Prof Andy Lynch

Professor of Statistics in Bioscience

Researcher profile

Phone

+44 (0)1334 463700

Email

andy.lynch@st-andrews.ac.uk

Biography

Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.

Research areas

Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma,  Oesophageal, Breast, Renal, Ovarian and Lung). 

PhD supervision

• Victor Velasco Pardo
• Xiaoyue Yang
• Naici Guo
• Filippo Abbondanza

Selected publications

• Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

  PCAWG Drivers and Functional Interpretation Working Group, PCAWG Structural Variation Working Group & PCAWG Consortium, 6 Feb 2020, In : Nature. 578, 7793, p. 102-111 10 p.

  Research output: Contribution to journal ? Article

• Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

  Cortés-Ciriano, I., Lee, J. J-K., Xi, R., Jain, D., Jung, Y. L., Yang, L., Gordenin, D., Klimczak, L. J., Zhang, C-Z., Pellman, D. S., PCAWG Structural Variation Working Group, Park, P. J. & PCAWG Consortium, Mar 2020, In : Nature Genetics. 52, 3, p. 331-341

  Research output: Contribution to journal ? Article

• Different laterality indexes are poorly correlated with one another but consistently show the tendency of males and females to be more left- and right- lateralized, respectively

  Castillo, C. B., Lynch, A. G. & Paracchini, S., 15 Apr 2020, In : Royal Society Open Science. 7, 4, 14 p., 191700.

  Research output: Contribution to journal ? Article

• Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

  Akdemir, K. C., Le, V. T., Chandran, S., Li, Y., Verhaak, R. G., Beroukhim, R., Campbell, P. J., Chin, L., Dixon, J. R., Futreal, P. A., PCAWG Structural Variation Working Group & PCAWG Consortium, Mar 2020, In : Nature Genetics. 52, 3, p. 294-305

  Research output: Contribution to journal ? Article

• High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

  Zhang, Y., Chen, F., Fonseca, N. A., He, Y., Fujita, M., Nakagawa, H., Zhang, Z., PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Creighton, C. J. & PCAWG Consortium, 5 Feb 2020, In : Nature Communications. 11, 14 p., 736.

  Research output: Contribution to journal ? Article

• Pan-cancer analysis of whole genomes

  The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, 6 Feb 2020, In : Nature. 578, 7793, p. 82-93 12 p.

  Research output: Contribution to journal ? Article

• Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

  PCAWG Structural Variation Working Group & PCAWG Consortium, Mar 2020, In : Nature Genetics. 52, 3, p. 306-319

  Research output: Contribution to journal ? Article

• Patterns of somatic structural variation in human cancer genomes

  Li, Y., Roberts, N. D., Wala, J. A., Shapira, O., Schumacher, S. E., Kumar, K., Khurana, E., Waszak, S., Korbel, J. O., Haber, J. E., Imielinski, M., PCAWG Structural Variation Working Group, Weischenfeldt, J., Beroukhim, R., Campbell, P. J. & PCAWG Consortium, 6 Feb 2020, In : Nature. 578, 7793, p. 112-121 10 p.

  Research output: Contribution to journal ? Article

• Whole-genome sequencing of a sporadic primary immunodeficiency cohort

  Primary Immunodeficiency Consortium for the NIHR Bioresource & Lynch, A. G., 6 May 2020, In : Nature.

  Research output: Contribution to journal ? Article

• Deciphering the genomic, epigenomic and transcriptomic landscapes of pre-invasive lung cancer lesions

  Texeira, V. H., Pipinikas, C. P., Pennycuick, A., Lee-Six, H., Chandrasekharan, D., Beane, J., Morris, T. J., Karpathakis, A., Feber, A., Breeze, C. E., Ntolios, P., Hynds, R. E., Falzon, M., Capitanio, A., Carroll, B., Durrenberger, P. F., Hardavella, G., Brown, J. M., Lynch, A. G., Farmery, H., Paul, D. S., Chambers, R. C., McGranahan, N., Navani, N., Thakrar, R. M., Swanton, C., Beck, S., George, P. J., Spira, A., Campbell, P. J., Thirwell, C. & Janes, S. M., Mar 2019, In : Nature Medicine. 25, 3, p. 517-525 9 p.

  Research output: Contribution to journal ? Article

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