Prof James Ainge
Director of Research
Research areas
The focus of the lab is to try and understand the neural mechanisms that support our ability to remember the things that have happened to us – episodic memory. Most of our work takes a systems neuroscience approach to examine how networks within the hippocampus and entorhinal cortex process memory information. We use in vivo electrophysiology to examine firing patterns of individual neurons as lab rats carry out memory tasks. We also use molecular and genetic tools to manipulate the network and understand the cellular mechanisms underlying episodic memory.
Complimenting the neuroscientific approach, other lines of research in the lab examine the cognitive mechanisms underlying episodic memory in both human adults and children. Ultimately, we aim to apply this work by using our knowledge of mammalian memory networks to help test therapeutic strategies for disorders of memory such as Alzheimer’s disease.
PhD supervision
- Veronika Ambrozova
- Stephen Duncan
- Silvia Ventura
- Samuel Warne
- Benjamin Thompson
Selected publications
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Open access
Lateral entorhinal cortex lesions impair odor-context associative memory in male rats
Persson, B. M., Ambrozova, V., Duncan, S., Wood, E., O'Connor, A. R. & Ainge, J., 22 Mar 2022, In: Journal of Neuroscience Research. 100, 4, p. 1030-1046 17 p.Research output: Contribution to journal › Article › peer-review
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Open access
Editorial: Spring Hippocampal Research Conference and Beyond
Ainge, J. A., Chisari, M., Cohen, A., Mennerick, S. J., Topolnik, L. & Meier, J. C., 12 Oct 2021, In: Frontiers in Molecular Neuroscience. 14, 773308.Research output: Contribution to journal › Editorial › peer-review
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Open access
Object and object-memory representations across the proximodistal axis of CA1
Vandrey, B., Duncan, S. & Ainge, J. A., 20 Jul 2021, In: Hippocampus. 31, 8, p. 881-896 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Perirhinal cortex and the recognition of relative familiarity
Ameen-Ali, K. E., Sivakumaran, M., Eacott, M. J., O'Connor, A. R., Ainge, J. A. & Easton, A., Jul 2021, In: Neurobiology of Learning and Memory. 182, 107439.Research output: Contribution to journal › Article › peer-review
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Open access
Distance- rather than location-based temporal judgements are more accurate during episodic recall in a real-world task
Kuruvilla, M. V., O'Connor, A. R. & Ainge, J. A., 25 Jun 2020, (E-pub ahead of print) In: Memory. Latest ArticlesResearch output: Contribution to journal › Article › peer-review
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Open access
Fan cells in layer 2 of lateral entorhinal cortex are critical for episodic-like memory
Vandrey, B. M., Garden, D. L. F., Ambrozova, V., McClure, C., Nolan, M. & Ainge, J. A., 6 Jan 2020, In: Current Biology. 30, 1, p. 169-175 e5.Research output: Contribution to journal › Article › peer-review
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Open access
Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations
Kuruvilla, M. V., Wilson, D. I. G. & Ainge, J. A., 14 Jul 2020, In: Brain and Neuroscience Advances. 4, p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease
Yu, Q., Wang, Y., Yan, S., Origlia, N., Rutigliano, G., Yu, H., Ainge, J. A., Yan, S. F., Gunn-Moore, F. & Yan, S. S., 30 Jul 2018, In: Nature Communications. 9, 14 p., 2968.Research output: Contribution to journal › Article › peer-review
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Open access
The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias
Sivakumaran, M. H., MacKenzie, A. K., Callan, I. R., Ainge, J. A. & O'Connor, A. R., 1 Aug 2018, In: Scientific Reports. 8, 11579.Research output: Contribution to journal › Article › peer-review
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Open access
The role of association in pre-schoolers' solutions to "spoon tests" of future planning
Dickerson, K. L., Ainge, J. A. & Seed, A. M., 23 Jul 2018, In: Current Biology. 28, 14, p. 2309-2313 e2.Research output: Contribution to journal › Article › peer-review