Dr Sally Shirran
Senior Scientific Officer
Research areas
I manage the BSRC mass spectrometry core facility, which supports the research of many of the researchers within the Biomedical Sciences Research Complex, the University of St Andrews, and many other Universities in the UK. I am the first point of contact for collaborations, and will advise on experiment design and assist with interpretation of results.
The facility is mainly Proteomics based, specialising in 2 main areas:
Protein Identification - From simple gel band ID to identification of all proteins in a complex pullodwn mixture. Confirmation of post-translational modifications, spin labelling, chemical crosslinks, point mutations, truncations, all aspects of protein identification are supported. Measurement of intact protein mass is also undertaken, including membrane proteins.
Protein Quantitation - Relative protein quantitation by both iTRAQ and SWATH. Global protein quantitation upon exposure to stress.
PhD supervision
- Qingtian Gong
Selected publications
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Open access
Characterising PMP22 proximal partners in a Schwann cell model of Charcot-Marie-Tooth disease type1A
Holt, I., Emery, N., Gates, M. A., Brown, S. J., Shirran, S. & Fuller, H. R., 5 Nov 2025, In: Biology. 14, 11, p. 1-32 32 p., 1552.Research output: Contribution to journal › Article › peer-review
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Open access
Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin
Ishimoto, N., Wong, J. L. C., He, S., Shirran, S., Wright-Paramio, O., Seddon, C., Singh, N., Balsalobre, C., Sonani, R. R., Clements, A., Egelman, E. H., Frankel, G. & Beis, K., 22 Apr 2025, In: Proceedings of the National Academy of Sciences. 122, 16, p. 1-8 8 p., e2427228122.Research output: Contribution to journal › Article › peer-review
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Open access
Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery
Ahmed, H., Fernandes, M. F., Abbas, K., Synowsky, S. A., Shirran, S. L., Ajjan, R. A. & Stewart, A. J., May 2025, In: Diabetes, Obesity and Metabolism. 27, 5, p. 2647-2657 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Characterising the HLA-I Immunopeptidome of plasma-derived extracellular vesicles in patients with melanoma
Boyne, C. M., Coote, A., Synowsky, S. A., Naden, A. B., Shirran, S. L. & Powis, S. J., Mar 2024, In: Journal of Extracellular Biology. 3, 3, 12 p., e146.Research output: Contribution to journal › Article › peer-review
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Open access
Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection
Kruger, L., Gaskell-Mew, L., Graham, S., Shirran, S. L., Hertel, R. & White, M., 8 Apr 2024, In: Nature Microbiology. 9, p. 1579-1592 33 p.Research output: Contribution to journal › Article › peer-review
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Open access
AAV9-mediated SMN gene therapy rescues cardiac desmin but not Lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice
Brown, S. J., Šoltić, D., Synowsky, S. A., Shirran, S. L., Chilcott, E., Shorrock, H. K., Gillingwater, T. H., Yáñez-Muñoz, R. J., Schneider, B., Bowerman, M. & Fuller, H. R., 15 Oct 2023, In: Human Molecular Genetics. 32, 20, p. 2950-2965 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Antiviral type III CRISPR signalling via conjugation of ATP and SAM
Chi, H., Hoikkala, V. P., Gruschow, S., Graham, S., Shirran, S. L. & White, M., 26 Oct 2023, In: Nature. 622, 7984, p. 826-833 22 p.Research output: Contribution to journal › Article › peer-review
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Open access
Assessing the impact of interfering organic matter on soil metaproteomic workflow
Waibel, M., McDonnell, K., Tuohy, M., Shirran, S., Synowsky, S., Thornton, B., Paterson, E., Brennan, F. & Abram, F., 22 Jun 2023, In: European Journal of Soil Science. 74, 3, 14 p., e13392.Research output: Contribution to journal › Article › peer-review
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Open access
Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., Smith, B. O., Kalinina, O. V., Müller, R. & Koehnke, J., 1 Apr 2023, In: Nature Chemistry. 15, 4, p. 560-568 9 p.Research output: Contribution to journal › Article › peer-review
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Open access
Carbapenem-only combination therapy against multi-drug resistant Pseudomonas aeruginosa: assessment of in vitro and in vivo efficacy and mode of action
Mackay, B., Parcell, B. J., Shirran, S. L. & Coote, P. J., 25 Oct 2022, In: Antibiotics. 11, 11, 19 p., 1467.Research output: Contribution to journal › Article › peer-review