SCIENTIFIC PROGRAM

SCIENTIFIC PROGRAM

August 12 - Monday

OPENING CEREMONIES

8:30 a.m.

Humanities Theatre, J.G. Hagey Hall

PLENARY LECTURES

August 12 (Monday) Humanities Theatre, J.G. Hagey Hall (HH)

9:30a.m.	PL-1	S. Hanessian, Université de Montréal, Canada
		Tactically Novel Synthetic Approaches to β-Lactam Antibotics
		(Chairman: V. Snieckus)
10:30 a.m.	PL-2	L. Ghosez, Université Catholique de Louvain, Belgium
		Design and Study of New Reagents for Heterocyclic Synthesis
		(Chairman: K.H. Pilgram)

SPECIAL SYMPOSIA

August 12 (Monday) Theatre of the Arts, ML 1:30 - 5:30 p.m.

Special Symposium S1			Heterocycles in Stereoselective Reactions
			(G.L. Lange, Organizer and Chairman)

1:30 p.m.	S1-1	P. Deslongchamps, Université de Sherbrooke, Canada (Invited Lecturer)
		Stereoelectronic Control in the Hydrolysis of Cyclic Orthoesters

2:30 p.m.	S1-2	D. Enders, Universität Bonn, Germany (Invited Contributed Paper)
		Diastereo- and Enantioselective C-C Bond Formations Using Derivatives of (S)- or (R)-2-Methoxymethyl-Pyrrolidine

3:00 p.m.	S1-3	A.B. Smith, III,M. Fukui, R.A. Rivero and H.A. Vaccaro, University of Pennsylvania, USA (Invited Contributed Paper)
		A Stereocontrolled Total Synthesis of Phyllanthoside

3:30 p.m.	S1-4	D.R. Williams,J.L. Moore and F.H. White, Indiana University, USA (Invited Contributed Paper)
		Stereocontrolled Preparation of Complex Tetrahydrofurans and Tetrahydropyrans

4:00 p.m.	S1-5	S.L. Schreiber, A.H. Hoveyda, K. Satake, Yale University, USA (Invited Contributed Paper)
		On the Furan Carbonyl Photocycloaddition Reaction

4:30 p.m.	S1-6	R.W. Franck, R.B. Gupta, D. Frechet and P.G. Williard, Hunter College, NY USA (Invited Contributed Paper)
		Isoquinolinium Salì Cycloaddition: Stereochemistry of Adducts
5:00 p.m.	S1-7	S.D. Burke, University of South Carolina, USA) (Invited Contributed Paper)
		C-Pyranoside Synthesis: Ilonophore and Macrolide Antibiotic Synthons

August 12 (Monday) Room: AL 113 2:30 - 5:30 p.m.

Special Symposium S2			Heterocyclic Agrochemicals I
			(K. Potts, Organizer and Chairman)
2:30 p.m.	S2-8	K.H. Pilgram, D.A. Kleier, J.R. Sanborn, M.E. Schroeder, R.D. Skiles and D.D. Stranz, Shell Development Co., CA, USA (Invited Lecture)
		Some Recent Progress in the Chemistry of Biologically Active 1,3,4- Oxadiazolin-5(4H)-ones

3:30 p.m.	S2-9	M. Los, P.J. Wepplo, E. Parker, J.J. Hand, R.K. Russell, J.M. Barton, G. Withers and D.W. Long, American Cyanamid, Princeton, NJ, USA (Invited Contributed Paper)
		Synthesis and Chemistry of the O-(5-Oxo-2-lmidazolin-2-yl)- Arylcarboxylates

4:00 p.m.	S2-10	L.A. Summers, University of Newcastle, Australia (Invited Contributed Paper)
		Synthesis and One Electron Transfer Properties of Diquaternary Salts of Heterocycles Related to the Bipyridinium Herbicides, Diquat and Paraquat
4:30 p.m.	S2-11	R.F. Mason, D.A. Wood, P.H. Briner, M.J. de Nie-Sarink, G. Scholes, D.W. Sopher and P.A. Verbrugge, Shell Agricultural Research Centre, England (Invited Contributed Paper)
		Chemical Hybridization Agents: Synthesis of Azetidine-3-Carboxylic Acid

5:00 p.m.	S2-12	V.J. Lee, American Cyanamid, Pearl River, NY, USA (Invited Contributed Paper)
		New Developments in 1,2,3-Thiadiazole Chemistry

August 12 (Monday) Room: AL 116 1:30 - 5:30 p.m.

