Prof Matthew Holden

Professor

Researcher profile

Phone

+44 (0)1334 463504

Email

mtgh@st-andrews.ac.uk

Research areas

Since the first bacterial genome was sequenced in 1995, whole genome sequencing (WGS) has provided unprecedented insights into the genetics and evolution of microbial pathogens. Having worked at the Sanger Institute 13 years on a broad range of bacterial genomes, I recently moved to the School of Medicine establishing a pathogenomics group. Research in my group is directed at two main areas: translational genomics, the application of WGS in clinical microbiology; and experimental genomics, using data WGS to investigate the relationship between pathogens? genotypes and phenotypes.

The research areas that the group are focused on include: developing rapid WGS to combat hospital-associated infections, the molecular basis of antibiotic resistance and virulence, and epidemiology and evolution of methicillin resistant S. aureus (MRSA).

PhD supervision

• Martin McHugh
• Rebecca Mekler
• Daniel Guerendiain Regalado
• Joanna Rivas

Selected publications

• Draft genome sequences of the type strains of Actinobacillus indolicus (46K2C) and Actinobacillus porcinus (NM319), two NAD-dependent bacterial species found in the respiratory tract of pigs

  Bossé, J. T., Li, Y., Fernandez Crespo, R., Angen, Ø., Holden, M. T. G., Weinert, L. A., Maskell, D. J., Tucker, A. W., Wren, B. W., Rycroft, A. N., Langford, P. R. & BRaDP1T Consortium, 2 Jan 2020, In : Microbiology Resource Announcements. 9, 3 p., e00716-19.

  Research output: Contribution to journal ? Article

• Antimicrobial resistance in atopic dermatitis: need for an urgent rethink

  Harkins, C. P., Holden, M. T. G. & Irvine, A. D., Mar 2019, In : Annals of Allergy Asthma & Immunology. 122, 3, p. 236-240 5 p.

  Research output: Contribution to journal ? Article

• Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

  Davies, M. R., McIntyre, L., Mutreja, A., Lacey, J. A., Lees, J. A., Towers, R. J., Duchêne, S., Smeesters, P. R., Frost, H. R., Price, D. J., Holden, M. T. G., David, S., Giffard, P. M., Worthing, K. A., Seale, A. C., Berkley, J. A., Harris, S. R., Rivera-Hernandez, T., Berking, O., Cork, A. J., Torres, R. S. L. A., Lithgow, T., Strugnell, R. A., Bergmann, R., Nitsche-Schmitz, P., Chhatwal, G. S., Bentley, S. D., Fraser, J. D., Moreland, N. J., Carapetis, J. R., Steer, A. C., Parkhill, J., Saul, A., Williamson, D. A., Currie, B. J., Tong, S. Y. C., Dougan, G. & Walker, M. J., Jun 2019, In : Nature Genetics. 51, 6, p. 1035-1043

  Research output: Contribution to journal ? Article

• Chlorhexidine and octenidine use, qac genes carriage, and reduced antiseptic susceptibility in methicillin-resistant Staphylococcus aureus isolates from a healthcare network

  Htun, H. L., Hon, P. Y., Holden, M. T. G., Ang, B. & Chow, A., Sep 2019, In : Clinical Microbiology and Infection. 25, 9, p. 1154.e1-1154.e7

  Research output: Contribution to journal ? Article

• Evolution and global transmission of a multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus lineage from the Indian subcontinent

  Steinig, E. J., Duchene, S., Robinson, D. A., Monecke, S., Yokoyama, M., Laabei, M., Slickers, P., Andersson, P., Williamson, D., Kearns, A., Goering, R. V., Dickson, E., Ehricht, R., Ip, M., O'Sullivan, M. V. N., Coombs, G. W., Petersen, A., Brennan, G., Shore, A. C., Coleman, D. C., Pantosti, A., de Lencastre, H., Westh, H., Kobayashi, N., Heffernan, H., Strommenger, B., Layer, F., Weber, S., Aamot, H. V., Skakni, L., Peacock, S. J., Sarovich, D., Harris, S., Parkhill, J., Massey, R. C., Holden, M. T. G., Bentley, S. D. & Tong, S. Y. C., 26 Nov 2019, In : mBio. 10, 6, p. 1-20 20 p., e01105.

  Research output: Contribution to journal ? Article

• Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei

  Chewapreecha, C., Mather, A. E., Harris, S. R., Hunt, M., Holden, M. T. G., Chaichana, C., Wuthiekanun, V., Dougan, G., Day, N. P. J., Limmathurotsakul, D., Parkhill, J. & Peacock, S. J., 22 Nov 2019, In : Communications Biology. 2, 11 p., 428.

  Research output: Contribution to journal ? Article

• Genomic identification of cryptic susceptibility to penicillins and ?-lactamase inhibitors in methicillin-resistant Staphylococcus aureus

  Harrison, E. M., Ba, X., Coll, F., Blane, B., Restif, O., Carvell, H., Köser, C. U., Jamrozy, D., Reuter, S., Lovering, A., Gleadall, N., Bellis, K. L., Uhlemann, A. C., Lowy, F. D., Massey, R. C., Grilo, I. R., Sobral, R., Larsen, J., Rhod Larsen, A., Vingsbo Lundberg, C., Parkhill, J., Paterson, G. K., Holden, M. T. G., Peacock, S. J. & Holmes, M. A., 24 Jun 2019, In : Nature Microbiology. 15 p.

  Research output: Contribution to journal ? Article

• Improved characterisation of MRSA transmission using within-host bacterial sequence diversity

  Hall, M. D., Holden, M. TG., Srisomang, P., Mahavanakul, W., Wuthiekanun, V., Limmathurotsakul, D., Fountain, K., Parkhill, J., Nickerson, E. K., Peacock, S. J. & Fraser, C., 8 Oct 2019, In : eLife. 8, e46402.

  Research output: Contribution to journal ? Article

• Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States

  Mohamed, N., Timofeyeva, Y., Jamrozy, D., Rojas, E., Hao, L., Silmon de Monerri, N. C., Hawkins, J., Singh, G., Cai, B., Liberator, P., Sebastian, S., Donald, R. G. K., Scully, I. L., Jones, C. H., Creech, C. B., Thomsen, I., Parkhill, J., Peacock, S. J., Jansen, K. U., Holden, M. T. G. & Anderson, A. S., 14 Jan 2019, In : PLoS ONE. 14, 1, 33 p., e0208356.

  Research output: Contribution to journal ? Article

• The emergence of successful Streptococcus pyogenes lineages through convergent pathways of capsule loss and recombination directing high toxin expression

  Turner, C. E., Holden, M. T. G., Blane, B., Horner, C., Peacock, S. J. & Sriskandan, S., 10 Dec 2019, In : mBio. 10, 6, p. 1-19 20 p., e02521.

  Research output: Contribution to journal ? Article

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