SCIENTIFIC PROGRAM

August 11, Monday

08:00

Opening Ceremony

Strand Union Ballrooms ABCD

PLENARY LECTURES

August 11, Monday

Strand Union Ballrooms ABCD

Chairman: P. Grieco

08:30

L. E. Overman, University of California, Irvine, USA

PL-1

Total Synthesis of Marine Alkaloids

Chairman: C. Moody

09:30

M. Shibasaki, The University of Tokyo, Japan

PL-2

Catalytic Asymmetric Synthesis of Biologically Significant Compounds

INVITED LECTURES

August 11, Monday

Strand Union 275/276

Session Ia: Organic Synthesis & Heterocycles

Chairman: S. Burke

11:00

P. Grieco, Indiana University, USA

IL-Ia-l

Organic Chemistry in Polar Media

11:30

G. Molander, University of Colorado at Boulder, USA

IL-Ia-2

Diverse Methods for Heterocyclic Synthesis

August 11, Monday

Gaines Hall 101

Session II: Asymmetric Synthesis & Heterocycles

Chairman: R. Hoffinann

11:00

M. E. Jung, D. D'Amico, C. J. Nichols, K. L. Anderson, S. Harashima, Y. Xu, University of California, Los Angeles, USA

IL-II-1

Oxacycles: New Syntheses and Reactions

11:30

T. Shioiri, T. Aoyama, Nagoya City University, Japan

IL-II-2

Trimethylsilyldiazomethane: A Useful Alkylidene Carbene Generator for the Construction of Heterocycles

August 11, Monday

Leon Johnson 339

Session III:  Heterocycles in Organometallic Transformations

Chairman: R. C. Larock

11:00

J.-E. Bäckvall, University of Uppsala, Sweden

IL-III-1

Stereoselective Synthesis of Heterocyclic Systems via Intramolecular Palladium(II)-Catalyzed l,4-Additions to Conjugated Dienes

11:30

L. S. Hegedus, Colorado State University, USA

IL-III-2

From Microcycles to Macrocycles. Azapenams to Cyclams

August 11, Monday

Strand Union Theatre

Session IV: Heterocyclic Pharmaceuticals & Agrochemicals

Chairman: V. Lee

11:00

P. J. Reider, Merck Research Laboratories, USA

IL-IV-l

New Therapies for Aids: The Asymmetric Synthesis of CRIXIVAN ^TM

11:30

T. Guzi, M. Labroli, l. Tepe, T. Macdonald, University of Virginia, USA

IL-IV-2

Substituted Piperidin-3-ones, ß-Carbolines and (Pyrido)quinolines as DNA Topoisomerase Inhibitors

August 11, Monday

Strand Union Ballrooms BCD

Session Ib: Organic Synthesis & Heterocycles

Chairman: Y. H. Kim

11:00

H. H. Wasserman, YaleUniversity, USA

IL-Ib-l

New Methodology in Heterocyclic Synthesis Using Vicinal Polycarbonyls

11:30

T. Gallagher, University of Bristol, UK

IL-Ib-2

A New Concept in ß-Lactam Symhesis

ORAL PRESENTATIONS

August 11, Monday

Strand Union 275/276

Session I: Organic Synthesis and Heterocycles

Chairman: S. Lang

13:30

A. Padwa, C. O. Kappe, T. Reger, Emory University, USA

OP-I-1

Tandem Diels-Alder N-Acyliminium Ion Cyclization Reactions as Entry into the Erythrinane Skeleton

13:50

H. Hiemstra, W G. Beyersbergen van Henegouwen, University of Amsterdam, The Netherlands

OP-I-2

Studies toward the Total Synthesis of Gelsedine: an Efficient Allene- Terminated N‑Acyliminium Ion Cyclization

14:10

E. D. Edstrom, University of Montana, USA

OP-I-3

Chemistry of Novel Cyclic C-Acyl Imiminum Ions

14:30

R. E. Gawley, Q. Zhang, S. Campagna, L. Keller, University of Miami, USA

OP-I-4

Alkylation and Sigmatropic Rearrangements of 2-Lithio Piperidines and Pyrrolidines: Configurationally Stable "Carbanions" with Considerable Synthetic Potential

15:10

S. D. Burke, B. Austad, University of Wisconsin, USA

OP-I-5

Progress Towards the Total Synthesis of Halichondrin B: Synthesis of the C(37)-C(54) Segment

15:30

S. D. Burke, C. J. O'Donnell, J. J. Hans, C. W Moon, R. A. Ng, T. W. Adkins, G. K. Packard, University of Wisconsin-Madison, USA

OP-I-6

Synthesis of Cyclic Hydropyran Oligolides with Convergent Amine, Amide, Phosphonate and Furan Appendages

15:50

A. Franz, K. Neuchschütz, T. Thyrann, J.. Schoepfer, R. Neier, University of Neuchâtel, Switzerland

OP-I-7

Novel Tandem Reactions for the Synthesis of Heterocycles

August 11, Monday

Gaines Hall 101

Session II: Asymmetric Synthesis & Heterocycles

Chairman: E. Rosenberg

13:30

T. S. Livinghouse, S. W. Riesinger, H. A. Heath, B. Wolfe, Montana State University, USA

 OP-II-l

P-Chiral Phosphines Containing Heterocyclic Backbones: New Ligands for Transition Metal Catalysis

13:50

D. J. R. O'Mahony, D. B. Belanger, T. Livinghouse, Montana State University, USA

OP-II-2

The Rhodium Catalysed Intramolecular [4+2] Cycloaddition: A Stereocontrolled Route to the Hexahydro-isoindoline Nucleus

