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Dr Uli Schwarz-Linek

Dr Uli Schwarz-Linek

Senior Lecturer

Researcher profile

Phone
+44 (0)1334 467188
Email
Uli.Schwarz-Linek@st-andrews.ac.uk

 

Research areas

Our research is directed at understanding structure, mechanism of host protein recognition and function of bacterial and viral virulence factors, with an emphasis on Gram-positive bacterial surface proteins. My group specialises in structural biology and protein biochemistry, complemented with biophysical and cell-based techniques. We have a particular interest in TIE (thioester, isopeptide, ester domain) proteins of Gram-positive pathogens including group A streptococci, vancomycin-resistant enterococci, Bacillus anthracis and Clostridium difficile. Our most significant contribution to the field was the discovery of bacteria-encoded, TIE protein-mediated covalent binding as a novel molecular principle in host-microbe interactions. The lab also exploits TIE domains for protein engineering to develop molecular tools for diagnostics, therapy and nanotechnology. Another focus of the group is the structural characterization of GAS M proteins, and the analysis of molecular mechanisms of post-streptococcal rheumatic sequelae. We also investigate structure and functions of single strand RNA virus NSs proteins, key virulence factors of a large class of clinically and economically important pathogens, with a focus on Rift Valley fever phlebovirus.

PhD supervision

  • Callum Turner

Selected publications

 

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