Dr Simon Powis

Reader

Researcher profile

Phone

+44 (0)1334 463627

Email

sjp10@st-andrews.ac.uk

Research areas

The immune system relies on the ability to detect when cells are virally infected, or potentially tumorigenic, and to specifically eliminate these cells. This is achieved by the actions of Major Histocompatibility Complex (MHC) class I molecules, which bind small peptides from the proteolytic turnover of proteins in the cytoplasm, and present these peptides on the cell surface to T lymphocytes. Detection of viral, or non-self, peptides can stimulate the generation of potent anti-viral cytotoxic T lymphocyte responses.

PhD supervision

• Jason Corbett
• Caitlin Boyne
• Roopam Gupta
• Dongmei Wu

Selected publications

• Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication

  Antoniou, A. N., Lenart, I., Kriston-Vizi, J., Iwawaki, T., Turmaine, M., McHugh, K., Ali, S., Blake, N., Bowness, P., Bajaj-Elliott, M., Gould, K., Nesbeth, D. & Powis, S. J., Jan 2019, In : Annals of the Rheumatic Diseases. 78, 1, p. 74?82 9 p., 213532.

  Research output: Contribution to journal ? Article

• Does natural killer cell deficiency (NKD) increase the risk of cancer? NKD may increase the risk of some virus induced cancer

  Moon, W. Y. & Powis, S. J., 19 Jul 2019, In : Frontiers in Immunology. 10, 5 p., 1703.

  Research output: Contribution to journal ? Review article

• High-content screening image dataset and quantitative image analysis of Salmonella infected human cells

  Antoniou, A. N., Powis, S. J. & Kriston-Vizi, J., 16 Dec 2019, In : BMC Research Notes. 12, 4 p., 808.

  Research output: Contribution to journal ? Article

• Label-free optical hemogram of granulocytes enhanced by artificial neural networks

  Gupta, R., Chen, M., Malcolm, G. P. A., Hempler, N., Dholakia, K. & Powis, S. J., 13 May 2019, In : Optics Express. 27, 10, p. 13706-13720 15 p.

  Research output: Contribution to journal ? Article

• Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells: a SWATH-MS study

  Arya, S., Wiatrek-Moumoulidis, D., Synowsky, S. A., Shirran, S. L., Botting, C. H., Powis, S. J. & Stewart, A. J., 13 Mar 2019, In : Scientific Reports. 9, 11 p., 4343.

  Research output: Contribution to journal ? Article

• Non-obstructive intracellular nanolasers

  Fikouras, A., Schubert, M., Karl, M., Kumar, J. D., Powis, S. J., Di Falco, A. & Gather, M. C., 16 Nov 2018, In : Nature Communications. 9, 7 p., 4817.

  Research output: Contribution to journal ? Letter

• Lasing in live mitotic and non-phagocytic cells by efficient delivery of microresonators

  Schubert, M., Volckaert, K., Karl, M., Morton, A., Liehm, P., Miles, G. B., Powis, S. J. & Gather, M. C., 19 Jan 2017, In : Scientific Reports. 7, 40877.

  Research output: Contribution to journal ? Article

• Long-term imaging of cellular forces with high precision by elastic resonator interference stress microscopy

  Kronenberg, N. M., Liehm, P., Steude, A., Knipper, J. A., Borger, J. G., Scarcelli, G., Franze, K., Powis, S. J. & Gather, M. C., 1 Jul 2017, In : Nature Cell Biology. 19, 7, p. 864-872

  Research output: Contribution to journal ? Article

• Multimodal discrimination of immune cells using a combination of Raman spectroscopy and digital holographic microscopy

  McReynolds, N., Cooke, F. G. M., Chen, M., Powis, S. J. & Dholakia, K., 3 Mar 2017, In : Scientific Reports. 7, 11 p., 43631 .

  Research output: Contribution to journal ? Article

• Polymorphisms in the F pocket of HLA-B27 subtypes strongly affect assembly, chaperone interactions and heavy-chain misfolding

  Guiliano, D. B., North, H., Panayoitou, E., Campbell, E. C., McHugh, K., Cooke, F. G. M., Silvestre, M., Bowness, P., Powis, S. J. & Antoniou, A. N., Mar 2017, In : Arthritis & Rheumatology. 69, 3, p. 610-621 12 p.

  Research output: Contribution to journal ? Article

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