Dr Judith Sleeman

Senior Lecturer

Researcher profile

Phone

+44 (0)1334 463524

Email

jes14@st-andrews.ac.uk

Research areas

Judith Sleeman is a former Royal Society University Research Fellow with key interests in the physical organisation of RNA processing in mammalian cells and the impact of this on human disease. Leading on from early work into the cellular organisation of splicing snRNP maturation, research in the Sleeman lab has expanded to include cytoplasmic transport of mRNA and the effects on cellular structure of triplet repeat disorders. Current projects in the group investigate the cellular and molecular basis of Spinal Muscular Atrophy, Myotonic Dystrophy Type 1 and Amyetrophic Lateral Sclerosis. Key techniques include live-cell and high-resolution microscopy and proteomics.

PhD supervision

• Selma Gulyurtlu
• Sotiroula Chatzimatthaiou
• Bobby Beaumont

Selected publications

• Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology

  Thompson, L. W., Morrison, K. D., Shirran, S. L., Groen, E. J. N., Gillingwater, T. H., Botting, C. H. & Sleeman, J. E., 17 Apr 2018, In : Journal of Cell Science. 131, 8, 18 p., jcs211482.

  Research output: Contribution to journal ? Article

• The Cajal body and the nucleolus: ?in a relationship? or ?it's complicated??

  Trinkle-Mulcahy, L. & Sleeman, J. E., 2017, In : RNA Biology. 14, 6, p. 739-751

  Research output: Contribution to journal ? Review article

• Nuclear bodies: new insights into assembly/dynamics and disease relevance

  Sleeman, J. E. & Trinkle-Mulcahy, L., Jun 2014, In : Current Opinion in Cell Biology. 28, p. 76-83 8 p.

  Research output: Contribution to journal ? Article

• Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking

  Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E., 14 Feb 2014, In : Journal of Cell Science. 127, 4, p. 812-827 15 p.

  Research output: Contribution to journal ? Article

• Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

  Coleman, S., Prescott, A. R. & Sleeman, J. E., 1 Mar 2014, In : Biochemical Journal. 458, 2, p. 267-280 13 p.

  Research output: Contribution to journal ? Article

• Small nuclear RNAs and mRNAs: linking RNA processing and transport to spinal muscular atrophy

  Sleeman, J., Aug 2013, In : Biochemical Society Transactions. 41, 4, p. 871-875 5 p.

  Research output: Contribution to journal ? Article

• Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy

  Clelland, A. K., Bales, A. B. E. & Sleeman, J. E., 1 Jun 2012, In : Journal of Cell Science. 125, 11, p. 2626-2637 12 p.

  Research output: Contribution to journal ? Article

• The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells

  Clelland, A. K., Kinnear, N. P., Oram, L., Burza, J. & Sleeman, J. E., Nov 2009, In : Traffic. 10, 11, p. 1585-1598 14 p.

  Research output: Contribution to journal ? Article

• A regulatory role for CRM1 in multi-directional trafficking of splicing snRNPs in the mammalian nucleus

  Sleeman, J. E., 1 May 2007, In : Journal of Cell Science. 120, 9, p. 1540-1550 11 p.

  Research output: Contribution to journal ? Article

• Alterations in nuclear architecture in differentiating neuroblastoma cells

  Burza, JR., Akbar, T. & Sleeman, J. E., Oct 2006, In : Differentiation. 74, p. 468 468 p.

  Research output: Contribution to journal ? Article

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