SCIENTIFIC PROGRAM

SCIENTIFIC PROGRAM

August 12, Monday

WELCOME

9:00 a.m.

Austin Auditorium, LaSells Stewart Center

PLENARY LECTURES

August 12 (Monday)	Austin Auditorium, LaSells Stewart Center
	A. Hassner, Chairman
9:15 a.m.	PL-1	W.N. Speckamp, University of Amsterdam, Netherlands
		New Aspects of Old Reactions: Cations and Radicals in Heterocyclic Synthesis
10:45 a.m.	PL-2	K.C. Nicolaou, Research Institute of Scripps Clinic and University of California, San Diego, USA
		Studies in the Area of Enediyne Antibiotics

SYMPOSIA

August 12 (Monday) Wilkinson 110

Symposium SY1	Heterocycles in Asymmetric Synthesis
	K. Gable, Chairman
1:30 p.m.	SY1-1	W.R. Roush, Indiana University, USA'
		Tartrate Ester Modified Allylboronates: Mechanistic and Synthetic Studies
2:10 p.m.	SY1-2	K. Narasaka, The University of Tokyo, Japan
		Asymmetric Reactions Catalyzed by Chiral Titanium Reagents
2:50 p.m.	SY1-3	S. Hanessian, Université de Montréal, Canada
		Topologically Inique Chiral Bicyclic Phosphonamides as Reagents in Asymmetric Synthesis
3:40 p.m.	SY1-4	A. Schultz, Rensselaer Polytechnic Institute, USA
		Asymmetric Synthesis of Chiral Cyclohexane Incorporated Ring Systems
4:20 p.m.	SY1-5	F.A. Davis, Drexel University, USA
		Applications of Enantiopure N-Sulfonyloxaziridines in Asymmetric Synthesis

August 12 (Monday) Withycombe 109

Symposium SY2	Metallaheterocycles
	K. Doxsee, Chairman
1:30 p.m.	SY2-6	W.D. Wulff, V. Dragisich, C.K. Murray and B.P. Wamer, University of Chicago, USA
		Imino Carbene Complexes as Synthons for Nitrile Ylides in [3+2] and [3+2+1] Cycloadditions
2:10 p.m.	SY2-7	L.S. Hegedus, Colorado State University, USA
		The Role of Chromacyclopropanones (Chromium-ketene Complexes) in the Photolytic Reactions of Chromium Carbene Complexes with Nucleophiles
2:50 p.m.	SY2-8	J.J. Eisch, State University of New York, Binghamton, USA
		Cyclic Organonickel Intermediates in the Controlled Oligomerization of Unsaturated Monomers
3:40 p.m.	SY2-9	G. Erker, Organisch-Chemisches Institut der Universität Münster, Germany
		Structural Aspects and Reactions of Oxazirconacycloalkane and –Alkene Ring Systems
4:20 p.m.	SY2-10	S.L. Buchwald, J.H. Tidwell, K.J. Barr and D.I. Cox, Massachusetts Institute of Technology, USA
		Zirconacycles as Intermediates in Organic Synthesis
August 12 (Monday) Cordley 1109
Symposium SY3	Free Radicals in Heterocyclic Chemistry
	J. Keana, Chairman
1:30 p.m.	SY3-11	M.D. Bachi, The Weizmann Institute of Science, Israel
		Synthesis of Heterocyclic Compounds Through Addition of Carbon-centered Radicals to Carbon-carbon Multiple Bonds
2:10 p.m.	SY3-12	D. Crich, University of Illinois at Chicago, USA
		Diastereoselective Radical Reactions in Glycoside Synthesis
3:00 p.m.	SY3-13	L.B. Volodarsky, Institute of Organic Chemistry, USSR
		Advances in the Chemistry of Heterocyclic Nitroxide Radicals
3:40 p.m.	SY3-14	D.P. Curran and J.G. Stack, University of Pittsburgh, USA
		Asymmetric Radical Reactions

August 12 (Monday) Const. & Engineering Hall, LaSellsStewartCenter

Symposium SY4	Biosynthesis of Heterocycles
	S. Gould, Chairman
1:30 p.m.	SY4-15	J.C. Vederas, University of Alberta, Canada
		Biosynthesis of Oxygen Containing Heterocycles via the Polyketide Pathway
2:10 p.m.	SY4-16	T.J. Simpson, M.P. Dillon, M.A Hayes and R. Guillermo, University of Bristol, England
		Biomimetic and Biosynthetic Studies on Monocerin. A Furanobenzopyrone Fungal Metabolite
2:50 p.m.	SY4-17	R.J. Parry and Y. Lii, Rice University, USA
		Investigations of the Biosynthesis of Sparsomycin
3:40 p.m.	SY4-18	J.H.H. Stöckigt, Johannes Gutengerg-Universität Mainz, Germany
		Enzymatic Biosynthesis of Rauwolfia AlkaJoids
4:20 p.m.	SY4-19	H. Seto, University of Tokyo, Japan
		Biosynthetic Studies on Unique Natural Products with C-P Bonds

GENERAL SESSIONS - ORAL PRESENTATIONS

August 12 (Monday) Wilkinson 108

General Session GE1		Biologically Active Heterocycles
		K. Feldman and C.J. Moody, Chairmen
1:30 p.m.	GE1-1		J. Scheigetz, C.K. Lau, P.C. Belanger, C. Dufresne, M. Thérien, B. Fitzsimmons, D. Riendeau and D. Denis, Merck Frosst Centre for Therapeutic Research, Quebec, Canada
			Synthesis of 2,3-Dihydrobenzofuranols as 5-Lipoxygenase Inhibitors
1:50 p.m.	GE1-2		R.R. Webb II, M.C. Venuti and C. Eigenbrot, Genentech, Inc., USA
			Synthesis of a Tetramethyl Teleocidin Analogue
2:10 p.m.	GE1-3		C.A. Boulet, S.J. Tregear ,T. Sawyer and A. Hansen, Defence Research Establishment, Suffield, Canada
			1,3,2-Oxazaphospholidine-2-Ones. Chiral Acetylcholinesterase Inhibitors
2:30 p.m.	GE1-4		U. Rose, Johannes Gutenberg-Universität, Mainz, Germany
			Racemic and Enantiomerically Pure Fused Dihydropyridines with Calcium Modulating Effects
2:50 p.m.	GE1-5		L.N. Jungheim and T.A. Shepherd, Eli Lilly and Co., USA
			Design and Synthesis of Novel Cephalosporin-Oncolytic Agent Prodrugs. A New Use for an “Old” Heterocycle in the Treatment of Cancer
3:10 p.m.	GE1-6		C.-M. Lee, J. Tadanier, D. Chu and E. McDonald, Abbott Laboratories, USA
			Synthesis of Tricyclic Analogs of 4-Quinolones
3:30 p.m.	GE1-7		M. Daneshtalab, M.D. Abel, D.Q. Nguyen, M.P. Singh and R.G. Micetich, SynPhar Laboratories Inc., Canada
			Effect of Substitution on the Activity of Fluoroquinolones
3:50 p.m.	GE1-8		D.L Flynn, D.P. Becker and R Nosal, G.D. Searle & Co., USA
			Synthetic Strategies for the Construction of Unnatural Azatricycle Systems: Novel 5-HT4 & 5-HT3 Serotonergic Agents
4:10 p.m.	GE1-9		D.P. Jindal and D. Pathak, Panjab University, India
			Synthesis of Heterocyclic Ring-fused Azasteroids
4:30 p.m.	GE1-10		U. Elben, L.L Martin, E. Paulus, E. Porsche-Wiebking and K. Rudolphi, PGU Vasotherapeutics, Germany
			Synthesis, Structure and Neuroprotective Properties of Certain Heterocyclic Amines
4:50 p.m.	GE1-11		S. Ozaki, K. Takai, I. Masaaki and A. Hoshi, Ehime University, Japan
			Synthesis of 5-Fluorouracil Derivatives
5:10 p.m.	GE1-12		K.B. Nair and D. Pandya, University of Baroda, India
			Synthesis of Some Novel Thiazolidinone Derivatives as Possible Biologically Active Agents

August 12 (Monday) Agriculture Science, LaSells Stewart Center

General Session GE2		Nucleosides
		T.S. Livinghouse and S.P. Tanis, Chairmen
1:30 p.m.	GE2-13		F.C. Alderweireldt, E. De Vos, E.L Esmans and JA Lepoivre, University of Antwerp, Belgium
			Synthesis of 2-(Carbamoylmethyl)-6-β-D-ribofuranosylpyridine
1:50 p.m.	GE2-14		V.N. Pathak and M. Jain, University of Rajasthan, India
			Novel Synthesis of 3-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl)-2-(fluoroaryl)-Indole Nucleosides
2:10 p.m.	GE2-15		T. Miyasaka, H. Tanaka, K. Haraguchi and Y. Itoh, Showa University, Japan
			The Cleavage of the Oxetane and Oxolane Rings on the Sugar Portion of Nucleosides with Nucleophilic Agents
2:30 p.m.	GE2-16		T.S. Rao, G.T. Revankar, R.S. Vinayak and R.K. Robins, Triplex Pharmaceutical Corp., USA
			Synthesis and Structural Studies of 4,6-Disubstnuted 7-β-D-Ribofuranosyl-and Arabinofuranosylpyrazolo[3,4-d]pyrimidines and Certain Related Compounds
2:50 p.m.	GE2-17		R.K. Robins, G.R. Revankar and K.V.B. Rao, University of Califonia, San Diego, USA
			Synthesis of 1,3-Azaphospholo[4.5-d]pyrimidines(9-Phosphapurines)
3:10 p.m.	GE2-18		R.S. Hosmane and F.N. Burnett, University of Maryland, Baltimore County, USA
			“FAT” Nucleosides and Nucleotides, Continued. 5:8-Fused Ring Systems. Synthetic Studies Toward Imidazo[4,5-e][1,2,4]triazocine Skeleton
3:30 p.m.	GE2-19		Y.S. Sanghvi, A. Ghose, L Dee Nord, R.K. Robins and G.R. Revankar, ICN Nucleic Acid Research Instnute, USA
			Synthesis and Molecular Modelling Studies of the Novel Nucleoside 9-Amino-4-(β-D-Ribofuranosylamino)pyrimido[4,5-b]-1.2,4-triazepine. A Structural Analog of the Antitumor Agent ARPP
3:50 p.m.	GE2-20		R.A. Scheuerman and F. Freeman, University of Califomia, Irvine, USA
			Oxazolo[5.4-d]pyrimidine C-Nucleosides
4:10 p.m.	GE2-21		J.A. Miller, G.M. Ullah and R.J. Young, Wellcome Research Laboratories, Kent, England
			New Stereospecific Routes to Nucleoside Analogues
4:30 p.m.	GE2-22		D.D. Weller, H. Wang and J.S. Nelson, Oregon State University, USA
			New Strategies in Solid Phase Synthesis
4:50 p.m.	GE2-23		WITHDRAWN
5:10 p.m.	GE2-24		WITHDRAWN