14:10

P. A. Evans, J. D. Roseman, T. Manangan, V S. Murthy, University of Delaware, USA

OP-II-3

Stereoselective Synthesis of Biologically Important Cyclic Ether Containing Natural Products via Intramolecular Radical Cyclizations

14:30

P. Garner, J. T. Anderson, Case Western Reserve University, USA

OP-II-4

The Development of Effective Heterocyclic Chiral Auxiliaries for Hydroxyalkyl Radicals

15:10

S. Kanemasa, Y. Oderaotoshi, Kyushu University, Japan

OP-II-5

A New Heterocyclic Tridentate Chiral Ligand, Dibenzofuran-4,6-diyl-2,2'-bis(4-phenyloxazoline) DBFOX. Transition Metal Aqua Complexes as Effective Lewis Acid Catalysts in Asymmetric Diels-Alder Reactions

15:30

W. S. Tian, Z. H. Y. Z. S. Luo, J. Q. Wang, Chinese Academy of Sciences, China

OP-II-6

Asymmetric Synthesis of Neoclausenamide and Related Lactams

15:50

S. W. Chang, B.-J. Uang, National Tsing Hua University, ROC

OP-II-7

Enantioselective Syntheses of (-)-Muricatacin and 5-epi-(-)-Muricatacin

August 11, Monday

Leon Johnson 339

Session III: Heterocyclic Pharmaceuticals & Agrochemicals

Chairman: C O. Kappe

13:30

W. S. Tian, Y. Ji, M.-S. He, H.-E Ying, Chinese Academy of Sciences, China

OP-III-1

Study on the Synthesis of Pyrazino Steroid Dimers

13:50

R. C. Gadwood, L. M. Thomasco, G. J. Cleek, R. C. Thomas, Pharmacia & Upjohn, USA

OP-III-2

Synthesis of Hexahydro-1H-thieno[3,4-c]pyrrole and Its Use in Preparation of Oxazolidinone Antibacterial Agents

14:10

J. Bergman, E. Desarbre, CNT, NOVUM Research Park, Sweden

OP-III-3

Synthesis of Indolo[2,3-c]carbazole derivatives

14:30

M. Butters, A. Bentley, S. P. Green, J. A. Harrison, M. C. Morland, C. W Murtiashaw, A. J. Pettman, Pfizer Central Research, UK

OP-III-4

Voriconazole - Process Development of a Novel, Broad Spectrum Triazole Antifungal

15:10

A. C. O'Sullivan, H. Szczepanski, H.-R. Waespe, Novartis Crop Protection AG, Switzerland

OP-III-5

3,4-Disubstituted Pyridines as Herbicides

15:30

A. M. Almerico, A. Lauria, F. Mingoia, P. Diana, P. Barraja, C. Milia, E. Congeddu, C. Musiu, M. Putzolu, P. La Colla, Università degli Studi, Italy

OP-III-6

Glycosidoderivatives Dideaza Analogues of Ribavirin: 1-ß-D-Ribofuranosylpyrroles as Potential Antiviral/Anticancer Agents

15:50

G. Cirrincione, P. Diana, P. Barraja, F. Mingoia, A. Lauria, A. M. Almerico, G. Dattolo, Università degli Studi, Italy

OP-III-7

Pyrrolo[2,1-d][1,2,3,5]tetrazines, a New Class of Azolotetrazines Deaza Analogues of the Antitumour Drug Temozolomide

August 11, Monday

Strand Union Theatre

Session IV: New Heterocyclic Materials

Chairman: A. C. Craig

13:30

R. S. Glass, Y. Liu, E. Lorance, The University of Arizona, USA

OP-IV-1

Synthesis and Redox Chemistry of Alpha-Stannyl Sulfur Heterocycles

13:50

X. L. M. Despinoy, H. McNab, D. A. Shannon, E. Stevenson, The University of Edinburgh, Scotland

OP-IV-2

New Routes to, and from, Pyrrolizinones

14:10

M. Regitz, U. Vogelbacher, U. Hees, S. Haber, University of Kaiserslautern, Germany

OP-IV-3

Azaphosphabenzenes and Their Valence Isomeres

14:30

M. J. Alves, T. L. Gilchrist, University of Liverpool, UK

OP-IV-4

Chemistry of Activated Azirine Esters

15:10

R. M. Letcher, L. Wing-Hong, The University of Hong Kong, Hong Kong

 OP-IV-5

Novel Heterocycles from 4,8-Dioxodibenz[b,f]azocine

15:30

Z. Riedl, G. Hajós, G. Kollenz, Hungarian Academy of Sciences, Hungary

OP-IV-6

Ring Transformations to Polyfused Pyridazines. Synthesis of a New Stable Radical Cation

August 11, Monday

Strand Union Ballrooms BCD

Session V: Miscellaneous

Chairman: J Lacour

13:30

T. Kappe, W Stadlbauer, Karl Franzens University of Graz, Austria

OP-V-1

Differential Scanning Calorimetry (DSC) - A Valuable Tool in Heterocyclic Synthesis

13:50

H. Neunhoeffer, C.-P. Drexel, Technical University Darmstadt, Germany

OP-V-2

Cydoaddition Reactions with 1,2,4-Triazin-5(4H)ones

14:10

E. Schaumann, N. Bräuer, O. Koch, T. Michel,  Technische Universität Clausthal, Germany

 OP-V-3

Silicon-Mediated Domino Reactions in Heterocyclic Synthesis

14:30

A. Mitra, P.J. Seaton, J. F. Capitani, Manhattan College/College of Mount St. Vincent, USA

 OP-V-4

Anomalous Concentration Dependencies Observed in the Chemical Shifts of Aromatic Heterocyclic Compounds

