Dr Derek Sloan
Reader/Consultant in Infectious Diseases
Research areas
Dr Sloan is an academic Infectious Diseases clinician, leading his own independent research group at the University of St Andrews. He has worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB), and continues to have extensive collaborative links with partners around the world. His research funding comes from external sources including the Wellcome Trust, UKRI / MRC (UK) and the Europe and Developing Countries Clinical Trial Partnership (EDCTP).
In additional to his role at the University of St Andrews, he works with Radboudumc in The Netherlands as international co-ordinator of UNITE4TB, a large public-private partnership consortium working to develop new treatments for TB, with 30 partner institutions and clinical trials sites 13 countries on 3 continents.
He has supervised 8 successful PhD students, and has five PhD students under current supervision.
Dr Sloan is also a practicing physician in NHS Fife, and has an interest in the acute management of infectious disease outbreaks and has supported humanitarian responses to Ebola Virus Disease (Sierra Leone, 2015 and preparedness deployments to Rwanda in 2018 and 2019), diphtheria (displaced Rohingya population in Bangladesh, 2018), HIV (Ukraine, 2022), and cholera (Malawi, 2023). He is the UK-Med and UK Emegency Medical Team technical referent for Infectious Diseases.
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Year |
My role |
Funding source |
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2016-2019 |
Co-investigator |
EDCTP HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV |
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2015-2018 |
Supervisor/ Advisor |
Commonwealth PhD Scholarship/ Epistem Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi) |
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2015-2018 |
Primary Supervisor |
Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum |
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2015-2017 |
Principal Investigator |
British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi |
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2015-2017 |
Principal Investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes |
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2015-2017 |
Co-investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Rational development of an optimal treatment regimen for isoniazid mono-resistant TB |
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2010-2012 |
Co-investigator & collaborator |
Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza |
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2008-2012 |
Principal Investigator |
Wellcome Trust Clinical PhD Fellowship |
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2008 |
Principal Investigator |
LSTM Equipment Grant (Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory) |
PhD supervision
- Muge Cevik
- Katherine Hill
- Eva Agnes Laker Odongpiny
- Tionge Sikwese
Selected publications
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Open access
Adverse drug reactions, particularly liver disorders, drive interruptions in anti‐tuberculosis treatment: a retrospective cohort study
Dixon, E. G., Biraua, E., Brencsēns, E., Pašuks, V., Riekstina, V., Šperberga, A., Muckian, M. D., Dear, J. W., Kuksa, L., Sloan, D. J. & Stagg, H. R., 11 Aug 2025, (E-pub ahead of print) In: British Journal of Clinical Pharmacology. Early View, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
A programmatic assessment of dolutegravir adverse events and discontinuations in Uganda
Laker Odongpiny, E. A., Nicol, M., Katana, E., Owori, J., Buzibye, A., Sedan, K., Kesby, M., Holden, M., Owarwo, N., Meya, D., Castelnuovo, B., Sloan, D. J. & Sekaggya, C., 24 Jan 2025, (E-pub ahead of print) In: HIV Medicine. Early View, 14 p.Research output: Contribution to journal › Article › peer-review
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Open access
Cardiac safety of bedaquiline, delamanid and moxifloxacin co-administered with or without varying doses of sutezolid or delpazolid for the treatment of drug-susceptible TB
