Research areas
I am a Research Fellow in the Harrison Lab working on on various research projects surrounding the role of the lipidome in the tumor microenvironment using the latest spatial and imaging technologies with a focus on mass spectrometry.
PhD supervision
- Greice Zickuhr
Selected publications
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Open access
Improved nucleoside (2'-deoxy)ribosyltransferases maximize enzyme promiscuity while maintaining catalytic efficiency
Tang, P., Zickuhr, G. M., Dickson, A. L., Harding, C. J., Devi, S., Lebl, T., Harrison, D. J., da Silva, R. G. & Melo Czekster, C., 17 Oct 2025, (E-pub ahead of print) In: ACS Chemical Biology. Article ASAP, 7 p.Research output: Contribution to journal › Letter › peer-review
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Open access
Kidney tumoroid characterisation by spatial mass spectrometry with same-section multiplex immunofluorescence uncovers tumour microenvironment lipid signatures associated with aggressive tumour phenotypes
Abdullah, H., Zickuhr, G. M., Um, I. H., Laird, A., Mullen, P., Harrison, D. J. & Dickson, A. L., 16 Sept 2025, In: npj Imaging. 3, p. 1-11 11 p., 43.Research output: Contribution to journal › Article › peer-review
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Open access
Defining the mode of action of cisplatin combined with NUC-1031, a phosphoramidate modification of gemcitabine
Patel, D., Dickson, A., Zickuhr, G. M., Um, I. H., Read, O. J., Melo Czekster, C., Mullen, P., Harrison, D. J. & Bre, J. L., 1 Dec 2024, In: Translational Oncology. 50, 11 p., 102114.Research output: Contribution to journal › Article › peer-review
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Open access
DESI-MSI-guided exploration of metabolic-phenotypic relationships reveals a correlation between PI 38:3 and proliferating cells in clear cell renal cell carcinoma via single-section co-registration of multimodal imaging
Zickuhr, G. M., Um, I. H., Laird, A., Harrison, D. J. & Dickson, A., Jul 2024, In: Analytical and Bioanalytical Chemistry. 416, 18, p. 4015–4028 14 p.Research output: Contribution to journal › Article › peer-review
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Open access
Snapshots of the reaction coordinate of a thermophilic 2'-deoxyribonucleoside/ribonucleoside transferase
Tang, P., Harding, C. J., Dickson, A., da Silva, R. G., Harrison, D. J. & Melo Czekster, C., 1 Mar 2024, In: ACS Catalysis. 14, 5, p. 3090-3102 13 p.Research output: Contribution to journal › Article › peer-review
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Open access
Catalytic cycle of the bifunctional enzyme phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-AMP cyclohydrolase
Fisher, G., Pecaver, E., Read, B., Leese, S., Laing, E., Dickson, A., Melo Czekster, C. & da Silva, R. G., 2 Jun 2023, In: ACS Catalysis. 13, 11, p. 7669-7679 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
HSD3B1 is an oxysterol 3β-hydroxysteroid dehydrogenase in human placenta
Dickson, A., Yutuc, E., Thornton, C. A., Dunford, J. E., Oppermann, U., Wang, Y. & Griffiths, W. J., 3 May 2023, In: Open Biology. 13, 5, 19 p., 220313.Research output: Contribution to journal › Article › peer-review
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Open access
Human 2'-deoxynucleoside 5'-phosphate N-hydrolase 1: mechanism of 2'-deoxyuridine 5'-monophosphate hydrolysis
Devi, S., Carberry, A. E., Zickuhr, G. M., Dickson, A., Harrison, D. J. & da Silva, R. G., 5 Sept 2023, In: Biochemistry. 62, 17, p. 2658-2668 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent
Bré, J. L., Dickson, A., Read, O. J., Zhang, Y., McKissock, F. G., Mullen, P., Tang, P., Zickuhr, G. M., Melo Czekster, C. & Harrison, D. J., 31 Mar 2023, In: Cancer Chemotherapy and Pharmacology. 12 p.Research output: Contribution to journal › Article › peer-review
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Open access
Identification of unusual oxysterols biosynthesised in human pregnancy by charge-tagging and liquid chromatography - mass spectrometry
Dickson, A. L., Yutuc, E., Thornton, C. A., Wang, Y. & Griffiths, W. J., 10 Nov 2022, In: Frontiers in Endocrinology. 13, 19 p., 1031013.Research output: Contribution to journal › Article › peer-review