Prof Frank J Gunn-Moore

Professor

Head of School

Researcher profile

Phone

+44 (0)1334 463525

Email

fjg1@st-andrews.ac.uk

Research areas

The prognosis for most neurodegenerative diseases is poor. The causes of the major diseases (eg: Alzheimer's, Parkinson's and Multiple Sclerosis) are complex, including genetic and environmental factors. All conspire to interfere with signalling pathways in neurons and glia which sustain growth and viability. My work focuses on factors that are involved in the promotion of correct neuronal function, and to do this we use a wide range of approaches that encompass biology, chemistry and physics. For more details, including my research team please see http://biology.st-andrews.ac.uk/contact/staffprofile.aspx?sunID=fjg1

PhD supervision

• Vanya Metodieva
• Wanjia Yu

Selected publications

• Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17?-HSD10 with implications to Alzheimer?s disease treatment

  Schmidt, M., Benek, O., Vinklarova, L., Hrabinova, M., Zemanova, L., Chribek, M., Kralova, V., Hroch, L., Dolezal, R., Lycka, A., Prchal, L., Jun, D., Aitken, L., Gunn-Moore, F., Kuca, K. & Musilek, K., 17 Mar 2020, In : International Journal of Molecular Sciences. 21, 6, 26 p., 2059.

  Research output: Contribution to journal ? Article

• Friend or enemy? Review of 17??HSD10 and its role in human health or disease

  Vinklarova, L., Schmidt, M., Benek, O., Kuca, K., Gunn-Moore, F. & Musilek, K., 23 May 2020, In : Journal of Neurochemistry. Early view

  Research output: Contribution to journal ? Review article

• Nanostructural diversity of synapses in the mammalian spinal cord

  Broadhead, M. J., Bonthron, C., Arcinas, L., Bez, S., Zhu, F., Goff, F. E., Nylk, J., Dholakia, K., Gunn-Moore, F. J., Grant, S. G. N. & Miles, G. B., 18 May 2020, In : Scientific Reports. 10, 18 p., 8189.

  Research output: Contribution to journal ? Article

• Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function

  Cheng, Y., Buchan, M., Vitanova, K., Aitken, L., Gunn-Moore, F. J., Ramsay, R. R. & Doherty, G., 8 Apr 2020, In : Journal of Neurochemistry. Early View, e15003.

  Research output: Contribution to journal ? Article

• Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis

  Abdul Razzak, R., Florence, G. J. & Gunn-Moore, F. J., 25 Jun 2019, In : International Journal of Molecular Sciences. 20, 12, 43 p., 3108.

  Research output: Contribution to journal ? Article

• Light sheet fluorescence microscopy for neuroscience

  Corsetti, S., Gunn-Moore, F. & Dholakia, K., 1 May 2019, In : Journal of Neuroscience Methods. 319, p. 16-27

  Research output: Contribution to journal ? Article

• Novel benzothiazole-based ureas as 17?-HSD10 inhibitors, a potential Alzheimer?s disease treatment

  Aitken, L., Benek, O., McKelvie, B., Hughes, R. E., Hroch, L., Schmidt, M., Major, L. L., Vinklarova, L., Kuca, K., Smith, T. K., Musilek, K. & Gunn-Moore, F. J., 29 Jul 2019, In : Molecules. 24, 15, 2757.

  Research output: Contribution to journal ? Article

• 1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

  Benek, O., Hroch, L., Aitken, L., Gunn-Moore, F., Vinklarova, L., Kuca, K., Perez, D. I., Perez, C., Martinez, A., Fisar, Z. & Musilek, K., 2018, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 33, 1, p. 665-670 6 p.

  Research output: Contribution to journal ? Article

• All-optical assay to study biological neural networks

  Afshar Saber, W., Gasparoli, F. M., Dirks, M. G., Gunn-Moore, F. J. & Antkowiak, M., 5 Jul 2018, In : Frontiers in Neuroscience. 12, 12 p., 451.

  Research output: Contribution to journal ? Article

• Alzheimer's disease in humans and other animals: a consequence of postreproductive life span and longevity rather than aging

  Gunn-Moore, D., Kaidanovich-Beilin, O., Gallego Iradi, M. C., Gunn-Moore, F. & Lovestone, S., Feb 2018, In : Alzheimer's and Dementia. 14, 2, p. 195-204

  Research output: Contribution to journal ? Article

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