August 12 (Monday) Withycombe 217

General Session G3		Heteroaromatic Chemistry I
		J.P. Freeman and H. Neunhoeffer, Chairmen
1:30 p.m.	GE3-25		P.K. Kadaba and L.P. Glavinos, University of Kentucky, USA
			Application of the Strecker Synthesis to Heterocyclic Substituted α-Amino Acids
1:50 p.m.	GE3-26		H. Vorbrüggen, B.D. Bohn and N. Heinrich, Schering AG, Germany
			Intramolecular Hammick Reactions .
2:10 p.m.	GE3-27		M.P. Groziak and A. Koohang, Southern Illinois University, USA
			Facile Hydration of a 6-Formyluridine Derivative
2:30 p.m.	GE3-28		N. Haider, University of Vienna, Austria
			[4+2]Cycloaddition Reactions of Pyridazino[4,5-d]pyridazines and Pyrido[3,4-d]pyridazines: Synthesisof Phthalazine and Isoquinoline Derivatives
2:50 p.m.	GE3-29		S. Seshadri and S. Pal, University of Bombay, India
			Synthesis of 3,4,Fused Pyrido Coumarins with a 2-(3-Coumarinyl)Substituent and the Respective Cyanated Products. A New Class of Sterically Hindered Helical Structures.
3:10 p.m.	GE3-30		G. Heinisch, W. Holzer and T. Huber, University of Vienna, Austria
			Recent Advances in the Chemistry of Heteroaromatic Isosters of the Diphenylmethane System
3:30 p.m.	GE3-31		B.J. Wakefield and J. Ferguson, University of Salford, England
			Synthesis and Reactions of 2-Trichloromethylquinoxaline
3:50 p.m.	GE3-32		L.H. Klemm and J.J. Lu, University of Oregon, USA
			Kinetics of Solvolysis of N-Acetyl-4-(1-carboethoxy-1-cyano)methylene-4,N-dihydroquinoline and-Thieno[2,3-b]pyridine Compounds
4:10 p.m.	GE3-33		J.W. Bunting and C.C.K. Heo, University of Toronto, Canada
			Pyridine Nucleophiles and Nucleofuges
4:30 p.m.	GE3-34		R.H. Mitchell and V.S. Iyer, University of Victoria, Canada
			A Novel Heteroaromatic Annelated Annulene
4:50 p.m.	GE3-35		S. Gronowitz, J. Malm, P. Björk and A.-B. Hömfeldt, Chemical Center, Sweden
			Preparation of Thienonaphthyridines
5:10 p.m.	GE3-36		M.T. Abdel-Aal and M.G. Marei, Menofeia University, Egypt
			Synthesis and Reactions of Pyrimidino[3,4-c]pyrimidines

August 12 (Monday) Cordley 1045

General Session GE4		Methods of Heterocycle Synthesis I
		J.P. Konopelski and D.A. Williams, Chairmen
1:30 p.m.	GE4-37		A.R. Nath, V.R.N. Reddy and T.S. Ramaiah, Osmania University, India
			Synthesis of Triterpenoidal Spiro-β-Lactams
1:50 p.m.	GE4-38		A.P.R. Reddy and M.H. Rao, Osmania University, India
			Synthesis of 4,10-Diphenyl-5,11-dimethyl-5,6,11,12-tetrahydroisoxazolo[5,4 d]pyrano[4,5-c]pyrano[5,6-d]isoxazoles From 3-Aryl-5(4H)-isoxazolones
2:10 p.m.	GE4-39		R.K. Rao and A.H. Siddiqui, Osmania University, India
			Synthesis of Steroidal Pyrimidines
2:30 p.m.	GE4-40		I. Ninomlya, O. Miyata, T. Shinada and T. Naito, Kobe Women's College of Pharmacy, Japan
			Stereospecific Addition of Thiols to Electron-Deficient Olefins and its Application to the Synthesis of Diltiazem
2:50 p.m.	GE4-41		J. Morris and D.G. Wishka, The Upjohn Company, USA
			Vinyl Sulfonyl Esters and Amides in the Synthesis of Substituted δ-Sultams and δ-Sultones
3:10 p.m.	GE4-42		E. Schaumann and H.-J. Breternitz, Institut für Organische Chemie, Germany
			Ring-opening of Aziridines by Hetero-substituted Allyl Anions
3:30 p.m.	GE4-43		J.B. White and W.-N. Chou, The University of Texas at Arlington, USA
			The Synthesis of Oxepins or Furans from 2,3-Divinyl Epoxides
3:50 p.m.	GE4-44		C. Betschart and L.S. Hegedus, Colorado State University, USA
			Synthesis of Azapenams by Photochemical Reaction of Chromium Carbene Complexes with Imidazolines
4:10 p.m.	GE4-45		R.A. Aitken and S.V. Raut, University of St. Andrews, Scotland
			The Versatile Cycloaddition Chemistry of Buⁿ₃P.CS₂ Leading to New Heterocyclic Systems
4:30 p.m.	GE4-46		R.A. Aitken, D.P. Armstrong and S.T.E. Mesher, University of St. Andrews, Scotland
			Unexpected Formation of New Heterocycles in the Pyrolysis of 3‑Benzyl-thiazolidine-2-one-1,1-dioxides
4:50 p.m.	GE4-47		J.-W. Chern, C.-G. Lee, L.-J. Ferng and K.-R. Wu, National Defense Medical Center, China
			Reactions of o-Amino-carboxamide and o-Amino-sulfonamide with β-Diketones
5:10 p.m.	GE4-48		Z.-T. Huang, M.-X. Wang and J.-K. Yang, Academia Sinica, China
			Some Reactions of Heterocyclic Ketene Aminals

August 12 (Monday) Cordley 2113

General Session GE5		Methods of Heterocycle Synthesis I
		A.G. Fallis and R. Neidlein, Chairmen
1:30 p.m.	GE5-49		L. Strekowski, L. Janda and S.E. Patterson, Georgia State University, USA
			An Activated Trifluoromethyl Group as a New Synthon for Heterocyclic Systems
1:50 p.m.	GE5-50		A. Dandia, C.S. Sharma and K.C. Joshi, University of Rajasthan, India
			Synthesis of Novel Fluorine Containing Spiro[3H-indol-3,4'(1'H)pyrano[2,3-d]imidazol]-2[1H]one
2:10 p.m.	GE5-51		K.C. Joshi, A. Dandia and R Joshi, University of Rajasthan, India
			A Novel Synthesis of Bioactive Spiroindolines
2:30 p.m.	GE5-52		V. Gupta, V. Saraswat, M. Jain and R.R Gupta, University of Rajasthan, India
			Synthesis of Bioactive Heterocycles Containing 1,4-Benzothiazine Nucleus
2:50 p.m.	GE5-53		R.R. Gupta, R.K. Rathore, V. Gupta and RS. Rathore, Rajasthan University, India
			Single Step Synthesis of 6-Bromo-2,3-disubstituted-4H-1,4-benzothiazines
3:10 p.m.	GE5-54		V.J. Naphade, Insitute of Science, India
			Oxidation in Isoxazolines: NBS and DMSQ-Iodine. A Comparative Study
3:30 p.m.	GE5-55		H.-J. Federsel, G. Glasare, C. Högström, B. Zinko and C. Ödman, Astra Pharmaceutical Production AB, Sweden
			OH^--induced Ring Expansion of Quaternized N-Haloalkyl Thiazoles - An Efficient Route to Large-Sized N,S-Heterocycles
3:50 p.m.	GE5-56		B. Sudhakar and T.S. Ramaiah, Osmania University, India
			Synthesis of Ring-A Fused[3,2-e]-1,2,4–Triazines of Pentacyclic Triterpenes
4:10 p.m.	GE5-57		C.K. McClure, K.-Y. Jung and C. Grote, University of Delaware, USA
			Pentacovalent Phosphorus in Organic Synthesis: A New Route to Substituted Phosphonates
4:30 p.m.	GE5-58		T. Toda, M. Yoshida, K. Watanabe, K. Yamaguchi and Y. Kitagawa, Utsunomiya University, Japan
			Iodocarbamirization: Synthesis of Cyclic Carbamates by Carbon Dioxide Fixation Under Extremely Mild Conditions
4:50 p.m.	GE5-59		A. Katoh, T.Tokumitsu and K. Mitsuhashi, Seikei University, Japan
			Unusual Reactivity in the Reaction of N-Alkoxyureas with β‑Diketones
5:10 p.m.	GE5-60		M. Panunzio, G. Cainelli and D. Giacomini, Dipartimento Chimico "G. Ciamician" Italy
			Addition of Nucleophiles to Imines: Synthesis of Aziridines

