Selected publications
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Open access
Non‐canonical binding of the Chaetomium thermophilum PolD4 N‐terminal PIP motif to PCNA involves Q‐pocket and compact 2‐fork plug interactions but no 310 helix
Yang, D., Alphey, M. S. & MacNeill, S., 22 Aug 2022, (E-pub ahead of print) In: FEBS Journal. Early View, 14 p., 16590.Research output: Contribution to journal › Article › peer-review
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Open access
Next generation glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: an extended SAR study to direct future design
Xiao, G., Alphey, M. S., Tran, F., Pirrie, L., Milbeo, P., Zhou, Y., Bickel, J. K., Kempf, O., Kempf, K., Naismith, J. H. & Westwood, N. J., 15 Nov 2021, In: Bioorganic & Medicinal Chemistry. 50, 116477.Research output: Contribution to journal › Article › peer-review
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Open access
Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine
Thomson, C. M., Alphey, M. S., Fisher, G. & da Silva, R. G., 16 Jul 2019, In: Biochemistry. 58, 28, p. 3078-3086Research output: Contribution to journal › Article › peer-review
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Open access
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase
Alphey, M. S., Fisher, G., Ge, Y., Gould, E. R., Guerreiro Machado, T. F., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 1 Jun 2018, In: ACS Catalysis. 8, 6, p. 5601-5610 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase
Stroek, R., Ge, Y., Talbot, P. D., Glok, M. K., Bernas, K. E., Thomson, C. M., Gould, E. R., Alphey, M. S., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 7 Feb 2017, In: Biochemistry. 56, 5, p. 793-803 11 p.Research output: Contribution to journal › Article › peer-review
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Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa
Alphey, M. S., Pirrie, L., Torrie, L. S., Abdelli Boulkeroua, W., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J., Feb 2013, In: ACS Chemical Biology. 8, 2, p. 387-396 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
Structural insights into the mechanism and inhibition of the beta-Hydroxydecanoyl-Acyl carrier protein dehydratase from pseudomonas aeruginosa
Moynie, L., Leckie, S. M., McMahon, S. A., Duthie, F. G., Koehnke, A., Taylor, J. W., Alphey, M. S., Brenk, R., Smith, A. D. & Naismith, J. H., 23 Jan 2013, In: Journal of Molecular Biology. 425, 2, p. 365-377 13 p.Research output: Contribution to journal › Article › peer-review
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Open access
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery
Moynie, L., Schnell, R., McMahon, S. A., Sandalova, T., Abdelli Boulkeroua, W., Schmidberger, J. W., Alphey, M., Cukier, C., Duthie, F., Kopec, J., Liu, H., Jacewicz, A., Hunter, W. N., Naismith, J. H. & Schneider, G., Jan 2013, In: Acta Crystallographica. Section F, Structural biology and crystallization communications . 69, 1, p. 25-34 10 p.Research output: Contribution to journal › Article › peer-review
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Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity
Byres, E., Alphey, M. S., Smith, T. K. & Hunter, W. N., 10 Aug 2007, In: Journal of Molecular Biology. 371, 2, p. 540-553 14 p.Research output: Contribution to journal › Article › peer-review
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Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids
Fyffe, S. A., Alphey, M. S., Buetow, L., Smith, T. K., Ferguson, M. A. J., Sorensen, M. D., Bjorkling, F. & Hunter, W. N., 3 Mar 2006, In: Journal of Molecular Biology. 356, 4, p. 1005-1013 9 p.Research output: Contribution to journal › Article › peer-review