Prof Andy Lynch

Prof Andy Lynch

Professor

Researcher profile

Phone
+44 (0)1334 46 3700
Email
andy.lynch@st-andrews.ac.uk
Office
332 MI
Location
Mathematical Institute

 

Biography

Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.

Research areas

Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma,  Oesophageal, Breast, Renal, Ovarian and Lung). 

PhD supervision

  • Victor Velasco Pardo
  • Naici Guo
  • Mariya Shtumpf
  • Katherine O'Neill

Selected publications

  • Open access

    The role of multidimensional poverty in antibiotic misuse: a mixed-methods study of self-medication and non-adherence in Kenya, Tanzania, and Uganda

     Green, D. L., Keenan, K., Fredricks, K. J., Huque, S. I., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Kesby, M., Lynch, A. G., Worthington, H., Olamijuwon, E., Abed Al Ahad, M., Aduda, A., Njeru, J. M., Mmbaga, B. T., Bazira, J., Sandeman, A., Stelling, J., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Holden, M. T. G., Smith, V. A., Decano, A. G., Maldonado-Barragán, A., Aanensen, D., Ntinginya, N. E., Elliott, A. & Clarkson, M., 1 Jan 2023, In: The Lancet Global Health. 11, 1, p. e59-e68 10 p.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

     Guo, N., Minas, G., Synowsky, S. A., Dunne, M. R., Ahmed, H., McShane, R., Bhardwaj, A., Donlon, N. E., Lorton, C., O'Sullivan, J., Reynolds, J. V., Caie, P. D., Shirran, S. L., Lynch, A., Stewart, A. J. & Arya, S., 30 Aug 2022, In: Journal of Proteomics. 266, 11 p., 104684.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Low-cost and clinically applicable copy number profiling using repeat DNA

     Abujudeh, S., Zeki, S., van Lanshot, M., Pusang, M., Weaver, J., li, X., Noorani, A., Metz, A., Bornschein, J., Bower, L., Miremedi, A., Fitzgerald, R., Morrissey, E. & Lynch, A., 17 Aug 2022, In: BMC Genomics. 23, 599.

    Research output: Contribution to journal › Article › peer-review

  • Open access

    Microbiomes of urine and the prostate are linked to human prostate cancer risk groups

     Hurst, R., Meader, E., Gihawi, A., Rallapalli, G., Clark, J., Kay, G. L., Webb, M., Manley, K., Curley, H., Walker, H., Kumar, R., Schmidt, K., Crossman, L., Eeles, R. A., Wedge, D. C., Lynch, A. G., Massie, C. E., CRUK-ICGC Prostate Group, Yazbek-Hanna, M., Rochester, M., Mills, R. D., Mithen, R. F., Traka, M. H., Ball, R. Y., O'Grady, J., Brewer, D. S., Wain, J. & Cooper, C. S., 1 Aug 2022, In: European Urology Oncology. 5, 4, p. 412-419 8 p.

    Research output: Contribution to journal › Article › peer-review

  • PCR duplicate proportion estimation and consequences for DNA copy number calculations

     Lynch, A., Smith, M., Eldridge, M. & Tavaré, S., 29 Nov 2022, Recent developments in statistics and data science: SPE2021, Évora, Portugal, October 13–16. Bispo, R., Henriques-Rodrigues, L., Alpizar-Jara, R. & de Carvalho, M. (eds.). Cham: Springer, Vol. 398. p. 259-279 21 p. (Springer proceedings in mathematics & statistics; vol. 398).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Open access

    Rare germline variants are associated with rapid biochemical recurrence after radical prostate cancer treatment: a PPCG study

     Burns, D., Anokiana, E., Saunders, E. J., Bristow, R. G., Fraser, M., Reimand, J., Schlomm, T., Sauter, G., Brors, B., Korbeli, J., Weischenfeldt, J., Waszak, S. M., Corcoran, N. M., Jung, C-H., Pope, B. J., Hovens, C. M., Cancel-Tassin, G., Cussenot, O., Loda, M., Sander, C., Hayes, V. M., Sorensen, K. D., Lu, Y-J., Hamdy, F. C., Foster, C. S., Gnanapragasam, V., Butler, A., Lynch, A., Massie, C. E., CR-UK/Prostate Cancer UK, ICGC, The PPCG, Woodcock, D. J., Cooper, C. S., Wedge, D. C., Brewer, D. S., Kote-Jarai, Z. & Eeles, R., 1 Aug 2022, In: European Urology. 82, 2, p. 201-211 11 p.

    Research output: Contribution to journal › Article › peer-review

  • Statistical challenges in mutational signature analyses of cancer sequencing data

     Velasco Pardo, V., Papathomas, M. & Lynch, A., 29 Nov 2022, Recent developments in statistics and data science: SPE2021, Évora, Portugal, October 13–16. Bispo, R., Henriques-Rodrigues, L., Alpizar-Jara, R. & de Carvalho, M. (eds.). Cham: Springer, p. 241-258 (Springer Proceedings in Mathematics & Statistics; vol. 398).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Open access

    The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates

     Buhigas, C., Warren, A. Y., Leung, W-K., Whitaker, H. C., Luxton, H. J., Hawkins, S., Kay, J., Butler, A., Xu, Y., Woodcock, D., Merson, S., Frame, F. M., Sahli, A., Abascal, F., CRUK-ICGC Prostate Group, Martincorena, I., Bova, G. S., Foster, C. S., Campbell, P., Maitland, N., Neal, D. E., Massie, C. E., Lynch, A., Eeles, R. A., Cooper, C. S., Wedge, D. C. & Brewer, D. S., 22 Sep 2022, In: Molecular Cancer. 21, 16 p., 183.

    Research output: Contribution to journal › Article › peer-review

  • Unravelling patient pathways in the context of antibacterial resistance in East Africa

     Keenan, K. L., Fredricks, K. J., Abed Al Ahad, M., Neema, S., Mwanga, J. R., Kesby, M., Mushi, M. F., Aduda, A., Green, D. L., Lynch, A., Huque, S. I., Mmbaga, B. T., Worthington, H., Kansiime, C., Olamijuwon, E. O., Ntinginya, N. E., Loza, O., Bazira, J., Maldonado, A., Smith, V. A., Decano, A., Mwaniki, J. N., Sandeman, A. F., Stelling, J., Elliott, A., Aanensen, D., Gillespie, S. H., Kibiki, G., Sabiiti, W., Sloan, D. J., Asiimwe, B. B., Mshana, S. E., Kiiru, J., Holden, M. & HATUA Consortium, 5 Aug 2022, (Submitted) In: BMC Infectious Diseases.

    Research output: Contribution to journal › Article

  • CamGFR v2: a new model for estimating the glomerular filtration rate from standardized or non-standardized creatinine in patients with cancer

     Williams, E. H., Flint, T. R., Connell, C. M., Giglio, D., Lee, H., Ha, T., Gablenz, E., Bird, N. J., Weaver, J. M. J., Potts, H., Whitley, C. T., Bookman, M. A., Lynch, A. G., Meyer, H. V., Tavaré, S. & Janowitz, T., Mar 2021, In: Clinical Cancer Research. 27, 5

    Research output: Contribution to journal › Article › peer-review

 

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