Dr Magnus Alphey
X-ray Facility Manager
Selected publications
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Open access
High-throughput screening of potent drug-like molecules targeting 17β-HSD10 for the treatment of Alzheimer's disease and cancer
Aitken, L., Baillie, G., Pannifer, A., Morrison, A., Major, L. L., Alphey, M. S., Sethi, R., Timmerman, M., Robinson, J., Riley, J., Shishikura, Y., Koekemoer, L., Von Delft, F., Rutjes, H., Read, K., Jones, P. S., McElroy, S. P., Smith, T. K. & Gunn-Moore, F. J., 18 Jun 2025, (E-pub ahead of print) In: ACS Chemical Biology. ASAP, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Crystal structure, steady-state and pre-steady-state kinetics of Acinetobacter baumannii ATP phosphoribosyltransferase
Read, B., Cadzow, A., Alphey, M. S., Mitchell, J. B. O. & da Silva, R. G., 16 Jan 2024, In: Biochemistry. 63, 2, p. 230-240 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Canonical binding of Chaetomium thermophilum DNA polymerase δ/ζ subunit PolD3 and flap endonuclease Fen1 to PCNA
Alphey, M. S., Wolford, C. & MacNeill, S., 18 Dec 2023, In: Frontiers in Molecular Biosciences. 10, 9 p., 1320648.Research output: Contribution to journal › Article › peer-review
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Open access
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation
Fisher, G., Corbella, M., Alphey, M. S., Nicholson, J., Read, B., Kamerlin, S. C. L. & da Silva, R. G., 9 Dec 2022, In: Nature Communications. 13, 15 p., 7607.Research output: Contribution to journal › Article › peer-review
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Open access
Non‐canonical binding of the Chaetomium thermophilum PolD4 N‐terminal PIP motif to PCNA involves Q‐pocket and compact 2‐fork plug interactions but no 310 helix
Yang, D., Alphey, M. S. & MacNeill, S., 22 Aug 2022, (E-pub ahead of print) In: FEBS Journal. Early View, 14 p., 16590.Research output: Contribution to journal › Article › peer-review
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Open access
Next generation glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: an extended SAR study to direct future design
Xiao, G., Alphey, M. S., Tran, F., Pirrie, L., Milbeo, P., Zhou, Y., Bickel, J. K., Kempf, O., Kempf, K., Naismith, J. H. & Westwood, N. J., 15 Nov 2021, In: Bioorganic & Medicinal Chemistry. 50, 116477.Research output: Contribution to journal › Article › peer-review
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Open access
Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine
Thomson, C. M., Alphey, M. S., Fisher, G. & da Silva, R. G., 16 Jul 2019, In: Biochemistry. 58, 28, p. 3078-3086Research output: Contribution to journal › Article › peer-review
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Open access
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase
Alphey, M. S., Fisher, G., Ge, Y., Gould, E. R., Guerreiro Machado, T. F., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 1 Jun 2018, In: ACS Catalysis. 8, 6, p. 5601-5610 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase
Stroek, R., Ge, Y., Talbot, P. D., Glok, M. K., Bernas, K. E., Thomson, C. M., Gould, E. R., Alphey, M. S., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 7 Feb 2017, In: Biochemistry. 56, 5, p. 793-803 11 p.Research output: Contribution to journal › Article › peer-review
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Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa
Alphey, M. S., Pirrie, L., Torrie, L. S., Abdelli Boulkeroua, W., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J., Feb 2013, In: ACS Chemical Biology. 8, 2, p. 387-396 10 p.Research output: Contribution to journal › Article › peer-review