Research areas
1) Biosynthesis and uptake of phospholipids in protozoan parasites.
2) The enzymology of biosynthetic enzymes in parasites.
3) Lipidomics and focussed metabolomics of pathogens.
4) Carbohydrate synthesis and “simple” chemistry towards drugs for neglected disease.
5) Structure, function & biosynthesis of parasite glycoconjugates including GPI anchors.
PhD supervision
- William Mosedale
- Rachel Humann
- Jagwinder Dhaliwal
- Nora Von Xylander
- Ngoc Anh Thu Trinh
- Berta Fatas
- Vytautas Kuodis
- Peter Black
- Veronica Harris
Selected publications
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Open access
A novel lipase with dual localisation in Trypanosoma brucei
Monic, S. G., Lamy, A., Thonnus, M., Bizarra-Rebelo, T., Bringaud, F., Smith, T. K., Figueiredo, L. M. & Rivière, L., 19 Mar 2022, In: Scientific Reports. 12, 4766.Research output: Contribution to journal › Article › peer-review
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Open access
Changes in plasma free fatty acids in obese patients before and after bariatric surgery highlight alterations in lipid metabolism
Hierons, S. J., Abbas, K., Sobczak, A. I. S., Cerone, M., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 12 Sep 2022, In: Scientific Reports. 12, 10 p., 15337.Research output: Contribution to journal › Article › peer-review
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Convenient synthesis of alternatively bridged tryptophan ketopiperazines and their activities against trypanosomatid parasites
Cockram, P. E., Turner, C., Slawin, A. M. Z. & Smith, T., 5 Jan 2022, (E-pub ahead of print) In: ChemMedChem. Early View, 12 p., e202100664.Research output: Contribution to journal › Article › peer-review
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Open access
Desaturases: structural and mechanistic insights into the biosynthesis of unsaturated fatty acids
Cerone, M. & Smith, T. K., 18 Sep 2022, (E-pub ahead of print) In: IUBMB Life. Early View, 16 p.Research output: Contribution to journal › Review article › peer-review
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The mitochondrial enzyme 17βHSD10 modulates ischemic and amyloid-β-induced stress in primary mouse astrocytes
Metodieva, V. V., Smith, T. K. & Gunn-Moore, F. J., 12 Sep 2022, (E-pub ahead of print) In: eNeuro. 68 p.Research output: Contribution to journal › Article › peer-review
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Open access
Desaturases: Structural and mechanistic insights into the biosynthesis of unsaturated fatty acids
Cerone, M. & Smith, T. K., 2022, (Accepted/In press) In: IUBMB Life.Research output: Contribution to journal › Review article › peer-review
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Open access
A brief journey into the history of, and future sources and uses of fatty acids
Cerone, M. & Smith, T. K., 20 Jul 2021, In: Frontiers in Nutrition. 8, 15 p., 570401.Research output: Contribution to journal › Review article › peer-review
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Open access
Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes
Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 21 Mar 2021, In: Chemical Science. 12, 11, p. 4079-4093 15 p.Research output: Contribution to journal › Article › peer-review
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Open access
Antileishmanial chemotherapy through clemastine fumarate mediated inhibition of the Leishmania inositol phosphorylceramide synthase
Mina, J. G. M., Charlton, R. L., Alpizar-Sosa, E., Escrivani, D. O., Brown, C., Alqaisi, A., Borsodi, M. P. G., Figueiredo, C. P., De Lima, E. V., Dickie, E. A., Wei, W., Coutinho-Silva, R., Merritt, A., Smith, T. K., Barrett, M. P., Rossi-Bergmann, B., Denny, P. W. & Steel, P. G., 8 Jan 2021, In: ACS Infectious Diseases. 7, 1, p. 47-63 17 p.Research output: Contribution to journal › Article › peer-review
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Open access
Excreted Trypanosoma brucei proteins inhibit Plasmodium hepatic infection
Temporão, A., Sanches-Vaz, M., Luís, R., Nunes-Cabaço, H., Smith, T. K., Prudêncio, M. & Figueiredo, L. M., 29 Oct 2021, In: PLoS Neglected Tropical Diseases. 15, 10, 28 p., e0009912.Research output: Contribution to journal › Article › peer-review