Dr Derek Sloan
Senior Lecturer/Consultant in Infectious Diseases
Research areas
I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.
My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.
I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.
| Year |
My role |
Funding source |
|
| 2016-2019 |
Co-investigator |
EDCTP HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV |
|
| 2015-2018 |
Supervisor/ Advisor |
Commonwealth PhD Scholarship/ Epistem Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi) |
|
| 2015-2018 |
Primary Supervisor |
Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum |
|
| 2015-2017 |
Principal Investigator |
British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi |
|
| 2015-2017 |
Principal Investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes |
|
| 2015-2017 |
Co-investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Rational development of an optimal treatment regimen for isoniazid mono-resistant TB |
|
| 2010-2012 |
Co-investigator & collaborator |
Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza |
|
| 2008-2012 |
Principal Investigator |
Wellcome Trust Clinical PhD Fellowship |
|
| 2008 |
Principal Investigator |
LSTM Equipment Grant (Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory) |
|
PhD supervision
- Marios Zachariou
- Evelin Dombay
- Daniela Alferes De Lima
- Kerry Falconer
Selected publications
-
A tuberculosis molecular bacterial load assay (TB-MBLA)
Sabiiti, W., Mtafya, B. A., Alferes De Lima, D., Dombay, E., Baron, V. O., Azam, K., Orascova, K., Sloan, D. J. & Gillespie, S. H., 30 Apr 2020, In : Journal of Visualized Experiments. 158, 10 p., e60460.Research output: Contribution to journal ? Article
-
Accuracy and consequences of using trial-of-antibiotics for TB diagnosis (ACT-TB study): protocol for a randomised controlled clinical trial
Divala, T. H., Fielding, K. L., Sloan, D. J., French, N., Nliwasa, M., MacPherson, P., Kandulu, C. C., Chiume, L., Chilanga, S., Ndaferankhande, M. J. & Corbett, E. L., Mar 2020, In : BMJ Open. 10, 3, 10 p., e033999.Research output: Contribution to journal ? Article
-
Longitudinal PKPD biomarkers correlate with treatment outcome in drug sensitive pulmonary tuberculosis; a population pharmacokinetic-pharmacodynamic analysis
Kloprogge, F., Mwandumba, H. C., Kamdolozi, M., Banda, G., Shani, D., Corbett, E. L., Kontogianni, N., Ward, S., Khoo, S. H., Davies, G. R. & Sloan, D. J., Jul 2020, In : Open Forum Infectious Diseases. 7, 7, 11 p., ofaa218.Research output: Contribution to journal ? Article
-
Pharmacokinetics, SAfety/tolerability, and EFficacy of high-dose RIFampicin in tuberculosis-HIV co-infected patients on efavirenz- or dolutegravir-based antiretroviral therapy: study protocol for an open-label phase II clinical trial (SAEFRIF)
Nabisere, R., Musaazi, J., Denti, P., Aber, F., Lamorde, M., Dooley, K. E., Aarnoutse, R., Sloan, D. J. & Sekaggya-Wiltshire, C., 13 Feb 2020, In : Trials. 21, 9 p., 181.Research output: Contribution to journal ? Article
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Tuberculosis bacillary load, an early marker of disease severity and treatment response: the utility of tuberculosis Molecular Bacterial Load Assay
Sabiiti, W., Azam, K., Farmer, E., Kuchaka, D., Mtafya, B., Bowness, R., Oravcova, K., Honeyborne, I., Evangelopoulos, D., McHugh, T. D., Khosa, C., Rachow, A., Heinrich, N., Kampira, E., Davies, G., Bhatt, N., Ntinginya, E. N., Viegas, S., Jani, I., Kamdolozi, M., Mdolo, A., Khonga, M., Boeree, M. J., Phillips, P. PJ., Sloan, D. J., Hoelscher, M., Kibiki, G. S. & Gillespie, S. H., Jul 2020, In : Thorax. 75, 7, p. 606-608 3 p.Research output: Contribution to journal ? Article
-
Utility of broad-spectrum antibiotics for diagnosing pulmonary tuberculosis in adults: a systematic review and meta-analysis
Divala, T. H., Fielding, K. L., Kandulu, C., Nliwasa, M., Gupta-Wright, A., Sloan, D. J. & Corbett, E. L., 18 May 2020, In : Lancet Infectious Diseases. Online First, 10 p.Research output: Contribution to journal ? Article
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Defining the roles of Data Manager and Epidemiologist in emergency medical teams
Bartolucci, A., Jafar, A. JN., Sloan, D. J. & Whitworth, J., 16 Oct 2019, In : Prehospital and Disaster Medicine. First View, 7 p.Research output: Contribution to journal ? Article
-
Genetic diversity of Mycobacterium tuberculosis clinical isolates in Blantyre, Malawi
Ndhlovu, V., Kiran, A., Sloan, D., Mandala, W., Kontogianni, K., Kamdolozi, M., Caws, M. & Davies, G., Oct 2019, In : Heliyon. 5, 10, 5 p., e02638.Research output: Contribution to journal ? Article
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Linezolid for drug-resistant pulmonary tuberculosis
Singh, B., Cocker, D., Ryan, H. & Sloan, D. J., 20 Mar 2019, In : Cochrane Database of Systematic Reviews. 2019, 3, CD012836.Research output: Contribution to journal ? Review article
-
NAT2 variants and toxicity related to anti-tuberculosis agents: a systematic review and meta-analysis
Richardson, M., Kirkham, J., Dwan, K., Sloan, D. J., Davies, G. & Jorgensen, A. L., 1 Mar 2019, In : International Journal of Tuberculosis and Lung Disease. 23, 3, p. 293-305 13 p.Research output: Contribution to journal ? Article