Prof Frank J Gunn-Moore
Acting Head of School
Professor
Research areas
The prognosis for most neurodegenerative diseases is poor. The causes of the major diseases (eg: Alzheimer's, Parkinson's and Multiple Sclerosis) are complex, including genetic and environmental factors. All conspire to interfere with signalling pathways in neurons and glia which sustain growth and viability. My work focuses on factors that are involved in the promotion of correct neuronal function, and to do this we use a wide range of approaches that encompass biology, chemistry and physics.
PhD supervision
- Pietro Esposito
- Stella Wigglesworth - Littlewood
Selected publications
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Open access
Alzheimer’s disease-like neuropathology in three species of oceanic dolphin
Vacher, M. C., Durrant, C. S., Rose, J., Hall, A. J., Spires-Jones, T. L., Gunn-Moore, F. & Dagleish, M. P., 1 Apr 2023, In: European Journal of Neuroscience. 57, 7, p. 1161-1179 19 p.Research output: Contribution to journal › Article › peer-review
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Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation
Benek, O., Vaskova, M., Miskerikova, M., Schmidt, M., Andrys, R., Rotterova, A., Skarka, A., Hatlapatkova, J., Karasova, J. Z., Medvecky, M., Hroch, L., Vinklarova, L., Fisar, Z., Hroudova, J., Handl, J., Capek, J., Rousar, T., Kobrlova, T., Dolezal, R., Soukup, O., & 3 others , 5 Oct 2023, In: European Journal Of Medicinal Chemistry. 258, 18 p., 115593.Research output: Contribution to journal › Article › peer-review
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Microlensed Fiber-based Poration
Dholakia, K., Ma, N., Ashok, P. C., Stevenson, D. J. & Gunn-Moore, F. J., 3 Jan 2023, Patent No. 2801671Research output: Patent
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Open access
The mitochondrial enzyme 17βHSD10 modulates ischemic and amyloid-β-induced stress in primary mouse astrocytes
Metodieva, V., Smith, T. K. & Gunn-Moore, F. J., 12 Sept 2022, In: eNeuro. 9, 5, 24 p.Research output: Contribution to journal › Article › peer-review
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Open access
Willin/FRMD6 mediates mitochondrial dysfunction relevant to neuronal Aβ toxicity
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 6 Oct 2022, In: Cells. 11, 19, 27 p., 3140.Research output: Contribution to journal › Article › peer-review
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Open access
Author Correction: Nanostructural Diversity of Synapses in the Mammalian Spinal Cord (Scientific Reports, (2020), 10, 1, (8189), 10.1038/s41598-020-64874-9)
Broadhead, M. J., Bonthron, C., Arcinas, L., Bez, S., Zhu, F., Goff, F., Nylk, J., Dholakia, K., Gunn-Moore, F., Grant, S. G. N. & Miles, G. B., Dec 2021, In: Scientific Reports. 11, 1, 23160.Research output: Contribution to journal › Comment/debate › peer-review
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Open access
Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 4 Nov 2021, In: Cells. 10, 11, 27 p., 3024.Research output: Contribution to journal › Review article › peer-review
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Open access
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment
Schmidt, M., Benek, O., Vinklarova, L., Hrabinova, M., Zemanova, L., Chribek, M., Kralova, V., Hroch, L., Dolezal, R., Lycka, A., Prchal, L., Jun, D., Aitken, L., Gunn-Moore, F., Kuca, K. & Musilek, K., 17 Mar 2020, In: International Journal of Molecular Sciences. 21, 6, 26 p., 2059.Research output: Contribution to journal › Article › peer-review
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Open access
Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease
Dey, M., Gunn-Moore, F. J., Platt, B. & Smith, T. K., 31 Aug 2020, In: Lipids in Health and Disease. 19, 17 p., 201.Research output: Contribution to journal › Article › peer-review
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Open access
Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease
Vinklarova, L., Schmidt, M., Benek, O., Kuca, K., Gunn-Moore, F. & Musilek, K., 23 May 2020, (E-pub ahead of print) In: Journal of Neurochemistry. Early viewResearch output: Contribution to journal › Review article › peer-review