Prof Terry K Smith
Professor
Research areas
1) Biosynthesis and uptake of phospholipids in protozoan parasites.
2) The enzymology of biosynthetic enzymes in parasites.
3) Lipidomics and focussed metabolomics of pathogens.
4) Carbohydrate synthesis and “simple” chemistry towards drugs for neglected disease.
5) Structure, function & biosynthesis of parasite glycoconjugates including GPI anchors.
PhD supervision
- Peter Black
- Vytautas Kuodis
- Ernst Kwa
Selected publications
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Open access
From mystery to mechanism: The role of base J in transcription termination and gene regulation in trypanosomatids and other kinetoplastids
Watts, E., Harris, V. & Smith, T. K., Sept 2026, In: Molecular and Biochemical Parasitology. 267, p. 1-7 7 p., 111748.Research output: Contribution to journal › Review article › peer-review
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Open access
Swapped and non-swapped TRAAK states co-exist in membranes at a ratio influenced by temperature
Ma, Y., Ackermann, K., Waheed, Q., Postis, V., Smith, T. K., Bode, B. E. & Pliotas, C., 16 Apr 2026, In: Nature Communications. 17, 16 p., 3522.Research output: Contribution to journal › Article › peer-review
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Open access
The inhibitors of 17β-HSD10: are they any good?
Kwa, E., Ogilvie, C. E., Kormos, N. C., Green, A. J. E., Smith, T. K. & Gunn-Moore, F. J., 28 May 2026, (E-pub ahead of print) In: RSC Chemical Biology. Advance Article, p. 1-18 18 p.Research output: Contribution to journal › Review article › peer-review
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Open access
Bioactivity profiles of progressively ring-fluorinated cyclohexyl motifs in the WKYMVm peptide as formylpeptide FPR2 agonists and in keto-piperazines as antitrypanosome agents
He, M., Thomson, C. M., Thompson, D., Kuodis, V., Smith, T. K., Dall'Angelo, S. & O'Hagan, D., 3 Oct 2025, (E-pub ahead of print) In: ChemBioChem. Early View, 8 p., 2500384.Research output: Contribution to journal › Article › peer-review
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Open access
Building a cell-factory in Crithidia fasciculata: a bio-sustainable system to produce high-value polyunsaturated fatty acids
Cerone, M., Major, L. L. & Smith, T. K., 23 Jun 2025, In: Microbial Cell Factories. 24, p. 1-16 16 p., 142.Research output: Contribution to journal › Article › peer-review
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Open access
Exploring the activity of the putative Δ6-desaturase and its role in bloodstream form life-cycle transitions in Trypanosoma brucei
Cerone, M. & Smith, T. K., 18 Feb 2025, In: PLoS Pathogens. 21, 2, p. 1-39 39 p., e1012691.Research output: Contribution to journal › Article › peer-review
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Open access
Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages
Alberione, M. P., Avalos-Padilla, Y., Rangel, G. W., Ramírez, M., Romero-Uruñuela, T., Fenollar, À., Ortega-Barrionuevo, J., Crispim, M., Smith, T. K., Llinás, M. & Izquierdo, L., 3 Jul 2025, In: PLoS Pathogens. 21, 7, p. 1-27 27 p., e1012832.Research output: Contribution to journal › Article › peer-review
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Open access
High-throughput screening of potent drug-like molecules targeting 17β-HSD10 for the treatment of Alzheimer's disease and cancer
Aitken, L., Baillie, G., Pannifer, A., Morrison, A., Major, L. L., Alphey, M. S., Sethi, R., Timmerman, M., Robinson, J., Riley, J., Shishikura, Y., Koekemoer, L., Von Delft, F., Rutjes, H., Read, K., Jones, P. S., McElroy, S. P., Smith, T. K. & Gunn-Moore, F. J., 18 Jun 2025, (E-pub ahead of print) In: ACS Chemical Biology. ASAP, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Inactivating SARS-CoV-2 virus with MOF-composites as smart face masks
Ettlinger, R., Desai, A. V., Cheong, H. L. J., Major, L. L., Smith, T. K., Naden, A. B., Hilton, J., Adamson, C. S., Armstrong, A. R. & Morris, R. E., 2 Oct 2025, (E-pub ahead of print) In: Advanced Functional Materials. Early View, p. 1-7 7 p.Research output: Contribution to journal › Article › peer-review
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Open access
N-Salicyl-amino acid derivatives with antiparasitic activity from Pseudomonas sp. UIAU-6B
Rajakulendran, J. E., Oluwabusola, E. T., Cerone, M., Smith, T. K., Adebisi, O. O., Adedotun, A., Preet, G., Soldatou, S., Deng, H., Ebel, R. & Jaspars, M., 4 Jul 2025, In: Beilstein Journal of Organic Chemistry. 21, p. 1388-1396 9 p.Research output: Contribution to journal › Article › peer-review