POSTER SESSION I

August 12 (Monday) LaSells Stewart Center

PO1-1	J. Bhattacharyya, A.K. Saha and H. Mandol, Universidade Federal da Paraiba, Brazil
	A Facile Synthesis of Some Pyrazolo[1,5-a]azines from the Free Bases of the Corresponding 1-Amino-2-methylazinium Salts
PO1-2	T. Tsuchiya, N. Kakusawa,S. YasuikeandJ. Kurita,HokurikuUniversity,Japan
	Synthesis of Pyrido-oxepins by the Reaction of Pyridazine N-Oxides with Pyridynes
PO1-3	J. Kurita, A.-I. Shiratori, S. Yasuike and T. Tsuchiya, Hokuriku University, Japan
	Synthesis of the First Examples of 1-Benzophosphepins
PO1-4	A.L. Schwan and R.A.P. Berg, University of Guelph, Canada
	The Reactions of Silylated Sulfides and Sulfoxides with Electrophilic Chlorine Reagents
PO1-5	A.L. Schwan and D.A. Wilson, University of Guelph, Canada
	Substituted Episulfoxides: Their One-pot Generation and Ring-destroying Reactions
PO1-6	Y. Okamoto, Y. Zama and K. Takagi, Kitasato University, Japan
	A Novel Synthesis of Pyrido[2,3-b][1,5]benzodiazepines
PO1-7	Y. Kurasawa, H.S. Kim and A. Takada, Kitasato University, Japan
	A Facile Synthesis of Triazolo[3,4-a]quinoxaline and Triazino[3,4-a]quinoxalines
PO1-8	K. Harada, E. Kaji and S. Zen, Kitasato University, Japan
	Ring Transformation of Isoxazoline-2-oxides
PO1-9	I. Matsuura, T. Ueda, N. Murakami, S.-i. Nagai and J. Sakakibara, Nagoya City University, Japan
	Two Facile Ring Transformations of Pyrimidinones into Imidazoles
PO1-10	D.T. Hurst, Kingston Polytechnic, England
	Some New Substituted Pyrimidines and Bicyclic N-Heterocycles
PO1-11	M. Iwao, Nagasaki University, Japan
	Synthesis of 2-(Phenykhio)indolines from Ortho-lithiated Aniline Derivatives and α-Silylated Vinyl Sulfoxides via Tandem Conjugate Addition-sila-Pummerer Rearrangement
PO1-12	M. Watanabe and S. Furukawa, Nagasaki University, Japan
	Directed Lithiation of Phenol Derivatives: Novel Syntheses of Benzofurans and 2,3-Dihydrobenzofuran Natural Products
PO1-13	M. Pomerantz and M. Levanon, The University of Texas at Arlington, USA
	Formation of Two Heterocyclic Dimers from Bis(methoxycarbonyl)carbene
PO1-14	F.P.J.T. Rutjes, F.O.H. Pirrung, H. Hiemstra and W.N. Speckamp, University of Amsterdam, The Netherlands
	Synthesis of Bridged1,2-Diaza Heterocycles via N-Acylhydrazonium lons
PO1-15	I.E. Kopka and R. Reamer, Merck Sharp and Dohme Research Laboratories, USA
	Synthesis of 4-(5H)-Thiazolones: Revision and Reassignment of Condensation Product Structures
PO1-16	J.G. Schantl and P. Nadenik, Universität Innsbruck, Austria
	Tandem [3+2]Cycloaddition with Azo-alkenes: 1,2,4,7-Tetraaza[3,3,0]bicyclooctanes
PO1-17	F.A. Amer and M.A. Metwally, University of Mansoura ,Egypt
	Synthesis of Some Aza- and Thiaza-steroids
PO1-18	C. Smlth and J.R. Malpass, University of Leicester, England
	Homotropanes – Synthetic Approaches to the 9-Azabicyclo[4.2.1]Nonane/ene Ring System
PO1-19	A.Y. Aksinenko, A.V. Levkovskii, A.N. Chekhlov, V.B. Sokolov and I.V. Martynov, Institute of Physiologically Active Substances, USSR
	Fluorotropic Cyclization. Synthesis of 1,4,2-Diazaphospholes
PO1-20	V.B. Sokolov, A.V. Levkovskii, A.Y. Aksinenko, A.N. Chekhlov, O.V. Korenchenko and I.V. Martynov, Institute of Physiologically Active Substances, USSR
	5-Cyanoimino-1,4,2-diazaphospholes as Dienophiles
PO1-21	V. Dragutan and I. Dragutan, Roumanian Academy, Romania
	Factors Governing Product Selectivity in Synthesis of N-Substituted 3-Methyl-5-pyrazolones
PO1-22	B. Nedjar-Kolli and A. Robert, USTHB, Algeria
	Regioselective Alkylation of 3,4-c Dihydropyrano-1,5-dihydrobenzodiazepine
PO1-23	W.O. Lin and AL da Rocha Couto, Istituto Militar de Engenharia, Brazil
	2,4-Diaminopyrido(2,3-d)pyrimidine
PO1-24	V.S. Dubey, Institute of Science, India
	Synthesis in Hydantoins
PO1-25	K.H. Reddy and V. Veeranagaiah, Osmania University, India
	Synthesis of Pyrazolo[1,5-a]pyrimidines and [3,4-d]pyrimidin-4(5H)-ones
PO1-26	H. Vallberg and J. Bergman, Department of Organic Chemistry, CNT, Sweden
	Synthesis of 5H-Pyrazino[2,3-b]indoles
PO1-27	P. Stanetty, J. Fröhlich, F. Sauter and B. Sigl, Technical University, Austria
	Synthesis of New Heterocyclic Spiro Compounds
PO1-28	P. Stanetty and H. Koller, Technical University, Austria
	Syntheses of Benzoxazoles via Directed Ortho-metalation Reactions Using Protected 2-Aminophenols
PO1-29	T. Yakura, Y. Matsumura and M. Ikeda, Kyoto Pharmaceutical University, Japan
	Stereoselective Synthesis of cis-3-Substituted-Oxo-2-pyrrolidineacetates
PO1-30	C.O. Kappe and G. Färber, Karl Franzens University of Graz, Austria
	Synthesis, Thermolysis, and Photolysis of 6-Diazidomethyl-1,2,3,4-tetrahydro-2-oxo-5-pyrimidinecarboxylates
PO1-31	C.O. Kappe, G. Kollenz, K. Peters and H.-G. von Schnering, University of Graz, Austria
	Unexpected Ring-rearrangements in Hetero-Diels-Alder Reactions
PO1-32	S. Hibino, T. Kuwada and E.Sugino, Fukuyama University, Japan
	Synthesis of Mutagenic Amino Alpha-carbolines by Electrocyclic Reaction of 2-Azahexa-1,3,5-triene Intermediates
PO1-33	E. Sugino, Y. Shintani and S. Hibino, Fukuyama University, Japan
	Synthesis of Mutagenic Amino Gamma-carbolines by Electrocyclic Reaction of 1-Azahexa-1,3,5-triene Systems
PO1-34	R. Yoneda, T. Kurihara and S.Harusawa, Osaka University of Pharmaceutical Sciences, Japan
	Meizenheimer Rearrangement of 2-Ethenyltetrahydro-2H-azetopyridoindole N-Oxides: New Route to the 12(S)-Carbaeudistomin Skeleton
PO1-35	M. Balogh, I. Hermecz and K. Simon, Chinoin Pharmaceutical and Chemical Works Ltd., Hungary
	Clay-catalyzed Reaction of Aminals with Methyl 3-Aminocrotonate
PO1-36	N.A. Meanwell, H.A. Roth, E.C.A. Smith, D.L. Wedding and J.J.K. Wright. The Bristol-Myers Squibb Pharmaceutical Research Institute, USA .
	A Mild and Efficient Procedure for the Preparation of C-5 Substituted Hydantoin Derivatives
PO1-37	J. Froböse and D. Geffken. University of Hamburg, Germany
	Cyclization and Rearrangement Reactions of N-[(1-Mathoxy-1-methyl)ethoxy] carboxamides
PO1-38	M.A. Metwally, M. Hammouda, Z.M. Abou-Zeid and M.T. Zimity, University of Mansoura, Egypt
	Amine Exchange Reactions of 2-(3-Dimethylaminopropionyl)indan-1,3-dione with Aminoazoles and 1,2-Phenylenediamines
PO1-39	M.A. Metwally, M. Hammouda, Z.M. Abou-Zeid and M.T. Zimity, University of Mansoura, Egypt
	2-(Acetyl, Cinnamoyl and Dimethylaminoproprionyl)indan-1,3-Dione in the Synthesis of Heterocycles of Pharmaceutical Interest
PO1-40	V.S. Rao and A.P. Reddy, Osmania University, India
	Studies on the Formation of Diazepino, Pyrazino and Imidazo Benzothiazoles
PO1-41	J.H. Bateson, A.C. Kaura and A. Southgate. Smith Kline Beecham Pharmaceuticals, England
	Ozonolysis of Ethylidene Azetidinones; Ozonide Fragmentation to α-Amino-N-carboxyanhydrides
PO1-42	M.P. Kirkup, A.S. Boland, S.W. McCombia and A.K. Ganguly, Schering-Plough Research. USA
	Novel Intermediates for the Synthesis of Penems and Carbapenems
PO1-43	M.P. Maguire, K.R. Sheets, A.P. Spada, R.M. Lyall and A. Zilberstein, Rhône-Poulenc Rorer Central Research, USA
	Palladium Mediated Synthesis of 5-Aryl-2(1H)-pyridones: Synthesis of Tyrosine Kinase Inhibitors Structurally Ralated to Erbstatin
PO1-44	G.S. Poindexter, MA. Folay and M.A. Mowery, Bristol-Myers Squibb Pharmaceutical Rasearch Institute, USA
	Regiospecific Metalation of Mixed 1,4-Dihydropyridine Amide Esters
PO1-45	T. Sakamoto, C. Satoh, A. Yasuhara and H. Yamanaka, Tohoku University. Japan
	Construction of Pyrrolo[2,3-d]-and [3,2-d]Pyrimidine Systems from 5,6-Disubstituted Pyrimidine Derivatives
PO1-46	T.Nishio, University of Tsukuba, Japan
	Sulfur Heterocycles Derived from Hydroxy-amides with Lawesson's Reagent
PO1-47	K. Ishii, M. Kotera and M. Sakamoto, Meiji College of Pharmacy, Japan
	Formation of Spiroketals, Intramolecular Photochemical Cyclization o f δ- Hydroxyalkyl α,β-Unsaturated γ,δ-Epoxy Nitrile
PO1-48	E.K. Fields, S.J. Behrend, M.L. Winzenburg and J. Kaduk, Amoco Chemical Company, USA
	Epoxy Anhydrides
PO1-49	M.M. Kayser and H. Yu, University of New Brunswick, Canada
	Condensations of Anhydrides with Stabilized Ylides. Factors Influencing Regio- and Stereoselectivity of These Reactions
PO1-50	J. Lacour, P. Magnus, B. Mugrage and V. Lynch, The University of Texas at Austin, USA
	Thermodynamically Preferred Axial Allylic-NHTs Substituent in Simple1-Triisopropylsilyl(oxy) Cyclohexenes: Solid State Conformation by X-ray Crystallography
PO1-51	T. Sano, M. Watanabe andY. Horiguchi, Showa College of Pharmaceutical Sciences, Japan
	Photo-induced Skeletal Rearrangement of 7-Vinyl-2-azabicyclo[3.2.0]heptan-2-ene Derivatives
PO1-52	D.J. Miller, P.D. Kennewell, S.M. Salem, A.M. Scrowston, R.K. Smalley and A.Westwood, Hull University, England
	Some 1,3-Dipolar Cycloaddition Reactions of 2-Ethoxyindol-3-one
PO1-53	B.J. Williams, P.D. Leeson, M. Chambers, J. McKenna and R. Baker, Merck Sharp and Dohme Research Laboratories, England
	Synthesis of cis 3-Amino-1,4-dihydroxypyrrolidin-2-one. A Partial Agonist at the Strychnine Insensitive Glycine Receptor
PO1-54	K. Kim and J. Cho, Seoul National University, Korea
	Reactions of Tetrasulfur Tetranitride with Some Aryl α-Bromomethyl Ketones: Synthesis of 3,5-Diaroyl-1,2,4-thiadiazoles
PO1-55	T. Horaguchi, H. Iwanami, E. Hasegawa and T. Shimizu, Niigata University, Japan
	Conformational Effects in Photocyclization of Six- and Seven-membered Ring Ketones

August 13 - Tuesday

PLENARY LECTURES

August 13 (Tuesday)	Austin Auditorium, LaSells Stewart Center
	T. Kappe,Chairman
8:45 a.m.	PL-3	H.G. Floss, University of Washington, USA
		Biosynthesis of Thiopeptide Antibiotics
10:00 a.m.	PL-4	I. Shinkal, Merck Sharp& Dohme Research Laboratories, USA
		The Design and Development of Practical Heterocyclic Syntheses
	V. Snieckus,Chairman
	ISHC Award Lecture
11:00 a.m.	PL-5	W. Pfleiderer, University of Konstanz, Germany
		Pteridines. Properties, Reactivities, and Biological Significance

August14 - Wednesday

PLENARY LECTURES

August 14 (Wednesday)		Austin Auditorium, LaSells Stewart Center
		H. Suschitzky, Chairman
9:00 a.m.	PL-6	G. Pattenden, Nottingham University, England
		Synthetic Studies with Natural Oxazoles and Thiazoles
10:30 a.m.	PL-7	D.A. Evans, J.R. Gage and J.L. Leighton, Harvard University, USA
		The Asymmetric Synthesis of Calyculin A

SPECIAL SYMPOSIA

August 14 (Wednesday) Const. & Engineering Hall, LaSells Stewart Center

Symposium SY5	Heterocyclic Agrochemicals
	M. Prisbylla, Chairman
1:30 p.m.	SY5-20	W.A. Ayer, University of Alberta, Canada
		The Camalexins: Phytoalexins Produced in the Leaves of Camelina Saliva
2:10 p.m.	SY5-21	G. Kneen, C.L. Cornell, P.J. Dudfield and S.O. Lindell, Schering Agrochemicals Limited, England
		The Synthesis and Fungicidal Properties of 2-Cyano-4-aroylimidazoles
2:50 p.m.	SY5-22	T.P. Selby, R.A. Andrea, L.A. Danes, B.L. Finkelstein, T.P. Fuesler and B.K. Smith, E. I. du Pont de Nemours and Company, USA
		Substituted Phenyl-1,2,4-triazolo[1,5-a]pyrimidines: A New Family of Carotenoid Biosynthesis Inhibitors
3:40 p.m.	SY5-23	F.X. Woolard, ICI Western Research Center, USA
		Phenyl Substituted 5-Membered Ring Heterocycles as Bleaching Herbicides
4:20 p.m.	SY5-24	L.F. Lee, L.Y.L. Sing, S.M. Auinbauh, K.L. Smith and E.L Williams, Monsanto Agricultural Company, USA
		Synthesis of 5-Heterocycle-3-pyridinecarboxylates as Herbicides
5:00 p.m.	SY5-25	J.T. Gupton and J.A. Sikorski, University of Central Florida, USA
		New Applications of Vinamidinium Salts in Heterocyclic Synthesis

August 14 (Wednesday) Wilkinson 110

Symposium SY6		Molecular Recognition by Heterocycles
		D. Weller, Chairman
1:30 p.m.	SY6-26		F. Diederich, University of California, Los Angeles, USA
			Supramolecular Cyclophane Chemistry
2:10 p.m.	SY6-27		S.C. Zimmerman, Z. Zeng, W. Wu, B.F. Duerr, K. Saionz and T. Murray, University of Illinois, USA
			Heterocycles as Building Blocks for the Construction of Molecules That Complex Other Molecules or Self-associate
3:00 p.m.	SY6-28		A.D. Hamilton, C. Vicent, F. Garcia-Tellado, S. Goswami and S. Geib, University of Pittsburgh, USA
			New Synthetic Receptors for Complexation and Catalysis
3:40 p.m.	SY6-29		T.R. Kelly, Boston College, USA
			Bisubstrate Reaction Templates

August 14 (Wednesday) Withycombe 109

Symposium SY7	Heteroaromatic Compounds
	P. Freeman, Chairman
1:30 p.m.	SY7-30	E. Vogel University of Cologne, Germany
		Isophlorins: Molecules at the Crossroads of Porphyrin and Annulene Chemistry
2:10 p.m.	SY7-31	K.M. Smith, M.D. Berber, C.J. Medforth and D.M. Wallace, University of California Davis, USA
		Syntheses and Chemistry of Some Novel Porphyrins
3:00 p.m.	SY7-32	A.J. Ashe, III, University of Michigan, USA
		Heteroaromatic Compounds with Unusual Heteroatoms
3:40 p.m.	SY7-33	A.R. Katritzky, University of Florida, USA
		Benzotriazole – A Versatile Synthetic Auxiliary

