Prof Frank J Gunn-Moore
Head of School
Research areas
The prognosis for most neurodegenerative diseases is poor. The causes of the major diseases (eg: Alzheimer's, Parkinson's and Multiple Sclerosis) are complex, including genetic and environmental factors. All conspire to interfere with signalling pathways in neurons and glia which sustain growth and viability. My work focuses on factors that are involved in the promotion of correct neuronal function, and to do this we use a wide range of approaches that encompass biology, chemistry and physics.
PhD supervision
- Doris Chen
- Pietro Esposito
- Marissa Vacher
Selected publications
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Open access
Author Correction: Nanostructural Diversity of Synapses in the Mammalian Spinal Cord (Scientific Reports, (2020), 10, 1, (8189), 10.1038/s41598-020-64874-9)
Broadhead, M. J., Bonthron, C., Arcinas, L., Bez, S., Zhu, F., Goff, F., Nylk, J., Dholakia, K., Gunn-Moore, F., Grant, S. G. N. & Miles, G. B., Dec 2021, In: Scientific Reports. 11, 1, 23160.Research output: Contribution to journal › Comment/debate › peer-review
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Open access
Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 4 Nov 2021, In: Cells. 10, 11, 27 p., 3024.Research output: Contribution to journal › Review article › peer-review
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Open access
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment
Schmidt, M., Benek, O., Vinklarova, L., Hrabinova, M., Zemanova, L., Chribek, M., Kralova, V., Hroch, L., Dolezal, R., Lycka, A., Prchal, L., Jun, D., Aitken, L., Gunn-Moore, F., Kuca, K. & Musilek, K., 17 Mar 2020, In: International Journal of Molecular Sciences. 21, 6, 26 p., 2059.Research output: Contribution to journal › Article › peer-review
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Open access
Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease
Dey, M., Gunn-Moore, F. J., Platt, B. & Smith, T. K., 31 Aug 2020, In: Lipids in Health and Disease. 19, 17 p., 201.Research output: Contribution to journal › Article › peer-review
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Open access
Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease
Vinklarova, L., Schmidt, M., Benek, O., Kuca, K., Gunn-Moore, F. & Musilek, K., 23 May 2020, (E-pub ahead of print) In: Journal of Neurochemistry. Early viewResearch output: Contribution to journal › Review article › peer-review
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Open access
Nanostructural diversity of synapses in the mammalian spinal cord
Broadhead, M. J., Bonthron, C., Arcinas, L., Bez, S., Zhu, F., Goff, F. E., Nylk, J., Dholakia, K., Gunn-Moore, F. J., Grant, S. G. N. & Miles, G. B., 18 May 2020, In: Scientific Reports. 10, 18 p., 8189.Research output: Contribution to journal › Article › peer-review
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Open access
Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function
Cheng, Y., Buchan, M., Vitanova, K., Aitken, L., Gunn-Moore, F. J., Ramsay, R. R. & Doherty, G., 13 Oct 2020, In: Journal of Neurochemistry. 155, 2, p. 191-206 e15003.Research output: Contribution to journal › Article › peer-review
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Open access
Willin/FRMD6 influences mechanical phenotype and neuronal differentiation in mammalian cells by regulating ERK1/2 activity
Kronenberg, N. M., Tilston-Lunel, A., Thompson, F. E., Chen, D., Yu, W., Dholakia, K., Gather, M. C. & Gunn-Moore, F. J., 4 Sep 2020, In: Frontiers in Cellular Neuroscience. 14, 11 p., 552213.Research output: Contribution to journal › Article › peer-review
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Open access
Approaches to CNS drug delivery with a focus on transporter-mediated transcytosis
Abdul Razzak, R., Florence, G. J. & Gunn-Moore, F. J., 25 Jun 2019, In: International Journal of Molecular Sciences. 20, 12, 43 p., 3108.Research output: Contribution to journal › Article › peer-review
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Open access
Light sheet fluorescence microscopy for neuroscience
Corsetti, S., Gunn-Moore, F. & Dholakia, K., 1 May 2019, In: Journal of Neuroscience Methods. 319, p. 16-27Research output: Contribution to journal › Article › peer-review