Special Symposium S3			Metalation of Heterocycles I
			(G.W. Gribble, Organizer and Chairman)
1:30 p.m.	S3-13	P. Beak, University of Illinois, USA (Invited Lecturer)
		Mechanistic Studies of the Lithiation Reaction in Heterocyclic and Related Systems

2:30 p.m.	S3-14	A.J. Carpenter and D.J. Chadwick, Liverpool University, England (Invited Contributed Paper)
		Directed Metallation in Heteroaromatic Synthesis

3:00 p.m.	S3-15	P. Mathies, J.M. Muchowski and R. Nae1, Syntex, CA, USA (Invited Contributed Paper)
		1-Triisopropylsilyl-2- or 3-Bromopyrrole, Formal Equivalents of 2- or 3-Lithiopyrrole

3:30 p.m.	S3-16	D.L. Comins, M.O. Killpack and N.B. Mantlo, Utah State University, USA (Invited Contributed Paper)
		Metalation of Heterocycles Directed by α-Amino Alkoxides

4:00 p.m.	S3-17	B. Rickborn, S.L. Crump, B. Hunt, J. Netka and D. Pollart, University of California, Santa Barbara, USA (Invited Coritributed Paper)
		Isobenzofuran-Aryne Cycloadditions

4:30 p.m.	S3-18	B.Iddon, B.L. Lim, N. Khan and M. Nicholas, University of Salford, England (Invited Contributed Paper)
		Useful Lithiated Azoles; Synthesis of Thienoimidazoles

5:00 p.m.	S3-19	R.A. Conley, D.L. Barton, M.M. Lam, S.M. Stefanick, A.C. Fabian and S.D. Levine, Ortho Pharmaceutical Corp., NJ, USA (Invited Contributed Paper)
		Preparation of Heterocyclic Precursors Via an Ortho-Lithiation Approach

August 12 (Monday) Room: AL 124 1:30 -5:00 p.m.

Special Symposium S4			X-Ray Crystallographic Studies of Biologically Active Heterocycles
			(P.W. Codding, Organizer and Chairlady)
1:30 p.m.	S4-20	G.A. Jeffrey, University of Pittsburg, PA, USA (Invited Lecturer)
		Carbohydrate Liquid Crystals

2:30 p.m.	S4-21	F.R. Ahmed, National Research Council, Ottawa, Canada (Invited Contributed Paper)
		Heterocyclic Analgesics

3:00 p.m.	S4-22	V. Cody, Medical Foundation of Buffalo, USA (Invited Contributed Paper)
		Antifolate Pteridines: Design of Anticancer Drugs

3:30 p.m.	S4-23	W.L. Duax, D.L Langs, W.A. Pangborn, G.D. Smith and P. Van Roey, Medical Foundation of Buffalo, NY, USA (Invited Contributed Paper),
		Mechanism of Complexation and Selectivity of Ionophores

4:00 p.m.	S4-24	J.J. Stezowski and E. Eckle, Universitat Stuttgart, Germany (Invited Contributed Paper)
		Heterocyclic Pseudo-Peptide Residues: Structurally and Biologically Interesting TRH Analogs

4:30 p.m.	S4-25	P.W. Codding and A.K.S. Muir, University of Calgary, Canada (Invited Contributed Paper)
		Structural Relationships in Heterocyclic Compounds that Bind to the Benzodiazepine Receptor

GENERAL SESSIONS - ORAL PRESENTATIONS

August 12 (Monday) Room: PAS 2083 2:30 - 5:30 p.m.

	General Session G1			Mechanism and Reactivity in Heterocyclic Chemistry
				(Co-Chaired by: R.R. Gupta and A.N. Hughes)
2:30 p.m.		G1-1	A.M. Kawasaki and LB. Townsend (University of Michigan, USA)
			An Unusual Reductive Ring-Opening of the 1,2,3,5,6,7-Hexaazaacenaphthalene Ring System

2:50 p.m.		G1-2	R.A. Firestone and G. Smith (Merck, Sharp & Dohme, USA)
			A New Interpretation of the Acceleration of Diels-Alder and 1,3-Dipolar Cycloaddition Reactions Induced by High Pressure

3:10 p.m.		G1-3	J.J. Fisch, P.M. Chobe and S.K. Dua (SUNY, Binghampton, USA)
			Azaspiro[2.5]Octadiene Intermediates in the Anionic and Free-Radical Rearrangements of Tertiary Amines

3:30 p.m.		G1-4	S. Shiraishi, K. Imamura and B.S. Holla (University of Tokyo, Japan)
			Isomerization and Rearrangement of Isoxazoline-Condensed Cyclohexenedione

3:50 p.m.		G1-5	H.S. Kasmai, J.F. Femia and M.E. Read (Hamilton College, NY, USA)
			Generation and Thermal Reorganization of 1-Benzoxocinide and Dibenz[b,f]Oxocindiide Anions

4:10 p.m.		G1-6	W. Eberbach and J. Roser (Universitat Freiburg, Germany)
			Thermal Rearrangement of cis-Enyne-Substituted Oxiranes. A Novel Route to 2-Vinylfurans

4:30 p.m.		G1-7	M.T.H. Liu (University of Prince Edward Island, Canada)
			Intramolecular vs Intermolecular Reactions in Benzylchlorocarbene

4:50 p.m.		G1-8	F. Babudri, S. Florio, E. Epifani and G. Ingrosso (Università Bari, Italy)
			Reactions of Aza-Aromatic Heterocycles with Grignard Reagents

5:10 p.m.		G1-9	A.L. Weis (Weizmann Institute, Israel)
			Chiral Substrates Containing Tetra- and Dihydropyrimidine Rings

August 12 (Monday) Room: AL 105 2:30 - 5:30 p.m.

