution to journal › Article › peer-review
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Open access
What is the role of HLA-I on cancer derived extracellular vesicles? Defining the challenges in characterisation and potential uses of this ligandome
Boyne, C., Lennox, D., Beech, O., Powis, S. J. & Kumar, P., 17 Dec 2021, In: International Journal of Molecular Sciences. 22, 24, 9 p., e13554.Research output: Contribution to journal › Article › peer-review
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Open access
Deep learning enabled laser speckle wavemeter with a high dynamic range
Gupta, R. K., Bruce, G. D., Powis, S. J. & Dholakia, K., Sept 2020, In: Laser & Photonics Reviews. 14, 9, 8 p., 2000120.Research output: Contribution to journal › Article › peer-review
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Open access
Robust estimation of bacterial cell count from optical density
iGEM Interlab Study Contributors, Melo Czekster, C. & Powis, S. J., 17 Sept 2020, In: Communications Biology. 3, 29 p., 512.Research output: Contribution to journal › Article › peer-review