August 14 (Wednesday) Cordley 1109

Symposium SY8	Heterocyclic Natural Products of Marine Origin
	W. Gerwick, Chairman
1:30 p.m.	SY8-34	W. Fenical, C. Pathirana and P.R. Jensen, University of California, San Diego, USA
		New Bioactive Heterocycles from Marine Microorganisms
2:10 p.m.	SY8-35	R.E. Moore, University of Hawaii. USA
		Unusual Marine-related Heterocycles from Blue-green Algae; Structure and Biosynthesis
2:50 p.m.	SY8-36	C.M. Ireland, J.C. Swersey, D.C. Radisky, L.A. McDonald, M.P. Foster and B.R. Copp, University of Utah, USA
		Structural and Biological Studies of Novel Heterocycles from Marine Invertebrate Animals
3:40 p.m.	SY8-37	D. Uemura, Shizuoka University, Japan
		Bioactive Heterocycles from Marine Organisms
4:20 p.m.	SY8-38	J. Clardy, T.J. Stout, A.Y. Lee and J.R. Steiner, Cornell University, USA
		Structural Studies on Marine Natural Products

GENERALSESSIONS.ORAL PRESENTATIONS

August 14(Wednesday) Cordley 2113

General Session GE6		Synthesis of Heterocyclic Natural Products
		J.K. Cha and J.P. Dirlam, Chairmen
1:30 p.m.	GE6-61		H.M.L. Davies, E. Saikali and W.B. Young, Wake Forest University, USA
			Synthesis of (±)-Ferruginine and (±)-Anhydroecgonine Methyl Ester by Reaction of Vinylcarbenoids with Pyrroles
1:50 p.m.	GE6-62		C.J. Moody and P.M. Jackson, Loughborough University of Technology, England
			The Diels-Alder Route to Heterocycles. Synthesis of Carbazole Natural Products
2:10 p.m.	GE6-63		Y. Murakami, H. Suzuki and Y. Yokoyama, Toho University, Japan
			A New General Route of 1-Substituted 4-Oxygenated β-Carbolines
2:30 p.m.	GE6-64		A. Goti, A. Brandi, F.M. Cordero, F. De Sarlo and A. Guarna, Università di Firenze, Italy
			The Isoxazolinespirocycloalkane Route to Azaheterocydes. Synthesis of Indolizidine and Quinolizidine Alkaloids
2:50 p.m.	GE6-65		L. Castedo, B. Gómez, C. Gonzalez, D. Pérez and E. Guitian, Universidad de Santiago, Spain
			Syntheses of Alkaloids by Intramolecular Cycloaddition
3:10 p.m.	GE6-66		M.-z. Zhang and R.-a. Yan, Peking University, China
			A Synthetic Study on the Biological Active Natural Piperidine Derivatives
3:30 p.m.	GE6-67		T. Livinghouse, C.H. Lee and M. Westling, Montana State University, USA
			A Total Synthesis of Dendrobine via an Acylnitrilium Ion Initiated Cyclization
3:50 p.m.	GE6-68		H. Neunhoeffer, B.Philipp and A. Schmidt, Technische Hochschule Darmstadt, Germany
			Synthesis of Pyrindine Alkaloids
4:10 p.m.	GE6-69		H. Neunhoeffer, S. Göring and B. Cullmann, Technische Hochschule Darmstadt, Germany
			Synthesis of Lavendamycin Analogs
4:30 p.m.	GE6-70		W.G. Bornmann and M.E. Kuehne, University of Vermont, USA
			A Second Generation Approach to the Total Synthesis of Vinblastine, Vincovaline, Leurosidine and 20’-Epivincovaline
4:50 p.m.	GE6-71		D.R. Williams and M.H. Ostarhout, Indiana University, USA
			Stereocontrol in the Electrophilic Cydizations to Substituted Heterocyclic Systems
5:10 p.m.	GE6-72		M. Ikeda M. Okano and H. Ishibashi, Kyoto Pharmaceutical University, Japan
			Total Synthesis of (±)-Cephalotaxine and its Analogue

August 14 (Wednesday) Wilkinson 108

General Session GE7		Heterocyclic Radicals and Betaines
		W.H. Pearson and J. Witte, Chairmen
1:30 p.m.	GE7-73		I. Dragutan, V. Dragutan and R.J. Mehlhorn, Roumanian Academy, Romania
			Synthesis of Novel Paramagnetic Heterocyclic Compounds Containing Nitrogen
1:50 p.m.	GE7-74		W. Kaim, H.-D. Hausen, A. Lichtblau, W. Matheis, J. Poppe and A. Schulz, Institutit für Anorganische Chemie der Universität Stuttgart, Germany
			Stability and Structure of New Crystalline Heterocyclic Cation Radicals
2:10 p.m.	GE7-75		A.L. Baumstark and P.C. Vasquez, Georgia State University, USA
			Thermolysis of Pentasubstituted-1,2-Dioxacyclopentan-3-ols
2:30 p.m.	GE7-76		K.S. Feldman, H.M. Berven, C.J. Burns and P.H. Weinreb, Pennsylvania State University, USA
			Free Radical Cyclization and Heterocycle Synthesis
2:50 p.m.	GE7-77		A.G. Fallis, J. Martynow and M. Dimitroff, University of Ottawa, Canada
			1,3-Oxathiolanes: Versatile Building Blocks and Control Elements for Total Synthesis
3:10 p.m.	GE7-78		O. Hoshino, M. Ishizaki, K.-I. Kurihara and K. Ozaki, Science University of Tokyo, Japan
			Heterocycle Synthesis Utilizing the Free-radical Reaction
3:30 p.m.	GE7-79		H. Wamhoff, J. Muhr, W. Schupp, A. Schmidt, E.B. Walsh and H. Wintersohl, Institutet für Organische Chemie und Biochemie der Universität Bonn, Germany
			Uracils in Performance: Novel Rearrangements, Cycloadditions and Heterocyclization Reactions
3:50 p.m.	GE7-80		J.P. Freeman, S.V. D’Andrea, A. Ghosh, W. Wang and J. Szmuszkovicz, University of Notre Dame, USA
			The Staudinger Reaction as a Route to 1,2,3-Triazoles
4:10 p.m.	GE7-81		G. Hajós, Z. Juhász-Riedl, G. Timári and A. Messmer, Hungarian Academy of Sciences, Hungary
			Selective Alkylations of Polyfused Heterocycles Containing Bridgehead Nitrogen
4:30 p.m.	GE7-82		C.-K. Sha and C.-P. Tsou, National Tsing Hua University, China
			Synthesis and Trapping of Mesomeric Betaine Derivatives of Thieno[3,4-c]pyrrole
4:50 p.m.	GE7-83		J.H. Boyer, K. Thangaraj, M.-L Soong, G. Sathyamoorthi, T.M. Ross, LT. Wolford and A.M. Haag, University of New Orleans,USA
			Pyrromethene-BF₂Complexes as Laser Dyes
5:10 p.m.	GE7-84		S. Eguchi, T. Okano, T. Uekawa, and N. Morishima, Nagoya University, Japan
			Synthesis of β-Trifluoromethylpyrroles via Cycloaddition of Electron-deficient CF₃-containing Olefins with Munchones

August 14 (Wednesday) Withycombe 217

General Session GE8		Heteraromatic Chemistry II
		E.D. Edstrom and J.A. Miller, Chairmen
1:30 p.m.	GE8-85		U. Zoller, F. Kukla, H. Quast, H. Harduf and D. Kavanaugh, Haifa University, Israel
			In Pursuit of the Elusive Polycyclic Arene Episulfides
1:50 p.m.	GE8-86		M.B. Hocking, F.W. VandervoortMaarschalk, J. McKiernan and J.I. Zink, University of Victoria, Canada
			Solvent Induced Triboluminescence of Triphenylphosphine
2:10 p.m.	GE8-87		E.M. Hanawalt, K.M. Doxsee, T.J.R. Weakley and H. Hope, University of Oregon, USA
			Phosphorus Heterocycles via Reactions of the Phosphacyclobutene Ring
2:30 p.m.	GE8-88		D.W. Boykin and A. Kumar, Georgia State University, USA
			¹⁷O NMR Spectroscopy: Intramolecular Hydrogen Bonding in Carbonyl Pyridinol Systems
2:50 p.m.	GE8-89		T.D. Lash and T.H. Nguyen, Illinois State University, USA
			Synthesis of Porphyrins with Fused Exocyclic Rings
3:10 p.m.	GE8-90		N. Ono, Ehime University, Japan
			Porphyrin Synthesis from Nitro Compounds
3:30 p.m.	GE8-91		M.G. Marei, Alexandria University, Egypt
			Action of Hydroxylamine on 3(2H)-Furanones
3:50 p.m.	GE8-92		I. Lalezari, Montefiore Medical Center and Albert Einstein College of Medicine, USA
			1,2,3-Triazoles from 1,2,3-Selenadiazoles
4:10 p.m.	GE8-93		P. Vedsø and M. Begtrup, Royal Danish School of Pharmacy, Denmark
			Introduction of Substituents in Exocyclic α-Positions of Azoles
4:30 p.m.	GE8-94		R.J. Ardecky, B.L. Wells, A. Chiu, P.Wong and P.B. Timmermans, The Du Pont-Merck Pharmaceutical Company, USA
			A New Synthesis of Highly Substituted Imidazoles via Palladium(0) Coupling Reactions
4:50 p.m.	GE8-95		J. E. Macor and M.E. Newman, Pfizer Inc, USA
			The Synthesis of Dihydropyrano[3,2-e]indoles and Dihydropyrano[2,3-f]indoles as Rotationally Restricted Phenolic Analogs of the Neurotransmitter Serotonin
5:10 p.m.	GE8-96		A.R. Martin, D.L. Nelson, J. Regan and Y. Yang, University of Arizona, USA
			Preparation of 5-Substituted Indoles via Halogen-metal Exehange and Palladium Catalyzed Cross Coupling Strategies

August 14 (Wednesday) Cordley 1045

General Session GE9		Methods of Heterocycle Synthesis III
		C.W. Holzapfel and P.W. Jennings, Chairmen
1:30 p.m.	GE9-97		D.S.H.L. Kim and F. Freeman, University of California, Irvine, USA
			The Chemistry of Aminopropanedinitrile 4-Methylbenzenesulfonate [Aminomalononitrile p-Toluenesulfonate(Tosylate)], AMNT
1:50 p.m.	GE9-98		B.J. Ghlya, Institute of Science, India
			New Technique In Coumarin Synthesis
2:10 p.m.	GE9-99		B.R. Babu and A. Ohno, Indian Institute of Technology, India
			Synthesis and Configurational Studies of Medium-sized Nitrogen Heterocyclic Ring Systems
2:30 p.m.	GE9-100		R. Verhé, L De Buyck and N. Schamp, University of Gent, Belgium
			Synthesis of Furans via Ring Closure of Chlorinated Aldehydes
2:50 p.m.	GE9-101		Y. Sugita, J.-I. Sakaki, M. Salo and C. Kaneko, Tohoku University, Japan
			Lactone Formation Reactions from 1,3-Dioxin-4-ones Having Hydroxyalkyl Groups at the 6-Position: Scope and Use For EPC Synthesis
3:10 p.m.	GE9-102		B. Stanovnik, Z. Cadez, A. Hvala, M. Kemtic, B. Ornik, J. Smodis, J. Svela and M. Tisler, University of Ljubljana, Yugoslavia
			Methyl 2-Acylamino-3-dimethylaminopropenoates, Useful Reagents in the Synthesis of Many New Heterocyclic Systems
3:30 p.m.	GE9-103		A. Shafiee, K. Parang, M. Khazen, H. Rezaii and R. Miri, Tehran Medical Sciences University, Iran
			Syntheses of Substituted 2-(1-Methyl-5-nitro-2-imidazolyl)quinolines
3:50 p.m.	GE9-104		M. Tisler and R. Zupet, University of Ljubljana, Yugoslavia
			Reaction of Heterocyclic Amines with Acetylketene Equivalent as the First Step Towards Further Fundionalization
4:10 p.m.	GE9-105		D. Geffken and J. Froböse, University of Hamburg, Germany
			1-Alkoxy(hydroxy)oxindoles and 1-Alkoxy(hydroxy)pyrrolinones from N-Alkoxy-2-hydroxycarboxamides
4:30 p.m.	GE9-106		B.A. Trofimov, L.N. Sobenina, A.I. Mikhaleva, M.P. Sergeeva, O.A. Tarasova and S.E. Korostova, Institute of Organic Chemistry, Ac. Sci., USSR
			Reactions of Pyrroles and N-Vinylpyrroles with Carbon Disulfide and Bases
4:50 p.m.	GE9-107		B.A. Trofimov, O.A Tarasova, A.I. Mikhaleva, L.V. Morozova and M.V. Sigalov, Institute of Organic Chemistry, Ac. Sci., USSR
			N-Allenylpyrroles
5:10 p.m.	GE9-108		S.K. Talapatra, P. Pal and B. Talapatra, University College of Science, India
			Simple Biomimetic Synthesis of Dimethylcoumarin and Trimethylcoumarin Derivatives

