Research areas
Novel ligand-gated ion channels in nerve cells.
Nerve cells communicate by releasing chemical messengers, often referred to as neurotransmitters. Some neurotransmitters exert fast effects (via ligand-gated ion channels) others slow effects (via enzyme coupled receptors). We have recently discovered fast actions of two transmitters hithertoo only thought to produce slow effects: a neuropeptide, FMRFamide, and dopamine. The channels directly gated by these substances are being studied in detail. The peptide gated channel (now cloned) is unique in showing a high selectivity for Na ions and also in being antagonised by another endogenous, related, peptide.
Selected publications
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Open access
Fast silencing reveals a lost role for reciprocal inhibition in locomotion
Moult, P. R., Cottrell, G. A. & Li, W., 9 Jan 2013, In: Neuron. 77, 1, p. 129-140 12 p.Research output: Contribution to journal › Article › peer-review
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Green laser light (532nm) activates a chloride current in the C1 neuron of Helix aspersa
Reece, P. J., Dholakia, K., Thomas, R. C. & Cottrell, G. A., 15 Mar 2008, In: Neuroscience Letters. 433, 3, p. 265-269 5 p.Research output: Contribution to journal › Article › peer-review
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Green light activates some and inhibits other neurons of snail ganglia
Reece, P. J., Dholakia, K. & Cottrell, G. A., 2007, Acta Physiologica.Research output: Book/Report › Book
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Domain near TM1 influences agonist and antagonist responses of peptide-gated Na(+) channels.
Cottrell, G. A., Jun 2005, In: Pflügers Archiv: European Journal of Physiology. 450, 3, p. 168-177 10 p.Research output: Contribution to journal › Article › peer-review
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Activity modes and modulation of the peptide-gated Na(+) channel of Helix neurones
Green, KA. & Cottrell, G. A., Mar 2002, In: Pflügers Archiv: European Journal of Physiology. 443, 5-6, p. 813-821 9 p.Research output: Contribution to journal › Article › peer-review
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Histochemical localisation of FMRFamide-gated Na+ channels in Helisoma trivolvis and Helix aspersa neurones
Davey, F. D., Harris, SJ. & Cottrell, G. A., Nov 2001, In: Journal of Neurocytology. 30, p. 877-84 8 p.Research output: Contribution to journal › Article › peer-review
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Location of a ligand recognition site of FMRFamide-gated Na Channels
Cottrell, G. A., Jeziorski, MC. & Green, KA., 26 Jan 2001, In: FEBS Letters. 489, p. 71-74 4 p.Research output: Contribution to journal › Article › peer-review
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Amiloride drugs both block and enhance the action of H+ ions on rat dorsal root ganglion neurones
Green, K. A., Powell, B. & Cottrell, G. A., Jan 2000, In: British Journal of Pharmacology. 129, 1 p.Research output: Contribution to journal › Article › peer-review
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Cloning and expression of a FMRFamide-gated Na+ channel from Helisoma trivolvis and comparison with the native neuronal channel
Cottrell, G. A., Jeziorski, MC., Green, KA. & Sommerville, J., 1 Jul 2000, In: The Journal of Physiology. 526, 1, p. 13-25 13 p.Research output: Contribution to journal › Article › peer-review
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The peptide-gated channel of snail neurones shows different types of activity
Green, K. A. & Cottrell, G. A., Sept 2000, In: The Journal of Physiology. 527, 1 p.Research output: Contribution to journal › Article › peer-review