Prof Andy Lynch
Professor
- Phone
- +44 (0)1334 46 3700
- andy.lynch@st-andrews.ac.uk
- Office
- 332 MI
- Location
- Mathematical Institute
Biography
Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.
Research areas
Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma, Oesophageal, Breast, Renal, Ovarian and Lung).
PhD supervision
- Filippo Abbondanza
- Victor Velasco Pardo
- Xiaoyue Yang
- Naici Guo
- Katherine O'Neill
Selected publications
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Open access
Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS
Guo, N., Minas, G., Synowsky, S. A., Dunne, M. R., Ahmed, H., McShane, R., Bhardwaj, A., Donlon, N. E., Lorton, C., O'Sullivan, J., Reynolds, J. V., Caie, P. D., Shirran, S. L., Lynch, A., Stewart, A. J. & Arya, S., 30 Aug 2022, In: Journal of Proteomics. 266, 11 p., 104684.Research output: Contribution to journal › Article › peer-review
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Microbiomes of urine and the prostate are linked to human prostate cancer risk groups
Hurst, R., Meader, E., Gihawi, A., Rallapalli, G., Clark, J., Kay, G. L., Webb, M., Manley, K., Curley, H., Walker, H., Kumar, R., Schmidt, K., Crossman, L., Eeles, R. A., Wedge, D. C., Lynch, A. G., Massie, C. E., CRUK-ICGC Prostate Group, Yazbek-Hanna, M., Rochester, M., Mills, R. D., Mithen, R. F., Traka, M. H., Ball, R. Y., O'Grady, J., Brewer, D. S., Wain, J. & Cooper, C. S., 18 Apr 2022, (E-pub ahead of print) In: European Urology Oncology.Research output: Contribution to journal › Article › peer-review
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Open access
Rare germline variants are associated with rapid biochemical recurrence after radical prostate cancer treatment: a PPCG study
Burns, D., Anokiana, E., Saunders, E. J., Bristow, R. G., Fraser, M., Reimand, J., Schlomm, T., Sauter, G., Brors, B., Korbeli, J., Weischenfeldt, J., Waszak, S. M., Corcoran, N. M., Jung, C-H., Pope, B. J., Hovens, C. M., Cancel-Tassin, G., Cussenot, O., Loda, M., Sander, C., Hayes, V. M., Sorensen, K. D., Lu, Y-J., Hamdy, F. C., Foster, C. S., Gnanapragasam, V., Butler, A., Lynch, A., Massie, C. E., CR-UK/Prostate Cancer UK, ICGC, The PPCG, Woodcock, D. J., Cooper, C. S., Wedge, D. C., Brewer, D. S., Kote-Jarai, Z. & Eeles, R., Aug 2022, In: European Urology. 82, 2, p. 201-211Research output: Contribution to journal › Article › peer-review
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Statistical challenges in mutational signature analyses of cancer sequencing data
Velasco Pardo, V., Papathomas, M. & Lynch, A., 1 Feb 2022, (Accepted/In press) Proceedings of the Portuguese Statistical Society. Alpizar-Jara, R., Bispo, R., de Carvalho, M. & Henriques-Rodrigues, L. (eds.).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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CamGFR v2: a new model for estimating the glomerular filtration rate from standardized or non-standardized creatinine in patients with cancer
Williams, E. H., Flint, T. R., Connell, C. M., Giglio, D., Lee, H., Ha, T., Gablenz, E., Bird, N. J., Weaver, J. M. J., Potts, H., Whitley, C. T., Bookman, M. A., Lynch, A. G., Meyer, H. V., Tavaré, S. & Janowitz, T., Mar 2021, In: Clinical Cancer Research. 27, 5Research output: Contribution to journal › Article › peer-review
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Open access
Protocol for an interdisciplinary cross-sectional study investigating the social, biological and community-level drivers of antimicrobial resistance (AMR): Holistic Approach to Unravelling Antibiotic Resistance in East Africa (HATUA)
Asiimwe, B. B., Kiiru, J., Mshana, S. E., Neema, S., Keenan, K., Kesby, M., Mwanga, J. R., Sloan, D. J., Mmbaga, B. T., Smith, V. A., Gillespie, S. H., Lynch, A. G., Sandeman, A., Stelling, J., Elliott, A., Aanensen, D. M., Kibiki, G. E., Sabiiti, W., Holden, M. T. G. & HATUA Consortium, Mar 2021, In: BMJ Open. 11, 3, 10 p., e041418.Research output: Contribution to journal › Article › peer-review
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Open access
Resolving the immune landscape of human prostate at a single-cell level in health and cancer
Tuong, Z. K., Loudon, K. W., Berry, B., Richoz, N., Jones, J., Tan, X., Nguyen, Q., George, A., Hori, S., Field, S., Lynch, A. G., Kania, K., Coupland, P., Babbage, A., Grenfell, R., Barrett, T., Warren, A. Y., Gnanapragasam, V., Massie, C. & Clatworthy, M. R., 21 Dec 2021, In: Cell Reports. 37, 12, 24 p., 110132.Research output: Contribution to journal › Article › peer-review
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The role of multidimensional poverty in antibiotic misuse: a study of self-medication and non-adherence in Kenya, Tanzania, and Uganda
Green, D. L., Keenan, K., Huque, S. I., Kesby, M., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Fredricks, K. J., Lynch, A. G., Worthington, H., Olamijuwon, E., Ahad, M. A. A., Aduda, A., Mmbaga, B. T., Bazira, J., Sandeman, A., Stelling, J., Gillespie, S. H., Kibiki, G., Sabiti, W., Sloan, D. J., Holden, M. T. G. & Consortium, H., 2021, In: SSRN Electronic Journal.Research output: Contribution to journal › Article
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Open access
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
PCAWG Drivers and Functional Interpretation Working Group, PCAWG Structural Variation Working Group & PCAWG Consortium, 6 Feb 2020, In: Nature. 578, 7793, p. 102-111 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
Cortés-Ciriano, I., Lee, J. J-K., Xi, R., Jain, D., Jung, Y. L., Yang, L., Gordenin, D., Klimczak, L. J., Zhang, C-Z., Pellman, D. S., PCAWG Structural Variation Working Group, Park, P. J. & PCAWG Consortium, Mar 2020, In: Nature Genetics. 52, 3, p. 331-341Research output: Contribution to journal › Article › peer-review