POSTER SESSIONS

August 14 (Wednesday) LaSells Stewart Center

PO2-56	N. White, M. Gardner and I. Paterson, Cambridge University, England
	A Synthetic Approach to Marine Furanocembranolides
PO2-57	D. Berney and K.Schuh, Sandoz Research Institute, Switzerland
	A Short Non-stereoselective Synthesis of Racemic Carboxykainic Acids with Various Stereochemistry
PO2-58	D. Gusterhuber, M. Schubert-Zsilavecz, A. Michelitsch and W. Likussar, University of Graz, Austria
	Synthesis of the Reniera Isoindole Alkaloid
PO2-59	A. Ohta, A. Kojima and Y. Aoyagi, Tokyo College of Pharmacy, Japan
	First Synthesis of (+)-Septorine
PO2-60	M. Nakagawa, J. Ma, T. Hosaka, Y. Torisawa and T. Hino, Chiba University, Japan
	Synthetic Approaches to Manzamine A, a Novel Antileukemic and Antimicrobacterial Alkaloid
PO2-61	X. Wang and V. Snieckus ,University of Waterloo, Canada
	Synthesis of 9-Phenanthrols by Remote Metalation of 2-Carboxamido-2'-methylbiaryls. Synthesis of Eupolauramine
PO2-62	Y. Kitahara, A. Kubo and M. Shimizu, Meiji College of Pharmacy, Japan
	Synthesis of 2-Quinolinonequinones and Related Quinoline Alkaloids
PO2-63	H. Takayama, C. Phisalaphong, M.K Uajima and S.-I. Sakai, Chib aUniversity, Japan
	Synthetic Studies on the New Gelsemium Alkaloid, 20-Hydroxydihydrorankinidine
PO2-64	D.B. MacLean, A.W. Rey and WA Szarek, McMaster University, Canada
	Stereoselective Synthesis of the Pentacyclic Indole Alkaloids Normalindine and Mostueine
PO2-65	P.K. Kadaba, University of Kentucky, USA
	Nonselective Cycloaddition of Aryl Azides to 4-Vinylpyridine: A Route to Pyridyl Substituted Aziridines
PO2-66	J.F.W. Keana and S.X. Cai, University of Oregon, USA
	Synthesis, Structure and Properties of New Boron-containing Heterocycles
PO2-67	A. Vidal-Ferran, P. Victory, J.I. Borrell, P. Castejón and J. Cirujeda, CETS Institut Quimic de Sarrià, Spain
	Synthesis of Pyrido[2,3-d]pyrimidines by Cyclization of 3-Cyano-2-cyanoaminopyridines
PO2-68	A.E. Moormann and D.L. Flynn, G.D. Searle & Co., USA
	The Synthesis of 3-Aminoindazoles and 1,2-Disubstituted 4-Imino-1,3-quinazolines from 2-Acylaminobenzonitriles
PO2-69	W. Tückmantel, Mayo Clinic Jacksonville, USA
	Synthesis of Pyrano[4,3-b]azepines by [4+2]-Gycloadditions of Photochemically Generated 3-Acyl-1,2-didehydroazepines with Enol Ethers
PO2-70	R.W. Sabnis, S.V. Dhamnaskar and D.W. Rangnekar, University of Bombay, India
	Synthesis of Pyrido[1,2-a]benzimidazoles and Their Applications in Dyes and Medicine
PO2-71	T.J. Delia and M. Baumann, Central Michigan University, USA
	Methylated Pyrimido[4,5-d]pyrimidines
PO2-72	P. Madsen and M. Begtrup, Royal Danish School of Pharmacy, Denmark
	Regioselective Introduction of Substituents at the 4-Position of Imidazoles
PO2-73	M. Begtrup and L.B.L. Hansen, Royal Danish School of Pharmacy, Denmark
	New Methods for Introduction of Substituents in Thiazoles
PO2-74	N. Haider, G. Heinisch and J. Moshuber, University of Vienna, Austria
	Novel Amino-Substituted Aryl Pyridazinyl Ketones: Potentially Useful Building Blocks for the Construction of Fused Heterocyclic Systems
PO2-75	M. Kocevar, V. Kepe, A. Patrie, S. Polanc and B. Vercek, University of Ljubljana, Yugoslavia
	A Simple and General Synthesis of Fused Pyrimidinones
PO2-76	F. Kóródi, Z. Cziáky and Z. Szabó, Alkaloida Chemical Company, Hungary
	Synthesis of Novel 1,2,4-Triazolo[5',1':2.3][1,3]thiazino[6,5:b]quinolines
PO2-77	M.E. Benz and E. LeGoff, Michigan State University, USA
	The Synthesis and Investigation of Some Mixed Heterocyclic Oligomers
PO2-78	L. Venemalm and J. Bergman, Department of Organic Chemistry, CNT, Sweden
	Efficient Synthesis of 2-Chloro, 2-Bromo, and 2-Iodoindole
PO2-79	C. Kashima, Y .Harada and A. Hosomi, University of Tsukuba, Japan
	The N-Alkylation of Imidazoles
PO2-80	I. Yokoe, Y. Sugita, Y. Shirataki and M. Komatsu, Josai University, Japan
	Michael Addition Reaction of 3-Iodochromone
PO2-81	J. Reiter and J. Barkóczy, EGIS Pharmaceuticals, Hungary
	Ring Closure of Some 5-Amino-1,2,4-triazolylthioamides
PO2-82	M.S. South and K.A Van Sant, Monsanto Agricultural Company, USA
	An Unusual Labilization of a 4-(Trifluoromethyl)thiazole and Reactions of a 4‑(Trifluoromethyl)thiazole Dianion
PO2-83	M.-J. Shiao, W.-L Chia and C.-P. Yu, Academia Sinica, Taiwan
	Synthesis of Functionalized 3- and 4-Dialkyl Substituted Pyridines
PO2-84	W.A. Cristofoli, B.A. Keay and J.-L.J. Bontront, University of Calgary, Canada
	The Synthesis of 2-Silylated-3,4-Disubstituted Furans
PO2-85	C. Rogers and B.A. Keay, University of Calgary, Canada
	Diastereoselective Intramolecular Diels-Alder Reactions of the Furan Diene
PO2-86	G.A. Poulton, M.J. Ashwood-Smith and T. Luchinski, University of Victoria, Canada
	Synthesis and Photochemical Studies of Coriandrin (4-Methoxy-7-methyl-5H-furo(2,3-g][2]benzopyran-5-one)
PO2-87	T.J. Kress, Eli Lilly and Company, USA
	Synthesis and Proton NMR Spectra of the Monomethyl- and Dimethylpyrimidine-5-carboxylic Acids. Regioselective Covalent Hydration at the 2- and 4-Ring Positions
PO2-88	E. Gössnitzer, W. Wendelin, J. Kerbl, U. Kendlbacher and P. Egger, Karl-Franzens-University, Austria
	Bromination and Chlorination of Dihydropyrimidines and Dihydropyrimidopyrimidines
PO2-89	W. Wendelin, J. Kerbl, M. Huber and U. Radner, Karl-Franzens-University, Austria
	Disproportionation Reactions of 4,6- and 4,5,6-Substituted 2-Amino-, 2-Methylthio- and 2-Thioxodihydropyrimidines
PO2-90	T.D. Lash, Y. Lin, S.-T. Armiger and W.H. Liu, Illinois State University, USA
	Synthesis of Oxophlorinl/Hydroxyporphyrin Analogs
PO2-91	T.D. Lash and M.C. Hoehner, Illinois State University, USA
	Synthesis of Pyrroles from N-Tosylglycine Esters and α,β-Unsaturated Aldehydes: Intermediacy of 2-Pyrrolines
PO2-92	N. Shimizu, T. Kitamura, K. Watanabe, T. Yamaguchi, H. Shigyo and T. Ohta, Kowa Co. Ltd., Japan
	A Convenient Synthesis of 3-Arylpyridines via Palladium Mediated Ullmann Reaction
PO2-93	M.El-Borai and A.A. EI-Saied, Tanta University, Egypt
	Reaction of o-Thiophenedicarboxaldehyde with p-Aminoacetophenone
PO2-94	P.C. Unangst, G.P. Shrum and D.T. Connor, Warner-Lambert Co., USA
	Synthesis and Transformations of 5-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-1,2,4-oxadiazoles
PO2-95	K.-i. Seki, K. Ohkura, N. Kanazashi, K. Okamura and T. Date, Higashit Nippon-Gakuen University, Japan
	Photocycloaddition of 6-Chloro-1,3-dimethyluracil to Methylbenzenes
PO2-96	R.M. Claramunt, C. Roussel, J.L. Stein, D. Thiery, V. Bobosic, C. López and J. Elguero, Ciudad Universitaria, Spain
	Separation on Chiral HPLC Columns of Bis- and Tris-(benzimidazol-1-yl)methanes
PO2-97	P. Mátyus, K. Czakó, I. Varga, Á. Behr, B. Podányi and F. Szederkényi, Institute for Drug Research, Hungary
	Experimental and Theoretical Investigation of the Reactivity of 4,5-Dichloro-3(2H)-pyridazinones with Nucleophiles
PO2-98	F. Yoneda, T. Kimachi and N. Mimura, Kyoto University, Japan
	Synthesis and Properties of 5-Deazaflavo-6,9-quinones
PO2-99	L.W. Castle, J.-K. Luo and M.O. Johnston, Jr., University of South Florida, USA
	Through Space Coupling of ¹⁹F with ¹H and ¹³C Observed on11-Fluoro[1]benzothieno[2,3-c]quinoline and13-Fluorobenzo[f][1]benzothieno[2,3-c]-quinoline
PO2-100	J.-K. Luo ,H. Kudo and R.N. Castle, University of South Florida, USA
	The Synthesis of Novel Polycyclic Heterocyclic Ring Systems via Photocyclization. [1]Benzothieno[2',3':4,5]thieno[2,3-c]quinoline, Benzo[h][1]benzothieno[2',3':4,5] thieno[2,3-c]quinoline and benzo[f][1]benzothieno[2',3':4,5]thieno[2,3-c]quinoline
PO2-101	J.-K. Luo, S.L. Castle and R.N. Castle, University of South Florida, USA
	Synthesis and Total Assignment of the ¹H and ¹³C NMR Spectra of Two Novel Heterocyclic Ring Systems. Benzo[h]naphtho[2',1':4,5]thieno[2,3-c]quinoline and Benzo[f]naphtho[2',1':4,5]thieno[2,3-c]quinoline
PO2-102	G. Seu and F. Cristiani, Università di Cagliari, Italy
	Acidity of 3-Substituted 1,2,4-Triazole-5-carboxylic Acid
PO2-103	E. Oishi, T. Horiuchi, K. Tanji and T. Higashino, University of Shizuoka, Japan
	Reaction of Furo[2,3-d]pyridazines with Nucleophiles
PO2-104	B.G. Rose and D.H Reid, University of the Witwatersrand, South Africa
	Synthesis and Reactions of Selenium-containing Heterocycles via1,2-Diselenolylium Salts
PO2-105	G.N. Karageorge, K.S. Takaki, W.L. Christopher and J.P. Yevich, Bristol-Myers Squibb Research Institute, USA
	The Synthesis of Novel Naphthothiophenimines as Potential Neuroprotective Agents
PO2-106	N. Kanomata, T. Oikawa and M. Tada, Waseda University, Japan
	Syntheses and Properties of the Strained NAD Model Having [n](2,4)Pyridinophane Structures
PO2-107	Y. Aoyagi, Y. Akita and A. Ohta, Tokyo College of Pharmacy, Japan
	Palladium-catalyzed Cross-coupling Reactions of 2-Chloropyrazines and Aryl Bromides with Aromatic Heterocycles
PO2-108	K. Van Aken and G. Hoomaert, KULeuven, Belgium
	Functionalisation of 2H-1,4-Oxazin-2-ones and Their Use in the Synthesis of Other Heterocyclic Systems
PO2-109	D. Vandenberghe and G. Hoornaert, KULeuven, Belgium
	Intramolecular Diels-Alder Reactions of 2(1H)-Pyrazinones. A Versatile Synthesis of Bicyclic Annelated 2(1H)-Pyridinones
PO2-110	G.Y. Remennikov, V.M. Cherkasov, S.G. Vishnevski and V.V. Pirozhenko, Institute of Biorganic Chemistry and Oil Chemistry, Ac. Sci., USSR
	1,6- and 2,5-Dihydropyrimidines from Anionic Sigma-complexes and Their Transformations

