Prof David O'Hagan
Professor
Biography
Professor David O'Hagan was born in Glasgow and studied chemistry at the University of Glasgow (1982). He carried out a Ph.D (1985) in polyketide antibiotic biosynthesis at the University of Southampton with Professor John A Robinson and then he spent a postdoctoral year at the Ohio State University with Professor Heinz G. Floss, investigating peptide antibiotic biosynthesis. In 1986 he was appointed to the University of Durham where he continued to explore natural product biosynthesis but also developed a strong interest in organo-fluorine chemistry. He remained at Durham until 2000 before moving to his current position as Professor and Head of Organic Chemistry at the University of St Andrews. His research interests extend from the synthesis and properties of organo-fluorine compounds, fluorination enzymology, fluorine-18 chemistry for positron emission tomography (PET) and through to fluorinated organic materials.
He was a founding member and a past Chair of the RSC Fluorine Group. He was awarded the IChemE, 'Judges Award' for fluorinase enzyme isolation in 2002, was elected FRSE in 2004, was awarded the RSC Malcolm Campbell Memorial Prize in Medicinal Chemistry in 2005, was a recipient of the RSC Tilden Medal in 2006/2007, was the RSC 'Natural Product Reports Award' Lecturer in 2009, was awarded the American Chemical Society (ACS) Award for 'Creative Work in Fluorine Chemistry' in 2012, was awarded a Royal Society Wolfson Merit Award in 2013 and was awarded the RSC Organic Stereochemistry award in 2015.
In 2018 David was awarded the Moissan Prize, which is awarded every three years by the Fondation de la Maison de la Chime in Paris for contributions to fluorine chemistry.
PhD supervision
- Luca Dobson
- Yawen Chen
- Thomas Poskin
- Mengfan He
- Dominic Spurling
- Josephine Stewart
- George Kingsley-Moore
- Nachiket Deepak More
Selected publications
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Open access
Conformational analysis explores the role of electrostatic non-classical CFHC hydrogen bonding interactions in selectively halogenated cyclohexanes
He, M., Piscelli, B., Cormanich, R. & O'Hagan, D., 5 Mar 2024, (E-pub ahead of print) In: The Journal of Organic Chemistry. 89, 6, p. 4009–4018 10 p.Research output: Contribution to journal › Article › peer-review
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Open access
3′-O-β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine is a natural product of the nucleocidin producers Streptomyces virens and Streptomyces calvus
Clarke, D., Feng, X., Deng, H., Zhang, Q. & O'Hagan, D., 27 Oct 2023, In: Journal of Natural Products. 86, 10, p. 2326-2332 7 p.Research output: Contribution to journal › Article › peer-review
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Open access
4′-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics
Lowe, P. T. & O’Hagan, D., 7 Jan 2023, In: Chemical Society Reviews. 52, 1, p. 248-276 29 p.Research output: Contribution to journal › Review article › peer-review
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Open access
Aryl (β, β', β''-trifluoro)-tert-butyl: a candidate motif for the discovery of bioactives
O'Hagan, D., Cordes, D. B., Dobson, L., Oke, O. O., Zhang, Q., Cormanich, R., Isanbor, C., McKay, B., Khan, M. F., Piscelli, B. & Murphy, C., 22 Sept 2023, In: Organic Letters. 25, 37, 6802 p.Research output: Contribution to journal › Article › peer-review
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Open access
Contribution of hyperconjugation and inductive effects to the pseudo-anomeric effect in 4-substituted methoxycyclohexanes
Piscelli, B. A., O’Hagan, D. & Cormanich, R. A., 26 Jan 2023, In: Journal of Physical Chemistry A. 127, 3, p. 724–728 5 p.Research output: Contribution to journal › Article › peer-review
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Open access
Direct syntheses of stereoisomers of 3-fluoro GABA and β-fluoroamine analogues of the calcium receptor (CaR) agonists, cinacalcet, tecalcet, fendilines and NPS R-467
Renault, Y. J. G., Diao, J., Cordes, D. B., Leach, K. & O'Hagan, D., 24 Jul 2023, In: Medicinal Chemistry Research. 32, p. 1532-1542 11 p.Research output: Contribution to journal › Article › peer-review
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Open access
Does perdeuteration increase the polarity of Janus face cycloalkanes?
Fang, Z., Yu, C., Bühl, M. & O'Hagan, D., 20 Feb 2023, In: Helvetica Chimica Acta. 106, 2, 5 p., e202200177.Research output: Contribution to journal › Article › peer-review
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Open access
Efficient biotransformations in Cunninghamella elegans and Streptomyces sp. JCM9888 of selectively fluorinated benzoic acids to the corresponding benzamides and benzyl alcohols
Oke, O. O., Chen, Y., Isanbor, C., Asekun, O. T. & O'Hagan, D., 12 Oct 2023, (E-pub ahead of print) In: Biocatalysis and Biotransformation. Latest ArticlesResearch output: Contribution to journal › Article › peer-review
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Open access
Future challenges and opportunities with fluorine in drugs?
O'Hagan, D. & Young, R. J., 1 Jul 2023, In: Medicinal Chemistry Research. 32, p. 1231-1234 4 p.Research output: Contribution to journal › Article › peer-review
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Open access
Identification of genes essential for fluorination and sulfamylation within the nucleocidin gene clusters of Streptomyces calvus and Streptomyces virens
Wojnowska, M., Feng, X., Chen, Y., Deng, H. & O'Hagan, D., 28 Feb 2023, In: ChemBioChem. 24, 5, 9 p., e202200684.Research output: Contribution to journal › Article › peer-review