Dr Derek Sloan
Senior Lecturer/Consultant in Infectious Diseases
Research areas
I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.
My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.
I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.
| Year |
My role |
Funding source |
|
| 2016-2019 |
Co-investigator |
EDCTP HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV |
|
| 2015-2018 |
Supervisor/ Advisor |
Commonwealth PhD Scholarship/ Epistem Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi) |
|
| 2015-2018 |
Primary Supervisor |
Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum |
|
| 2015-2017 |
Principal Investigator |
British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi |
|
| 2015-2017 |
Principal Investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes |
|
| 2015-2017 |
Co-investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Rational development of an optimal treatment regimen for isoniazid mono-resistant TB |
|
| 2010-2012 |
Co-investigator & collaborator |
Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza |
|
| 2008-2012 |
Principal Investigator |
Wellcome Trust Clinical PhD Fellowship |
|
| 2008 |
Principal Investigator |
LSTM Equipment Grant (Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory) |
PhD supervision
- Marios Zachariou
- Hellen Onyango
- Joanna Rivas
- Ritah Nakiboneka
- Eva Agnes Laker Odongpiny
Selected publications
-
Decreased dolutegravir and efavirenz concentrations with preserved virological suppression in patients with TB and HIV receiving high-dose rifampicin
Sekaggya-Wiltshire, C., Nabisere, R., Musaazi, J., Otaalo, B., Aber, F., Alinaitwe, L., Nampala, J., Najjemba, L., Buzibye, A., Omali, D., Gausi, K., Kengo, A., Lamorde, M., Aarnoutse, R., Denti, P., Dooley, K. E. & Sloan, D. J., 21 Jul 2022, (E-pub ahead of print) In: Clinical Infectious Diseases. Advance Article, 10 p.Research output: Contribution to journal › Article › peer-review
-
Open access
Detection and quantification of viable Mycobacterium tuberculosis bacilli in saline-processed stool samples by Tuberculosis Molecular Bacterial Load Assay: a potential alternative for processing stool
Musisi, E., Ssesolo, A., Sloan, D. J., Gillespie, S. H. & Sabiiti, W., 12 May 2022, In: Microbiology Spectrum. Ahead of Print, 3 p., 00274-22.Research output: Contribution to journal › Letter › peer-review
-
Open access
Detection and quantification of viable Mycobacterium tuberculosis bacilli in saline-processed stool samples by Tuberculosis Molecular Bacterial Load Assay: a potential alternative for processing stool
Musisi, E., Ssesolo, A., Sloan, D. J., Gillespie, S. H. & Sabiiti, W., 12 May 2022, In: Microbiology Spectrum. 10, 3, 3 p., 00274-22.Research output: Contribution to journal › Letter › peer-review
-
Extracting and classifying salient fields of view from microscopy slides of tuberculosis bacteria
Zachariou, M., Arandelovic, O., Dombay, E., Sabiiti, W., Mtafya, B. A. & Sloan, D. J., 2022, Pattern Recognition and Artificial Intelligence: Third International Conference, ICPRAI 2022, Paris, France, June 1–3, 2022, Proceedings, Part I. El Yacoubi, M., Granger, E., Yuen, P. C., Pal, U. & Vincent, N. (eds.). Springer, p. 146–157 (Lecture Notes in Computer Science; vol. 13363).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
-
Open access
High Mycobacterium tuberculosis bacillary loads detected by tuberculosis molecular bacterial load assay in patient stool: a potential alternative for nonsputum diagnosis and treatment response monitoring of tuberculosis
Musisi, E., Sessolo, A., Kaswabuli, S., Zawedde, J., Byanyima, P., Kasiinga, S., Sanyu, I., Uwimaana, E., Walimbwa, S., Ola, J., Ssengooba, W., Sekaggya, C., Joloba, M. L., Worodria, W., Huang, L., Gillespie, S. H., Sloan, D. J. & Sabiiti, W., 23 Feb 2022, In: Microbiology Spectrum. 10, 1, 12 p., e02100-21.Research output: Contribution to journal › Article › peer-review
-
Open access
High intrapulmonary rifampicin and isoniazid concentrations are associated with rapid sputum bacillary clearance in patients with pulmonary tuberculosis
McCallum, A. D., Pertinez, H. E., Chirambo, A. P., Sheha, I., Chasweka, M., Malamba, R., Shani, D., Chitani, A., Mallewa, J. E., Meghji, J. Z., Ghany, J. F., Corbett, E. L., Gordon, S. B., Davies, G. R., Khoo, S. H., Sloan, D. J. & Mwandumba, H. C., 3 May 2022, (E-pub ahead of print) In: Clinical Infectious Diseases. Advance Article, 9 p., ciac228.Research output: Contribution to journal › Article › peer-review
-
Open access
Tuberculosis bacteria detection and counting in fluorescence microscopy images using a multi-stage deep learning pipeline
Zachariou, M., Arandjelović, O., Sabiiti, W., Mtafya, B. & Sloan, D., 18 Feb 2022, In: Information. 13, 2, 16 p., 96.Research output: Contribution to journal › Article › peer-review
-
Open access
Use of a molecular bacterial load assay to distinguish between active TB and post-TB lung disease
Mbelele, P. M., Sabiiti, W., Heysell, S. K., Sauli, E., Mpolya, E. A., Mfinanga, S., Gillespie, S. H., Addo, K. K., Kibiki, G., Sloan, D. J. & Mpagama, S. G., 1 Mar 2022, In: International Journal of Tuberculosis and Lung Disease. 26, 3, p. 276-278 3 p.Research output: Contribution to journal › Letter › peer-review
-
Co-prevalent infections in adults with HIV-associated cryptococcal meningitis are associated with an increased risk of death: a nested analysis of the Advancing Cryptococcal meningitis Treatment for Africa (ACTA) cohort [version 1; peer review: awaiting peer review]
Ellis, J., Kalata, N., Dziwani, E., Matope, A., Wang, D., Molloy, S. F., Harrison, T. S., Lalloo, D. G., Sloan, D. J. & Heyderman, R. S., 1 Feb 2021, (Submitted) In: Wellcome Open Research.Research output: Contribution to journal › Article › peer-review
-
Open access
MicroRNA-122 and cytokeratin-18 have potential as a biomarkers of drug-induced liver injury in European and African patients on treatment for mycobacterial infection
Rupprechter, S. A. E., Sloan, D. J., Oosthuyzen, W., Bachmann, T. T., Hill, A. T., Dhaliwal, K., Templeton, K., Matovu, J., Sekaggya-Wiltshire, C. & Dear, J. W., 26 Jan 2021, (E-pub ahead of print) In: British Journal of Clinical Pharmacology. Early View, 12 p.Research output: Contribution to journal › Article › peer-review