Research areas
I'm a research fellow in Professor David Harrison's group, and my work primarily revolves around transcriptomic profiling of cancer. We utilise long-read sequencing techniques on various samples, including in-vitro cell lines, patient-derived tumouroids, and biopsies. Our particular focus lies in understanding drug-induced changes to RNA regulation within cancer cells. Employing various approaches including spatial transcriptomics and multiplex protein analysis, we aim to understand the RNA regulatory impact on protein expression and cellular phenotype.
PhD supervision
- Hazem Abdullah
- Minyeoung Kweon
- Etang Collins Etang
Selected publications
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Open access
Transcription factor NFE2L1 decreases in glomerulonephropathies after podocyte damage
Elshani, M., Um, I. H., Leung, S., Reynolds, P. A., Chapman, A., Kudsy, M. & Harrison, D. J., 29 Aug 2023, In: Cells. 12, 17, 2165.Research output: Contribution to journal › Article › peer-review
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Open access
NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells
Shahid, M. A., Um, I. H., Elshani, M., Zhang, Y. & Harrison, D. J., 15 Dec 2022, In: PLoS ONE. 17, 12, 13 p., e0278209.Research output: Contribution to journal › Article › peer-review
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Open access
Spatial analysis of NQO1 in non-small cell lung cancer shows its expression is independent of NRF1 and NRF2 in the tumor microenvironment
Kaghazchi, B., Um, I. H., Elshani, M., Read, O. J. & Harrison, D. J., 8 Nov 2022, In: Biomolecules. 12, 11, 16 p., 1652.Research output: Contribution to journal › Article › peer-review
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Open access
The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial
Schwenzer, H., De Zan, E., Elshani, M., van Stiphout, R., Kudsy, M., Morris, J., Ferrari, V., Um, I. H., Chettle, J., Kazmi, F., Campo, L., Easton, A., Nijman, S., Serpi, M., Symeonides, S., Plummer, R., Harrison, D. J., Bond, G. & Blagden, S. P., 8 Sept 2021, (E-pub ahead of print) In: Clinical Cancer Research. Early, 15 p.Research output: Contribution to journal › Article › peer-review
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Open access
Tissue-specific immunopathology in fatal COVID-19
ICECAP consortium, Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., Millar, T., Lerpiniere, C. E. B., Tagliavini, G., Hartley, C. S., Randle, N. P., Gachanja, N. N., Potey, P. M. D., Dong, X., Anderson, A. M., Campbell, V. L., Duguid, A. J., Al Qsous, W. & BouHaidar, R. & 9 others, , 15 Jan 2021, In: American Journal of Respiratory and Critical Care Medicine. 203, 2, p. 192-201Research output: Contribution to journal › Article › peer-review
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Open access
YAP translocation precedes cytoskeletal rearrangement in podocyte stress response: a podometric investigation of diabetic nephropathy
Haley, K., Elshani, M., Um, I. H., Bell, C., Caie, P. D., Harrison, D. J. & Reynolds, P. A., 15 Jul 2021, In: Frontiers in Physiology. 12, 10 p., 625762.Research output: Contribution to journal › Article › peer-review
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Open access
Podocyte injury elicits loss and recovery of cellular forces
Haley, K., Kronenberg, N. M., Liehm, P., Elshani, M., Bell, C., Harrison, D. J., Gather, M. C. & Reynolds, P. A., 27 Jun 2018, In: Science Advances. 4, 6, 9 p., eaap8030.Research output: Contribution to journal › Article › peer-review