Prof Gareth Miles

Professor of Neuroscience

Head of School

Researcher profile

Phone

+44 (0)1334 462050

Email

gbm4@st-andrews.ac.uk

Research areas

The primary goal of the research in my laboratory is to provide a better understanding of the neural control of movement with a focus on motor systems of the brainstem and spinal cord. A detailed knowledge of the normal physiology of these systems is required to enable us to understand and ultimately treat neurodegenerative diseases and injuries which can afflict them. My lab's interests extend from the level of ion channels on individual neurons up to entire neuronal networks involved in  motor behaviours. We study the physiology and anatomy of motor systems both in their normal 'healthy' state and when they are affected by conditions such as Motor Neuron Disease (MND).

Lab website: http://ncm.wp.st-andrews.ac.uk/

PhD supervision

• Arauthy Gnanasampanthan
• Francesca Sorrell
• Calum Bonthron

Selected publications

• Synaptic mechanisms underlying modulation of locomotor-related motoneuron output by premotor cholinergic interneurons

  Nascimento, F., Broadhead, M. J., Tetringa, E., Tsape, E., Zagoraiou, L. & Miles, G. B., 9 Mar 2020, In : eLife. 9, e54170.

  Research output: Contribution to journal ? Article

• Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology

  Zhao, C., Devlin, A-C., Chouhan, A. K., Selvaraj, B., Stavrou, M., Burr, K., Brivio, V., He, X., Mehta, A., Story, D., Shaw, C., Dando, O., Hardingham, G., Miles, G. B. & Chandran, S., 11 Mar 2020, In : Glia. 68, 5, p. 1046-1064 19 p.

  Research output: Contribution to journal ? Article

• Sodium pumps mediate activity-dependent changes in mammalian motor networks

  Picton, L. D., Nascimento, F., Broadhead, M. J., Sillar, K. T. & Miles, G. B., 25 Jan 2017, In : Journal of Neuroscience. 37, 4, p. 906-921 16 p.

  Research output: Contribution to journal ? Article

• Stimulation of glia reveals modulation of mammalian spinal motor networks by adenosine

  Acton, D. & Miles, G. B., 7 Aug 2015, In : PLoS One. 10, 8, 17 p., e0134488.

  Research output: Contribution to journal ? Article

• Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

  Devlin, A-C., Burr, K., Borooah, S., Foster, J. D., Cleary, E. M., Geti, I., Vallier, L., Shaw, C. E., Chandran, S. & Miles, G. B., 12 Jan 2015, In : Nature Communications. 6, 12 p., 5999.

  Research output: Contribution to journal ? Article

• A cluster of cholinergic premotor interneurons modulates mouse locomotor activity

  Zagoraiou, L., Akay, T., Martin, J. F., Brownstone, R. M., Jessell, T. M. & Miles, G. B., 10 Dec 2009, In : Neuron. 64, 5, p. 645-662

  Research output: Contribution to journal ? Article

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