August 15 - Thursday

PLENARY LECTURES

August 15 (Thursday)		Austin Auditorium, LaSells Stewart Center
		J. Bergman, Chairman
9:00am.	PL-8	E. Winterfeldt, Instkut für Organische Chemie der Universität Hannover, Germany
		Directed Stereoselectivity in Alkaloid Synthesis
10:30 a.m.	PL-9	P. Magnus, A. Stamford, D. Parry, J. Rodrfguez-López, J. Mendoza, T. Illiadis and L. McQuire, University of Texas at Austin, USA
		Synthetic and Mechanistic Aspects of Nitrogen Heterocycles

SPECIAL SYMPOSIA

August 15 (Thursday) Wilkinson 110

Symposium SY9		Methods of Heterocycle Synthesis
		E. Stirchak, Chairman
1:30 p.m.	SY9-39		S.M. Weinreb, The PennsylvaniaState University, USA
			Alkaloid Total Synthesis via N-Tosyl Imines
2:10 p.m.	SY9-40		T. Gallagher, M.E. Giles and M.S. Hadley, Bath University, England
			Generation of Regiospecific Heterocyclic Enolates. Synthesis of Polyhydroxy Indolizidines.
2:50 p.m.	SY9-41		R.H. Schlessinger and D.J. Von Langen, University of Rochester, USA
			Asymmetric Induction via Aggregates Derived from Lithium Enolates of Vinylogous Urethanes
3:40 p.m.	SY9-42		I. Paterson, A.N. Hulme, M.A. Lister and R.D. Norcross, Cambridge University, England
			The Stereocontrolled Synthesis of Small and Large Ring Lactones: Ebelactone A and Oleandomycin
4:20 p.m.	SY9-43		P.A. Jacobi, S. Buddhu, G. Cai, D. Fry and S. Rajeswari, Wesleyan University, USA
			A Novel Synthesis of Dihydropyrromethenones

August 15 (Thursday) Withycombe 109

Special Symposium SY10			Heterocyclic Bioinorganic Chemistry
			A. Finke, Chairman
1:30 p.m.	SY10-44	J.L. Sessier, A.K. Burrell, M.J. Cyr, D. Ford, G. Hemmi, T.D. Mody, T. Morishima and K. Schreder, University of Texas, USA
		Expanded Porphyrins: Cation Chelands and Anion Acceptors
2:10 p.m.	SY10-45	F.-P. Montforts, U.M. Schwartz, G. Scheurich, F. Romanowski, A Meier, G. Haake, G. Mai, F.Höper, D. Struv, B. Gerlach, C. Müller and E. Töllner, Universität Bremen, Germany
		Porphinoid Macrotetracycles: Synthesis, Structure, and Function
3:00 p.m.	SY10-46	D. Dolphin, University of British Columbia, Canada
		A "Common" Mechanism of Action for Heme Proteins
3:40 p.m.	SY10-47	J. Fajer, K.M. Barkigia, L.R. Furenlid, K.M. Smith and M.W. Renner, Brookhaven National Laboratory, USA
		Structural and Electronic Control of Reaction Sites and Reactivity in Hydroporphyrins

August 15 (Thursday) Const. & Engineering Hall, LaSells Stewart Center

Special Symposium SY11			Heteroaromatic Betaines
			H. Wamhoff, Chairman
1:30 p.m.	SY11-48	K.T. Potts, Rensselaer Polytechnic Institute, USA
		Intramolecular 1,4-Dipolar Cycloadditions with Heteroaromatic Betaines: A New Approach to the Assembly of Ring-fused Heterocydes
2:10 p.m.	SY11-49	A. Padwa and D.L. Hertzog, Emory University,USA
		Synthesis of Nitrogen Containing Polycycles Using Isomunchnones Derived from Cyclic Diazoimides
2:50 p.m.	SY11-50	W. Friedrlchsen, A. Bergner, T. Debaerdemaeker, A-G. Koch, B. Künkemeier, K. Pagel and M. Schildberg, Institut für Organische Chemie der Universität Kiel, Germany
		Contemporary Studies in the Field of Dipolar Heterocydes
3:40 p.m.	SY11-51	T. Kappe, C. Kos, P. Roschger, C.O. Kappe and B. Schnell, Karl-Franzens-University, Austria
		Cross-conjugated and Pseudo-cross-conjugated Mesomeric Betaines. Synthesis, Rearrangement and Cycloaddition Reactions
4:20 p.m.	SY11-52	H.W. Moore, University of California, Irvine, USA
		Synthetic Utility and Biological Activity of 4-Alkynylcyclobutenones

August15 (Thursday) Cordley1109

Symposium SY12		Carbohydrates as Heterocycles
		B. Branchaud, Chairman
1:30 p.m.	SY12-53		G.D. Dayes, Jr., H. Zhang, R Farr and M. Brakta, Rensselaer Polytechnic Institute, USA
			Chemistry of C-Glycosyl Bond Formation
2:10 p.m.	SY12-54		A. Dondoni, University of Ferrara, Italy
			Interplay of Heterocyclic and Carbohydrate Chemistry. Thiazoles as Aldehyde Equivalents in Sugar Synthesis
2:50 p.m.	SY12-55		D. Horton, The Ohio State University, USA
			Synthetic Potential of Sugar Enones
3:40 p.m.	SY12-56		R. R. Schmidt, Universität Konstanz, Germany
			Dihydropyrans – Versatile Chiral Intermediates en Route to and from Carbohydrates and to Natural Products
4:20 p.m.	SY12-57		P. Vogel, l'Université de Lausanne, Switzerland
			“Naked Sugars”; Asymmetric Synthesis of Rare Carbohydrates and Analogues from Furan

GENERAL SESSIONS – ORAL PRESENTATIONS

August 15 (Thursday) Cordley 2113

General Session GE10		Molecular Recognition and Asymmetric Synthesis
		L. N. Jungheim and J. B. White, Chairmen
1:30 p.m.	GE10-109	W.K. Fife, Indiana University-Purdue University at Indianapolis, USA
		Pyridine and Selected Derivatives as Catalysts in Transacylation Reactions
1:50 p.m.	GE10-110	E.V. Anslyn, L.S. Flatt and K. Ariga, The University of Texas, USA
		Polyaza Clefts for the Recognition and Cleavage of Phosphodiesters
2:10 p.m.	GE10-111	O.L. Acevedo, R.S. Andrews, R.H. Springer, S. Freier, G.D. Hoke and P.D. Cook, ISIS Pharmaceuticals, USA
		Synthesis of Oligonucleotides Containing 3-Deaza-3-substituted Guanines: A Biophysical Evaluation
2:30 p.m.	GE10-112	N. Katagiri, M. Yamamoto and C. Kaneko, Tohoku University, Japan
		Chiral 2-Vinyl-1,3,2-oxazaphospholidin-2-ones: New Dienophiles for Asymmetric Diels-Alder Reaction
2:50 p.m.	GE10-113	M. Sato, N. Kitazawa and C. Kaneko, Tohoku University, Japan
		Chiral Spirocyclic 1,3-Oxazine-4,6-diones as Versatile Synthetic Intermediates for Enantiomerically Pure Compounds
3:10 p.m.	GE10-114	D.C. Horwell, M.C. Pritchard, G.M. Bourne and D. Crich, Parke-Davis Research Unit, England
		Asymmetric Synthesis of [D]- and [L]-α-Methyltryptophan and Functionalized α-Substituted Tryptophanes and Their Incorporation Into 'Dipeptoid' Analogues of the Neuropeptide Cholecystokinin
3:30 p.m.	GE10-115	J.P. Konopelski, K.S. Chu and G.R. Negrete, University of California, Santa Cruz, USA
		Enantiomerically Pure Dihydropyrimidinones in Synthesis. The Asymmetric Total Synthesis of (+)-Jasplakinolide
3:50 p.m.	G10-116	W.H. Pearson and A.C. Lindbeck, The University of Michigan, USA
		Generation of Chiral α-Amino Anions from Organostannanes
4:10 p.m.	GE10-117	P.M. Mashava and G.I. Georg, University of Zimbabwe, Zimbabwe
		Synthesis of Optically Active β-Lactams: A Route to the Taxol Side Chain and its Derivatives
4:30 p.m.	GE10-118	Q. Chen, Z. Geng, P. Cao and B. Huang, Beijing Normal University, China
		A Novel Tandem Asymmetric Michael Addition-elimination Reaction of Some Chiral 5-(1-Menthyloxy)-3,4-dihalo-2(5H)-furanones
4:50 p.m.	GE10-119	Q. Chen, R. Shu, J. Zhu, Z. Geng and B. Huang, Beijing Normal University, China
		Asymmetric 1,3-Dipolar Cycloaddition Reactions by Chiral Source, 5-(1-Menthyloxy)-2(5H)-furanone
5:10 p.m.	GE10-120	M.P. Sibi, J.W. Christensen, B. Li and R. Sharma, North Dakota State University, USA
		Convergent Approaches to the Total Synthesis of Indolizidine Alkaloids: Utilization of Amino Acid Precursors

August 15 (Thursday) Agriculture Science, La Sells Stewart Center

General Session GE11		General
		D.L. Flynn and C.K. McClure, Chairmen
1:30 p.m.	GE11-121	P.L. McGrane, M.D. Jensen and T.S. Livinghouse, Montana State University, USA
		Group IV Imido Complexes:A Novel Method for Pyrroline and Piperidiene Synthesis
1:50 p.m.	GE11-122	P.W. Jennings and F.F. Stewart, Montana State University, USA
		Stereospecific Synthesis of 2,7-Divinyl Derivatives of Benzofuran
2:10 p.m.	GE11-123	K.M. Doxsee, J.B. Farahi, E.M. Hanawalt, J.K.M. Mouser and G.S. Shen, University of Oregon, USA
		Titanium-Mediated Syntheses of Nitrogen and Phosphorus Heterocycles
2:30 p.m.	GE11-124	A. Dandia, V. Kaur and P. Singh, University of Rajasthan, India
		Synthesis and Insecticidal Activity of Some Novel Indole Derivatives
2:50 p.m.	GE11-125	S.G. Hegde, Monsanto Agricultural Company, USA
		Selective Ether Cleavage Reactions of 4,6-Dialkoxy-2-(trifluoromethyl)-pyridine Mono- and Dicarboxylates
3:10 p.m.	GE11-126	R. Jain and Shipra, University of Rajasthan, India
		Novel Organophosphorus Pesticides Derived from 2-Amino-4-arylthiazole
3:30 p.m.	GE11-127	H. Szczepanski and G. Pissiotas, Ciba - Geigy, Switzerland
		The Chemistry of Some New Herbicides
3:50 p.m.	GE11-128	H. Suschitzky, B. Iddon, A.G. Robinson and W. Kramer, University of Salford, England
		Synthesis with 2H-Benzimidazoles: A New Route to Triclabendazole and Congeneric Benzimidazoles
4:10 p.m.	GE11-129	S. Seshadri and A.M. Crasto, University of Bombay, India
		Heterocyclic Analogues of Pyrethroids
4:30 p.m.	GE11-130	C.W. Holzapfel, G.J. Engelbrecht and T. van der Merwe, Rand Afrikaans University, South Africa
		Pd-mediated Conversion of Pseudoglycals to Tetrahydropyranoid Chirons
4:50 p.m.	GE11-131	R.M. Paton and A.A. Young, University of Edinburgh, Scotland
		Synthesis of Higher Monosaccharides via Isoxazolines
5:10 p.m.	GE11-132	M.S. Cai, O.X. Oiu, Z.J. Li, J.X. Yu, X.Y. Jiao, L.N. Cai and C.F. Yu, Beijing Medical University, China
		Efficient Stereoselective Synthesis of C, O, S, N-Glycosides from Glycosyl Trifluoroacetate in High Yield

