Prof Andy Lynch
Professor of Statistics in Bioscience
Biography
Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.
Research areas
Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma, Oesophageal, Breast, Renal, Ovarian and Lung).
PhD supervision
- Victor Velasco Pardo
- Xiaoyue Yang
- Naici Guo
- Filippo Abbondanza
Selected publications
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Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
PCAWG Drivers and Functional Interpretation Working Group, PCAWG Structural Variation Working Group & PCAWG Consortium, 6 Feb 2020, In : Nature. 578, 7793, p. 102-111 10 p.Research output: Contribution to journal ? Article
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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Cortés-Ciriano, I., Lee, J. J-K., Xi, R., Jain, D., Jung, Y. L., Yang, L., Gordenin, D., Klimczak, L. J., Zhang, C-Z., Pellman, D. S., PCAWG Structural Variation Working Group, Park, P. J. & PCAWG Consortium, Mar 2020, In : Nature Genetics. 52, 3, p. 331-341Research output: Contribution to journal ? Article
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Different laterality indexes are poorly correlated with one another but consistently show the tendency of males and females to be more left- and right- lateralized, respectively
Castillo, C. B., Lynch, A. G. & Paracchini, S., 15 Apr 2020, In : Royal Society Open Science. 7, 4, 14 p., 191700.Research output: Contribution to journal ? Article
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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Akdemir, K. C., Le, V. T., Chandran, S., Li, Y., Verhaak, R. G., Beroukhim, R., Campbell, P. J., Chin, L., Dixon, J. R., Futreal, P. A., PCAWG Structural Variation Working Group & PCAWG Consortium, Mar 2020, In : Nature Genetics. 52, 3, p. 294-305Research output: Contribution to journal ? Article
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High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
Zhang, Y., Chen, F., Fonseca, N. A., He, Y., Fujita, M., Nakagawa, H., Zhang, Z., PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Creighton, C. J. & PCAWG Consortium, 5 Feb 2020, In : Nature Communications. 11, 14 p., 736.Research output: Contribution to journal ? Article
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Pan-cancer analysis of whole genomes
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, 6 Feb 2020, In : Nature. 578, 7793, p. 82-93 12 p.Research output: Contribution to journal ? Article
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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
PCAWG Structural Variation Working Group & PCAWG Consortium, Mar 2020, In : Nature Genetics. 52, 3, p. 306-319Research output: Contribution to journal ? Article
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Patterns of somatic structural variation in human cancer genomes
Li, Y., Roberts, N. D., Wala, J. A., Shapira, O., Schumacher, S. E., Kumar, K., Khurana, E., Waszak, S., Korbel, J. O., Haber, J. E., Imielinski, M., PCAWG Structural Variation Working Group, Weischenfeldt, J., Beroukhim, R., Campbell, P. J. & PCAWG Consortium, 6 Feb 2020, In : Nature. 578, 7793, p. 112-121 10 p.Research output: Contribution to journal ? Article
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Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Primary Immunodeficiency Consortium for the NIHR Bioresource & Lynch, A. G., 6 May 2020, In : Nature.Research output: Contribution to journal ? Article
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Deciphering the genomic, epigenomic and transcriptomic landscapes of pre-invasive lung cancer lesions
Texeira, V. H., Pipinikas, C. P., Pennycuick, A., Lee-Six, H., Chandrasekharan, D., Beane, J., Morris, T. J., Karpathakis, A., Feber, A., Breeze, C. E., Ntolios, P., Hynds, R. E., Falzon, M., Capitanio, A., Carroll, B., Durrenberger, P. F., Hardavella, G., Brown, J. M., Lynch, A. G., Farmery, H., Paul, D. S., Chambers, R. C., McGranahan, N., Navani, N., Thakrar, R. M., Swanton, C., Beck, S., George, P. J., Spira, A., Campbell, P. J., Thirwell, C. & Janes, S. M., Mar 2019, In : Nature Medicine. 25, 3, p. 517-525 9 p.Research output: Contribution to journal ? Article