Prof Andy Lynch

Professor

Researcher profile

Phone

+44 (0)1334 46 3700

Email

andy.lynch@st-andrews.ac.uk

Office

332 MI

Location

Mathematical Institute

 

Biography

Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.

Research areas

Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma,  Oesophageal, Breast, Renal, Ovarian and Lung). 

PhD supervision

• Filippo Abbondanza
• Victor Velasco Pardo
• Xiaoyue Yang
• Naici Guo
• Katherine O'Neill

Selected publications

• Open access

  Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

  Guo, N., Minas, G., Synowsky, S. A., Dunne, M. R., Ahmed, H., McShane, R., Bhardwaj, A., Donlon, N. E., Lorton, C., O'Sullivan, J., Reynolds, J. V., Caie, P. D., Shirran, S. L., Lynch, A., Stewart, A. J. & Arya, S., 30 Aug 2022, In: Journal of Proteomics. 266, 11 p., 104684.

  Research output: Contribution to journal › Article › peer-review

• Microbiomes of urine and the prostate are linked to human prostate cancer risk groups

  Hurst, R., Meader, E., Gihawi, A., Rallapalli, G., Clark, J., Kay, G. L., Webb, M., Manley, K., Curley, H., Walker, H., Kumar, R., Schmidt, K., Crossman, L., Eeles, R. A., Wedge, D. C., Lynch, A. G., Massie, C. E., CRUK-ICGC Prostate Group, Yazbek-Hanna, M., Rochester, M., Mills, R. D., Mithen, R. F., Traka, M. H., Ball, R. Y., O'Grady, J., Brewer, D. S., Wain, J. & Cooper, C. S., 18 Apr 2022, (E-pub ahead of print) In: European Urology Oncology.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Rare germline variants are associated with rapid biochemical recurrence after radical prostate cancer treatment: a PPCG study

  Burns, D., Anokiana, E., Saunders, E. J., Bristow, R. G., Fraser, M., Reimand, J., Schlomm, T., Sauter, G., Brors, B., Korbeli, J., Weischenfeldt, J., Waszak, S. M., Corcoran, N. M., Jung, C-H., Pope, B. J., Hovens, C. M., Cancel-Tassin, G., Cussenot, O., Loda, M., Sander, C., Hayes, V. M., Sorensen, K. D., Lu, Y-J., Hamdy, F. C., Foster, C. S., Gnanapragasam, V., Butler, A., Lynch, A., Massie, C. E., CR-UK/Prostate Cancer UK, ICGC, The PPCG, Woodcock, D. J., Cooper, C. S., Wedge, D. C., Brewer, D. S., Kote-Jarai, Z. & Eeles, R., Aug 2022, In: European Urology. 82, 2, p. 201-211

  Research output: Contribution to journal › Article › peer-review

• Statistical challenges in mutational signature analyses of cancer sequencing data

  Velasco Pardo, V., Papathomas, M. & Lynch, A., 1 Feb 2022, (Accepted/In press) Proceedings of the Portuguese Statistical Society. Alpizar-Jara, R., Bispo, R., de Carvalho, M. & Henriques-Rodrigues, L. (eds.).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• CamGFR v2: a new model for estimating the glomerular filtration rate from standardized or non-standardized creatinine in patients with cancer

  Williams, E. H., Flint, T. R., Connell, C. M., Giglio, D., Lee, H., Ha, T., Gablenz, E., Bird, N. J., Weaver, J. M. J., Potts, H., Whitley, C. T., Bookman, M. A., Lynch, A. G., Meyer, H. V., Tavaré, S. & Janowitz, T., Mar 2021, In: Clinical Cancer Research. 27, 5

  Research output: Contribution to journal › Article › peer-review

• Open access

  Protocol for an interdisciplinary cross-sectional study investigating the social, biological and community-level drivers of antimicrobial resistance (AMR): Holistic Approach to Unravelling Antibiotic Resistance in East Africa (HATUA)

  Asiimwe, B. B., Kiiru, J., Mshana, S. E., Neema, S., Keenan, K., Kesby, M., Mwanga, J. R., Sloan, D. J., Mmbaga, B. T., Smith, V. A., Gillespie, S. H., Lynch, A. G., Sandeman, A., Stelling, J., Elliott, A., Aanensen, D. M., Kibiki, G. E., Sabiiti, W., Holden, M. T. G. & HATUA Consortium, Mar 2021, In: BMJ Open. 11, 3, 10 p., e041418.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Resolving the immune landscape of human prostate at a single-cell level in health and cancer

  Tuong, Z. K., Loudon, K. W., Berry, B., Richoz, N., Jones, J., Tan, X., Nguyen, Q., George, A., Hori, S., Field, S., Lynch, A. G., Kania, K., Coupland, P., Babbage, A., Grenfell, R., Barrett, T., Warren, A. Y., Gnanapragasam, V., Massie, C. & Clatworthy, M. R., 21 Dec 2021, In: Cell Reports. 37, 12, 24 p., 110132.

  Research output: Contribution to journal › Article › peer-review

• The role of multidimensional poverty in antibiotic misuse: a study of self-medication and non-adherence in Kenya, Tanzania, and Uganda

  Green, D. L., Keenan, K., Huque, S. I., Kesby, M., Mushi, M. F., Kansiime, C., Asiimwe, B., Kiiru, J., Mshana, S. E., Neema, S., Mwanga, J. R., Fredricks, K. J., Lynch, A. G., Worthington, H., Olamijuwon, E., Ahad, M. A. A., Aduda, A., Mmbaga, B. T., Bazira, J., Sandeman, A., Stelling, J., Gillespie, S. H., Kibiki, G., Sabiti, W., Sloan, D. J., Holden, M. T. G. & Consortium, H., 2021, In: SSRN Electronic Journal.

  Research output: Contribution to journal › Article

• Open access

  Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

  PCAWG Drivers and Functional Interpretation Working Group, PCAWG Structural Variation Working Group & PCAWG Consortium, 6 Feb 2020, In: Nature. 578, 7793, p. 102-111 10 p.

  Research output: Contribution to journal › Article › peer-review

• Open access

  Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

  Cortés-Ciriano, I., Lee, J. J-K., Xi, R., Jain, D., Jung, Y. L., Yang, L., Gordenin, D., Klimczak, L. J., Zhang, C-Z., Pellman, D. S., PCAWG Structural Variation Working Group, Park, P. J. & PCAWG Consortium, Mar 2020, In: Nature Genetics. 52, 3, p. 331-341

  Research output: Contribution to journal › Article › peer-review

 

See more publications