Dr Lamia Hachoumi

Research Fellow

Email: lh201@st-andrews.ac.uk

Research areas

The focus of my research is to understand how 5-HT modulates the spinal CPG network in Xenopus laevis tadpoles via the Na⁺-pump (Na⁺/K⁺-ATPase) mediated ultra-slow afterhyperpolarisation (usAHP). The usAHP is an important neuronal property because it decreases the excitability of the network following intense rhythmic swimming activity and functions as a short-term motor memory mechanism to influence future activity (Zhang and Sillar, 2012).

Utilising electrophysiological and pharmacological approaches, I am currently investigating the underlying mechanisms by which 5-HT modulates locomotion via the Na⁺-pump mediated usAHP with a particular focus on cAMP signalling and voltage-gated ion channels. In addition, I am interested in understanding how 5-HT influences the short-term motor memory mechanism in the CPG swim network.

Selected publications

Open access

Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord
Hachoumi, L., Rensner, R., Richmond, C., Picton, L., Zhang, H. & Sillar, K. T., 14 Mar 2022, In: Current Biology. 32, 5, p. 1038-1048.e2
Research output: Contribution to journal › Article › peer-review
Open access

Developmental stage-dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networks
Hachoumi, L. & Sillar, K. T., 20 Nov 2019, (E-pub ahead of print) In: Developmental Neurobiology. Early View
Research output: Contribution to journal › Review article › peer-review
Open access

Does the 5-HT_1A rs6295 polymorphism influence the safety and efficacy of citalopram therapy in the oldest old?
Scutt, G., Overall, A., Scott, R., Patel, B., Hachoumi, L., Yeoman, M. & Wright, J., 1 Jul 2018, In: Therapeutic Advances in Drug Safety. 9, 7, p. 355-366 12 p.
Research output: Contribution to journal › Article › peer-review
Open access

Does age matter? The impact of rodent age on study outcomes
Jackson, S. J., Andrews, N., Ball, D., Bellantuono, I., Gray, J., Hachoumi, L., Holmes, A., Latcham, J., Petrie, A., Potter, P., Rice, A., Ritchie, A., Stewart, M., Strepka, C., Yeoman, M. & Chapman, K., 1 Apr 2017, In: Laboratory Animals. 51, 2, p. 160-169 10 p.
Research output: Contribution to journal › Article › peer-review
Open access

Electrochemical sensor for the detection of multiple reactive oxygen and nitrogen species from ageing central nervous system homogenates
Fagan-Murphy, A., Hachoumi, L., Yeoman, M. S. & Patel, B. A., Dec 2016, In: Mechanisms of Ageing and Development. 160, p. 28-31 4 p.
Research output: Contribution to journal › Article › peer-review

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