Koele, S. E., Stoycheva, K., Mtweve, C., Manyama, C., Mpagama, S., Mhimbira, F., Wallis, R., Ntinginya, N. E., Liyoyo, A., Huglin, B., Minja, L. T., Wagnerberger, L., Zumba, T., Noreña, I., Peter, D. D., Beattie, T., Makkan, H., Sloan, D. J., Te Brake, L. & Aarnoutse, R. E. & 9 others, , Aug 2025, In: Journal of Antimicrobial Chemotherapy. 80, 8, p. 2305-2313 9 p.Research output: Contribution to journal › Article › peer-review
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Open access
Modelling interventions to combat antibacterial resistance in East Africa using causal Bayesian networks
Ke, X., Smith, V. A., Mshana, S. E., Asiimwe, B., Neema, S., Kiiru, J., Mushi, M. F., Mmbaga, B. T., Mwanga, J. R., Kibiki, G., Stelling, J., Gillespie, S. H., Green, D. L., Benvari, S., Sabiiti, W., Kesby, M., Lynch, A. G., Sandeman, A., Sloan, D. J. & Holden, M. T. & 2 others, , 4 Feb 2025, Research Square.Research output: Working paper › Preprint
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Open access
Patterns of antibiotic resistance in urinary tract infections before and during the COVID-19 pandemic in Uganda and Tanzania
Silago, V., Keenan, K., Mushi, M. F., Kansiime, C., Asiimwe, B., Sunday, B., Bazira, J., Sandeman, A., Sabiiti, W., Seni, J., Holden, M. T. G., Mshana, S. E. & behalf of the HATUA and CARE Consortia, Apr 2025, In: JAC-Antimicrobial Resistance. 7, 2, p. 1-4 4 p., dlaf038.Research output: Contribution to journal › Article › peer-review
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Open access
Performance evaluation of alternative bacteriological measures of response to MDR/RR-TB therapy during the initial 16 weeks of treatment
Ssengooba, W., Musisi, E., Semugenze, D., Komakech, K., Ndema, M., Sekaggya-Wiltshire, C., Adakun, S., Sloan, D., Katamba, A., Lamorde, M., Joloba, M. & Sabiiti, W., 15 Oct 2025, In: BMC Infectious Diseases. 25, p. 1-11 11 p., 1336.Research output: Contribution to journal › Article › peer-review
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Open access
Performance evaluation of alternative bacteriological measures of response to MDR-TB therapy during the initial 16 weeks of treatment
Ssengooba, W., Musisi, E., Semugenze, D., Komakech, K., Ndema, M., Sekaggya, C. W., Adakun, S., Sloan, D. J., Katamba, A., Lamorde, M., Joloba, M. & Sabiiti, W., 10 Apr 2025, Research Square, p. 1-25, 25 p. (Research square).Research output: Working paper › Preprint
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Open access
Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043–02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial
Heinrich, N., de Jager, V., Dreisbach, J., Gross-Demel, P., Schultz, S., Gerbach, S., Kloss, F., Dawson, R., Narunsky, K., Matt, L., Wildner, L., McHugh, T. D., Fuhr, U., Aldana, B. H., Mouhdad, C., Brake, L. T., Boeree, M. J., Aarnoutse, R. E., Svensson, E. M. & Gong, X. & 4 others, , 7 Jan 2025, (E-pub ahead of print) In: The Lancet Microbe. Online first, 12 p., 100952.Research output: Contribution to journal › Article › peer-review
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Open access
Unpacking 'irrational' behaviours: situating the antibiotic selling practices of drug sellers in East Africa
Loza, O., Kesby, M., Fredricks, K. J., Neema, S., Mwanga, J. R., Aduda, A., Keenan, K., Huque, S., Sandeman, A., Mushi, M. F., Maldonado-Barragan, A., Olamijuwon, E., Gillespie, S. H., Sloan, D. J., Sabiiti, W., Asiimwe, B., Mshana, S. E., Kiiru, J. N., Holden, M. T. G. & HATUA Consortium, 30 Nov 2025, In: Global Public Health. 20, 1, 22 p., 2589540.Research output: Contribution to journal › Article › peer-review
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Open access
Bedaquiline-pretomanid-moxifloxacin-pyrazinamide for drug-sensitive and drug-resistant pulmonary tuberculosis treatment: a phase 2c, open-label, multicentre, partially randomised controlled trial
Cevik, M., Thompson, L. C., Upton, C., Rolla, V. C., Malahleha, M., Mmbaga, B., Ngubane, N., Abu Bakar, Z., Rassool, M., Variava, E., Dawson, R., Staples, S., Lalloo, U., Louw, C., Conradie, F., Eristavi, M., Samoilova, A., Skornyakov, S. N., Ntinginya, N. E. & Haraka, F. & 28 others, , 1 Sept 2024, In: The Lancet Infectious Diseases. 24, 9, p. 1003-1014 12 p.Research output: Contribution to journal › Article › peer-review