Ms Nuria Torres
Research Fellow
Biography
2020 – present: Postdoctoral research fellow, University of St Andrews, UK.
2016-2019: PhD in Genetics, Faculty of Biology, University of Barcelona, Spain; in agreement with ‘Vall d’Hebron’ Research institute (VHIR) and ‘Fundació Docència i Recerca Mútuta Terrassa’ (FMT).
PhD project: Massive genetic studies in ischemic stroke: factors of risk and outcome (Supervisor: Dr Israel Fernandez-Cadenas).
2015-2016: Specialized technician in charge of laboratory cultures of marine chordates and microalgae in Dr. Albalat and Dr. Cañestro’s laboratory.
2014-2015: Master in Genetics and Genomics, Faculty of Biology, University of Barcelona, Spain.
Honours project: Genetic analysis of the developmental alterations of Oikopleura dioica caused by toxins produced in the blooms of diatoms associated with the global warming (Co-supervisors: Prof Ricard Albalat & Dr Cristian Cañestro).
2010-2014: Bachelor’s Degree in Biotechnology, Faculty of Biology, University of Barcelona, Spain.
Honours project: Study of the production and toxicity of mircoalgae during the culture of Oikopleura dioica (Co-supervisors: Prof Ricard Albalat & Dr Cristian Cañestro).
Research areas
Diversification of TCF family genes
The TCF family genes are the major mediators of Wnt/β-catenin signalling, which is necessary during development and has been found altered in different diseases, such as cancer and diabetes.
Comparing vertebrates and invertebrates reveals a huge diversity of vertebrate TCF transcription factors, which may lead to subfunctionalization and/or neo-functionalization of vertebrate TCFs.
This proyect aim to understand vertebrate-specific functions of Wnt/β-catenin signalling, which will be ultimately relevant for human and animal disease.
Selected publications
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DNA methylation and ischemic stroke risk: an epigenome-wide association study
Cullell, N., Soriano-Tárraga, C., Gallego-Fábrega, C., Cárcel-Márquez, J., Torres-Águila, N. P., Muiño, E., Lledós, M., Llucià-Carol, L., Esteller, M., Castro de Moura, M., Montaner, J., Fernández-Sanlés, A., Elosua, R., Delgado, P., Martí-Fábregas, J., Krupinski, J., Roquer, J., Jiménez-Conde, J. & Fernández-Cadenas, I., 19 Jun 2022, (E-pub ahead of print) In: Thrombosis and Haemostasis.Research output: Contribution to journal › Article › peer-review
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Open access
Evolutionary diversification of the canonical Wnt signaling effector TCF/LEF in chordates
Torres-Aguila, N. P., Salonna, M., Hoppler, S. & Ferrier, D. E. K., 28 Apr 2022, In: Development, Growth & Differentiation. 64, 3, p. 120-137 18 p.Research output: Contribution to journal › Article › peer-review
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Open access
Multi-Ancestry GWAS reveals excitotoxicity associated with outcome after ischaemic stroke
Ibanez, L., Heitsch, L., Carrera, C., Farias, F. H. G., Del Aguila, J. L., Dhar, R., Budde, J., Bergmann, K., Bradley, J., Harari, O., Phuah, C. L., Lemmens, R., Souza, A. A. V. O., Moniche, F., Cabezas-Juan, A., Arenillas, J. F., Krupinksi, J., Cullell, N., Torres-Aguila, N., Muiño, E., Cárcel-Márquez, J., Marti-Fabregas, J., Delgado-Mederos, R., Marin-Bueno, R., Hornick, A., Vives-Bauza, C., Navarro, R. D., Tur, S., Jimenez, C., Obach, V., Segura, T., Serrano-Heras, G., Chung, J. W., Roquer, J., Soriano-Tarraga, C., Giralt-Steinhauer, E., Mola-Caminal, M., Pera, J., Lapicka-Bodzioch, K., Derbisz, J., Davalos, A., Lopez-Cancio, E., Muñoz, L., Tatlisumak, T., Molina, C., Ribo, M., Bustamante, A., Sobrino, T., Castillo-Sanchez, J., Campos, F., Rodriguez-Castro, E., Arias-Rivas, S., Rodríguez-Yáñez, M., Herbosa, C., Ford, A. L., Gutierrez-Romero, A., Uribe-Pacheco, R., Arauz, A., Lopes-Cendes, I., Lowenkopf, T., Barboza, M. A., Amini, H., Stamova, B., Ander, B. P., Sharp, F. R., Moon Kim, G., Bang, O. Y., Jimenez-Conde, J., Slowik, A., Stribian, D., Tsai, E. A., Burkly, L. C., Montaner, J., Fernandez-Cadenas, I., Lee, J. M. & Cruchaga, C., 1 Jul 2022, In: Brain. 145, 7, p. 2394-2406 13 p.Research output: Contribution to journal › Article › peer-review
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Early neurological change after ischemic stroke is associated with 90-day outcome