15:10

R. H. Prager, C. M. Williams, D. S. Millan,  Flinders University of South Australia, Australia

 OP-V-5

A New Synthesis of Thiazoles and 1,3-Oxazin-6-ones from Thioacylisoxazolones

15:30

G. Himbert, E. Pierron, S. Matheis, Fachbereich Chemie, Germany

OP-V-6

Five-membered cyclic Betaines bearing two Carbonyl Groups and a quaternary Nitrogen Atom as Parts of the Ring Parameter

15:50

V. A. Bakulev, O. C. Kappe, Ural State Technical University, Russia

OP-V-7

Hetero Electrocyclic Reactions

POSTER SESSION I

August 11, Monday

Hosaeus Health & PE Center

POI-1

T. M. Abdel-Rahman, Faculty of Specific Education, Egypt

Synthesis of Some New Biologically Active 2,3-Disubstituted Quinazolin-4-ones

POI-2

R. Miranda, J. M. Aceves, F. Delgado, A. Cabrera, M. Salmón, Universidad Nacional Autónoma de México, Mexico

Synergetic Oxidation of Hantzsch Esters Induced by Taff-Metallic Nitrates

POI-3

R. A. Aitken, L. Hill, University of St.Andrews, UK

Phosphine-Mediated Synthesis of Sulfur Heterocycles

POI-4

A. M. Allsebrook, N. P. Botting, University of St.Andrews, UK

Studies on QPRTase - Synthesis of Quinolinic Acid Analogues and Decarboxylation of N‑Substituted Quinolinic Acids

POI-5

A. Amer, A. M. EI Massry, M. Badawi, B. H. Ali, A. Bashir, United Arab Emirates University, Egypt

Design and Synthesis of Potentially Biologically Active Quinoxaline Derivatives

POI-6

F. M. Anderson, S. M. Lacy, N. D. Henderson, D. J. Robins, University of Glasgow, UK

Synthesis of Novel Bifunctional Alkylating Agents for Biological Evaluation as Anti-Cancer Prodrugs

POI-7

Y. Arai, T. Masuda, Y. Masaki, Gifu Pharmaceutical University, Japan

Lewis Acid-Promoted Asymmetric Diels-Alder Reaction Using Chiral l-(2-p-Tolylsulfinyl)pyrrolyl α,β-Uusaturated Ketones as a Dienophile

POI-8

G. L. Araldi, A. P. Kozikowski, Georgetown University MedicaI Center, USA

Synthesis and Biological Evaluation of Cocaine Analogues, the 6- and 7- Substituted 3‑Phenyltropanes

POI-9

M. Arisawa, T. Takada, H. Tohma, J. Eichhorn, M. H. Zenk, Y. Kita, Osaka University, Japan

An Oxidative Intramolecular Phenolic Coupling Reactions Induced by a Hypervalent Iodine (III) Reagent: Synthesis of Galanthamine type Amaryllidaceae Alkaloids

POI-10

F Y. A. Azev, Ural Research Institute of Technology of Medicinal Compounds, Russia

Transformation of 5-Azauracil in the Reaction with Nucleophiles

POI-11

Y.A. Rozin, A. Yakimov, V. A. Bakulev, Ural State Technical University, Russia

Synthesis of N-Amino-l,2,3-Triazoles

POI-12

E. V.Tarasov, Y.Y. Morzherin, V. A. Bakulev, Ural State Technical University, Russia

Synthesis of Assemblies of 1,2,3-Thiadiazole and 1,2,3-Triazole Rings

POI-13

V. Y. Sosnovskikh, V. A. Bakulev, Ural State University, Russia

Ring-Chain Isomerism of Derivatives of 2-Hydroxy-4,6-Dimethylacetophenone with Nitriles

POI-14

A. Balbi, Department of Pharmaceutical Sciences, Italy

Behaviour of 2-(Dialkylamino)chromone Derivatives in Reactions with Dinucleophlic Reagents

POI-15

G. B. Barlin, L. P. Davies, P. W. Harrison, S. J. Ireland, John Curtin School of Medical Research, Australia

Some Imidazo[l,2-b]pyridazines with Selectivity for Mitochondrial or Central Benzodiazepine Receptors

POI-16

A. L. Baumstark, E. Michelena-Baez, A. Rodriguez, H. Banks, P.C. Vasquez, Georgia State University, USA

Oxidation of Alkenes by Dimethyldioxirane

POI-17

L. W. Castle, J. Beck, Idaho State University, USA

Synthesis of Indolo[2,3-c][1,10]phenanthroline via Photocyclization

POI-18

J.Atzrodt, R. Beckert, Friedrich Schiller University Jena, Germany

Novel Interesting Derivatives of 4H-Imidazoles by Simple Cycloacylation Reactions

POI-19

M. Belley, M. De Vleeschauwer, B. Hill, Merck Frosst Centre for Therapeutic Research, Canada

Aromatic Ring Opening of Fused Thiophenes via Alkyllithium Addition to Sulfur

POI-20

T. Belliotti, W. Brink, D. Wustrow, L. Wise

The Synthesis and Separation of Isoindolinone Enantiomers by Fractional Crystallization

POI-21

V. Beylin, O. Goel, J. Hollenbeck, M. Marlatt, Warner-Lambert Company, USA

Orthothioesters in the synthesis of heterocycles. An improved process for preparation of 5‑alkylthio-2[2-[4,6-di-t-butyl-5-hydroxy]-1,3-pyrimidinyl]-1,3,4-thiadiazoles

POI-22

T. J. Bleisch, M. B. Arnold, P.L. Ornstein, Lilly Research Laboratories, USA

The Use of 5,5-Disubstituted- Imidazolidine-2,4-Diones in the Synthesis of α- Substituted Carboxycyclopropylglycines. Part I

