Research areas
Professor John Zajicek trained in Medicine at Cambridge and St Mary’s Hospital in London. He completed a PhD in cell biology in Cambridge, moved to Plymouth in 1995 as a Consultant Neurologist, and took up the Chair of Clinical Neuroscience at Plymouth University. In Plymouth he was Director of the Peninsula Clinical Trials Unit, and Chair of the UK NIHR Nervous System Disorders Specialty Group. He has recently moved to the University of St Andrews, where he is Professor of Medicine. Zajicek has served on the UK MRC Neuroscience and Mental Health Board and the MRC Methodology Panel. He is particularly interested in the way we do trials for neurodegenerative diseases, has been Chief Investigator in several large multicentre randomized controlled trials, including the investigation of cannabinoid use to slow neurodegeneration. He has authored many papers on cannabinoids, multiple sclerosis and the methodology of clinical trials in neurodegeneration, including Alzheimer’s and Parkinson’s diseases.
Selected publications
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Open access
Evaluation of simvastatin as a disease-modifying treatment for patients with parkinson disease: a randomized clinical trial
Stevens, K. N., Creanor, S., Jeffrey, A., Whone, A., Foggo, A., Jones, B., Chapman, R., Cocking, L., Wilks, J., Webb, D., Carroll, C. & PD STAT Study Group, 1 Dec 2022, In: JAMA Neurology. 79, 12, p. 1232-1241 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Balance Right in Multiple Sclerosis (BRiMS): a feasibility randomised controlled trial of a falls prevention programme
Gunn, H., Stevens, K. N., Creanor, S., Andrade, J., Paul, L., Miller, L., Green, C., Ewings, P., Barton, A., Berrow, M., Vickery, J., Marshall, B., Zajicek, J. & Freeman, J. A., 4 Jan 2021, In: Pilot and Feasibility Studies. 7, 1, 2.Research output: Contribution to journal › Article › peer-review
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Open access
A self-management programme to reduce falls and improve safe mobility in people with secondary progressive MS: the BRiMS feasibility RCT
Gunn, H., Andrade, J., Paul, L., Miller, L., Creanor, S., Stevens, K., Green, C., Ewings, P., Barton, A., Berrow, M., Vickery, J., Marshall, B., Zajicek, J. P. & Freeman, J., 1 Jun 2019, In: Health Technology Assessment. 23, 27, p. 1-166Research output: Contribution to journal › Article › peer-review
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Open access
Assessment of a home-based standing frame programme in people with progressive multiple sclerosis (SUMS): a pragmatic, multi-centre, randomised, controlled trial and cost-effectiveness analysis
Freeman, J. A., Hendrie, W., Jarrett, L., Hawton, A., Barton, A., Dennett, R., Jones, B., Zajicek, J. P. & Creanor, S., Aug 2019, In: Lancet Neurology. 18, 8, p. 736-747Research output: Contribution to journal › Article › peer-review
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Open access
Simvastatin as a neuroprotective treatment for Parkinson's disease (PD STAT): protocol for a double-blind, randomised, placebo-controlled futility study
Carroll, C. B., Webb, D., Stevens, K. N., Vickery, J., Eyre, V., Ball, S., Wyse, R., Webber, M., Foggo, A., Zajicek, J., Whone, A. & Creanor, S., 7 Oct 2019, In: BMJ Open. 9, 10, 11 p., e029740.Research output: Contribution to journal › Article › peer-review
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Open access
Improving the quality of cognitive screening assessments: ACEmobile, an iPad-based version of the Addenbrooke's Cognitive Examination-III
Newman, C. G. J., Bevins, A. D., Zajicek, J. P., Hodges, J. R., Vuillermoz, E., Dickenson, J. M., Kelly, D. S., Brown, S. & Noad, R. F., 2018, In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 10, p. 182-187 6 p.Research output: Contribution to journal › Article › peer-review
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Open access
Machine-learning based identification of undiagnosed dementia in primary care: a feasibility study
Jammeh, E. A., Carroll, C. B., Pearson, S. W., Escudero, J., Anastasiou, A., Zhao, P., Chenore, T., Zajicek, J. & Ifeachor, E., 12 Jun 2018, In: BJGP Open. 2, 2, 13 p., bjgpopen18X101589.Research output: Contribution to journal › Article › peer-review
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Open access
Balance Right in Multiple Sclerosis (BRiMS): a guided self-management programme to reduce falls and improve quality of life, balance and mobility in people with secondary progressive multiple sclerosis: a protocol for a feasibility randomised controlled trial
Gunn, H., Andrade, J., Paul, L., Miller, L., Creanor, S., Green, C., Marsden, J., Ewings, P., Berrow, M., Vickery, J., Barton, A., Marshall, B., Zajicek, J. & Freeman, J. A., 27 Jul 2017, In: Pilot and Feasibility Studies. 4, 12 p., 26.Research output: Contribution to journal › Article › peer-review
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Open access
A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer’s disease and Parkinson’s disease
McGhee, D. J. M., Ritchie, C. W., Zajicek, J. P. & Counsell, C. E., 16 Jun 2016, In: BMC Neurology. 16, p. 1-13 13 p., 92.Research output: Contribution to journal › Article › peer-review
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Open access
Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis
Zeissler, M-L., Eastwood, J., McCorry, K., Hanemann, C. O., Zajicek, J. P. & Carroll, C. B., 27 Jun 2016, In: Oncotarget. 7, 29, p. 46603-46614 12 p.Research output: Contribution to journal › Article › peer-review