Dr Javier Tello

Lecturer in Pharmacology

Researcher profile

Phone

+44 (0)1334 463517

Email

jt65@st-andrews.ac.uk

Research areas

My research interfaces cellular biology, pharmacology, and reproductive physiology, with the goal of understanding and treating fertility disorders emanating from the brain and pituitary. Neuropeptides play a critical role in a number of homeostatic processes, including metabolism, body composition, sleep/wake cycles, response to stress and ageing. However, irregular activity in any one of these processes can usurp normal reproductive function and lead to infertility.

The main goal of my research is to understand how neural networks are modulated by these peptides in the brain relevant to normal development and ageing, and to understand the molecular basis of neuropeptide signalling in both fertile and disease models.

My lab uses transgenic animals, brain slice physiology and molecular approaches to elucidate the cellular events involved with neuroendocrine responses in the hypothalamus and amygdala. We also employ state-of-the art viral vector transduction techniques (e.g. chemogenetics and optogenetics) combined with live calcium imaging and multi-labelling techniques to answer questions related to the neural circuitry underlying these physiological effects. Use of these combined techniques build a powerful arsenal for answering questions related to puberty and fertility.

Current research funding is provided by:

The Northwood Charitable Trust

The Society for Endocrinology - Early Career Grant

The Society for Endocrinology - Equipment Grant

http://www.endocrinology.org/

The British Society for Neuroendocrinology - Project Support Grant

Medical Research Scotland - Summer Studentship

PhD supervision

• Chryso Ioannou

Selected publications and performances

• Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus

  Coyle, C. S., Caso, F., Tolla, E., Barrett, P. J., Onishi, K. G., Tello, J. A. & Stevenson, T. J., 11 Feb 2020, In : Journal of Neuroendocrinology. 32, 2, e12819.

  Research output: Contribution to journal ? Article

• Medial amygdala Kiss1 neurons mediate female pheromone stimulation of luteinizing hormone in male mice

  Aggarwal, S., Tang, C., Sing, K., Kim, H. W., Millar, R. P. & Tello, J. A., Apr 2019, In : Neuroendocrinology. 108, 3, p. 172?189 18 p.

  Research output: Contribution to journal ? Article

• Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes

  Morton, A., Murawski, C., Deng, Y., Keum, C., Miles, G. B., Tello, J. A. & Gather, M. C., 18 Mar 2019, In : Advanced Biosystems. 3, 3, 8 p., 1800290.

  Research output: Contribution to journal ? Article

• The KIAA0319 dyslexia susceptibility gene presents a highly specific expression pattern during zebrafish development and plays a role in cytoskeleton dynamics

  Paracchini, S., Diaz, R., Gostic, M., Kronenberg, N., Martinelli, A., Sillar, K., Tello, J. & Gather, M., 26 Jul 2019, In : European Neuropsychopharmacology. 29, S4, p. 1195-1195 1 p.

  Research output: Contribution to journal ? Abstract

• The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration

  Gostic, M., Martinelli, A., Tucker, C., Yang, Z., Gasparoli, F. M., Ewart, J-Y., Dholakia, K., Sillar, K., Tello, J. & Paracchini, S., 1 Nov 2019, In : Journal of Comparative Neurology. 527, 16, p. 2634-2643 10 p.

  Research output: Contribution to journal ? Article

• Light-sheet microscopy with attenuation-compensated propagation-invariant beams

  Nylk, J., McCluskey, K. A., Preciado, M., Mazilu, M., Yang, Z., Gunn-Moore, F. J., Aggarwal, S., Tello, J. A., Ferrier, D. E. K. & Dholakia, K., 6 Apr 2018, In : Science Advances. 4, 4, 13 p., eaar4817.

  Research output: Contribution to journal ? Article

• Multimode fibre based imaging for optically cleared samples

  Gusachenko, I., Nylk, J., Tello, J. A. & Dholakia, K., 1 Nov 2017, In : Biomedical Optics Express. 8, 11, p. 5179-5190

  Research output: Contribution to journal ? Article

• Probing neural tissue with airy light-sheet microscopy: investigation of imaging performance at depth within turbid media

  Nylk, J., McCluskey, K., Aggarwal, S., Tello, J. A. & Dholakia, K., 17 Feb 2017, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXIV. Brown, T. G., Cogswell, C. J. & Wilson, T. (eds.). SPIE, p. 1-7 7 p. 100700B. (Proceedings of SPIE; vol. 10070).

  Research output: Chapter in Book/Report/Conference proceeding ? Conference contribution

• Enhancement of image quality and imaging depth with Airy light-sheet microscopy in cleared and non-cleared neural tissue

  Nylk, J., McCluskey, K. A., Aggarwal, S., Tello, J. & Dholakia, K., 1 Oct 2016, In : Biomedical Optics Express. 7, 10, p. 4021-4033

  Research output: Contribution to journal ? Article

• Nanoparticle suspensions enclosed in methylcellulose: a new approach for quantifying nanoparticles in transmission electron microscopy

  Hacker, C., Asadi, J., Pliotas, C., Ferguson, S. G. A., Sherry, L., Marius, P., Tello, J., Jackson, D., Naismith, J. H. & Lucocq, J. M., 4 May 2016, In : Scientific Reports. 6, 13 p., 25275 .

  Research output: Contribution to journal ? Article

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