August 15 (Thursday) Wilkinson 108

General Session GE12		Biosynthesis and Marine Natural Products
		D.B. Maclean and T.O. Lash, Chairmen
1:30 p.m.	GE12-133		P. Bergon, S. Breazeale, C.-G. Kim, A. Kirschning and H.G. Ross, University of Washington, USA
			Synthesis of 4-Amino-3,4-dideoxy-D-arabinoheptulosonic Acid 7-Phosphate
1:50 p.m.	GE12-134		J. Guo and S.J. Gould, Oragon State University, USA
			Biosynthesis of Blasticidin S: Pathway and Enzymes for the Nucleoside Formation and Blastidic Acid Assembly
2:10 p.m.	GE12-135		J.P. Dirlam, A.P. Ricketts, J.A. Olson, W.P. Cullen, J.E Shively, Y. Kojima and S. Iwakawa, Pfizer Inc., USA
			Discovery and Identification of Novel Fermentation Derived Anticoccidial Agents
2:30 p.m.	GE12-136		Z.D. Jiang and W.H. Gerwick, Oregon State University, USA
			Alkaloids from Two Red Marine Algae
2:50 p.m.	GE12-137		M.W. Bernart, W.H. Gerwick, E.E. Corcoran, A.Y. Lee and J. Clardy, Oragon State University, USA
			Laurencione, a New Heterocycle from the Dragon Alga Laurencia Spectabilis
3:10 p.m.	GE12-138		D.M. Ketcha, J.A. Schreier and Y. Xie, Wright State University, USA
			Synthesis of Natural Products from Pyrrole
3:30 p.m.	GE12-139		J.K. Cha and K. Whang, Vanderbilt University, USA
			Total Synthesis of α-Pyrone Polyene Mycotoxins: (+)-Verrucosidin, (-)-Citreoviridin and (+)-Citreoviral
3:50 p.m.	GE12-140		H. Suginome, K. Kobayashi, H. Shimizu and A. Sasaki, Hokkaido University, Japan
			One-step General Synthesis of Furonaphthoquinones by New [2+3] Photoaddition of 2-Hydroxy-1,4-naphthoquinone with Various Alkenes and its Application to a Synthesis of Maturinone
4:10 p.m.	GE12-141		B. Pelcman and G.W. Gribble, Astra Paio Control, Sweden
			Total Synthesis of Fascaplysin and Homofascaplysins
4:30 p.m.	GE12-142		M.P. Gore, S.J. Gould and D. D. Weller, Oregon State University, USA
			Total Synthesis of Phenanthroviridin Aglycone: The First Naturally-occuring Benzo[b]phenanthridine
4:50 p.m.	GE12-143		E. Yoshii, K. Hori and K. Nomura, Toyama Medical and Pharmaceutical University, Japan
			Synthesis of the Acyitetronic Acid Ionophore Antibiotic Tetronomycin
5:10 p.m.	GE12-144		S.P. Tanis, E.D. Robinson and M.C. McMills, The Upjohn Company, USA
			Efficient Syntheses of (+/-)-and (-)-Fastigilin-C

August 15 (Thursday) Withycombe 217

General Session GE13		Heteroaromatic Chemistry III
		L.H. Klemm and R.H. Mitchell, Chairmen
1:30 p.m.	GE13-145		M.-J. Chen, Q.-Y. Chen and C.-S. Chi, Accademia Sinica, China
			New Approach to Synthesis of 2,2-Dimethyl-5-trinitrobenzothiazoline and 2-Thioperfluoroalkyl Subsmuted Benzothiazol
1:50 p.m.	GE13-146		C.R. Kumar and Y.U. Devi, Nizam College, India
			Synthesis of 3-Aryl-2',3'-dihydroisoxazolo[5,4-d]-1,2,3-thiadiazoles
2:10 p.m.	GE13-147		K.-C. Liu, National Defense Medical Center, China
			Synthesis of 3-Substituted Naphtho[1,8-de][1,2,4]triazolo[3,4-b][1,3]thiazine
2:30 p.m.	GE13-148		J. Reiter, J. Barkóczy and É. Szabó, EGIS Pharmaceuticals, Hungary
			Unexpected Thermal Rearrangement of Spiro(1,8)-1,2,4-triazolo[1,5-0]-1,2,4,6-tetrazepin-5-thiones
2:50 p.m.	GE13-149		G. Kaugars, V.L. Rizzo and J.P. Atherton, The Upjohn Company, USA
			TheReactions of 5-Amino-1,2,3,4-thiatriazoles with Isocyanates
3:10 p.m.	GE13-150		L. Lai and D.H. Reid, University of the Witwatersrand, South Africa
			Synthesis of New Types of 1,6,6aλ⁴-Triheterapentalenes from Cyclic Thioureas and Selenoureas by Using 2,4-Dinitrobenzyl Chloride as a Dual Function Reagent
3:30 p.m.	GE13-151		G. Kollenz, E. Terpetschnig, H. Sterk, K. Peters and H.-G. von Schnering, University of Graz, Austria
			Heterocyclic 2,3-Diones – Versatile Synthons in Photocycloaddition Reactions
3:50 p.m.	GE13-152		J.Y. Gauthier, D. Guay, D. Mayhew, N. Zajac and R Zamboni, Merck Frosst Centre for Therapeutic Research, Canada
			The Preparation and Uses of Heteroaromatic Asymmetric Dithioacetals
4:10 p.m.	GE13-153		T. Otsubo, N. Hozo, Y. Kono, Y. Aso and F. Ogura, Hiroshima University, Japan
			3,3':4,4'-Bis(thieno[2,3-b]thiophene) and its Derivatives as Novel Peri-condensed Heteroarenes
4:30 p.m.	GE13-154		O. Meth-Cohn, T. Modro and E. Vuorinen, Sunderl and Polytechnic, England
			The Remarkable Chemistry of S-Substituted Thiophenes
4:50 p.m.	GE13-155		T.M. Williams, R.J. Hudcosky, C.A. Hunt, K.L. Shepard and M.B. Young, Merck Sharp and Dohme Research Laboratories, USA
			Synthesis and Selective Functionalization of 2,3-Dihydrothieno[2,3-b]thiophene
5:10 p.m.	GE13-156		J. Nakayama and K. Kuroda, Saitama University, Japan
			A Thiophene with Two Fused Four-membered Rings, Dicyclobuta[b,d]thiophene

August 15 (Thursday) Cordley 1045

General Session GE14		Methods of Heterocyclic Synthesis IV
		H.M.L. Davies and H. Vorbrüggen, Chairmen
1:30 p.m.	GE14-157		W. Eberbach and W. Maier, University of Freiburg, Germany
			Synthesis and Reactivity of Derivatives of Pyrido[1,2-a]azepine, a New Heterocyclic System
1:50 p.m.	GE14-158		D.K. Bates and K.A. Tafel, Michigan Technological University, USA
			Acyl Pyrroles in Heterocyclic Synthesis: Preparation of Pyrrolo[2,1-b]benzothiazin-9-one via Intramolecular Reaction with Electrophilic Sulfur Species
2:10 p.m.	GE14-159		M.M. Mishrikey and M.G. Marei, Alexandria University, Egypt
			Synthesis and Reactions of Pyrazolo[1,5-c]pyrimidinethiones
2:30 p.m.	GE14-160		M.G. Marei, Alexandria University, Egypt
			Synthesis and Reactions of 1,4-Dihydropyridines
2:50 p.m.	GE14-161		B.S. Hastak and B.J. Ghiya, Institute of Science, India
			Synthesis of Isothiazoles and Isothiazolines
3:10 p.m.	GE14-162		G. Lidgren and J. Bergman, Center for Nutrition and Toxicology, Sweden
			Synthesis and Reactions of Oxazolones from Tryptophan and Haloacetic Anhydrides
3:30 p.m.	GE14-163		M.N. Jachak, U. Kriessmann, M. Mittelbach and H. Junek, University of Graz, Austria
			Synthesis of 1-Substituted 5-Amino- and 4-Cyanopyrazoles
3:50 p.m.	GE14-164		B.C. Hamper, M. Kurtzweil, J. Beck and T. Murray, Monsanto Agricultural Company, USA
			Preparation and Use of β-(Perhalo)alkyl-α-acetylenic Esters as Intermediates for Heterocycle Synthesis
4:10 p.m.	GE14-165		C. Dufresne, J. Crawford, J. Chambers, C.K. Lau, D. Guay and M. Poirier, Merck Frosst Centre for Therapeutic Research, Canada
			Intramolecular Cyclization of 3-Substituted Phenols Using Phenylboronic Acid and Reactions of the Resulting Tricyclic 2-Phenyl-1,3,2-dioxaborins
4:30 p.m.	GE14-166		E.D. Edstrom and W. Yuan, Utah State University, USA
			Annulation of Pyrrole Rings onto Six-membered Rings
4:50 p.m.	GE14-167		R. Neldlein, D. Kikelj and Z. Sui, Pharmazeutisch-Chemisches Institut der Universität Heidelberg, Germany
			Simple Synthons – Directed Syntheses of Heterocycles
5:10 p.m.	GE14-168		B.A. Trofimov, A.I. Mikhaleva, A.M. Vasil’tsov and R.N. Nesterenko, Irkutsk Instnute of Organic Chemistry, USSR
			Stereochemistry of the Pyrrole Synthesis from Subsmuted 4-Piperidone Oximes and Acetylene in the KOH-DMSO System