POI-23

J. Teixidó, J. I. Borrell, B. Serra, C. Colominas, Universitat Ramon Llull, Spain

Cyclization of Tautomeric 1,5-Dinitrile Systems with Hydrogen Halides: A Definitive Mechanistic Rationalization

POI-24

S. A. Boyd, R. A. Mantei, A. S. Tasker, G. Liu, B. K. Sorensen, K. J. Henry Jr., T. W von Geldern, M. Winn, J. R. Wu-Wong, W. J. Chiou, D. B. Dixon, T. J. Opgenorth, Abbott Laboratories, USA

Discovery of a Series of Pyrrolidine-Based Endothelin Receptor Antagonists with Enhanced ET_A Receptor Selectivity

POI-25

P. Bandiera, P. Bravo, L. Bruché, M. Zanda, Centro di Studio sulle Sostanze Organiche Naturali, Italy

Synthesis of Chiral Fluorinated Heterocycles Using a Sulfoxide Function as Asymmetric Inductor

POI-26

V. Brovarets, R. Vydzhak, K. Ziouz, National Academy of Sciences of Ukraine, Ukraine

Phosphonium Syntheses of 1,3-Azoles Derivative

POI-27

T. L. Gibson, J. C. Baum, A. B. Brown, M. R. Cassler, J. E. Goolsby, R. M. Hurtado, M. E. Frodyma, Flordia Institute of Technology, USA

An Approach to High-Sensitivity Fluorescence Detection of Hydrazine, Based on Molecular Recognition by a Novel Heterocyclophane

POI-28

A. B. Brown, M. H. Baloga, R. T. Mott, S. O. Miyumo, S. B. Forlow, B. C. Steurer, C. C. Morgan, Florida Institute of Technology, USA

Improved Routes to 4,5-Acridinediol and 1,8-Carbazolediol

POI-29

G. D. Brown, S.-C. Lee, G. A. Williams, The University of Hong Kong, Hong Kong

Tribenzyl-2-Oxo-Dihydrofurans and Dibenzyl, Diphenyl-2-Oxo-Octahydrobenzofurans From Kyrtuthrix maculans

POI-30

S. Burke, R. A. Ng, J. A. Morrison, M. J. Alberti, University of Wisconsin-Madison, USA

Glycolate Claisen - Olefin Metathesis Sequence for the Synthesis of Functionalized Dihydropyrans

POI-31

B. E. A. Burm, S. Gremmen, M. J. Wanner, G.-J. Koomen, University of Amsterdam, The Netherlands

Analogues of the ß-Carboline Nazlinine; Synthesis of New Bridged Alkaloids

POI-32

C. K. McClure, B. Cai, Montana State University, USA

Mechanistic Investigation of the Reaction Between Pentacovalent Oxaphospholenes and Isocyanates via NMR Spectroscopy

POI-33

S. Cappelle, K. Buysens, D. Vandenberghe, G. Hoornaert, K.U. Leuven, Belgium

Intramolecular Diels-Alder Reactions of 2(1H)-Pyrazinones: Synthesis of Various Pyrrolo-, Furano-, Pyrido-, and Pyrano-Fused Pyridine and Pyridone Systems

POI-34

C.-W. Chan, A. J. P. White, D. J. Williams, D. M. P. Mingos, Open Learning Institute of Hong Kong, Hong Kong

2,4-Diamino-6-(2-pyridyl)-1,3,5-triazine (L¹) and 2-Amino-4-phenylamino-6-(2-pyridyl)-1,3,5-triazine (L²): A Class of Pseudo 2,2'-Bipyridine with Hydrogen-Bonding Abilities

POI-35

O. N. Chupakhin, V. N. Charushin, H. C. van der Plas, Urals State Technical University, Russia

Nucleophilic Aromatic Substitution of Hydrogen

POI-36

G .N. Lipunova, E. V. Nosova, L. P. Sidorova, V. N. Charushin, Urals State Technical University, Russia

Synthesis of Fluorinated Derivatives of 1,3,4-Thiadiazino[6,5,4-i,j]quinoline-6-carboxylic Acid

POI-37

R. H. K. Chen, S. Palmer, C. Campen, The R. W. J. Pharmaceutical Research Institute, USA

Synthesis and SAR of a Novel Series of Spirobenzothiazepine Derivatives with Antiprogestin Activity

POI-38

C.-Y. Cheng, J. –P. Liou, M.-J. Lee, National Taiwan University, Taiwan

Synthesis of Morphine Fragments Spiro[benzofuran-3(2H)-4'-piperidine] and Octahydro-1H-benzofuro[3,2-e]isoquinoline by Intramolecular Heck Reaction

POI-39

J.-W Chern, J.-C. Lo, N.-Y. Lai, C. O. Usifoh, National Taiwan University, Taiwan

Synthesis and Pharmacological Evaluation of 1,2,4-Benzothiadiazine 1,1-Dioxide Biphenyl Tetrazoles as Angiotensin II Antagonists

POI-40

M. Christlieb, J. Eames, R. V. Jones, B. E. Looker, S. Warren, University of Cambridge, UK

The Stereoselective Synthesis of Oxetanes

POI-41

O. N. Chupakhin, E. N. Ulomsky, S. L. Deev, V. L. Rusinov, Urals StateTechnical University, Russia

Triazine Ring Cleavage in Triazolo[5,1-c][1,2,4]triazines

POI-42

F. Compernolle, P. R. Carly, S. L. Cappelle, G. J. Hoornaert, Department of Chemistry K.U. Leuven, Belgium

Diels-Alder Reactions of Pyridine o-Quinodimethane Analogues

POI-43

F. J. M. Crespo, J. A. Palop, Y. Sainz, S. Narro, V. Senador, M. González, A. López de Cerain, A. Monge, Universidad de Navarra, Spain