	General Session G2			Heterocycles in Organic Synthesis
				(Co-Chaired by E Warnhoff and Z.-T. Huang)
2:30 p.m.		G2-10	H. Suschitzky, R. Neidlein and H. Uhl (University of Salford, England)
			Synthetic Uses of 5-Azidoisobenzimidazole

2:50 p.m.		G2-11	J.L. Charlton and M.M.Alauddin (University of Manitoba, Canada)
			E,E- and E,Z-o-Quinodimethanes: Preparation and Reactions

3:10 p.m.		G2-12	A. Schwan and J. Warkentin (McMaster University, Canada)
			A New Δ¹ 1-1,2,4-Triazoline

3:30 p.m.		G2-13	M. Westling and T. Livinghouse (University of Minnesota, USA)
			An Approach to the Synthesis of Heterocycles Via Nitrilium Ion and Related Cyclizations

3:50 p.m.		G2-14	U.-H. Dolling, D.L. Hughes, A. Bhattacharya, K.M. Ryan, S. Karady, L.M. Weinstock and E.J.J. Grabowski (Merck, Sharp & Dohme, USA)
			Quaternary Ammonium lons Derived fram Cinchona Alkaloids as Chiral Phase Transfer Catalysts: Applications and Mechanism

4:10 p.m.		G2-15	A. Deratani, N.-H. Li, D. Horak, G.D. Darling and J.M.J. Fréchet (University of Ottawa, Canada)
			Polymer-Bound Catalysts Based on Resins Containing Pyridine or Benzimidazole Moieties

4:30 p.m.		G2-16	G.S. Poindexter and EP. Woo (Dow Chemical, USA)
			Use of 2-Oxazolidinones as Latent Aziridine Equivalents - Aminoethylations of Anilines, Phenol, and Thiophenols

4:50 p.m.		G2-17	H. Neunhoeffer and S. Göring (Universität Darmstadt, Germany)
			Cycloadditions with 1,2,4-Triazines

5:10 p.m.		G2-18	L.H. Klemm, J.N. Louris, W. Boisvert, C. Higgins and D.R. Muchiri (University of Oregon, USA)
			Synthetic Routes to 5- and 7-Substituted Thieno [3,2-b]pyridines from the N-Oxide

August 12 (Monday) Room: ML 354 2:30 - 5:30 p.m.

General Session G3				Novel Heterocyclic Pharmaceuticals
				(Co-Chaired by: R.R. Schmidt and G.A. Poulton)
	2:30 p.m.	G3-19	E. Esmans, M. Belmans, F. Alderweireldt and J. Lepoivre (University of Antwerp, Belgium)
			Synthesis of 2-Pyridine-C-Nucleosides

	2:50 p.m.	G3-20	S.W. Schneller, P.D. Stull and D.R. Sauer (University of South Florida, USA)
			The Synthesis and Biological Properties of Two Formycin Analogues

	3:10 p.m.	G3-21	M. Cushman, W.C. Wong and A. Bacher (Purdue University, IN, USA)
			Synthesis of Bis(Trifluoromethylated) Pyrazine-Containing Nitrogen Heterocycles from Hexafluorobiacetyl and Ortho Diamines. Stabilization of the Covalent Dihydrates of Pteridines and Pyrido [3,4-b]pyrazines by Trifluoromethyl Groups

	3:30 p.m.	G3-22	G. Bernáth, J. Kóbor, F. Fűlöp, and P. Sóhar, (University Medical School, Szeged, Hungary)
			Synthesis of Stereoisomeric Isoquinoline-Condensed Heterocycles as Potential Pharmacons

	3:50 p.m.	G3-23	M. Nakane and J.A. Reid (Squibb, Princeton, NJ, USA)
			A Stereospecific Synthesis of 7-Thiabicyclo[2.2.1]heptane Prostaglandin Analogs: Potent Thromboxane A2 Receptor Antagonists

	4:10p.m.	G3-24	T.F. Tam, R.W. Spencer, E.M. Thomas, L. Copp, A. Krantz, Syntex, Canada
			Novel Suicide Inhibitors of Serine Proteinases. Inactivation of Human Leukocyte Elastase by Yneno Lactones

