Prof Andy Lynch
Professor of Statistics in Bioscience
Biography
Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.
Research areas
Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma, Oesophageal, Breast, Renal, Ovarian and Lung).
PhD supervision
- Katie O'Neill
- Bruin Snow
Selected publications
-
Hypoxia spurs evolution of aggressive prostate cancer
Pan Prostate Cancer Group (PPCG), 4 Sept 2026, In: Nature Communications.Research output: Contribution to journal › Article › peer-review
-
Open access
Recurrent mechanisms of biallelic epigenetic inactivation reveal new putative tumour suppressor genes in prostate cancer
Pan Prostate Cancer Group (PPCG), Kiriy, D., Favero, F., Gerhäuser, C., Heilmann, J., Lutsik, P., Gonzalez, F. G. R., Locallo, A., Jespersen, J. S., Gruber, A. J., Olsen, A. V., Hernando, B., Cheng, K. C. L., Pellegrina, D., Macintyre, G., Bova, G. S., Brewer, D. S., Bristow, R. G., Brook, M. N. & Brors, B. & 29 others, , Dec 2026, In: Nature Communications. 17, 1, 9646.Research output: Contribution to journal › Article › peer-review
-
Open access
Modelling interventions to combat antibacterial resistance in East Africa using causal Bayesian networks
Ke, X., Smith, V. A., Mshana, S. E., Asiimwe, B., Neema, S., Kiiru, J., Mushi, M. F., Mmbaga, B. T., Mwanga, J. R., Kibiki, G., Stelling, J., Gillespie, S. H., Green, D. L., Benvari, S., Sabiiti, W., Kesby, M., Lynch, A. G., Sandeman, A., Sloan, D. J. & Holden, M. T. & 2 others, , 4 Feb 2025, Research Square.Research output: Working paper › Preprint
-
Open access
Patterns of antibiotic resistance in urinary tract infections before and during the COVID-19 pandemic in Uganda and Tanzania
Silago, V., Keenan, K., Mushi, M. F., Kansiime, C., Asiimwe, B., Sunday, B., Bazira, J., Sandeman, A., Sabiiti, W., Seni, J., Holden, M. T. G., Mshana, S. E. & behalf of the HATUA and CARE Consortia, Apr 2025, In: JAC-Antimicrobial Resistance. 7, 2, p. 1-4 4 p., dlaf038.Research output: Contribution to journal › Article › peer-review
-
Open access
Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa
Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J. & Sloan, D. J. & 7 others, , 15 Feb 2024, Rochester, NY: SSRN, 26 p. (Preprints with The Lancet).Research output: Working paper › Preprint
-
Open access
Genomic evolution shapes prostate cancer disease type
CRUK-ICGC Prostate Group, Woodcock, D. J., Sahli, A., Teslo, R., Bhandari, V., Gruber, A. J., Ziubroniewicz, A., Gundem, G., Xu, Y., Butler, A., Anokian, E., Pope, B. J., Jung, C.-H., Tarabichi, M., Dentro, S. C., Farmery, J. H. R., Van Loo, P., Warren, A. Y., Gnanapragasam, V. & Hamdy, F. C. & 16 others, , 13 Mar 2024, (E-pub ahead of print) In: Cell Genomics. 4, 13, 31 p., 100511.Research output: Contribution to journal › Article › peer-review
-
Open access
Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use
Keenan, K. L., Papathomas, M., Mshana, S., Asiimwe, B., Kiiru, J., Lynch, A., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Jing, W., Green, D. L., Olamijuwon, E. O., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiiti, W., Bazira, J. & Sloan, D. J. & 8 others, , 31 Oct 2024, In: Nature Communications. 15, 11 p., 9418.Research output: Contribution to journal › Article › peer-review
-
Open access
Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action
Maldonado-Barragán, A., Mshana, S. E., Keenan, K., Ke, X., Gillespie, S. H., Stelling, J., Maina, J., Bazira, J., Muhwezi, I., Mushi, M. F., Green, D. L., Kesby, M., Lynch, A. G., Sabiiti, W., Sloan, D. J., Sandeman, A., Kiiru, J., Asiimwe, B. & Holden, M. T. G., Feb 2024, In: JAC-Antimicrobial Resistance. 6, 1, 11 p., dlae019.Research output: Contribution to journal › Article › peer-review
-
Open access
Prostate cancer detection through unbiased capture of methylated cell-free DNA
Lleshi, E., Milne-Clark, T., Lee Yu, H., Martin, H. W., Hanson, R., Lach, R., Rossi, S. H., Riediger, A. L., Görtz, M., Sültmann, H., Flewitt, A., Lynch, A. G., Gnanapragasam, V. J., Massie, C. E. & Dev, H. S., 20 Jun 2024, (E-pub ahead of print) In: iScience. 27, 7, 17 p., 110330.Research output: Contribution to journal › Article › peer-review
-
Open access
Ultra-sensitive detection of circulating tumour DNA enriches for patients with greater risk of recurrence in clinically localised prostate cancer
Pope, B., Park, G., Lau, E., Belic, J., Lach, R., George, A., McCoy, P., Nguyen, A., Grima, C., Campbell, B., Jung, C.-H., Ditter, E.-J., Zhao, H., Wedge, D., Brewer, D., Lynch, A., Dev, H., Gnanpragasam, V., Rosenfeld, N. & Hovens, C. & 3 others, , 1 Apr 2024, In: European Urology. 85, 4, p. 407-410 4 p.Research output: Contribution to journal › Letter › peer-review