4-Cyano-2-oxo-1,2,4-oxadiazolo [2,3-a]quinoxaline 5-N-oxides. New Synthetic Method and Reaction with Alcohols. Potencial Cytotoxic Activity

POI-44

M. L. Fascio, N. B. D'Accorso, Universidad de Buenos Aires, Argentina

A Novel Structure Obtained by Intramolecular 1,3-Dipolar Cycloaddition

POI-45

M. A. M. Alho, N. B. D'Accorso, Universidad de Buenos Aires, Argentina

Some Sulphur Heterocycles From Monosaccharides-Synthesis and Characterization

POI-46

V. J. Montesano, M. L. Fasico, N. B. D'Accorso, Universidad de Buenos Aires, Argentina

Synthesis and Characterization of Some 3-Glycosyl-5-Substituted-Isoxazoles

POI-47

K. Dastlik, R. Giles, G. Roos, Murdoch University, Australia

Enantioselective Synthesis of (+)Iforrestine

POI-48

P. R. Dave, GEO-CENTERS, INC., USA

N-Dealkylarive Acylarion of Azeridines: Facile Access to Some Important Azetidines

POI-49

D. A. Davis, G. W. Gribble, Dartmouth College, USA

Preparation and Biological Studies of 6-Aminoindolo[1,2-b][2,7]naphtrhyridine-5,12-quinones

POI-50

M. Davis, G. A. Waechter, S. G. Franzblau, A. R. Martin, University of Arizona, USA

Some Pyridine, Pyrazine, and Diazaborine Derivatives for Growth Inhibition of M. tuberculosis

POI-51

N. De Kimpe, K. A. Tehrani, C. Srevens, University of Gent, Belgium

Synthesis of 2-Aryl-3-Halopyrroles and 2-Aroyl-3-halopyrroles

POI-52

T. J. Delia, A. Nagarajan, Central Michigan University, USA

Reaction of Phenolates with 2,4,6-Trichloropyrimidine

POI-53

P. Double, G. Pattenden, S. Bower, University of Nottingham, England

Acyl Radical Mediated Cascades: The Synthesis of Aza Steroids

POI-54

V. Dragutan, I. Dragutan, Romanian Academy, Romania

Influence of Steric and Electronic Factors on Product Selectivity in Synthesis of N‑Substituted 3-Methyl-5-Pyrazolones

POI-55

D. Dubreuil, J. P. Pradère, G. Prestar, F. Purseigle, Laboratoire de Synthèse Organique associée au CNRS, France

N'-Thio and Seleno Acylamidines: Versatile Building Blocks

POI-56

S. Ebdrup, M. S. Jensen, P. Vedsø, Novo Nordisk A/S, Denmark

Synthesis of Substituted N-Alkyl-Phenothiazines

POI-57

S. V Ley, H. Eick, R. Boyce, R. Oownham, A. Humphries, University of Cambridge, UK

Towards the Total Synthesis of Okadaic Acid

POI-58

A. M. K EI-Dean, Assiut University, Egypt

Synthesis of Some Pyrimidothienopyrimidine Derivatives

POI-59

B. L. Eriksen, P. Vedsø, M. Begtrup, Royal Danish School of Pharmacy, Denmark

Synthesis of 2-, 4- and 5-Substituted 1-Hydroxyimidazoles through Directed Lithiation of 1-Benzyloxyimidazoles

POI-60

J. Felding, P.Vedsø, M. Begtrup, The Royal Danish School of Pharmacy, Denmark

Palladium Catalysed Arylation and Acylation of 1-Benzyloxy-l,2,3-triazole through Directed ortho Lithiation and Transmetalation

POI-61

G. A. Rodrigo, K. B. Piton, D. G. Bekerman, A. E. Robinsohn, M. I. Abasolo, B. M. Fernandez, University of Buenos Aires, Argentina

Quinoxalinones, Benzoquinoxalinones and Benzothiazinones. Comparative Studies on the Synthesis and Kinetics of the 3-Phenyl Substituted Derivative

POI-62

S. Fielder, D. D. Rowan, M. S. Sherburn, Massey University, New Zealand

Synthesis of α-Farnesene Peroxides

POI-63

J. Finlay, M. A. McKervey, The Queen's University, Northern Ireland

Oxidation of Furans and Related Heterocycles with Urea Hydrogen Peroxide Catalysed by Methyl Trioxorhenium

POI-64

C. S. French, D. M. Smith, University of St. Andrews, Scotland

Some Cyclisations of N-(o-Nitrophenyl)amino Acid Esters

POI-65

J. Fröhlich, C. Hametner, B. Winter, R. Bobrovsky, W Skranc, Vienna University of Technology, Austria

Novel Heterocyclic Halogen Dance Products and Their Synthetic Scope

POI-66

T. Fursy, A. Nemazany, M. C. Kang, K. C. Rice, National Institute of Diabetes, Digestive and Kidney Diseases, USA

New Regioselective Synthesis of Condensed Pyrimidines with Bridgehead Nitrogen Atom

POI-67

G. Penieres, J. Garcia, C. Alvarez, F. Delgado, R. Miranda, J. Aceves, Facultad de Estudios Superiores Cuautitlan UNAM, México

Selective Synthesis of Diindolylmethanes

POI-68

A. A. Geies, Assiut University, Egypt

Synthesis of Pyrido[2,3-d]pyrimidines via the Reaction of Activated Nitriles With Aminopyrimidines