International Stroke Genetics Consortium, Heitsch, L., Ibanez, L., Carrera, C., Binkley, M. M., Strbian, D., Tatlisumak, T., Bustamante, A., Ribó, M., Molina, C., Dávalos, A., López-Cancio, E., Muñoz-Narbona, L., Soriano-Tárraga, C., Giralt-Steinhauer, E., Obach, V., Slowik, A., Pera, J., Lapicka-Bodzioch, K., Derbisz, J., Sobrino, T., Castillo, J., Campos, F., Rodríguez-Castro, E., Arias-Rivas, S., Segura, T., Serrano-Heras, G., Vives-Bauza, C., Díaz-Navarro, R., Tur, S., Jimenez, C., Martí-Fàbregas, J., Delgado-Mederos, R., Arenillas, J., Krupinski, J., Cullell, N., Torres-Aguila, N. P., Muiño, E., Cárcel-Márquez, J., Moniche, F., Cabezas, J. A., Ford, A. L., Dhar, R., Roquer, J., Khatri, P., Jiménez-Conde, J., Fernandez-Cadenas, I., Montaner, J., Rosand, J., Cruchaga, C. & Lee, J-M., 1 Jan 2021, In: Stroke. 52, 1, p. 132-141 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies
Helsinki Stroke, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group, National Institute of Neurological Disorders and Stroke (NINDS), Stroke Genetics Network, UK DNA Lacunar Stroke Study Investigators, International Stroke Genetics Consortium, Traylor, M., Persyn, E., Tomppo, L., Klasson, S., Abedi, V., Bakker, M. K., Torres, N., Li, L., Bell, S., Rutten-Jacobs, L., Tozer, D. J., Griessenauer, C. J., Zhang, Y., Pedersen, A., Sharma, P., Jimenez-Conde, J., Rundek, T., Grewal, R. P., Lindgren, A., Meschia, J. F., Salomaa, V., Havulinna, A., Kourkoulis, C., Crawford, K., Marini, S., Mitchell, B. D., Kittner, S. J., Rosand, J., Dichgans, M., Jern, C., Strbian, D., Fernandez-Cadenas, I., Zand, R., Ruigrok, Y., Rost, N., Lemmens, R., Rothwell, P. M., Anderson, C. D., Wardlaw, J., Lewis, C. M. & Markus, H. S., 1 May 2021, In: Lancet Neurology. 20, 5, p. 351-361 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment
Muiño, E., Maisterra, O., Jiménez-Balado, J., Cullell, N., Carrera, C., Torres-Aguila, N. P., Cárcel-Márquez, J., Gallego-Fabrega, C., Lledós, M., González-Sánchez, J., Olmos-Alpiste, F., Espejo, E., March, Á., Pujol, R., Rodríguez-Campello, A., Romeral, G., Krupinski, J., Martí-Fàbregas, J., Montaner, J., Roquer, J. & Fernández-Cadenas, I., 25 Mar 2021, In: Scientific Reports. 11, 12 p., 6846.Research output: Contribution to journal › Article › peer-review
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Open access
Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma
The International Stroke Genetic Consortium and the Spanish Stroke Genetic Consortium, Carrera, C., Cárcel-Márquez, J., Cullell, N., Torres-Águila, N., Muiño, E., Castillo, J., Sobrino, T., Campos, F., Rodríguez-Castro, E., Llucià-Carol, L., Millán, M., Muñoz-Narbona, L., López-Cancio, E., Bustamante, A., Ribó, M., Álvarez-Sabín, J., Jiménez-Conde, J., Roquer, J., Giralt-Steinhauer, E., Soriano-Tárraga, C., Mola-Caminal, M., Vives-Bauza, C., Navarro, R. D., Tur, S., Obach, V., Arenillas, J. F., Segura, T., Serrano-Heras, G., Martí-Fàbregas, J., Delgado-Mederos, R., Freijo-Guerrero, M. M., Moniche, F., Cabezas, J. A., Castellanos, M., Gallego-Fabrega, C., González-Sanchez, J., Krupinsky, J., Strbian, D., Tatlisumak, T., Thijs, V., Lemmens, R., Slowik, A., Pera, J., Kittner, S., Cole, J., Heitsch, L., Ibañez, L., Cruchaga, C., Lee, J. M. & Montaner, J., 16 Mar 2021, (E-pub ahead of print) In: Brain. 144, 8, p. 2416-2426 11 p.Research output: Contribution to journal › Article › peer-review
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A parsimonious score with a free web tool for predicting disability after an ischemic stroke: the Parsifal Score
Muiño, E., Bustamante, A., Rodriguez-Campello, A., Gallego-Fabrega, C., Ois, A., Carrera, C., Cullell, N., Torres-Aguila, N., Cárcel-Márquez, J., Rubiera, M., Molina, C. A., Cuadrado-Godia, E., Giralt-Steinhauer, E., Jiménez-Conde, J., Montaner, J., Fernández-Cadenas, I. & Roquer, J., Oct 2020, In: Experimental Neurology. 267, 10, p. 2871-2880 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues
Gallego-Fabrega, C., Cullell, N., Soriano-Tárraga, C., Carrera, C., Torres-Aguila, N. P., Muiño, E., Cárcel-Márquez, J., de Moura, M. C., Fernández-Sanlés, A., Esteller, M., Elosua, R., Jiménez-Conde, J., Roquer, J., Montaner, J., Krupinski, J. & Fernandez-Cadenas, I., 10 Mar 2020, In: Oncotarget. 11, 10, p. 905-912 8 p.Research output: Contribution to journal › Article › peer-review
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Open access
Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain
Cullell, N., Carrera, C., Muiño, E., Torres-Aguila, N-P., Cárcel-Márquez, J., González-Sánchez, J., Gallego-Fabrega, C., Molina, J., Besora, S., Sotoca, J., Buongiorno, M-T., Jiménez-Conde, J., Giralt-Steinhauer, E., de Torres-Chacón, R., Montaner, J., Mancha, F., Cabezas, J. A., Martí-Fàbregas, J., Prats-Sánchez, L., Camps-Renom, P., Purroy, F., Cambray, S., Del Mar Freijo, M., Vives-Bauzá, C., Tur, S., Font, M-À., López-Cancio, E., Hernandez-Perez, M., Obach, V., Calleja, A., Arenillas, J., Rodríguez-Yáñez, M., Castillo, J., Sobrino, T., Fernández-Cádenas, I. & Krupinski, J., 18 Feb 2020, In: Scientific Reports. 10, 7 p., 2806.Research output: Contribution to journal › Article › peer-review