Dr Derek Sloan
Senior Lecturer/Consultant in Infectious Diseases
Research areas
I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.
My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.
I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.
Year |
My role |
Funding source |
|
2016-2019 |
Co-investigator |
EDCTP HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV |
|
2015-2018 |
Supervisor/ Advisor |
Commonwealth PhD Scholarship/ Epistem Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi) |
|
2015-2018 |
Primary Supervisor |
Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum |
|
2015-2017 |
Principal Investigator |
British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi |
|
2015-2017 |
Principal Investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes |
|
2015-2017 |
Co-investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Rational development of an optimal treatment regimen for isoniazid mono-resistant TB |
|
2010-2012 |
Co-investigator & collaborator |
Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza |
|
2008-2012 |
Principal Investigator |
Wellcome Trust Clinical PhD Fellowship |
|
2008 |
Principal Investigator |
LSTM Equipment Grant (Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory) |
PhD supervision
- Eva Agnes Laker Odongpiny
- Katherine Hill
- Marios Zachariou
- Hellen Onyango
- Joanna Rivas
- Ritah Nakiboneka
Selected publications
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Open access
Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa
Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J., Sloan, D. J., & 7 others , 15 Feb 2024, Rochester, NY: SSRN, 26 p.Research output: Working paper › Preprint
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Open access
Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action
Maldonado-Barragán, A., Mshana, S. E., Keenan, K., Ke, X., Gillespie, S. H., Stelling, J., Maina, J., Bazira, J., Muhwezi, I., Mushi, M. F., Green, D. L., Kesby, M., Lynch, A. G., Sabiiti, W., Sloan, D. J., Sandeman, A., Kiiru, J., Asiimwe, B. & Holden, M. T. G., Feb 2024, In: JAC-Antimicrobial Resistance. 6, 1, 11 p., dlae019.Research output: Contribution to journal › Article › peer-review
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Open access
Treatment seeking and antibiotic use for urinary tract infection symptoms in the time of COVID-19 in Tanzania and Uganda
Olamijuwon, E. O., Keenan, K. L., Mushi, M. F., Kansiime, C., Konje, E. T., Kesby, M., Neema, S., Asiimwe, B., Mshana, S. E., Fredricks, K. J., Sunday, B., Bazira, J., Sandeman, A. F., Sloan, D. J., Mwanga, J. R., Sabiiti, W., Holden, M. & CARE Consortium, 19 Jan 2024, (E-pub ahead of print) In: Journal of Global Health. 14, 10 p., 05007.Research output: Contribution to journal › Article › peer-review
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Open access
Treatment seeking behaviours, antibiotic use and relationships to multi-drug resistance: a study of urinary tract infection patients in Kenya, Tanzania and Uganda
Sado, K., Keenan, K., Manataki, A., Kesby, M., Mushi, M. F., Mshana, S. E., Mwanga, J. R., Neema, S., Asiimwe, B., Bazira, J., Kiiru, J., Green, D. L., Ke, X., Maldonado-Barragán, A., Abed Al Ahad, M., Fredricks, K. J., Gillespie, S. H., Sabiiti, W., Mmbaga, B. T., Kibiki, G., & 6 others , 16 Feb 2024, In: PLOS Global Public Health. 4, 2, 20 p., e0002709.Research output: Contribution to journal › Article › peer-review
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Open access
Antibiotic dispensing practices during COVID-19 and implications for antimicrobial resistance (AMR): parallel mystery client studies in Uganda and Tanzania
Olamijuwon, E., Konje, E., Kansiime, C., Kesby, M., Keenan, K., Neema, S., Asiimwe, B., Mshana, S. E., Mushi, M. F., Loza, O., Sunday, B., Sandeman, A., Sloan, D. J., Benitez-Paez, F., Mwanga, J. R., Sabiiti, W., Holden, M. T. G. & CARE Consortium, 11 Feb 2023, In: Antimicrobial Resistance & Infection Control. 12, 1, 14 p., 10.Research output: Contribution to journal › Article › peer-review
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Open access
Automated methods for tuberculosis detection/diagnosis: a literature review
Zachariou, M., Arandelovic, O. & Sloan, D. J., 1 Sept 2023, In: BioMedInformatics. 3, 3Research output: Contribution to journal › Literature review › peer-review
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Decreased dolutegravir and efavirenz concentrations with preserved virological suppression in patients with TB and HIV receiving high-dose rifampicin
Sekaggya-Wiltshire, C., Nabisere, R., Musaazi, J., Otaalo, B., Aber, F., Alinaitwe, L., Nampala, J., Najjemba, L., Buzibye, A., Omali, D., Gausi, K., Kengo, A., Lamorde, M., Aarnoutse, R., Denti, P., Dooley, K. E. & Sloan, D. J., 1 Feb 2023, In: Clinical Infectious Diseases. 76, 3, p. e910-e919 10 p.Research output: Contribution to journal › Article › peer-review
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Dolutegravir pharmacokinetics in Ugandan patients with TB and HIV receiving standard- versus high-dose rifampicin
Kengo, A., Nabisere, R., Gausi, K., Musaazi, J., Buzibye, A., Omali, D., Aarnoutse, R., Lamorde, M., Dooley, K. E., Sloan, D. J., Denti, P. & Sekaggya-Wiltshire, C., Nov 2023, In: Antimicrobial Agents and Chemotherapy. 67, 11, 14 p.Research output: Contribution to journal › Article › peer-review
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Localization and phenotyping of tuberculosis bacteria using a combination of deep learning and SVMs
Zachariou, M., Arandjelovic, O., Dombay, E., Sabiiti, W., Mtafya, B., Ntinginya, NE. & Sloan, DJ., Dec 2023, In: Computers in Biology and Medicine. 167, 13 p., 107573.Research output: Contribution to journal › Article › peer-review
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Open access
Forgiveness is the attribute of the strong: nonadherence and regimen-shortening in drug-sensitive TB
Stagg, H. R., Thompson, J. A., Lipman, M. C. I., Sloan, D. J., Flook, M. & Fielding, K. L., 15 Jan 2023, In: American Journal of Respiratory and Critical Care Medicine. 207, 2, p. 193-205 13 p.Research output: Contribution to journal › Article › peer-review