Prof Terry K Smith
Director of Biomedical Sciences Research Complex
Professor
Research areas
1) Biosynthesis and uptake of phospholipids in protozoan parasites.
2) The enzymology of biosynthetic enzymes in parasites.
3) Lipidomics and focussed metabolomics of pathogens.
4) Carbohydrate synthesis and “simple” chemistry towards drugs for neglected disease.
5) Structure, function & biosynthesis of parasite glycoconjugates including GPI anchors.
PhD supervision
- Peter Black
- Vytautas Kuodis
- Ernst Kwa
- Ngoc Anh Thu Trinh
Selected publications
-
Open access
Bioactivity profiles of progressively ring-fluorinated cyclohexyl motifs in the WKYMVm peptide as formylpeptide FPR2 agonists and in keto-piperazines as antitrypanosome agents
He, M., Thomson, C. M., Thompson, D., Kuodis, V., Smith, T. K., Dall'Angelo, S. & O'Hagan, D., 3 Oct 2025, (E-pub ahead of print) In: ChemBioChem. Early View, 8 p., 2500384.Research output: Contribution to journal › Article › peer-review
-
Open access
Building a cell-factory in Crithidia fasciculata: a bio-sustainable system to produce high-value polyunsaturated fatty acids
Cerone, M., Major, L. L. & Smith, T. K., 23 Jun 2025, In: Microbial Cell Factories. 24, p. 1-16 16 p., 142.Research output: Contribution to journal › Article › peer-review
-
Open access
Exploring the activity of the putative Δ6-desaturase and its role in bloodstream form life-cycle transitions in Trypanosoma brucei
Cerone, M. & Smith, T. K., 18 Feb 2025, In: PLoS Pathogens. 21, 2, p. 1-39 39 p., e1012691.Research output: Contribution to journal › Article › peer-review
-
Open access
Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages
Alberione, M. P., Avalos-Padilla, Y., Rangel, G. W., Ramírez, M., Romero-Uruñuela, T., Fenollar, À., Ortega-Barrionuevo, J., Crispim, M., Smith, T. K., Llinás, M. & Izquierdo, L., 3 Jul 2025, In: PLoS Pathogens. 21, 7, p. 1-27 27 p., e1012832.Research output: Contribution to journal › Article › peer-review
-
Open access
High-throughput screening of potent drug-like molecules targeting 17β-HSD10 for the treatment of Alzheimer's disease and cancer
Aitken, L., Baillie, G., Pannifer, A., Morrison, A., Major, L. L., Alphey, M. S., Sethi, R., Timmerman, M., Robinson, J., Riley, J., Shishikura, Y., Koekemoer, L., Von Delft, F., Rutjes, H., Read, K., Jones, P. S., McElroy, S. P., Smith, T. K. & Gunn-Moore, F. J., 18 Jun 2025, (E-pub ahead of print) In: ACS Chemical Biology. ASAP, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
-
Open access
Inactivating SARS-CoV-2 virus with MOF-composites as smart face masks
Ettlinger, R., Desai, A. V., Cheong, H. L. J., Major, L. L., Smith, T. K., Naden, A. B., Hilton, J., Adamson, C. S., Armstrong, A. R. & Morris, R. E., 2 Oct 2025, (E-pub ahead of print) In: Advanced Functional Materials. Early View, p. 1-7 7 p.Research output: Contribution to journal › Article › peer-review
-
Open access
N-Salicyl-amino acid derivatives with antiparasitic activity from Pseudomonas sp. UIAU-6B
Rajakulendran, J. E., Oluwabusola, E. T., Cerone, M., Smith, T. K., Adebisi, O. O., Adedotun, A., Preet, G., Soldatou, S., Deng, H., Ebel, R. & Jaspars, M., 4 Jul 2025, In: Beilstein Journal of Organic Chemistry. 21, p. 1388-1396 9 p.Research output: Contribution to journal › Article › peer-review
-
Open access
Rhodium-catalysed connective synthesis of diverse reactive probes bearing S(VI) electrophilic warheads
Rice, S., Chesti, J., Mosedale, W. R. T., Wright, M. H., Marsden, S. P., Smith, T. K. & Nelson, A., 17 Sept 2025, In: Beilstein Journal of Organic Chemistry. 21, p. 1924-1931 8 p.Research output: Contribution to journal › Article › peer-review
-
Open access
The effect of depth on the composition and saturation of total fatty acids present within the tissues and skeletons of two reef-building corals
von Xylander, N. S. H., Hedouin, L., Smith, T. K. & Allison, N., 1 May 2025, In: Marine Biology. 172, 5, 16 p., 65.Research output: Contribution to journal › Article › peer-review
-
Open access
Click chemistry methodology: the novel paintbrush of drug design
Oprea, I. & Smith, T. K., 27 Dec 2024, (E-pub ahead of print) In: ACS Chemical Biology. Articles ASAP, 14 p.Research output: Contribution to journal › Article › peer-review