POI-69

A. E. S. Gelpke, H. Hiemstra, University of Amsterdam, The Netherlands

Novel Dibenzofuran-Based Phosphine Ligands for Transition Metal Catalysis in Aqueous Media

POI-70

M. Ginnelly, D. Levin, S. Warren, P.Wyatt, University Chemical Laboratory, Cambridge, England

The Synthesis and Applications of Homochiral Phosphepin Oxides

POI-71

F. Freeman, G. Govindarajoo, University of California, Irvine, USA

The Synthesis of 2-Azapropenes, 2-Azabutadienes and Piperazines from Aminomalononitrile and Heteroaromatic Aldehydes

POI-72

A. N. Grishakov, T. V. Matveeva, V. P. Krasnov, Urals Division of Russia Academy of Sciences, Russia

Synthesis of Fused Isoindoline Heterocycles from Derivatives of Glutamic Acid

POI-73

M. P. Groziak, H. Ding, SRI International, USA

Imidazole and Benzimidazole Platforms for the Construction of New Heterocycles and Nucleosides

POI-74

R. R. Gupta, P. K. Dev, D. Rai, M. K. Nyati, M. Jain, A. Gupta, Rajasthan University, India

Synthesis of Anticancer Activities of 4-(N-Alkyl)N-Nitrosoamides: Development of a New Class of Nitrosoureas as Anticancer Agents

POI-75

H.-J. Ha, Y.-S. Lee, Y.-G. Ahn, Hankuk University of Foreign Studies, Korea

Addition of Propagyltrimethylsilanes to N-Methyleneamine Equivalents: Generation and Electrophilic Cyclization of Vinyl Cations

POI-76

A. A. A. Hafez, H. S. El-Kashef, Assiut University, Egypt

Synthesis and Reactions of 2-Ethoxymethyleneamino-4,5-Dihydro-5-oxo-1-phenylpyrrole-3-carbonitrile

POI-77

C. J. Peake, B. D. Bennett, J. W. Buser, M. K. Chaguturu, P.A. Cruickshank, T. G. Cullen, J. A. Dybas, R. N. Henrie II, A. C. Lew, A. C. Oliphant, G. T. Payne, E. L. Plummer, M. J. Plummer, P. S. Ray, D. A. Shook, W. H. Yeager,FMC Corporation, Agricultural Products Group, USA

DHFR-Inhibiting Insecticides: 2,4-Diamino-5-Substituted Pyrimidines

POI-78

T. Choshi, T. Sada, H. Fujimoto, R. Takahashi, Y. Mihara, E. Sugino, S. Hibino, Fukuyama University, Japan

Total Syntheses of Carazostatin, Hyellazole and Carbazoquinocins B to F

POI-79

G. Himbert, E. Pierron, S. Matheis, Fachbereich Chemie, Germany

Five-membered Cyclic Betaines Bearing two Carbonyl Groups and a Quaternary Nitrogen Atom as Parts of the Ring Parameter

POI-80

J. O. Hoberg, K. Desai, J. Bozell, National Renewable Energy Laboratory, USA

Ring-expansion of Cyclopropanated Carbohydrates

POI-81

S. J. Hodson, M. J. Bishop, B. E. Marron

Spiropiperidinehydantoin: A scaffold for solid phase synthesis of 7-TM targeted libraries

POI-83

J. Rogiers, X. Wu, K. Dubois, G. Hoornaert, K. U. Leuven, Belgium

Cycloadducts of 2H-1,4-Oxazin-2-ones with Alkynes and Alkenes and Their Conversions into Specifically Substituded Pyridine and Piperidine Derivates

POI-84

Y. Horiguchi, A. Toeda, K. Tomoda, T. Sano, Showa College of Pharmaceutical Sciences, Japan

Regio-controlled Diels-Alder Reaction of 4-Oxygenated Quinoline Quinones

POI-85

O. Hoshino, K. Shimidzu, M. Fukuzawa, Science University of Tokyo, Japan

Synthetic Studies on 3,3-Dimethyl-3-Silasteroids

POI-86

V. Rajappan, R. S. Hosmane, University of Maryland Baltimore County, USA

Hepatitis Virus Infection and the Elevated Guanase Activity: Synthesis and Biochemical Screening of Several Ring-Expanded Purine Analogues as Inhibitors of Guanase

POI-87

V. S. Bhadti, L. Wang, R. S. Hosmane, University of Maryland Baltimore County, USA

Ring-Expanded Nucleosides as Novel Anti-Hepatitis Viral Agents Synthesis and IN VITRO Anti-HBV Screening of Several Nucleosides Containing the Imidazo[4,5-e][1,3]Diazepine and Imidazo[4,5-e] [1,2,4]Triazepine Ring Systems

POI-88

A. Howard, L Green, J. Shin, Eastern Michigan University, USA

The Synthesis of Some Aza-alkaloid Precursors

POI-89

B. A. Howell, G. Han, Central Michigan University, USA

Hydrogenolysis of Tetrahydro-1,2-oxazine: A Convenient Synthesis of 4-Amino-1-Butanol

POI-90

B. A. Howell, J. W. Robinson, CentraI Michigan University, USA

The Acid-Induced Hydrolysis of 2-Methyl-2-(p-Chlorophenyl)Oxirane

POI-91

B. A. Howell, G. Han, D. J. Pakyz, J. E. Southwell, Central Michigan University, USA

Water-Soluble Polymers Derived from Tetrahydro-1,2-oxazine

POI-92

L-Y. Hsu, Y.-F. Kang, National Defense Medical Center, ROC

Investigation of the Synthesis of Anti-Conformationally Restricted Acyclic Pyrimidine Nucleosides

