Dr Derek Sloan

Senior Lecturer/Consultant in Infectious Diseases

Researcher profile

Phone

+44 (0)1334 46 3577

Email

djs26@st-andrews.ac.uk

 

Research areas

I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.

My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.

I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.

Year	My role	Funding source
2016-2019	Co-investigator	EDCTP HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV
2015-2018	Supervisor/ Advisor	Commonwealth PhD Scholarship/ Epistem Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi)
2015-2018	Primary Supervisor	Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum
2015-2017	Principal Investigator	British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi
2015-2017	Principal Investigator	Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes
2015-2017	Co-investigator	Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Rational development of an optimal treatment regimen for isoniazid mono-resistant TB
2010-2012	Co-investigator & collaborator	Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza
2008-2012	Principal Investigator	Wellcome Trust Clinical PhD Fellowship
2008	Principal Investigator	LSTM Equipment Grant (Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory)

PhD supervision

• Eva Agnes Laker Odongpiny
• Marios Zachariou
• Hellen Onyango
• Joanna Rivas
• Ritah Nakiboneka
• Katherine Hill

Selected publications

• Open access

  Antibiotic dispensing practices during COVID-19 and implications for antimicrobial resistance (AMR): parallel mystery client studies in Uganda and Tanzania

  Olamijuwon, E., Konje, E., Kansiime, C., Kesby, M., Keenan, K., Neema, S., Asiimwe, B., Mshana, S. E., Mushi, M. F., Loza, O., Sunday, B., Sandeman, A., Sloan, D. J., Benitez-Paez, F., Mwanga, J. R., Sabiiti, W., Holden, M. T. G. & CARE Consortium, 11 Feb 2023, In: Antimicrobial Resistance & Infection Control. 12, 1, 14 p., 10.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Automated methods for tuberculosis detection/diagnosis: a literature review

  Zachariou, M., Arandelovic, O. & Sloan, D. J., 1 Sept 2023, In: BioMedInformatics. 3, 3

  Research output: Contribution to journal › Literature review › peer-review

• Forgiveness is the attribute of the strong: nonadherence and regimen-shortening in drug-sensitive TB

  Stagg, H. R., Thompson, J. A., Lipman, M. C. I., Sloan, D. J., Flook, M. & Fielding, K. L., 15 Jan 2023, In: American Journal of Respiratory and Critical Care Medicine. 207, 2, p. 193-205 13 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  No action is without its side effects: adverse drug reactions and missed doses of anti-tuberculosis therapy, a scoping review

  Dixon, E. G., Rasool, S., Otaalo, B., Motee, A., Dear, J. W., Sloan, D. & Stagg, H. R., 4 Sept 2023, (Accepted/In press) In: British Journal of Clinical Pharmacology.

  Research output: Contribution to journal › Review article › peer-review

• Open access

  Protocol for a feasibility randomized controlled trial to evaluate the efficacy, safety and tolerability of N-acetylcysteine in reducing adverse drug reactions among adults treated for multidrug-resistant tuberculosis in Tanzania

  Mpagama, S. G., Mvungi, H. C., Mbelele, P. M., Semvua, H. H., Liyoyo, A. A., de Guex, K. P., Sloan, D., Kibiki, G. S., Boeree, M., Phillips, P. P. J. & Heysell, S. K., 1 Apr 2023, In: Pilot and Feasibility Studies. 9, 13 p., 55.

  Research output: Contribution to journal › Article › peer-review

• Open access

  The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda

  Green, D. L., Keenan, K., Fredricks, K. J., Huque, S. I., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Kesby, M., Lynch, A. G., Worthington, H., Olamijuwon, E., Abed Al Ahad, M., Aduda, A., Njeru, J. M., Mmbaga, B. T., Bazira, J., & 14 others Sandeman, A., Stelling, J., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Holden, M. T. G., Smith, V. A., Decano, A. G., Maldonado-Barragán, A., Aanensen, D., Ntinginya, N. E., Elliott, A. & Clarkson, M., 1 Jan 2023, In: The Lancet Global Health. 11, 1, p. e59-e68 10 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Treatment seeking behaviours, antibiotic use and relationships to multi-drug resistance: a study of urinary tract infection patients in Kenya, Tanzania and Uganda

  HATUA Consortium, 20 Mar 2023, medRxiv.

  Research output: Working paper › Preprint

• Open access

  Trial-of-antibiotics to assist tuberculosis diagnosis in symptomatic adults in Malawi (ACT-TB study): a randomised controlled trial

  Divala, T. H., Corbett, E. L., Kandulu, C., Moyo, B., MacPherson, P., Nliwasa, M., French, N., Sloan, D. J., Chiume, L., Ndaferankhande, M. J., Chilanga, S., Majiga, S. T., Odland, J. Ø. & Fielding, K. L., 1 Apr 2023, In: The Lancet Global Health. 11, 4, p. e556-e565 10 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Unravelling patient pathways in the context of antibacterial resistance in East Africa

  HATUA Consortium, Keenan, K., Fredricks, K. J., Al Ahad, M. A., Neema, S., Mwanga, J. R., Kesby, M., Mushi, M. F., Aduda, A., Green, D. L., Lynch, A. G., Huque, S. I., Mmbaga, B. T., Worthington, H., Kansiime, C., Olamijuwon, E., Ntinginya, N. E., Loza, O., Bazira, J., Maldonado-Barragán, A., & 15 others Smith, VA., Decano, A. G., Njeru, J. M., Sandeman, A., Stelling, J., Elliott, A., Aanensen, D., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Asiimwe, B. B., Kiiru, J., Mshana, S. E. & Holden, M. T. G., 19 Jun 2023, In: BMC Infectious Diseases. 23, 1, 12 p., 414.

  Research output: Contribution to journal › Article › peer-review

• Open access

  “It is not easy”: experiences of people living with HIV and tuberculosis on Tuberculosis treatment in Uganda

  Nabisere-Arinaitwe, R., Namatende-Sakwa, L., Bayiga, J., Nampala, J., Alinaitwe, L., Aber, F., Otaalo, B., Musaazi, J., King, R., Kesby, M., Sloan, D. J. & Sekaggya-Wiltshire, C., Dec 2023, In: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases. 33, 100385.

  Research output: Contribution to journal › Article › peer-review

 

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