Dr Judith Sleeman
Senior Lecturer
Research areas
Judith Sleeman is a former Royal Society University Research Fellow with key interests in the physical organisation of RNA processing in mammalian cells and the impact of this on human disease. Leading on from early work into the cellular organisation of splicing snRNP maturation, research in the Sleeman lab has expanded to include cytoplasmic transport of mRNA and the effects on cellular structure of triplet repeat disorders. Current projects in the group investigate the cellular and molecular basis of Spinal Muscular Atrophy, Myotonic Dystrophy Type 1 and Amyetrophic Lateral Sclerosis. Key techniques include live-cell and high-resolution microscopy and proteomics.
PhD supervision
- Bobby Beaumont
- Kimberley Vincent
Selected publications
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Open access
Condensation properties of stress granules and processing bodies are compromised in myotonic dystrophy type 1
Gulyurtlu, S., Magon, M. S., Guest, P. N., Papavasiliou, P. P., Morrison, K., Prescott, A. & Sleeman, J. E., 2 Aug 2022, In: Disease Models & Mechanisms. 15, 7, dmm049294.Research output: Contribution to journal › Article › peer-review
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Open access
The ‘most expensive drug in the world’, how it works and the devastating disease it treats
Sleeman, J. E., 19 Jul 2021, The Conversation.Research output: Contribution to specialist publication › Article
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Open access
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology
Thompson, L. W., Morrison, K. D., Shirran, S. L., Groen, E. J. N., Gillingwater, T. H., Botting, C. H. & Sleeman, J. E., 17 Apr 2018, In: Journal of Cell Science. 131, 8, 18 p., jcs211482.Research output: Contribution to journal › Article › peer-review
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Open access
The Cajal body and the nucleolus: “in a relationship” or “it's complicated”?
Trinkle-Mulcahy, L. & Sleeman, J. E., 2017, In: RNA Biology. 14, 6, p. 739-751Research output: Contribution to journal › Review article › peer-review
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Nuclear bodies: new insights into assembly/dynamics and disease relevance
Sleeman, J. E. & Trinkle-Mulcahy, L., Jun 2014, In: Current Opinion in Cell Biology. 28, p. 76-83 8 p.Research output: Contribution to journal › Article › peer-review
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Open access
Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking
Prescott, A. R., Bales, A., James, J., Trinkle-Mulcahy, L. & Sleeman, J. E., 14 Feb 2014, In: Journal of Cell Science. 127, 4, p. 812-827 15 p.Research output: Contribution to journal › Article › peer-review
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Open access
Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1
Coleman, S., Prescott, A. R. & Sleeman, J. E., 1 Mar 2014, In: Biochemical Journal. 458, 2, p. 267-280 13 p.Research output: Contribution to journal › Article › peer-review
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Small nuclear RNAs and mRNAs: linking RNA processing and transport to spinal muscular atrophy
Sleeman, J., Aug 2013, In: Biochemical Society Transactions. 41, 4, p. 871-875 5 p.Research output: Contribution to journal › Article › peer-review
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Open access
Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy
Clelland, A. K., Bales, A. B. E. & Sleeman, J. E., 1 Jun 2012, In: Journal of Cell Science. 125, 11, p. 2626-2637 12 p.Research output: Contribution to journal › Article › peer-review
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Open access
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells
Clelland, A. K., Kinnear, N. P., Oram, L., Burza, J. & Sleeman, J. E., Nov 2009, In: Traffic. 10, 11, p. 1585-1598 14 p.Research output: Contribution to journal › Article › peer-review