Research areas
My research is interdisciplinary and sits at the interface between the basic sciences and medicine. Research in my laboratory is focused upon how metal ions are handled in the body and the roles they play in regulating medically/physiologically relevant processes. Collectively, my work provides detailed and reliable data relating to the transport and speciation of metal ions (particularly zinc and calcium) in the circulation and new insights into their cellular functions and role in disease states. Currently my team are examining ways in which defective metal handling contributes to pathogenesis of cardiovascular diseases, including vascular eye disease and dementia.
PhD supervision
- Stephen Hierons
- Jordan Marsh
- Quenton Hurst
- Hasnain Ahmed
- Boyang Lin
- Claudia Harper
Selected publications
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Changes in fibrin clot properties in patients after Roux en-Y gastric bypass surgery
Abbas, K., Hierons, S. J., Pechlivani, N., Phoenix, F., Alexander, R., King, R., Ajjan, R. A. & Stewart, A. J., 19 Mar 2024, In: Research and Practice in Thrombosis and Haemostasis. 8, 8 p., e102361.Research output: Contribution to journal › Article › peer-review
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Open access
Recent advances in metalloproteomics
Coverdale, J. P. C., Polepalli, S., Arruda, M. A. Z., Santos Da Silva, A. B., Stewart, A. J. & Blindauer, C. A., 13 Jan 2024, In: Biomolecules. 14, 1, 31 p., 104.Research output: Contribution to journal › Review article › peer-review
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Open access
Editorial: Insulin resistance and cardiovascular disease
Stewart, A. J., Tuncay, E., Pitt, S. J. & Rainbow, R. D., 4 Aug 2023, In: Frontiers in Endocrinology. 14, 3 p., 1266173.Research output: Contribution to journal › Editorial › peer-review
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Open access
Five new diarylbutyrolactones and sesquilignans from Saussurea medusa and their inhibitory effects on LPS-induced NO production
Cao, J-Y., Wang, Z-Y., Stewart, A. J., Dong, Q., Zhao, Y., Mei, L-J., Tao, Y-D. & Yu, R-T., 1 Jun 2023, In: Planta Medica. 89, 06, p. 663-673 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Investigating native metal ion binding sites in mammalian histidine-rich glycoprotein
Ackermann, K., Khazaipoul, S., Wort, J., Sobczak, A. I. S., El Mkami, H., Stewart, A. J. & Bode, B. E., 12 Apr 2023, In: Journal of the American Chemical Society. 145, 14, p. 8064-8072 9 p.Research output: Contribution to journal › Article › peer-review
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Open access
Magnesium deficiency and cardiometabolic disease
Fritzen, R., Davies, A., Veenhuizen, M., Campbell, M., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., 17 May 2023, In: Nutrients. 15, 10, 19 p., 2355.Research output: Contribution to journal › Article › peer-review
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Open access
Optimised plasma sample preparation and LC-MS analysis to support large-scale proteomic analysis of clinical trial specimens: application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial
O'Rourke, M. B., Januszewski, A. S., Sullivan, D. R., Lengyel, I., Stewart, A. J., Arya, S., Ma, R., Galande, S., Hardikar, A. A., Joglekar, M. V., Keech, A. C., Jenkins, A. J. & Molloy, M. P., 16 May 2023, In: Proteomics - Clinical Applications. 17, 3, 10 p., 2200106.Research output: Contribution to journal › Article › peer-review
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Open access
Structural and biochemical characterisation of Co2+-binding sites on serum albumins and their interplay with fatty acids
Wu, D., Gucwa, M., Czub, M. P., Cooper, D. R., Shabalin, I. G., Fritzen, R., Arya, S., Schwarz-Linek, U., Blindauer, C. A., Minor, W. & Stewart, A. J., 21 Jun 2023, In: Chemical Science. 14, 23, p. 6244-6258 15 p.Research output: Contribution to journal › Article › peer-review
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Open access
The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart
Dorward, A. M., Stewart, A. J. & Pitt, S. J., 16 Jun 2023, In: Journal of General Physiology. 155, 7, 18 p., e202213206.Research output: Contribution to journal › Article › peer-review
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Open access
Total plasma magnesium, zinc, copper and selenium concentrations in obese patients before and after bariatric surgery
Hierons, S. J., Catchpole, A., Abbas, K., Wong, W., Giles, M. S., Miller, G. V., Ajjan, R. A. & Stewart, A. J., 1 Apr 2023, In: BioMetals. 36, 2, p. 241-253 13 p.Research output: Contribution to journal › Article › peer-review