POI-93

M.-K. Hu, F.-J. Yang, M.-H. Yen, National Defense MedicaI Center, ROC

Studies on the Backbone Modification of Leualacin, a Calcium Channel Blocker

POI-94

D. T. Hurst, Kingston University, UK

Interactions Between Purine Metabolising Enzymes and Some Nucleoside and Nucleotide Analogues of Pharmaceutical Interest

POI-95

D. T. Hurst, Kingston University, UK

Some New Pyrimidines as Potential Agricultural Chemicals and as Pharmaceutical Intermediates

POI-96

S. A. Ibrahim, A. M. Hammam, M. A. El-Gahami, and D. M. Ibrahim, Assiut University, Egypt

Cobalt (II), Nickel (II) and Copper (II) Complexes of Potentially Dinucleating Tris(2-pyridyl)-1,3,5-triazine and Sulfur Donor Ligands

POI-97

J. Ichikawa, Y. Wada, H. Miyazaki, T. Okauchi, T. Minami, Kyushu Institute of Technology, Japan

Construction of Ring-FIuorinated Heterocycles via Inter- and Intramolecular Cyclizations of Functionalized gem-Difluoroolefins

POI-98

L. Ignatovich, S. Belyakov, S. Germane, E. Lukevics, Larvian Institute of Organic Synthesis, Latvia

Synthesis, Molecular Structure and Toxicity of Thienylgermoxazolidines

POI-99

M. Ikeda, Y. Kugo, T. Sato, Kyoto Pharmaceutical University, Japan

Regioselctive Synthesis of Bridged Azabicyclic Compounds using Radical Translocation/Cyclization

POI-100

D.-L. Wang, K. Imafuku, Kumamoto University, Japan

Synthesis and Reactions of 9-Oxocyclohepta[b]pyrylium Perchlorates

POI-101

T. Imanishi, D. Nambu, K.-i. Morio, S. Obika, Oska University, Japan

Synthesis and Property of Novel Conformationally Constrained Nucleoside and Oligonucleotide Analogs

POI-102

I. Iovel, Cb. Kortus, G. Oehme, E. Lukevics, Larvian Institute of Organic Synthesis, Latvia

Catalytic Asymmetric Synthesis of Heterocyclic Alcohols

POI-103

F. Ishibashi, Y. Miyazaki, M. Iwao, Nagasaki University, Japan

The First Total Syntheses of Marine Polycyclic Alkaloids, Lamellarin D and H

POI-104

S. Sugiyama, K. Morishita, K. Ishii, Meiji College of Pharmacy, Japan

Synthesis of Optical Active S-Halomethyl-2-oxazolidinones

POI-105

T. Kataoka, T. Iwama, Gifu Pharmaceutical University, Japan

Tandem Intramolecular Cyclization of Cationic Intermediates Generated from 1,2‑Thiazetidine 1,1-Dioxides with EtAlCl₂

POI-106

M. Iwao, O. Motoi, Nagasaki University, Japan

Synthesis of Pyrroloiminoquinone Marine Alkaloids, Makaluvamines A, D, I and K

POI-107

N. N. Jaganova, S. A. Kiseleva,Agricultural Academy, Russia

Arylmethyleneaminoalkanoles: ring-chain tautomerism and regioselection reactions with electrophilic reagents

POI-108

J. D. Rodgers, B. L. Johnson, H. Wang, S. Erickson-Viitanen, R. M. Klabe, B. Cordova, L. Bacheler, S. Garber, I. DeLucca, C.-H. Chang, Dupont Merck Pharmaceutical Company, USA

Synthesis and Biological Activity of Potent Cyclic Urea HIV Protease Inhibitors with Improved Resistance Profiles

POI-109

C. Jones, N. S. Simpkins, University of Nottingham, England

Total Synthesis of the Frog Alkaloid Epibatidine

POI-110

G. Jones II, J. Jimenez, J. Morais, Y. C. Yip, Boston University, USA

Flourescence and Acid-Base Properties of Coumarin Laser Dyes Linked to Benzimidazoles

POI-111

A. Franz, P.-Y. Eschler, M. Tharin, R. Neier, Institut de Chi mie de l'Université de Neuchatel, Switzerland; R. C. F. Jones, P. Dimopouos, The Open University, UK

Tandem Reaction of N-Butadienyl Ketene-N,O-Acetals, and a Related but Divergent Annulation of Cyclic Amidines

POI-112

U. Jordis, J. Frohlich, B. Kiienburg, L. Czollner, W Frantsits, Vienna University of Technology, Austria

New KG-Synthesis of the Anti-Alzheimer Drug (-)-Galanthamine

POI-113

U. Jordis, K. Varmuza, G. Wolf, A. Kerber, R. Laue, Vienna University of Technology, Austria

Unknown Small Heterocycles: Database-Mining of Beilstein Crossfire

POI-114

L. P.Junnikova, A. L. Junnikov, Agricultural Academy, Russia

New Method for Synthesis of the Derivatives N-Alkylacridane

POI-115

S. H. Kang, J. S. Kim, Korea Advanced Institute of Science and Technology, Korea

Versatile Synthetic Routes to Indolizidine Alkaloids, (+)-Castanospermine, Its Analogues and

(-) -Slaframine

POI-116

N. Kanomata, T. Ohhama, T. Nakata, The Institute of Physical and Chemical Research, Japan

The Bridged NADH Models. Design, Synthesis and Highly Enantioselective Reduction

POI-117

C. Kashima, K. Fukusaka, Y. Tsukamoto, S. Tsuruoka, University of Tsukuba, Japan

Asymmetric α-Alkylation of Pyrazoleacetic Esters Using 3-Phenyl-l-menthopyrazole

POI-118

H. S. Kasmai, D. Smith, East Tennessee State University, USA

A Simple Method for Generation and NMR Observation of Cyclic and Heterocyclic Conjugated Carbanions; An Undergraduate Laboratory Experiment

