Prof Andy Lynch

Professor

Researcher profile

Phone

+44 (0)1334 46 3700

Email

andy.lynch@st-andrews.ac.uk

Office

218 MI

Location

Mathematical Institute

 

Biography

Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.

Research areas

Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma,  Oesophageal, Breast, Renal, Ovarian and Lung). 

Selected publications

• Open access

  Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa

  Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J. & Sloan, D. J. & 7 others, Mmbaga, B. T., Kibiki, G., Stelling, J., Smith, V. A., Sandeman, A., Holden, M. T. G. & HATUA Consortium, 15 Feb 2024, Rochester, NY: SSRN, 26 p.

  Research output: Working paper › Preprint

• Open access

  Genomic evolution shapes prostate cancer disease type

  CRUK-ICGC Prostate Group, Woodcock, D. J., Sahli, A., Teslo, R., Bhandari, V., Gruber, A. J., Ziubroniewicz, A., Gundem, G., Xu, Y., Butler, A., Anokian, E., Pope, B. J., Jung, C.-H., Tarabichi, M., Dentro, S. C., Farmery, J. H. R., Van Loo, P., Warren, A. Y., Gnanapragasam, V. & Hamdy, F. C. & 16 others, Bova, G. S., Foster, C. S., Neal, D. E., Lu, Y.-J., Kote-Jarai, Z., Bristow, R. G., Boutros, P. C., Costello, A. J., Corcoran, N. M., Hovens, C. M., Massie, C. E., Lynch, A. G., Brewer, D. S., Eeles, R. A., Cooper, C. S. & Wedge, D. C., 13 Mar 2024, (E-pub ahead of print) In: Cell Genomics. 4, 13, 31 p., 100511.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use

  Keenan, K. L., Papathomas, M., Mshana, S., Asiimwe, B., Kiiru, J., Lynch, A., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Jing, W., Green, D. L., Olamijuwon, E. O., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiiti, W., Bazira, J. & Sloan, D. J. & 8 others, HATUA Consortium, Kibiki, G., Mmbaga, B. T., Aanensen, D., Stelling, J., Smith, V. A., Sandeman, A. & Holden, M., 31 Oct 2024, In: Nature Communications. 15, 11 p., 9418.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action

  Maldonado-Barragán, A., Mshana, S. E., Keenan, K., Ke, X., Gillespie, S. H., Stelling, J., Maina, J., Bazira, J., Muhwezi, I., Mushi, M. F., Green, D. L., Kesby, M., Lynch, A. G., Sabiiti, W., Sloan, D. J., Sandeman, A., Kiiru, J., Asiimwe, B. & Holden, M. T. G., Feb 2024, In: JAC-Antimicrobial Resistance. 6, 1, 11 p., dlae019.

  Research output: Contribution to journal › Article › peer-review

• Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use

  HATUA Consortium, 31 Oct 2024, In: Nature Communications. 15, 1, p. 9418

  Research output: Contribution to journal › Article › peer-review

• Open access

  Prostate cancer detection through unbiased capture of methylated cell-free DNA

  Lleshi, E., Milne-Clark, T., Lee Yu, H., Martin, H. W., Hanson, R., Lach, R., Rossi, S. H., Riediger, A. L., Görtz, M., Sültmann, H., Flewitt, A., Lynch, A. G., Gnanapragasam, V. J., Massie, C. E. & Dev, H. S., 20 Jun 2024, (E-pub ahead of print) In: iScience. 27, 7, 17 p., 110330.

  Research output: Contribution to journal › Article › peer-review

• Ultrasensitive Detection of Circulating Tumour DNA enriches for Patients with a Greater Risk of Recurrence of Clinically Localised Prostate Cancer

  Pan Prostate Cancer Group (PPCG), 19 Feb 2024, In: European Urology. 85, 4, p. 407-410 4 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Ultra-sensitive detection of circulating tumour DNA enriches for patients with greater risk of recurrence in clinically localised prostate cancer

  Pope, B., Park, G., Lau, E., Belic, J., Lach, R., George, A., McCoy, P., Nguyen, A., Grima, C., Campbell, B., Jung, C.-H., Ditter, E.-J., Zhao, H., Wedge, D., Brewer, D., Lynch, A., Dev, H., Gnanpragasam, V., Rosenfeld, N. & Hovens, C. & 3 others, Corcoran, N., Massie, C. & CR-UK/Prostate Cancer UK, ICGC, The PPCG, 1 Apr 2024, In: European Urology. 85, 4, p. 407-410 4 p.

  Research output: Contribution to journal › Letter › peer-review

• Open access

  The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda

  Green, D. L., Keenan, K., Fredricks, K. J., Huque, S. I., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Kesby, M., Lynch, A. G., Worthington, H., Olamijuwon, E., Abed Al Ahad, M., Aduda, A., Njeru, J. M., Mmbaga, B. T. & Bazira, J. & 14 others, Sandeman, A., Stelling, J., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Holden, M. T. G., Smith, V. A., Decano, A. G., Maldonado-Barragán, A., Aanensen, D., Ntinginya, N. E., Elliott, A. & Clarkson, M., 1 Jan 2023, In: The Lancet Global Health. 11, 1, p. e59-e68 10 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Unravelling patient pathways in the context of antibacterial resistance in East Africa

  HATUA Consortium, Keenan, K., Fredricks, K. J., Al Ahad, M. A., Neema, S., Mwanga, J. R., Kesby, M., Mushi, M. F., Aduda, A., Green, D. L., Lynch, A. G., Huque, S. I., Mmbaga, B. T., Worthington, H., Kansiime, C., Olamijuwon, E., Ntinginya, N. E., Loza, O., Bazira, J. & Maldonado-Barragán, A. & 15 others, Smith, V., Decano, A. G., Njeru, J. M., Sandeman, A., Stelling, J., Elliott, A., Aanensen, D., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Asiimwe, B. B., Kiiru, J., Mshana, S. E. & Holden, M. T. G., 19 Jun 2023, In: BMC Infectious Diseases. 23, 1, 12 p., 414.

  Research output: Contribution to journal › Article › peer-review

 

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