Prof Gareth Miles
Professor of Neuroscience
Research areas
Lab website: http://ncm.wp.st-andrews.ac.uk/
The primary goal of the research in my laboratory is to provide a better understanding of the neural control of movement with a focus on motor systems of the brainstem and spinal cord. A detailed knowledge of the normal physiology of these systems is required to enable us to understand and ultimately treat neurodegenerative diseases and injuries which can afflict them. My lab's interests extend from the level of ion channels on individual neurons up to entire neuronal networks involved in motor behaviours. We study the physiology and anatomy of motor systems both in their normal 'healthy' state and when they are affected by conditions such as Motor Neuron Disease (MND).
PhD supervision
- Jui-Yi Chen
- Alyssa Corbett
- Sophie Cuthbertson
- Ahmad Jibai
- Qi Li
Selected publications
-
Open access
A cholinergic spinal pathway for the adaptive control of breathing
Lin, M., Calabrese, G., Incognito, A. V., Moore, M. T., Agarwal, A., Wilson, R. J. A., Zagoraiou, L., Sharples, S., Miles, G. & Philippidou, P., 26 Aug 2025, In: Cell Reports. 44, 8, p. 1-17 17 p., 116078.Research output: Contribution to journal › Article › peer-review
-
Open access
Selective vulnerability of tripartite synapses in Amyotrophic Lateral Sclerosis
Broadhead, M. J., Bonthron, C., Waddington, J., Smith, W. V., Lopez, M. F., Burley, S., Valli, J., Zhu, F., Komiyama, N. H., Smith, C., Grant, S. G. N. & Miles, G. B., Apr 2022, In: Acta Neuropathologica. 143, 4, p. 471–486Research output: Contribution to journal › Article › peer-review
-
Open access
Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development
Sharples, S. A. & Miles, G. B., 3 Dec 2021, In: eLife. 10, e71385.Research output: Contribution to journal › Article › peer-review
-
Open access
Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
Devlin, A.-C., Burr, K., Borooah, S., Foster, J. D., Cleary, E. M., Geti, I., Vallier, L., Shaw, C. E., Chandran, S. & Miles, G. B., 12 Jan 2015, In: Nature Communications. 6, 12 p., 5999.Research output: Contribution to journal › Article › peer-review
-
Open access
A cluster of cholinergic premotor interneurons modulates mouse locomotor activity
Zagoraiou, L., Akay, T., Martin, J. F., Brownstone, R. M., Jessell, T. M. & Miles, G. B., 10 Dec 2009, In: Neuron. 64, 5, p. 645-662Research output: Contribution to journal › Article › peer-review