Miss Greice Zickuhr
Technician (Discipline & Hopping Fellow)
Research areas
PhD student with Professor David Harrison and Dr Alison Dickson developing a multi-modal imaging workflow by applying Mass spectrometry Imaging, Histology and Immunolabeling on a single human tissue section to study the metabolic crosstalk in the tumour microenvironment of clear cell Renal Cell Carcinoma (ccRCC).
Selected publications
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Open access
Probing the human 4-oxo-L-proline reductase-catalysed reaction by deuterium kinetic and equilibrium isotope effects
Pečaver, E., Kabu, M., Zickuhr, G. M., Harrison, D. J. & da Silva, R. G., 4 Aug 2026, In: Biochemistry. 65, 15, p. 2419-2430 12 p.Research output: Contribution to journal › Article › peer-review
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Open access
Improved nucleoside (2'-deoxy)ribosyltransferases maximize enzyme promiscuity while maintaining catalytic efficiency
Tang, P., Zickuhr, G. M., Dickson, A. L., Harding, C. J., Devi, S., Lebl, T., Harrison, D. J., da Silva, R. G. & Melo Czekster, C., 21 Nov 2025, In: ACS Chemical Biology. 20, 11, p. 2547–2553 7 p.Research output: Contribution to journal › Letter › peer-review
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Open access
Kidney tumoroid characterisation by spatial mass spectrometry with same-section multiplex immunofluorescence uncovers tumour microenvironment lipid signatures associated with aggressive tumour phenotypes
Abdullah, H., Zickuhr, G. M., Um, I. H., Laird, A., Mullen, P., Harrison, D. J. & Dickson, A. L., 16 Sept 2025, In: npj Imaging. 3, p. 1-11 11 p., 43.Research output: Contribution to journal › Article › peer-review
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Open access
Kinetic and thermodynamic characterization of human 4-oxo-L-proline reductase catalysis
Pecaver, E., Zickuhr, G. M., Machado, T. F. G., Harrison, D. J. & da Silva, R. G., 18 Feb 2025, In: Biochemistry. 64, 4, p. 860-870 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Defining the mode of action of cisplatin combined with NUC-1031, a phosphoramidate modification of gemcitabine
Patel, D., Dickson, A., Zickuhr, G. M., Um, I. H., Read, O. J., Melo Czekster, C., Mullen, P., Harrison, D. J. & Bre, J. L., 1 Dec 2024, In: Translational Oncology. 50, 11 p., 102114.Research output: Contribution to journal › Article › peer-review
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Open access
DESI-MSI-guided exploration of metabolic-phenotypic relationships reveals a correlation between PI 38:3 and proliferating cells in clear cell renal cell carcinoma via single-section co-registration of multimodal imaging
Zickuhr, G. M., Um, I. H., Laird, A., Harrison, D. J. & Dickson, A., Jul 2024, In: Analytical and Bioanalytical Chemistry. 416, 18, p. 4015–4028 14 p.Research output: Contribution to journal › Article › peer-review
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Open access
Antibiotics under our feet
Cornwell, R. M., Melo Czekster, C., Gibeily, C., Ionescu, D., Harper, S., Kennedy, M., Sutherland, E. J., Simpson, M. C., Easton, E., Vaughan, R., Jones, C. E., Lynch, R., Yong, E., Athukoralage, J. S., Hogrel, G., Zickuhr, G. M., Hynes, J., Williams, R.-J., Ross, K. S. & Kruger, L. & 9 others, , 24 Apr 2023, University of St Andrews.Research output: Other contribution
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Open access
Human 2'-deoxynucleoside 5'-phosphate N-hydrolase 1: mechanism of 2'-deoxyuridine 5'-monophosphate hydrolysis
Devi, S., Carberry, A. E., Zickuhr, G. M., Dickson, A., Harrison, D. J. & da Silva, R. G., 5 Sept 2023, In: Biochemistry. 62, 17, p. 2658-2668 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent
Bré, J. L., Dickson, A., Read, O. J., Zhang, Y., McKissock, F. G., Mullen, P., Tang, P., Zickuhr, G. M., Melo Czekster, C. & Harrison, D. J., 31 Mar 2023, In: Cancer Chemotherapy and Pharmacology. 12 p.Research output: Contribution to journal › Article › peer-review