Dr Simon Young
Associate Lecturer in Biochemistry/Molecular Biology & Virology/Microbiology
Teaching
Associate Lecturer in the School of Biology
Research areas
Wellcome Trust-funded research concerning the discovery of novel drug targets in lipid metabolism in Trypanosoma brucei, the causative agent of human African sleeping sickness.
Selected publications
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Open access
Sterols, free fatty acids, and total fatty acid content in the massive Porites spp. corals cultured under different pCO2 and temperature treatments
von Xylander, N. S. H., Young, S., Cole, C. S., Smith, T. K. & Allison, N., 1 Apr 2023, In: Coral Reefs. 42, p. 551-566 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Leishmania dual specificity tyrosine regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype
Rocha, V. P. C., Dacher, M., Young, S. A., Kolokousi, F., Efstathiou, A., Späth, G. F., Pereira Soares, M. B. & Smirlis, D., 11 Feb 2020, (E-pub ahead of print) In: Molecular Microbiology. Early ViewResearch output: Contribution to journal › Article › peer-review
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Open access
Dual β-lactam combination therapy for multi-drug resistant Pseudomonas aeruginosa infection: enhanced efficacy in vivo and comparison with monotherapies of penicillin-binding protein inhibition
Siriyong, T., Murray, R. M., Bidgood, L. E., Young, S. A., Wright, F., Parcell, B. J., Voravuthikunchai, S. P. & Coote, P. J., 24 Jun 2019, In: Scientific Reports. 9, 13 p., 9098.Research output: Contribution to journal › Article › peer-review
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Open access
Substrate specificity of the neutral sphingomyelinase from Trypanosoma brucei
Dickie, E. A., Young, S. A. & Smith, T. K., Apr 2019, In: Parasitology. 146, 5, p. 604-616 13 p.Research output: Contribution to journal › Article › peer-review
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Open access
Screening of the MMV and GSK open access chemical boxes using a viability assay developed against the kinetoplastid Crithidia fasciculata
Kipandula, W., Young, S. A., MacNeill, S. A. & Smith, T. K., Jun 2018, In: Molecular and Biochemical Parasitology. 222, p. 61-69 9 p.Research output: Contribution to journal › Article › peer-review
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Open access
Structure-based design of a eukaryote-selective antiprotozoal fluorinated aminoglycoside
Kanazawa, H., Saavedra, O. M., Maianti, J. P., Young, S. A., Izquierdo, L., Smith, T. K., Hanessian, S. & Kondo, J., 10 Aug 2018, In: ChemMedChem. 13, 15, p. 1541-1548 8 p.Research output: Contribution to journal › Article › peer-review
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ADIPOSE TISSUE IS A MAJOR RESERVOIR OF FUNCTIONALLY DISTINCT TRYPANOSOMA BRUCEI PARASITES
Trindade, S., Rijo-Ferreira, F., Carvalho, T., Pinto-Neves, D., Guegan, F., Aresta-Branco, F., Bento, F., Young, S. A., Pinto, A., Van den Abbeele, J., Ribeiro, R. M., Dias, S., Smith, T. K. & Figueiredo, L. M., Nov 2017, In: American Journal of Tropical Medicine and Hygiene. 95, 5, p. 606-606 1 p.Research output: Contribution to journal › Abstract › peer-review
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Open access
Trypanosoma brucei parasites occupy and functionally adapt to the adipose tissue in mice
Trindade, S., Rijo-Ferreira, F., Carvalho, T., Pinto-Neves, D., Guegan, F., Aresta-Branco, F., Bento, F., Young, S. A., Pinto, A., Van Den Abbeele, J., Ribeiro, RM., Dias, S., Smith, T. K. & Figueiredo, LM., 8 Jun 2016, In: Cell Host & Microbe. 19, 6, p. 837-848 13 p.Research output: Contribution to journal › Article › peer-review
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The Importance of Targeting Lipid Metabolism in Parasites for Drug Discovery
Young, S. A., Roberts, M. D. & Smith, T. K., 19 Oct 2016, Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery. 1st ed. Germany: Wiley-VCH, Weinheim, Vol. 7. p. 335 361 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Open access
Lipids and liposomes in the enhancement of health and treatment of disease
Young, S. & Smith, T. K., 3 Jun 2015, Drug Discovery and Development - From Molecules to Medicine. Vallisuta, O. & Olimat, S. (eds.). InTech, p. 131-162Research output: Chapter in Book/Report/Conference proceeding › Chapter