Selected publications
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Open access
Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis
Xiong, Z., Yang, X., Wang, S., Smart, C. J., Sisson, H. M., Lin, Z., Hu, T., Ran, Y., Xu, C., Yang, X., Zhao, Y., Jowsey, W. J., Cook, G. M., Mcneil, M. B., Guddat, L. W., Rao, Z. & Zhang, B., 29 May 2025, In: Nature Communications. 16, 1, 11 p., 4976.Research output: Contribution to journal › Article › peer-review
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Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity
Fountain, A. J., Waller, N. J. E., Cheung, C. Y., Jowsey, W., Chrisp, M. T., Troll, M., Edelstein, P. H., Cook, G. M., Mcneil, M. B. & Ramakrishnan, L., 22 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 16, 8 p., e2426827122.Research output: Contribution to journal › Article › peer-review
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A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis
Adolph, C., Cheung, C.-Y., McNeil, M. B., Jowsey, W. J., Williams, Z. C., Hards, K., Harold, L. K., Aboelela, A., Bujaroski, R. S., Buckley, B. J., Tyndall, J. D. A., Li, Z., Langer, J. D., Preiss, L., Meier, T., Steyn, A. J. C., Rhee, K. Y., Berney, M., Kelso, M. J. & Cook, G. M., 18 Apr 2024, In: Cell Chemical Biology. 31, 4, 24 p.Research output: Contribution to journal › Article › peer-review
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Antibiotic resistance in Mycobacterium tuberculosis alters tolerance to cell wall-targeting inhibitors
Jowsey, W. J., Cook, G. M. & McNeil, M. B., 4 Jun 2024, In: JAC-Antimicrobial Resistance. 6, 3, 10 p., dlae086.Research output: Contribution to journal › Article › peer-review
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Identification of Chemical Scaffolds That Inhibit the Mycobacterium tuberculosis Respiratory Complex Succinate Dehydrogenase
Adolph, C., Hards, K., Williams, Z. C., Cheung, C.-Y., Keighley, L. M., Jowsey, W. J., Kyte, M., Inaoka, D. K., Kita, K., Mackenzie, J. S., Steyn, A. J. C., Li, Z., Yan, M., Tian, G.-B., Zhang, T., Ding, X., Furkert, D. P., Brimble, M. A., Hickey, A. J. R. & McNeil, M. B. & 1 others, , 13 Sept 2024, In: ACS Infectious Diseases. 10, 10, p. 3496-3515 20 p.Research output: Contribution to journal › Article › peer-review
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Open access
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis
Wang, X., Jowsey, W. J., Cheung, C.-Y., Smart, C. J., Klaus, H. R., Seeto, N. E. J., Waller, N. J. E., Chrisp, M. T., Peterson, A. L., Ofori-Anyinam, B., Strong, E., Nijagal, B., West, N. P., Yang, J. H., Fineran, P. C., Cook, G. M., Jackson, S. A. & McNeil, M. B., 13 Nov 2024, In: Nature Communications. 15, 1, 18 p., 9791.Research output: Contribution to journal › Article › peer-review
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Open access
DUF2285 is a novel helix-turn-helix domain variant that orchestrates both activation and antiactivation of conjugative element transfer in proteobacteria
Jowsey, W. J., Morris, C. R. P., Hall, D. A., Fagerlund, R. D., Eto, K. Y., Solomon, P. D., Mackay, J. P., Bond, C. S., Ramsay, J. P. & Ronson, C. W., 21 Jul 2023, In: Nucleic Acids Research. 51, 13, p. 6841-6856 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
An epigenetic switch activates bacterial quorum sensing and horizontal transfer of an integrative and conjugative element
Jowsey, W., 25 Jan 2022, In: Nucleic Acids Research. 50, 2, p. 975–988Research output: Contribution to journal › Article › peer-review
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Open access
Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis
Jowsey, W., 24 Aug 2022, In: Frontiers in Cellular and Infection Microbiology. 980844.Research output: Contribution to journal › Review article › peer-review