Dr Sally Shirran
Senior Scientific Officer
Research areas
I manage the BSRC mass spectrometry core facility, which supports the research of many of the researchers within the Biomedical Sciences Research Complex, the University of St Andrews, and many other Universities in the UK. I am the first point of contact for collaborations, and will advise on experiment design and assist with interpretation of results.
The facility is mainly Proteomics based, specialising in 2 main areas:
Protein Identification - From simple gel band ID to identification of all proteins in a complex pullodwn mixture. Confirmation of post-translational modifications, spin labelling, chemical crosslinks, point mutations, truncations, all aspects of protein identification are supported. Measurement of intact protein mass is also undertaken, including membrane proteins.
Protein Quantitation - Relative protein quantitation by both iTRAQ and SWATH. Global protein quantitation upon exposure to stress.
PhD supervision
- Qingtian Gong
Selected publications
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Open access
Androgen receptor localisation and protein interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer
Bleach, R., Bozkurt, E., Xin, J., Sheehan, K. M., Shirran, S., Agbana, S., Ola, M., Young, L., Spoelstra, N. S., Richer, J. K., Vargas, A. C., Goldstein, L. D., Milloli, H. H., Chaffer, C. L., O'Reilly, M. W., Prehn, J. H. & McIlroy, M., 6 May 2026, In: npj Breast Cancer. 12, p. 1-17 17 p., 65.Research output: Contribution to journal › Article › peer-review
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Open access
Investigating the interactomic landscape of survival motor neuron (SMN) and the SMNΔ7 truncated protein
Beaumont, B., Synowsky, S. A., Shirran, S. L. & Sleeman, J. E., 2 Dec 2026, In: Biotechniques. 78, 1-12, p. 207-220 14 p.Research output: Contribution to journal › Review article › peer-review
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Quantitative proteomic profiling of plasma alterations associated with thrombotic risk and insulin resistance in type 1 diabetes
Harper, C. A. A., Marsh, J. S., Fernandes, M. F., Sagar, R. C., Synowsky, S. A., Ahmed, H., Shirran, S. L., Naseem, K., Ajjan, R. A. & Stewart, A. J., 10 May 2026, (Accepted/In press) In: Thrombosis and Haemostasis.Research output: Contribution to journal › Article › peer-review
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Open access
Characterising PMP22 proximal partners in a Schwann cell model of Charcot-Marie-Tooth disease type1A
Holt, I., Emery, N., Gates, M. A., Brown, S. J., Shirran, S. & Fuller, H. R., 5 Nov 2025, In: Biology. 14, 11, p. 1-32 32 p., 1552.Research output: Contribution to journal › Article › peer-review
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Open access
Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin
Ishimoto, N., Wong, J. L. C., He, S., Shirran, S., Wright-Paramio, O., Seddon, C., Singh, N., Balsalobre, C., Sonani, R. R., Clements, A., Egelman, E. H., Frankel, G. & Beis, K., 22 Apr 2025, In: Proceedings of the National Academy of Sciences. 122, 16, p. 1-8 8 p., e2427228122.Research output: Contribution to journal › Article › peer-review
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Open access
Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge
Vassen, V., Tanaka, E., Moll, K., Spoerry, C., Synowsky, S., Shirran, S. L., Schwarz-Linek, U., Loh, E., Svensson, M. & Norrby-Teglund, A., 6 May 2025, In: Microbiology Spectrum. 13, 5, e02450-24.Research output: Contribution to journal › Article › peer-review
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Open access
Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery
Ahmed, H., Fernandes, M. F., Abbas, K., Synowsky, S. A., Shirran, S. L., Ajjan, R. A. & Stewart, A. J., May 2025, In: Diabetes, Obesity and Metabolism. 27, 5, p. 2647-2657 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Characterising the HLA-I Immunopeptidome of plasma-derived extracellular vesicles in patients with melanoma
Boyne, C. M., Coote, A., Synowsky, S. A., Naden, A. B., Shirran, S. L. & Powis, S. J., Mar 2024, In: Journal of Extracellular Biology. 3, 3, 12 p., e146.Research output: Contribution to journal › Article › peer-review
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Open access
Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells
Storey, E. C., Holt, I., Brown, S., Synowsky, S., Shirran, S. & Fuller, H. R., May 2024, In: Neuromuscular Disorders. 38, p. 26-41 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection
Kruger, L., Gaskell-Mew, L., Graham, S., Shirran, S. L., Hertel, R. & White, M., 8 Apr 2024, In: Nature Microbiology. 9, p. 1579-1592 33 p.Research output: Contribution to journal › Article › peer-review