Dr Javier Tello
Lecturer in Pharmacology
Research areas
My research interfaces cellular biology, pharmacology, and reproductive physiology, with the goal of understanding and treating fertility disorders emanating from the brain and pituitary. Neuropeptides play a critical role in a number of homeostatic processes, including metabolism, body composition, sleep/wake cycles, response to stress and ageing. However, irregular activity in any one of these processes can usurp normal reproductive function and lead to infertility.
The main goal of my research is to understand how neural networks are modulated by these peptides in the brain relevant to normal development and ageing, and to understand the molecular basis of neuropeptide signalling in both fertile and disease models.
My lab uses transgenic animals, brain slice physiology and molecular approaches to elucidate the cellular events involved with neuroendocrine responses in the hypothalamus and amygdala. We also employ state-of-the art viral vector transduction techniques (e.g. chemogenetics and optogenetics) combined with live calcium imaging and multi-labelling techniques to answer questions related to the neural circuitry underlying these physiological effects. Use of these combined techniques build a powerful arsenal for answering questions related to puberty and fertility.
Current research funding is provided by:
Tenovus Scotland - Large Project Grant
The Cunningham Trust - PhD Studentship
The Wellcome Trust - ISSF PhD Studentship
The British Society for Neuroendocrinology - Project Support Grant
RS MacDonald Trust - Neurophotonics Grant
Carnegie Trust - Vacations Scholarship Studentship
Medical Research Scotland - Summer Studentship
The Society for Endocrinology - Early Career Grant
http://www.endocrinology.org/
PhD supervision
- Morag Milne
Selected publications
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Open access
Neurokinin 3 receptor antagonists compared with serotonin norepinephrine reuptake inhibitors for non-hormonal treatment of menopausal hot flushes: a systematic qualitative review
Menown, S. J. & Tello, J. A., 1 Oct 2021, In: Advances in Therapy. 38, 10, p. 5025–5045 21 p.Research output: Contribution to journal › Review article › peer-review
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Open access
Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus
Coyle, C. S., Caso, F., Tolla, E., Barrett, P., Onishi, K. G., Tello, J. A. & Stevenson, T. J., 11 Feb 2020, In: Journal of Neuroendocrinology. 32, 2, 10 p., e12819.Research output: Contribution to journal › Article › peer-review
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Open access
Suppression of ovarian hormones in adolescent rats has no effect on anxiety-like behaviour or c-fos activation in the amygdala
Hodgson, A., Richmond, C., Tello, J. & Brown, G. R., Sept 2020, In: Journal of Neuroendocrinology. 32, 9, 14 p., e12897.Research output: Contribution to journal › Article › peer-review
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Open access
Medial amygdala Kiss1 neurons mediate female pheromone stimulation of luteinizing hormone in male mice
Aggarwal, S., Tang, C., Sing, K., Kim, H. W., Millar, R. P. & Tello, J. A., Apr 2019, In: Neuroendocrinology. 108, 3, p. 172–189 18 p.Research output: Contribution to journal › Article › peer-review
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Open access
Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes
Morton, A., Murawski, C., Deng, Y., Keum, C., Miles, G. B., Tello, J. A. & Gather, M. C., 18 Mar 2019, In: Advanced Biosystems. 3, 3, 8 p., 1800290.Research output: Contribution to journal › Article › peer-review
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The KIAA0319 dyslexia susceptibility gene presents a highly specific expression pattern during zebrafish development and plays a role in cytoskeleton dynamics
Paracchini, S., Diaz, R., Gostic, M., Kronenberg, N., Martinelli, A., Sillar, K., Tello, J. & Gather, M., 26 Jul 2019, In: European Neuropsychopharmacology. 29, S4, p. 1195-1195 1 p.Research output: Contribution to journal › Abstract › peer-review
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Open access
The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration
Gostic, M., Martinelli, A., Tucker, C., Yang, Z., Gasparoli, F. M., Ewart, J-Y., Dholakia, K., Sillar, K., Tello, J. & Paracchini, S., 1 Nov 2019, In: The Journal of Comparative Neurology. 527, 16, p. 2634-2643 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Light-sheet microscopy with attenuation-compensated propagation-invariant beams
Nylk, J., McCluskey, K. A., Preciado, M., Mazilu, M., Yang, Z., Gunn-Moore, F. J., Aggarwal, S., Tello, J. A., Ferrier, D. E. K. & Dholakia, K., 6 Apr 2018, In: Science Advances. 4, 4, 13 p., eaar4817.Research output: Contribution to journal › Article › peer-review
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Open access
Multimode fibre based imaging for optically cleared samples
Gusachenko, I., Nylk, J., Tello, J. A. & Dholakia, K., 1 Nov 2017, In: Biomedical Optics Express. 8, 11, p. 5179-5190Research output: Contribution to journal › Article › peer-review
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Open access
Probing neural tissue with airy light-sheet microscopy: investigation of imaging performance at depth within turbid media
Nylk, J., McCluskey, K., Aggarwal, S., Tello, J. A. & Dholakia, K., 17 Feb 2017, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXIV. Brown, T. G., Cogswell, C. J. & Wilson, T. (eds.). SPIE, p. 1-7 7 p. 100700B. (Proceedings of SPIE; vol. 10070).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution