Research areas
I am a postdoc in Alan Stewart's group. I am using fluorescence to assess the effect of zinc and other factor on insulin hexamers assembly and disassembly.
PhD supervision
- Boyang Lin
Selected publications
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Open access
Abnormal plasma/serum magnesium, copper and zinc concentrations associate with the future development of cardiovascular diseases
Lin, B., Alexander, R., Fritzen, R., Mills, S., Stewart, A. J. & McCowan, C., 25 Apr 2025, In: Nutrients. 17, 9, p. 1-14 14 p., 1447.Research output: Contribution to journal › Article › peer-review
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Open access
Investigating the conformational landscape of human histidine-rich glycoprotein using amide HDX-MS
Hierons, S. J., Lin, B., Fritzen, R., Blindauer, C. A., Ajjan, R. A., Masson, G. R. & Stewart, A. J., 17 Nov 2025, In: Biochemical Journal. 482, 22, p. 1721-1735 15 p.Research output: Contribution to journal › Article › peer-review
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Open access
Properties of the major Zn2+-binding site of human alpha-fetoprotein, a potential foetal plasma zinc carrier
Lu, J., Hierons, S. J., Arya, S., Fritzen, R., Polepalli, S., Khazaipoul, S., Stewart, A. J. & Blindauer, C. A., 4 Feb 2025, In: Chemical Communications. 61, 10, p. 2099-2102 4 p.Research output: Contribution to journal › Article › peer-review
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Open access
Targeted removal of the FA2 site on human albumin prevents fatty acid-mediated inhibition of Zn2+-binding
Wu, D., Hierons, S. J., Polepalli, S., Gucwa, M., Fritzen, R., Markiewicz, M., Sabín, J., Minor, W., Murzyn, K., Blindauer, C. A. & Stewart, A. J., 1 Jun 2024, In: Journal of Lipid Research. 65, 6, 12 p., 100560.Research output: Contribution to journal › Article › peer-review
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Open access
Magnesium deficiency and cardiometabolic disease
Fritzen, R., Davies, A., Veenhuizen, M., Campbell, M., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., 17 May 2023, In: Nutrients. 15, 10, 19 p., 2355.Research output: Contribution to journal › Review article › peer-review
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Open access
Structural and biochemical characterisation of Co2+-binding sites on serum albumins and their interplay with fatty acids
Wu, D., Gucwa, M., Czub, M. P., Cooper, D. R., Shabalin, I. G., Fritzen, R., Arya, S., Schwarz-Linek, U., Blindauer, C. A., Minor, W. & Stewart, A. J., 21 Jun 2023, In: Chemical Science. 14, 23, p. 6244-6258 15 p.Research output: Contribution to journal › Article › peer-review
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T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens
Weller, S., Sterlin, D., Fadeev, T., Coignard, E., Aires, A. V. D. L., Goetz, C., Fritzen, R., Bahuaud, M., Batteux, F., Gorochov, G., Weill, J.-C. & Reynaud, C.-A., 27 Jan 2023, In: Science Immunology. 8, 79, 18 p., eade1413.Research output: Contribution to journal › Article › peer-review
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Open access
Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification
Descatoire, M., Fritzen, R., Rotman, S., Kuntzelman, G., Leber, X. C., Droz-Georget, S., Thrasher, A. J., Traggiai, E. & Candotti, F., 8 Mar 2022, In: Cell Reports. 38, 10, 17 p., 110474.Research output: Contribution to journal › Article › peer-review
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Open access
Strategies for therapeutic amelioration of aberrant plasma Zn2+ handling in thrombotic disease: targeting fatty acid/serum albumin-mediated effects
Regan-Smith, S., Fritzen, R., Hierons, S. J., Ajjan, R. A., Blindauer, C. A. & Stewart, A. J., 7 Sept 2022, In: International Journal of Molecular Sciences. 23, 18, 18 p., 10302.Research output: Contribution to journal › Review article › peer-review
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Open access
Asymmetric base-pair opening drives helicase unwinding dynamics
Colizzi, F., Perez-Gonzalez, C., Fritzen, R., Levy, Y., White, M. F., Penedo, J. C. & Bussi, G., 5 Nov 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 45, p. 22471-22477 7 p.Research output: Contribution to journal › Article › peer-review