Prof Matthew Holden

Professor

Researcher profile

Phone

+44 (0)1334 463504

Email

mtgh@st-andrews.ac.uk

Research areas

Since the first bacterial genome was sequenced in 1995, whole genome sequencing (WGS) has provided unprecedented insights into the genetics and evolution of microbial pathogens. Having worked at the Sanger Institute 13 years on a broad range of bacterial genomes, I recently moved to the School of Medicine establishing a pathogenomics group. Research in my group is directed at two main areas: translational genomics, the application of WGS in clinical microbiology; and experimental genomics, using data WGS to investigate the relationship between pathogens? genotypes and phenotypes.

The research areas that the group are focused on include: developing rapid WGS to combat hospital-associated infections, the molecular basis of antibiotic resistance and virulence, and epidemiology and evolution of methicillin resistant S. aureus (MRSA).

PhD supervision

• Martin McHugh
• Rebecca Mekler
• Daniel Guerendiain Regalado

Selected publications

• "Gene accordions" cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus

  Belikova, D., Jochim, A., Power, J., Holden, M. T. G. & Heilbronner, S., 14 Jul 2020, In : Nature Communications. 11, 15 p., 3526.

  Research output: Contribution to journal ? Article

• A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage

  Fox, S., Goswami, C., Holden, M., Connolly, J. P. R., Mordue, J., O?Boyle, N., Roe, A., Connor, M., Leanord, A. & Evans, T. J., 5 Mar 2020, In : Scientific Reports. 10, 11 p., 4135.

  Research output: Contribution to journal ? Article

• Comparative epidemiology and factors associated with major healthcare-associated methicillin-resistant Staphylococcus aureus clones among interconnected acute, intermediate- and long-term healthcare facilities in Singapore

  Chow, A., Htun, H. L., Hon, P-Y., Ang, B., Kanagasabai, K., Koh, J., Holden, M. T. G. & Hsu, L-Y., 29 Jul 2020, In : Clinical Microbiology and Infection. In press

  Research output: Contribution to journal ? Article

• Draft genome sequences of the type strains of Actinobacillus indolicus (46K2C) and Actinobacillus porcinus (NM319), two NAD-dependent bacterial species found in the respiratory tract of pigs

  Bossé, J. T., Li, Y., Fernandez Crespo, R., Angen, Ø., Holden, M. T. G., Weinert, L. A., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., Langford, P. R. & BRaDP1T Consortium, 2 Jan 2020, In : Microbiology Resource Announcements. 9, 3 p., e00716-19.

  Research output: Contribution to journal ? Article

• Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines

  Argimón, S., Masim, M. A. L., Gayeta, J. M., Lagrada, M. L., Macaranas, P. K. V., Cohen, V., Limas, M. T., Espiritu, H. O., Palarca, J. C., Chilam, J., Jamoralin, M. C., Villamin, A. S., Borlasa, J. B., Olorosa, A. M., Hernandez, L. F. T., Boehme, K. D., Jeffrey, B., Abudahab, K., Hufano, C. M., Sia, S. B., Stelling, J., Holden, M. T. G., Aanensen, D. M. & Carlos, C. C., 1 Jun 2020, In : Nature Communications. 11, 15 p., 2719.

  Research output: Contribution to journal ? Article

• Origin, maintenance and spread of antibiotic resistance genes within plasmids and chromosomes of bloodstream isolates of Escherichia coli

  Goswami, C., Fox, S., Holden, M. T. G., Connor, M., Leanord, A. & Evans, T. J., Apr 2020, In : Microbial Genomics. 6, 4, 17 p., 000353.

  Research output: Contribution to journal ? Article

• SpeS: a novel superantigen and its potential as a vaccine adjuvant against strangles

  Dominguez-Medina, C. C., Rash, N. L., Robillard, S., Robinson, C., Efstratiou, A., Broughton, K., Parkhill, J., Holden, M., Lopez-Alvarez, M. R., Paillot, R. & Waller, A. S., 23 Jun 2020, In : International Journal of Molecular Sciences. 21, 12, 15 p., 4467.

  Research output: Contribution to journal ? Article

• The molecular basis of thioalcohol production in human body odour

  Rudden, M., Herman, R., Rose, M., Bawdon, D., Cox, D. S., Dodson, E., Holden, M. T. G., Wilkinson, A. J., James, A. G. & Thomas, G. H., 27 Jul 2020, In : Scientific Reports. 10, 14 p., 12500.

  Research output: Contribution to journal ? Article

• Antimicrobial resistance in atopic dermatitis: need for an urgent rethink

  Harkins, C. P., Holden, M. T. G. & Irvine, A. D., Mar 2019, In : Annals of Allergy Asthma & Immunology. 122, 3, p. 236-240 5 p.

  Research output: Contribution to journal ? Article

• Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

  Davies, M. R., McIntyre, L., Mutreja, A., Lacey, J. A., Lees, J. A., Towers, R. J., Duchêne, S., Smeesters, P. R., Frost, H. R., Price, D. J., Holden, M. T. G., David, S., Giffard, P. M., Worthing, K. A., Seale, A. C., Berkley, J. A., Harris, S. R., Rivera-Hernandez, T., Berking, O., Cork, A. J., Torres, R. S. L. A., Lithgow, T., Strugnell, R. A., Bergmann, R., Nitsche-Schmitz, P., Chhatwal, G. S., Bentley, S. D., Fraser, J. D., Moreland, N. J., Carapetis, J. R., Steer, A. C., Parkhill, J., Saul, A., Williamson, D. A., Currie, B. J., Tong, S. Y. C., Dougan, G. & Walker, M. J., Jun 2019, In : Nature Genetics. 51, 6, p. 1035-1043

  Research output: Contribution to journal ? Article

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