Dr Gerald Prescott
Senior Lecturer
Research areas
I am an education-focussed academic whose primary interests lie in the enhancement of bioscience education. I am particularly interested in considering how bioscience pedagogy may need to change to enable students to engage with the ever increasing pace and volume of bioscience research. I am also interested in considering how to enhance the resilience of students in the face or complex scientific problems or wider societal situations.
Prior to becoming an education-focussed academic, my research interests lay in the areas of membrane trafficking and regulated exocytosis. My research focussed on the role of protein isoforms in regulated exocytosis and the role that post-translational modifications (phosphorylation and palmitoylation) play in this process.
Selected publications
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Open access
Phosphorylation of Cysteine string protein triggers a major conformational switch
Patel, P., Prescott, G. R., Burgoyne, R. D., Lian, L-Y. & Morgan, A., 2 Aug 2016, In: Structure. 24, 8, p. 1380-1386 7 p.Research output: Contribution to journal › Article › peer-review
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Endoplasmic Reticulum Localization of DHHC Palmitoyltransferases Mediated by Lysine-based Sorting Signals
Gorleku, O. A., Barns, A-M., Prescott, G. R., Greaves, J. & Chamberlain, L. H., 11 Nov 2011, In: Journal of Biological Chemistry. 286, 45, p. 39573-39584 12 p.Research output: Contribution to journal › Article › peer-review
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Open access
Regional and developmental brain expression patterns of SNAP25 splice variants
Prescott, G. R. & Chamberlain, L. H., 28 Apr 2011, In: BioMed Central Neuroscience. 12, 9 p., 35.Research output: Contribution to journal › Article › peer-review
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Open access
Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis
Graham, M. E., Prescott, G. R., Johnson, J. R., Jones, M., Walmesley, A., Haynes, L. P., Morgan, A., Burgoyne, R. D. & Barclay, J. W., 21 Mar 2011, In: PLoS One. 6, 3, 12 p., e17999.Research output: Contribution to journal › Article › peer-review
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Regulation of SNAP-25 trafficking and function by palmitoylation
Greaves, J., Prescott, G. R., Gorleku, O. A. & Chamberlain, L. H., Feb 2010, In: Biochemical Society Transactions. 38, p. 163-166 4 p.Research output: Contribution to journal › Article › peer-review
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Palmitoylation of the synaptic vesicle fusion machinery
Prescott, G. R., Gorleku, O. A., Greaves, J. & Chamberlain, L. H., Aug 2009, In: Journal of Neurochemistry. 110, 4, p. 1135-1149 15 p.Research output: Contribution to journal › Review article › peer-review
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The Hydrophobic Cysteine-rich Domain of SNAP25 Couples with Downstream Residues to Mediate Membrane Interactions and Recognition by DHHC Palmitoyl Transferases
Greaves, J., Prescott, G. R., Fukata, Y., Fukata, M., Salaun, C. & Chamberlain, L. H., 15 Mar 2009, In: Molecular Biology of the Cell. 20, 6, p. 1845-1854 10 p.Research output: Contribution to journal › Article › peer-review
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The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)
Greaves, J., Prescott, G. R., Gorleku, O. A. & Chamberlain, L. H., 2009, In: Molecular Membrane Biology. 26, 1-2, p. 67-79 13 p.Research output: Contribution to journal › Review article › peer-review
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Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding
Prescott, G. R., Jenkins, R. E., Walsh, C. M. & Morgan, A., 19 Dec 2008, In: Biochemical and Biophysical Research Communications. 377, 3, p. 809-814 6 p.Research output: Contribution to journal › Article › peer-review
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Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size
Evans, G. J. O., Barclay, J. W., Prescott, G. R., Jo, S. R., Burgoyne, R. D., Birnbaum, M. J. & Morgan, A., 20 Jan 2006, In: Journal of Biological Chemistry. 281, 3, p. 1564-1572 9 p.Research output: Contribution to journal › Article › peer-review