Prof Terry K Smith
Professor
Director of Biomedical Sciences Research Complex
Research areas
1) Biosynthesis and uptake of phospholipids in protozoan parasites.
2) The enzymology of biosynthetic enzymes in parasites.
3) Lipidomics and focussed metabolomics of pathogens.
4) Carbohydrate synthesis and ?simple? chemistry towards drugs for neglected disease.
5) Structure, function & biosynthesis of parasite glycoconjugates including GPI anchors.
PhD supervision
- Jagwinder Dhaliwal
- Leigh-Ann Booth
- Michela Cerone
- Vanya Metodieva
- Rebecca Woods
- William Mosedale
- Rachel Humann
Selected publications
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The importance of 1,5-oxygen···chalcogen interactions in enantioselective isochalcogenourea catalysis
Young, C. M., Elmi, A., Pascoe, D. J., Morris, R. K., McLaughlin, C., Woods, A., Frost, A., De La Houpliere, A., Ling, K. B., Smith, T. K., Slawin, A. M. Z., Willoughby, P. H., Cockroft, S. L. & Smith, A. D., 3 Feb 2020, In : Angewandte Chemie International Edition. Early ViewResearch output: Contribution to journal ? Article
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Babesia divergens glycosylphosphatidylinositols modulate blood coagulation and induce Th2-biased cytokine profiles in antigen presenting cells
Debierre-Grockiego, F., Smith, T. K., Delbecq, S., Ducournau, C., Lantier, L., Schmidt, J., Brès, V., Dimier-Poisson, I., Schwarz, R. T. & Cornillot, E., 5 Jul 2019, In : Biochimie Open. In pressResearch output: Contribution to journal ? Article
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Babesia divergens glycosylphosphatidylinositols modulate blood coagulation and induce Th2-biased cytokine profiles in antigen presenting cells
Debierre-Grockiego, F., Smith, T. K., Delbecq, S., Ducournau, C., Lantier, L., Schmidt, J., Brès, V., Dimier-Poisson, I., Schwarz, R. T. & Cornillot, E., Dec 2019, In : Biochimie. 167, p. 135-144 10 p.Research output: Contribution to journal ? Article
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Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
Kapsalis, C., Wang, B., El Mkami, H., Pitt, S. J., Schnell, J., Smith, T. K., Lippiat, J., Bode, B. E. & Pliotas, C., 10 Oct 2019, In : Nature Communications. 10, 14 p., 4619.Research output: Contribution to journal ? Article
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Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents
Ashok, P., Chander, S., Smith, T. K., Prakash Singh, R., Nath Jha, P. & Sankaranarayanan, M., Mar 2019, In : Bioorganic Chemistry. 84, p. 98-105Research output: Contribution to journal ? Article
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Novel benzothiazole-based ureas as 17?-HSD10 inhibitors, a potential Alzheimer?s disease treatment
Aitken, L., Benek, O., McKelvie, B., Hughes, R. E., Hroch, L., Schmidt, M., Major, L. L., Vinklarova, L., Kuca, K., Smith, T. K., Musilek, K. & Gunn-Moore, F. J., 29 Jul 2019, In : Molecules. 24, 15, 2757.Research output: Contribution to journal ? Article
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Oligopeptide signaling through TbGPR89 drives trypanosome quorum sensing
Rojas, F., Silvester, E., Young, J., Milne, R., Tettey, M., Houston, D. R., Walkinshaw, M. D., Pérez-Pi, I., Auer, M., Denton, H., Smith, T. K., Thompson, J. & Matthews, K. R., 10 Jan 2019, In : Cell. 176, 1-2, p. 306-317 12 p., e16.Research output: Contribution to journal ? Article
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Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation
Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 28 Aug 2019, In : biorxiv. 2019, 38 p.Research output: Contribution to journal ? Article
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Structure?based design, synthesis and biological evaluation of bis?tetrahydropyran furan acetogenin mimics targeting the trypanosomatid F1 component of ATP synthase
Zacharova, M., Tulloch, L., Gould, E., Fraser, A., King, E., Menzies, S., Smith, T. K. & Florence, G. J., 1 Sep 2019, In : European Journal of Organic Chemistry. 2019, 31-32, p. 5434-5440 8 p.Research output: Contribution to journal ? Article
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Substrate specificity of the neutral sphingomyelinase from Trypanosoma brucei
Dickie, E. A., Young, S. A. & Smith, T. K., Apr 2019, In : Parasitology. 146, 5, p. 604-616 13 p.Research output: Contribution to journal ? Article