Prof Andy Lynch

Prof Andy Lynch

Professor of Statistics in Bioscience

Researcher profile

Phone
+44 (0)1334 46 3700
Email
andy.lynch@st-andrews.ac.uk

 

Biography

Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.

Research areas

Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma,  Oesophageal, Breast, Renal, Ovarian and Lung). 

PhD supervision

  • Victor Velasco Pardo
  • Naici Guo
  • Katherine O'Neill
  • Xiaoyue Yang

Selected publications

  • Open access

    Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa

     Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J., Sloan, D. J., & 7 others Mmbaga, B. T., Kibiki, G., Stelling, J., Smith, V. A., Sandeman, A., Holden, M. T. G. & HATUA Consortium, 15 Feb 2024, Rochester, NY: SSRN, 26 p.

    Research output: Working paper › Preprint

  • Open access

    Genomic evolution shapes prostate cancer disease type

    CRUK-ICGC Prostate Group, Woodcock, D. J., Sahli, A., Teslo, R., Bhandari, V., Gruber, A. J., Ziubroniewicz, A., Gundem, G., Xu, Y., Butler, A., Anokian, E., Pope, B. J., Jung, C-H., Tarabichi, M., Dentro, S. C., Farmery, J. H. R., Van Loo, P., Warren, A. Y., Gnanapragasam, V., Hamdy, F. C., & 16 others Bova, G. S., Foster, C. S., Neal, D. E., Lu, Y-J., Kote-Jarai, Z., Bristow, R. G., Boutros, P. C., Costello, A. J., Corcoran, N. M., Hovens, C. M., Massie, C. E., Lynch, A. G., Brewer, D. S., Eeles, R. A., Cooper, C. S. & Wedge, D. C., 13 Mar 2024, (E-pub ahead of print) In: Cell Genomics. 4, 13, 31 p., 100511.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action

     Maldonado-Barragán, A., Mshana, S. E., Keenan, K., Ke, X., Gillespie, S. H., Stelling, J., Maina, J., Bazira, J., Muhwezi, I., Mushi, M. F., Green, D. L., Kesby, M., Lynch, A. G., Sabiiti, W., Sloan, D. J., Sandeman, A., Kiiru, J., Asiimwe, B. & Holden, M. T. G., Feb 2024, In: JAC-Antimicrobial Resistance. 6, 1, 11 p., dlae019.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Ultra-sensitive detection of circulating tumour DNA enriches for patients with greater risk of recurrence in clinically localised prostate cancer

    Pope, B., Park, G., Lau, E., Belic, J., Lach, R., George, A., McCoy, P., Nguyen, A., Grima, C., Campbell, B., Jung, C., Ditter, E-J., Zhao, H., CR-UK/Prostate Cancer UK, ICGC, The PPCG, Wedge, D., Brewer, D., Lynch, A., Dev, H., Gnanpragasam, V., Rosenfeld, N., & 3 others Hovens, C., Corcoran, N. & Massie, C., 19 Feb 2024, (E-pub ahead of print) In: European Urology. In Press, 4 p.

    Research output: Contribution to journal › Letter › peer-review

  • Open access

    The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda

     Green, D. L., Keenan, K., Fredricks, K. J., Huque, S. I., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Kesby, M., Lynch, A. G., Worthington, H., Olamijuwon, E., Abed Al Ahad, M., Aduda, A., Njeru, J. M., Mmbaga, B. T., Bazira, J., & 14 others Sandeman, A., Stelling, J., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Holden, M. T. G., Smith, V. A., Decano, A. G., Maldonado-Barragán, A., Aanensen, D., Ntinginya, N. E., Elliott, A. & Clarkson, M., 1 Jan 2023, In: The Lancet Global Health. 11, 1, p. e59-e68 10 p.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Unravelling patient pathways in the context of antibacterial resistance in East Africa

    HATUA Consortium, Keenan, K., Fredricks, K. J., Al Ahad, M. A., Neema, S., Mwanga, J. R., Kesby, M., Mushi, M. F., Aduda, A., Green, D. L., Lynch, A. G., Huque, S. I., Mmbaga, B. T., Worthington, H., Kansiime, C., Olamijuwon, E., Ntinginya, N. E., Loza, O., Bazira, J., Maldonado-Barragán, A., & 15 others Smith, VA., Decano, A. G., Njeru, J. M., Sandeman, A., Stelling, J., Elliott, A., Aanensen, D., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Asiimwe, B. B., Kiiru, J., Mshana, S. E. & Holden, M. T. G., 19 Jun 2023, In: BMC Infectious Diseases. 23, 1, 12 p., 414.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

     Guo, N., Minas, G., Synowsky, S. A., Dunne, M. R., Ahmed, H., McShane, R., Bhardwaj, A., Donlon, N. E., Lorton, C., O'Sullivan, J., Reynolds, J. V., Caie, P. D., Shirran, S. L., Lynch, A., Stewart, A. J. & Arya, S., 30 Aug 2022, In: Journal of Proteomics. 266, 11 p., 104684.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Low-cost and clinically applicable copy number profiling using repeat DNA

     Abujudeh, S., Zeki, S., van Lanshot, M., Pusang, M., Weaver, J., li, X., Noorani, A., Metz, A., Bornschein, J., Bower, L., Miremedi, A., Fitzgerald, R., Morrissey, E. & Lynch, A., 17 Aug 2022, In: BMC Genomics. 23, 599.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Microbiomes of urine and the prostate are linked to human prostate cancer risk groups

    Hurst, R., Meader, E., Gihawi, A., Rallapalli, G., Clark, J., Kay, G. L., Webb, M., Manley, K., Curley, H., Walker, H., Kumar, R., Schmidt, K., Crossman, L., Eeles, R. A., Wedge, D. C., Lynch, A. G., Massie, C. E., CRUK-ICGC Prostate Group, Yazbek-Hanna, M., Rochester, M., & 8 others Mills, R. D., Mithen, R. F., Traka, M. H., Ball, R. Y., O'Grady, J., Brewer, D. S., Wain, J. & Cooper, C. S., 1 Aug 2022, In: European Urology Oncology. 5, 4, p. 412-419 8 p.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    PCR duplicate proportion estimation and consequences for DNA copy number calculations

     Lynch, A., Smith, M., Eldridge, M. & Tavaré, S., 29 Nov 2022, Recent developments in statistics and data science: SPE2021, Évora, Portugal, October 13–16. Bispo, R., Henriques-Rodrigues, L., Alpizar-Jara, R. & de Carvalho, M. (eds.). Cham: Springer, Vol. 398. p. 259-279 21 p. (Springer proceedings in mathematics & statistics; vol. 398).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

 

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