POI-119

A. Katoh, T. Fujimoto, N. Suzuki, J. Ohkanda, Seikei University, Japan

2,3-Disubstituted 6-(bromoacetyl)aminoquinoxalines-Synthesis and Their Applications to Fluorescence Derivatization and Optical Purity Determination Reagents

POI-120

I. Kawasaki, N. Taguchi, M. Yamashita, S. Ohta, Kyoto Pharmaceutical University, Japan

Total Synthesis of Kealiiquinone, an Imidazole Marine Alkaloid

POI-121

T. Kawasaki, H. Suzuki, I. Sakata, H. Nakanishi, M. Sakamoto, Meiji College of Pharmacy, Japan

Abnormal Pummerer Reaction of Carbazole Sulfoxide

POI-122

E. Kawashima, T. Sekine, K. Umabe, Y. Ishido, Tokyo University of Pharmacy and Life Science, Japan

Synthesis of [5'-¹³C]Nucleosides Involving Efficient Synthetic Approaches to D-[5-¹³C]Ribose from D-Ribose

POI-123

M. M. Kayser, G. Chen, University of New Brunswick, Canada

Synthesis of Optically Pure Lactones Using "Designer Yeast": New, Enantioselective, Environmentally Compatible Reagent

POI-124

Y. Kita, Y. Takeda, K. Iio, S. Akai, Osaka Univeristy, Japan

Intramolecular [4+2] Cycloaddition of o-[(ω-Phenylthioethynyl)acyl]phenols Followed by the Aromatic Pummerer-type Reaction: An Efficient Preparation of the ABCD-Ring of Fredericamycin A

POI-125

K. Nakagawa, late K. Tori, K. Kitahonoki, Ikoma International Research Institute, Japan

Stereocontroled Diels-Alder Reaction of 2,5-Dialkylhydroquinones Depending Upon the Alkyl Groups - A New Type of the Simple Enols -

POI-126

J. Bergman, D. Koch, CNT Novum Research Park, Sweden

Synthesis of Bisindoles from Bisimidazolines

POI-127

R. Smounig, G. Kollenz, KF-Universität Graz, Austria

On the Synthesis and Complexation Properties of some Novel Lariat-Crownethers

POI-128

M. Komatsu, N. Sakai, S. Minakata, I. Ryu, Osaka University, Japan

[Polyfluoro]silane-mediated Generation and Cycloaddition of Azomethine Ylide

POI-129

Y. Tominaga, K. Komiya, S. Itonaga, S. Kataoka, K. Sasaki, T. Hirota, Nagasaki University, Japan

Synthesis of New Methine Class of Dyes Bearing Maleimide Ring System

POI-130

T. Konakahara, S. Nouse, H. Wakai, S. Tamura, Science University of Tokyo, Japan

Salt Effects on Methylation and Cross-Linking of DBA by Methyl- and 2-Chloroethyl-nitrosoureas Linked to Methidium Chloride Analogues

POI-131

Y. Kondo, A. Yoshida, T. Sakamoto, Tohoku University, Japan

Magnesiation of Indoles with Magnesium Amides

POI-132

Y. Kosugi, T. Imai, T. Nagasaka, University of Pharmacy and Life Science, Japan

Synthesis of Polyfunctionalized 2-Pyrrolidinone Derivatives via Bicyclic α,β-Unsaturated Lactams

POI-133

O. N. Chupakhin, S. K. Kotovskaya, V. N. Charushin, Urals State Technical University, Russia

Synthesis of Fluorinated Quinoxaline N,N'-Dioxides

POI-134

J. Kristensen, M. Begtrup, P. Vedsø, Royal Danish School of Pharmacy, Denmark

Preparation of 5-Acyl and 5-Aryl Substituted 1-Benzyloxypyrazoles via a Negishi Type Cross Coupling

POI-135

J. J. Krutak, D. Carico, C. A. Coates, B. Jackson, W W Parham, M. A. Weaver, Eastman Chemical Company, USA

Design and Synthesis of Polymeric Heterocyclic Dyes from Acetaldehyde, 1,3-Dihydro-7-Methoxycarbonyl-1,1,3-trimethyl-2H-benz[e]indol-2-ylidene

POI-136

M. Omote, A. Ando, M. Koyama, T. Takagi, I. Kumadaki, Setsunan University, Japan

Derivatization of a Chiral 2,2,2-Trifluoro-l-hydroxyethylated Pyrrole to Chiral Porphyrins

POI-137

M. Omote, A. Ando, M. Koyama, T. Takagi, I. Kumadaki, Setsunan University, Japan

Synthesis of a Chiral (2,2,2-Trifluoro-1-Hydroxyethyl) Pyrrole by Asymmetric Reduction of a (Trifluoroacetyl)Pyrrole

POI-138

M. Kumar, N. Sharma, V. Srivastav, R. Gupta, R. R. Gupta, University of Rajasthan, India

Synthesis of 7-Fluoro-5-Methyl Benzothiazines

POI-139

M. Kuroki, Y. Tunashima, N. Fujihashi, Shibaura Institute of Technology, Japan

Synthesis of Trisubstituted 7H,11-Azabenzanthrene-7-Ones

POI-140

A-R. Lee, Y.-C. Tsai, W-H. Huang, C.-H. Chiang, P.-L. Tao, National Defense Medical Center, Taiwan, ROC

Arylpiperazine Derivatives with High 5-HT₁ Affinity as Novel Antiglaucomatous Agents

POI-141