Prof David O'Hagan
Professor
Biography
Professor David O'Hagan was born in Glasgow and studied chemistry at the University of Glasgow (1982). He carried out a Ph.D (1985) in polyketide antibiotic biosynthesis at the University of Southampton with Professor John A Robinson and then he spent a postdoctoral year at the Ohio State University with Professor Heinz G. Floss, investigating peptide antibiotic biosynthesis. In 1986 he was appointed to the University of Durham where he continued to explore natural product biosynthesis but also developed a strong interest in organo-fluorine chemistry. He remained at Durham until 2000 before moving to his current position as Professor and Head of Organic Chemistry at the University of St Andrews. His research interests extend from the synthesis and properties of organo-fluorine compounds, fluorination enzymology, fluorine-18 chemistry for positron emission tomography (PET) and through to fluorinated organic materials.
He was a founding member and a past Chair of the RSC Fluorine Group. He was awarded the IChemE, 'Judges Award' for fluorinase enzyme isolation in 2002, was elected FRSE in 2004, was awarded the RSC Malcolm Campbell Memorial Prize in Medicinal Chemistry in 2005, was a recipient of the RSC Tilden Medal in 2006/2007, was the RSC 'Natural Product Reports Award' Lecturer in 2009, was awarded the American Chemical Society (ACS) Award for 'Creative Work in Fluorine Chemistry' in 2012, was awarded a Royal Society Wolfson Merit Award in 2013 and was awarded the RSC Organic Stereochemistry award in 2015.
In 2018 David was awarded the Moissan Prize, which is awarded every three years by the Fondation de la Maison de la Chime in Paris for contributions to fluorine chemistry.
PhD supervision
- Yohann Renault
- Luca Dobson
- Thomas Poskin
- Mengfan He
- Dominic Spurling
- Josephine Stewart
Selected publications
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Open access
4′-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics
Lowe, P. T. & O’Hagan, D., 7 Jan 2023, In: Chemical Society Reviews. 52, 1, p. 248-276 29 p.Research output: Contribution to journal › Review article › peer-review
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Contribution of hyperconjugation and inductive effects to the pseudo-anomeric effect in 4-substituted methoxycyclohexanes
Piscelli, B. A., O’Hagan, D. & Cormanich, R. A., 26 Jan 2023, In: Journal of Physical Chemistry A. 127, 3, p. 724–728 5 p.Research output: Contribution to journal › Article › peer-review
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Open access
Does perdeuteration increase the polarity of Janus face cycloalkanes?
Fang, Z., Yu, C., Bühl, M. & O'Hagan, D., 20 Feb 2023, In: Helvetica Chimica Acta. 106, 2, 5 p., e202200177.Research output: Contribution to journal › Article › peer-review
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Open access
Identification of genes essential for fluorination and sulfamylation within the nucleocidin gene clusters of Streptomyces calvus and Streptomyces virens
Wojnowska, M., Feng, X., Chen, Y., Deng, H. & O'Hagan, D., 28 Feb 2023, In: ChemBioChem. 24, 5, 9 p., e202200684.Research output: Contribution to journal › Article › peer-review
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Open access
Janus faced fluorocyclohexanes for supramolecular assembly: synthesis and solid state structures of equatorial mono-, di- and tri alkylated cyclohexanes and with tri-axial C–F bonds to impart polarity
Poskin, T. J., Piscelli, B. A., Yoshida, K., Cordes, D. B., Slawin, A. M. Z., Cormanich, R. A., Yamada, S. & O'Hagan, D., 21 Jul 2022, In: Chemical Communications. 58, 57, p. 7968-7971 4 p.Research output: Contribution to journal › Article › peer-review
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Open access
Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro
Kittilä, T., Calero, P., Fredslund, F., Lowe, P. T., Tezé, D., Nieto-Domínguez, M., O’Hagan, D., Nikel, P. I. & Welner, D. H., 27 Jan 2022, (E-pub ahead of print) In: Microbial Biotechnology. Early View, 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Selectively fluorinated citronellol analogues support a hydrogen bonding donor interaction with the human OR1A1 olfactory receptor
He, M., Liu, W., Zhang, C., Liu, Y., Zhuang, H. & O'Hagan, D., 10 Jun 2022, (E-pub ahead of print) In: Organic Letters. Articles ASAP, 6 p.Research output: Contribution to journal › Article › peer-review
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Open access
Unexpected triaxial preferences in some all-syn 1,3,5-trifluorocyclohexanes
Yu, C., Piscelli, B. A., Maharik, N. A., Cordes, D. B., Slawin, A. M. Z., Cormanich, R. A. & O'Hagan, D., 28 Nov 2022, In: Chemical Communications. 58, 92, p. 12855-12858 4 p.Research output: Contribution to journal › Article › peer-review
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Open access
Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 are producers of the antibiotic nucleocidin and 4'-fluoroadenosine is identified as a co-product
Chen, Y., Zhang, Q., Feng, X., Wojnowska, M. & O'Hagan, D., 3 Nov 2021, (E-pub ahead of print) In: Organic & Biomolecular Chemistry. Advance Article, 4 p.Research output: Contribution to journal › Article › peer-review
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Open access
Effect of fluoroalkyl-substituent in bistolane-based photoluminescence liquid crystals on their physical behavior
Yamada, S., Wang, Y., Morita, M., Zhang, Q., O'Hagan, D., Nagata, M., Agou, T., Fukumoto, H., Kubota, T., Hara, M. & Konno, T., 20 Apr 2021, In: Crystals. 11, 4, 15 p., 450.Research output: Contribution to journal › Article › peer-review