Dr Derek Sloan
Senior Lecturer/Consultant in Infectious Diseases
Research areas
I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.
My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.
I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.
Year |
My role |
Funding source |
|
2016-2019 |
Co-investigator |
EDCTP HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV |
|
2015-2018 |
Supervisor/ Advisor |
Commonwealth PhD Scholarship/ Epistem Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi) |
|
2015-2018 |
Primary Supervisor |
Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum |
|
2015-2017 |
Principal Investigator |
British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi |
|
2015-2017 |
Principal Investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes |
|
2015-2017 |
Co-investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Rational development of an optimal treatment regimen for isoniazid mono-resistant TB |
|
2010-2012 |
Co-investigator & collaborator |
Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza |
|
2008-2012 |
Principal Investigator |
Wellcome Trust Clinical PhD Fellowship |
|
2008 |
Principal Investigator |
LSTM Equipment Grant (Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory) |
PhD supervision
- Eva Agnes Laker Odongpiny
- Marios Zachariou
- Hellen Onyango
- Joanna Rivas
- Ritah Nakiboneka
- Katherine Hill
Selected publications
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Open access
Antibiotic dispensing practices during COVID-19 and implications for antimicrobial resistance (AMR): parallel mystery client studies in Uganda and Tanzania
Olamijuwon, E., Konje, E., Kansiime, C., Kesby, M., Keenan, K., Neema, S., Asiimwe, B., Mshana, S. E., Mushi, M. F., Loza, O., Sunday, B., Sandeman, A., Sloan, D. J., Benitez-Paez, F., Mwanga, J. R., Sabiiti, W., Holden, M. T. G. & CARE Consortium, 11 Feb 2023, In: Antimicrobial Resistance & Infection Control. 12, 1, 14 p., 10.Research output: Contribution to journal › Article › peer-review
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Open access
Automated methods for tuberculosis detection/diagnosis: a literature review
Zachariou, M., Arandelovic, O. & Sloan, D. J., 1 Sept 2023, In: BioMedInformatics. 3, 3Research output: Contribution to journal › Literature review › peer-review
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Forgiveness is the attribute of the strong: nonadherence and regimen-shortening in drug-sensitive TB
Stagg, H. R., Thompson, J. A., Lipman, M. C. I., Sloan, D. J., Flook, M. & Fielding, K. L., 15 Jan 2023, In: American Journal of Respiratory and Critical Care Medicine. 207, 2, p. 193-205 13 p.Research output: Contribution to journal › Article › peer-review
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Open access
No action is without its side effects: adverse drug reactions and missed doses of anti-tuberculosis therapy, a scoping review
Dixon, E. G., Rasool, S., Otaalo, B., Motee, A., Dear, J. W., Sloan, D. & Stagg, H. R., 4 Sept 2023, (Accepted/In press) In: British Journal of Clinical Pharmacology.Research output: Contribution to journal › Review article › peer-review
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Open access
Protocol for a feasibility randomized controlled trial to evaluate the efficacy, safety and tolerability of N-acetylcysteine in reducing adverse drug reactions among adults treated for multidrug-resistant tuberculosis in Tanzania
Mpagama, S. G., Mvungi, H. C., Mbelele, P. M., Semvua, H. H., Liyoyo, A. A., de Guex, K. P., Sloan, D., Kibiki, G. S., Boeree, M., Phillips, P. P. J. & Heysell, S. K., 1 Apr 2023, In: Pilot and Feasibility Studies. 9, 13 p., 55.Research output: Contribution to journal › Article › peer-review
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Open access
The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda
Green, D. L., Keenan, K., Fredricks, K. J., Huque, S. I., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Kesby, M., Lynch, A. G., Worthington, H., Olamijuwon, E., Abed Al Ahad, M., Aduda, A., Njeru, J. M., Mmbaga, B. T., Bazira, J., & 14 others , 1 Jan 2023, In: The Lancet Global Health. 11, 1, p. e59-e68 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Treatment seeking behaviours, antibiotic use and relationships to multi-drug resistance: a study of urinary tract infection patients in Kenya, Tanzania and Uganda
HATUA Consortium, 20 Mar 2023, medRxiv.Research output: Working paper › Preprint
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Open access
Trial-of-antibiotics to assist tuberculosis diagnosis in symptomatic adults in Malawi (ACT-TB study): a randomised controlled trial
Divala, T. H., Corbett, E. L., Kandulu, C., Moyo, B., MacPherson, P., Nliwasa, M., French, N., Sloan, D. J., Chiume, L., Ndaferankhande, M. J., Chilanga, S., Majiga, S. T., Odland, J. Ø. & Fielding, K. L., 1 Apr 2023, In: The Lancet Global Health. 11, 4, p. e556-e565 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Unravelling patient pathways in the context of antibacterial resistance in East Africa
HATUA Consortium, Keenan, K., Fredricks, K. J., Al Ahad, M. A., Neema, S., Mwanga, J. R., Kesby, M., Mushi, M. F., Aduda, A., Green, D. L., Lynch, A. G., Huque, S. I., Mmbaga, B. T., Worthington, H., Kansiime, C., Olamijuwon, E., Ntinginya, N. E., Loza, O., Bazira, J., Maldonado-Barragán, A., & 15 others , 19 Jun 2023, In: BMC Infectious Diseases. 23, 1, 12 p., 414.Research output: Contribution to journal › Article › peer-review
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Open access
“It is not easy”: experiences of people living with HIV and tuberculosis on Tuberculosis treatment in Uganda
Nabisere-Arinaitwe, R., Namatende-Sakwa, L., Bayiga, J., Nampala, J., Alinaitwe, L., Aber, F., Otaalo, B., Musaazi, J., King, R., Kesby, M., Sloan, D. J. & Sekaggya-Wiltshire, C., Dec 2023, In: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 33, 100385.Research output: Contribution to journal › Article › peer-review