Prof Gareth Miles
Professor of Neuroscience
Research areas
Lab website: http://ncm.wp.st-andrews.ac.uk/
The primary goal of the research in my laboratory is to provide a better understanding of the neural control of movement with a focus on motor systems of the brainstem and spinal cord. A detailed knowledge of the normal physiology of these systems is required to enable us to understand and ultimately treat neurodegenerative diseases and injuries which can afflict them. My lab's interests extend from the level of ion channels on individual neurons up to entire neuronal networks involved in motor behaviours. We study the physiology and anatomy of motor systems both in their normal 'healthy' state and when they are affected by conditions such as Motor Neuron Disease (MND).
PhD supervision
- Jui-Yi Chen
- Struan Nisbet
- Alyssa Corbett
- Ahmad Jibai
Selected publications
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Open access
Selective vulnerability of tripartite synapses in Amyotrophic Lateral Sclerosis
Broadhead, M. J., Bonthron, C., Waddington, J., Smith, W. V., Lopez, M. F., Burley, S., Valli, J., Zhu, F., Komiyama, N. H., Smith, C., Grant, S. G. N. & Miles, G. B., Apr 2022, In: Acta Neuropathologica. 143, 4, p. 471–486Research output: Contribution to journal › Article › peer-review
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Open access
Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development
Sharples, S. A. & Miles, G. B., 3 Dec 2021, In: eLife. 10, e71385.Research output: Contribution to journal › Article › peer-review
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Open access
Synaptic mechanisms underlying modulation of locomotor-related motoneuron output by premotor cholinergic interneurons
Nascimento, F., Broadhead, M. J., Tetringa, E., Tsape, E., Zagoraiou, L. & Miles, G. B., 9 Mar 2020, In: eLife. 9, 26 p., e54170.Research output: Contribution to journal › Article › peer-review
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Open access
Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology
Zhao, C., Devlin, A.-C., Chouhan, A. K., Selvaraj, B., Stavrou, M., Burr, K., Brivio, V., He, X., Mehta, A., Story, D., Shaw, C., Dando, O., Hardingham, G., Miles, G. B. & Chandran, S., 11 Mar 2020, In: Glia. 68, 5, p. 1046-1064 19 p.Research output: Contribution to journal › Article › peer-review
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Open access
Bi-directional communication between neurons and astrocytes modulates spinal motor circuits
Broadhead, M. J. & Miles, G. B., 27 Feb 2020, In: Frontiers in Cellular Neuroscience. 14, 14 p., 30.Research output: Contribution to journal › Article › peer-review
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Open access
Sodium pumps mediate activity-dependent changes in mammalian motor networks
Picton, L. D., Nascimento, F., Broadhead, M. J., Sillar, K. T. & Miles, G. B., 25 Jan 2017, In: Journal of Neuroscience. 37, 4, p. 906-921 16 p.Research output: Contribution to journal › Article › peer-review
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Open access
Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
Devlin, A.-C., Burr, K., Borooah, S., Foster, J. D., Cleary, E. M., Geti, I., Vallier, L., Shaw, C. E., Chandran, S. & Miles, G. B., 12 Jan 2015, In: Nature Communications. 6, 12 p., 5999.Research output: Contribution to journal › Article › peer-review
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Open access
A cluster of cholinergic premotor interneurons modulates mouse locomotor activity
Zagoraiou, L., Akay, T., Martin, J. F., Brownstone, R. M., Jessell, T. M. & Miles, G. B., 10 Dec 2009, In: Neuron. 64, 5, p. 645-662Research output: Contribution to journal › Article › peer-review