Prof Terry K Smith

Professor

Director of Biomedical Sciences Research Complex

Researcher profile

Phone

+44 (0)1334 463412

Email

tks1@st-andrews.ac.uk

Research areas

1) Biosynthesis and uptake of phospholipids in protozoan parasites.

2) The enzymology of biosynthetic enzymes in parasites.

3) Lipidomics and focussed metabolomics of pathogens.

4) Carbohydrate synthesis and ?simple? chemistry towards drugs for neglected disease.

5) Structure, function & biosynthesis of parasite glycoconjugates including GPI anchors.

PhD supervision

• Jagwinder Dhaliwal
• Leigh-Ann Booth
• Michela Cerone
• Vanya Metodieva
• Rebecca Woods
• William Mosedale
• Rachel Humann

Selected publications

• The importance of 1,5-oxygen···chalcogen interactions in enantioselective isochalcogenourea catalysis

  Young, C. M., Elmi, A., Pascoe, D. J., Morris, R. K., McLaughlin, C., Woods, A., Frost, A., De La Houpliere, A., Ling, K. B., Smith, T. K., Slawin, A. M. Z., Willoughby, P. H., Cockroft, S. L. & Smith, A. D., 3 Feb 2020, In : Angewandte Chemie International Edition. Early View

  Research output: Contribution to journal ? Article

• Babesia divergens glycosylphosphatidylinositols modulate blood coagulation and induce Th2-biased cytokine profiles in antigen presenting cells

  Debierre-Grockiego, F., Smith, T. K., Delbecq, S., Ducournau, C., Lantier, L., Schmidt, J., Brès, V., Dimier-Poisson, I., Schwarz, R. T. & Cornillot, E., 5 Jul 2019, In : Biochimie Open. In press

  Research output: Contribution to journal ? Article

• Babesia divergens glycosylphosphatidylinositols modulate blood coagulation and induce Th2-biased cytokine profiles in antigen presenting cells

  Debierre-Grockiego, F., Smith, T. K., Delbecq, S., Ducournau, C., Lantier, L., Schmidt, J., Brès, V., Dimier-Poisson, I., Schwarz, R. T. & Cornillot, E., Dec 2019, In : Biochimie. 167, p. 135-144 10 p.

  Research output: Contribution to journal ? Article

• Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

  Kapsalis, C., Wang, B., El Mkami, H., Pitt, S. J., Schnell, J., Smith, T. K., Lippiat, J., Bode, B. E. & Pliotas, C., 10 Oct 2019, In : Nature Communications. 10, 14 p., 4619.

  Research output: Contribution to journal ? Article

• Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents

  Ashok, P., Chander, S., Smith, T. K., Prakash Singh, R., Nath Jha, P. & Sankaranarayanan, M., Mar 2019, In : Bioorganic Chemistry. 84, p. 98-105

  Research output: Contribution to journal ? Article

• Novel benzothiazole-based ureas as 17?-HSD10 inhibitors, a potential Alzheimer?s disease treatment

  Aitken, L., Benek, O., McKelvie, B., Hughes, R. E., Hroch, L., Schmidt, M., Major, L. L., Vinklarova, L., Kuca, K., Smith, T. K., Musilek, K. & Gunn-Moore, F. J., 29 Jul 2019, In : Molecules. 24, 15, 2757.

  Research output: Contribution to journal ? Article

• Oligopeptide signaling through TbGPR89 drives trypanosome quorum sensing

  Rojas, F., Silvester, E., Young, J., Milne, R., Tettey, M., Houston, D. R., Walkinshaw, M. D., Pérez-Pi, I., Auer, M., Denton, H., Smith, T. K., Thompson, J. & Matthews, K. R., 10 Jan 2019, In : Cell. 176, 1-2, p. 306-317 12 p., e16.

  Research output: Contribution to journal ? Article

• Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

  Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 28 Aug 2019, In : biorxiv. 2019, 38 p.

  Research output: Contribution to journal ? Article

• Structure?based design, synthesis and biological evaluation of bis?tetrahydropyran furan acetogenin mimics targeting the trypanosomatid F1 component of ATP synthase

  Zacharova, M., Tulloch, L., Gould, E., Fraser, A., King, E., Menzies, S., Smith, T. K. & Florence, G. J., 1 Sep 2019, In : European Journal of Organic Chemistry. 2019, 31-32, p. 5434-5440 8 p.

  Research output: Contribution to journal ? Article

• Substrate specificity of the neutral sphingomyelinase from Trypanosoma brucei

  Dickie, E. A., Young, S. A. & Smith, T. K., Apr 2019, In : Parasitology. 146, 5, p. 604-616 13 p.

  Research output: Contribution to journal ? Article

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