POSTER SESSIONS

August 15 (Thursday) LaSells Stewart Center

PO3-111	A. Persad and N. Simpkins, University of Nottingham, England
	Asymmetric Synthesis Using Cyclic Sulphur Heterocycles
PO3-112	D.B. Taylor and R.A. Aitken, University of St. Andrews, Scotland
	Catalytic Asymmetric Aziridination of Double Bonds Using Quinoline Alkaloids
PO3-113	A. Hodgson, P. Hallett and T. Gallagher, University of Bath, England
	Asymmetric Alkylation of β-Keto Esters: Applications in Synthesis
PO3-114	W.-S. Li, J. Thottathil, R. Mueller and M. Murphy, Bristol-Myers Squibb Pharmaceutical Research Institute, USA
	Fluoride-catalyzed Michael Addition of Nitrotoluenes to Chiral Activated α,β-Unsaturated Esters
PO3-115	M. Campbell, V. Snieckus, C. Unrau and B. DeLaBarre, University of Waterloo, Canada
	Potential Amino Acid Receptors. Synthesis via Directed Ortho Metalation and Cross Coupling Tactics
PO3-116	E. Fan, S.K. Chang and A.D. Haminon, University of Pittsburgh, USA
	Molecular Recognition by Directed Hydrogen Bonding
PO3-117	C. A. Lipinski, D.F. Burdi and D.L. Bussolotti, Pfizer Central Research, USA
	Hydantoin Bioisosteres. Hydroxyacetic Acid Aldose Reductase Inhibitors
PO3-118	W. Verboom, J.-D. van Loon and D.N. Reinhoudt, University of Twente, The Netherlands
	Molecular Receptors Based on Heterocycle Containing Calix[4]arenes
PO3-119	H. Muratake and M. Natsume, Research Foundation Itsuu Laboratory, Japan
	Synthetic Study of Cytotoxic Fish Antifeedants Herbindoles A, B, and C
PO3-120	U. Hanefeld and H. Laatsch, University of Washington, USA
	Synthesis of Isopentabromopseudilin
PO3-121	A. Kubo, N. Saito and M. Nishida, Meiji College of Pharmacy, Japan
	Synthetic Studies Toward Dimeric Isoquinolinequinones from Actinomycetes and Marine Sponges
PO3-122	Y. Kita, H. Tohma, M. Inagaki, K. Hatanaka, K. Kikuchi and T. Yakura, Osaka University, Japan
	Synthetic Approach to the Anticancer Marine Alkaloid Discorhabdin C
PO3-123	L.D.M. Lolkema, H. Hiemstra and W.N. Speckamp, University of Amsterdam, The Netherlands
	α-Alkoxyester Cations and Radicals in Organic Synthesis
PO3-124	H. Ishibashi, N. Nakamura, T. Salo and M. Ikeda, Kyoto Pharmaceutical University, Japan
	Radical Cyclizations of N-Vinylic α-Chloroacetamides. 5-Endo- Trig and 4-Exo- Trig Cyclizations
PO3-125	X. Huang, M.S. Gai, D.X. Qiu, Z.J. Li, J.X. Yu, P.L. Liu and Y.F. Wang, Beijing Medical University, China
	Stereoselective Synthesis of C, O, S-Glycosides from Glycosyl Trimethysilyl Ether
PO3-126	P. Prasit, S. Léger, P. Roy and M. Blouin, Merck Frosst Centre for Therapeutic Research, Canada
	Rearrangement of Substituted Pyranones to Highly Functionalized Cyclopentenones
PO3-127	K.J. Penman and R.M. Paton, University of Edinburgh, Scotland
	The Nitrile Oxide-isoxazoline Approach to c-Disaccharides
PO3-128	A.M. Simas, S.E. Galembeck, J. Miller, M.N. Ramos, M.B. de Oliveira, A.B. Pereira and K.-K. Cheung, UFPE, Brazil
	The Nature of the Chemical Bond in Mesoionic Molecules: 1,3-Dithiolium-4-thiolate
PO3-129	K. Turnbull and E.N. Beal, Wright State University, USA
	Preparation and Reactions of Sydnonimines
PO3-130	T. Ibata, H. Suga and X.-I. Shi, Osaka University, Japan
	Reaction of Oxazoles with CarbonylCompounds in the Presence of Lewis Acids: Formation of Oxazolines
PO3-131	M.P. Moon and D.L. Douglass, E.I. du Pont de Nemours and Company, USA
	Synthesis and Herbicidal Activity of Benzothiadiazole and Benzotriazole Sulfonamides
PO3-132	J. Stetter, R. Gehring and O. Schallner, Bayer AG, Germany
	1-Aryl-4-azolyl-pyrazoles – A New Class of Selective Herbicides
PO3-133	D. Wicklser, G. O'Doherty and R. Boisvenue, Eli Lilly and Company, USA
	Synthesis of Some Trichloromethyl Substituted Heterocycles as Potential Anthelmintics
PO3-134	M.P. Dillon, T.J. Simpson and J.B. Sweeney, University of Bristol, England
	A Novel Approach to the Stereospecific Synthesis of Monocerin, Fusarentins and Analogues Potential Antifungal and Insecticidal Compounds
PO3-135	M.G. Hoffmann, Hoechst AG, Germany
	Synthesis and Fungicidal Properties of New Substituted 4-(2-Pyridyl)pyrimidines
PO3-136	T. Ogura, Y. Kawamura and T. Numata, Nissan Chemical Industries, Japan
	Potent 3(2H)-Pyridazinone Compounds as Insect Control Agents
PO3-137	T. Higuchi, N. Maruyama, S. Uzu and M. Hirobe, University of Tokyo, Japan
	The Relative Effect of Axial Thiolate/Imidazole Ligand on the Catalytic Actvity of Iron Porphyrin
PO3-138	H. Ohtake, T. Higuchi and M. Hirobe, University of Tokyo, Japan
	Highly Efficient Epoxidation of Olefins with Heteroaromatic N-oxides Catalyzed by Ruthenium Porphyrins
PO3-139	T.J. O'Hare and H.G. Floss, University of Washington, USA
	Biosynthesis of Riboflavin: Mechanism of Formation of L-3,4-Dihydroxy-2-butanone-4-phosphate from D-Ribulose-5-phosphate
PO3-140	C.W. Van't Land, U. Mocek and H.G. Floss, University of Washington, USA
	Biosynthesis of the Phenazine Antibiotics Esmeraldin A and B and Related Metabolites
PO3-141	W. He and S.J. Gould, Oregon State University, USA
	Studies on Naphthridinomycin Biosynthesis
PO3-142	B. Stanovnik, M. Zlicar, B. Jelen and M. Tisler, University of Ljubljana, Yugoslavia
	A Novel Synthesis of C-Nucleosides and α-Heteroaryl-α-amino Acid Derivatives from Stable Azomethine Imines
PO3-143	F. Seela, H. Rosemeyer and M. Krecmerova, Universität Osnabrück, Germany
	2'-Deoxyxylonucleosides: Building Blocks for Solid-phase Syntheses and Unusual DNA Structures
PO3-144	F. Seela, W. Bourgeois and A. Roling, Universität Osnabrück, Germany
	Benzimidazole-2'-desoxyribofuranosides: Stereoselective Synthesis and Incorporation into Oligonucleotides
PO3-145	I. Maeba, K. Osaka, N. Morishita and Y. Ito, Meijo University, Japan
	Synthesis of Thiosemicarbazone Derivatives of Pyridazinecarbaldehyde C-Nucleoside as Antiviral Activity
PO3-146	K. Tanaka and K. Fuji, Kyoto University, Japan
	Synthesis and Properties of Redox Coenzyme Model-Oligodeoxynucleotide Conjugates
PO3-147	J. Van hemel, E.L. Esmans, F.C. Alderweireldt and J.A. Lepoivre, University of Antwerp, Belgium
	Investigation of the Synthesis of Acyclic Pyridine-G-Nucleosides
PO3-148	F. Verberckmoes, E.L. Esmans, J.A. Lepoivre and F. C. Alderweireldt, University of Antwerp, Belgium
	Investigation of the Synthesis of D-Lyxofuranosyl Pyridine-C-nucleosides
PO3-149	S.W. Schneller, S. Patil and M. Koga, University of South Florida, USA
	The 5'-Nor Analogue of Carbocyclic 2'-Deoxyguanosine and its Phosphonate Derivative
PO3-150	D.H. Boschelli and D.T. Connor, Warner-Lambert Company, USA
	Preparation of Heterocyclic Analogs of the Fenamates
PO3-151	T.F. Walsh, K.J. Fitch, R.S.L. Chang, S.D. Kivlighn, V.J. Lotti, P.K.S. Siegl, A.A. Patchett and W.J. Greenlee, Merck Sharp & Dohme Research Laboratories, USA
	Synthesis of Novel Imidazo[1,2-b]pyridazine Isosteres of Potent Imidazo[4,5-b]pyridine Angiotensin II Receptor Antagonists
PO3-152	G. Grandolini, V. Ambrogi, L. Perioli and C. Rossi, Instituto di Chimica Farmaceutica e Tecnica Farmaceutica, Italy
	Synthesis and Biological Activity of Some Derivatives of Indolo[2,3-b][1,5] benzothiazepine, A Novel Heterocyclic Ring System
PO3-153	V. Fetisov, A. Maslov and S. Tkachenko, Institute of Physiologically Active Substances Ac. Sci., Chernogolovka, USSR
	N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its Analogs Biphasically Modulate Gaba-induced C1 Uptake
PO3-154	J.P. Wepsiec, D. Beauvois and T.J. Kress, Eli Lilly and Company, USA
	Synthesis of 6-Substituted 1,3,4,5-Tetrahydrobenz[cd]indole-4-amines via Palladium Catalyzed Carbonylations
PO3-155	N.K. Augenstein, M.B. Arnold and P.L. Ornstein, Lilly Corporate Center, USA
	The Synthesis of 6-Ketodecahydroisoquinoline-3-carboxylates. Applications to the Synthesis of Conformationally Constrained NMDA Receptor Antagonists
PO3-156	W.A. Remers, B.S. Iyenger and R.T. Dorr, University of Arizona, USA
	5'-ARA-CMP Conjugate of 2,7-Diaminomitosene. Synthesis, Properties, and Antitumor Activity
PO3-157	W. Löwe, A. Kietzmann and B. Schweinberger, Free University of Berlin, Germany
	A Sulfur Bridged Bischloroquine
PO3-158	M.W. Wilson, M.D. Mullican, C. Kostlan and D.T. Connor, Warner-Lambert Co., USA
	Synthesis and Physical Chemical Properties of 3,5-Di-t-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, 1,3,4-Oxadiazoles and 1,2,4-Triazoles
PO3-159	M.F. Reich, J.P. Dusza, J.W. Hanifin, B.D. Johnson, R.H. Lenhard, Y.-i. Lin, M.E. Tarrant, L.W. Torley and S. Wrenn, American Cyanamid Company, USA
	4-Heteroaryl-2-aminophenylpyrimidines as Potential Antiallergy Agents
PO3-160	D.R. Sidler, M.W. Baum, T.C. Lovelace, M. Bhupathy, J. Bergan, J.M. McNamara, A.W. Douglas and P.J. Reider, Merck Sharp and Dohme Research Laboratories, USA
	Chemoenzymatic Synthesis of a Novel LTD₄ Antagonist, Venzair™ (MK-0679)
PO3-161	M. Daneshtalab, D.Q. Nguyen, H.M. LeLong, M.W. Wolowyk and R.G. Micetich, SynPhar Laboratories Inc., Canada
	Novel Azolylalkyl Carboxylate Derivatives of Dihydropyridines
PO3-162	J.F. Witte, R.W. McClard and A. Maga, Reed College, USA
	Synthesis and Enzymology of a Potent Glucosidase Inhibitor and Compounds Related to the Immunoragulator FR 900483
PO3-163	J.E. Lawson, G.S. Poindexter, D.A. Owens, R.L. Cavanagh, J.G. Sarmento, E.O. Weselcouch and B.B. Bleiberg, Bristol-Myers Squibb Pharmaceutical Research Institute, USA
	Synthesis and Preliminary Biological Evaluation of BMY 42803, A Combination Calcium and α₁-Adrenoceptor Antagonist
PO3-164	Y. Mikl, H Hachiken and S. Takemura, Kinki University, Japan
	Synthesis of Pyrazolo[1,5-a]pyridine Derivatives as Aza-analogues of Pindolol
PO3-165	N. Mizutanl, K. Itoh, Y. Naoi, H. Matushita, T. Ebata, K. Koseki and H. Kawakami, Yuki Gosei Kogyo Co., Japan
	The Synthesis of 2',3'-Didehydro-2',3'-dideoxy Nucleosides Utilizing Hydrous Zirconium Oxide as a Catalyst
PO3-166	P. Biuerle, Universität Stuttgart, Germany
	End-capped Oligothiophenes – New Model-compounds for Polythiophenes

August 16 - Friday

PLENARY LECTURES

August 16 (Friday)		Austin Auditorium, LaSells Stewart Center
		S. Schneller, Chairman
9:00 a.m.	PL-10		M. Isobe, Nagoya University, Japan
			Methodologies for Synthesis of Heterocyclic Compounds
10:30 a.m.	PL-11		C.W. Rees, Imperial College, London University, England
			Polysulfur-Nitrogen Heterocyclic Chemistry
CLOSE
11:30 a.m.	Austin Auditorium, LaSells Stewart Center