	4:30 p.m.	G3-25	D. Kronenthal, P. Kuester and W.H. Koster (Squibb, Princeton, NJ, USA)
			Monobactam Analogs. Total Synthesis and Biological Activity of 2-Oxa-1-azabicyclo[4.2.0]octan-8-one-3-Carboxylic Acids

	4:50 p.m.	G3-26	P.D. Weeks, D.K. Pirie and RA. Volkmann (Pfizer, USA)
			Boron Trifluoride Mediated Condensations of Oxime Ethers with 6-Halo-penicillinate Grignard Reagents

	5:10 p.m.	G3-27	G.I. Georg, H.S. Gill and C. Gerhard (University of Kansas, USA)
			Stereo- and Enantioselective Synthesis of Chiral 3-(1' -Hydroxyethyl)-2-azetidinones from 3-Hydroxybutyrates

POSTER SESSIONS

August 12 (Monday) Federation Hall 11:30 a.m. - 1:30 p.m.

				5:30 p.m. - 7:00 p.m.
Poster Session P1					Heterocycles in Organic Synthesis
P1-1	L.Ciszewski, Medical Academy Banacha, Warsaw, Poland
	A Nucleophilic Substitution of D,L,Cis-Trans Trisubstituted 1,3-Dioxolane in Dependence on the Reaction Conditions
P1-2	L.Ciszewski, Medical Academy Banacha, Warsaw, Poland
	A New Total Synthesis of R,S-2,3,4-Trisubstituted 1-Azabicylo[2.2.2]octane by Phase- Transfer Catalysis
P1-3	G.D. Darling, and J.M.J. Fréchet, University of Ottawa, Canada
	Polymers Containing Pendant N-Alkyl-2-Halopyridinium Moieties and Their Applications in Organic Synthesis
P1-4	W.K. Fife and P. Floreancig, Purdue University at Indianapolis, IN, USA
	Synthetic Applications of 1-Acyloxypyridinium Ions: Alkylation with Carbanions and Carbanion Equivalents
P1-5	Y. Okamato, T. Kinoshita, M. Shirai, and Y. Matsumoto, Kitasato University, Japan
	Capture of Borane in Aqueous Media. 2-Amino-N-Heterocycles as Trapping Tool
P1-6	Ph. Guerry, St. Huber, R. Neier, Universitat Fribourg, Switzerland
	Photochemical Cycloadditions to 5,6-Dihydropyridinones-4
P1-7	T. Nagasaka, H. Tamano, and F. Hamaguchi, Tokyo College of Pharmacy, Japan
	Conversion of Lactams to α-Substituted Cyclic Amines
P1-8	H. Takahata, T. Suzuki, N. Hamada, and T. Yamazaki, Toyama University, Japan
	Reaction of Lithiated Thiolactams with Electrophiles
P1-9	R.S. Ward,University Collega of Swansea, Wales
	Reactions of β-Ketoesters with 2-Cyano-1,2,5,6-tetrahydropyridines
P1-10	D.M. Roland and W. Macchia, CIBA-GEIGY, Ardsley, NY, USA
	Preparation of Substituted 2-Aminopyridines
P1-11	G.R. Newkome, G.E. Kiefer, and N. Matsumara, Louisiana State University, USA
	Synthesis of Vinyl Derivatives of Phenanthroline and Dipyridine
P1-12	M.A. EI Sekily and S. Mancy, Alexandria University, Egypt
	Heterocycles from Carbohydrate Precursors. Studies on Dehydro-D-arabino Ascorbic Acid 2-Arylhydrazone 3-oximes: Conversion into Substituted Triazoles and Isoxazolines
P1-13	I. Maeba, O. Hara, M. Suzuki, and H. Furukawa, Meijo University, Nagoya, Japan
	Synthesis of 5-Hydroxy-5-(β-D-Ribofuranosyl)-3-pyrrolin-2-one from Glycosyl Furan
P1-14	Z.J. Witczak, Purdue University, West Lafayette, IN, USA
	The Preparation and Chemical Transformation of Glycopyranosyl Selenocyanates
P1-15	J.M. Koekemoer, C.W. Holzapfel, A.D. Swanepoel, and A.E. von Platen, Rand Afrikaans University, Johannesburg, S. Africa.
	Approaches to the Synthesis of Heteroprostanoids Using Carbohydrate Derived Heterocycles
P1-16	A.C.C. Freitas, M.A Khan and M. de O. Rodrigues, Universidade Federal do Rio de Janeiro, Brazil
	Transformations in the Pyrazole Series
P1-17	A. Jonczyk, J. Wlostowska, W. Wozniak, and M. Makosza, Technical University, Warsaw, Poland
	Reactions of Tosylhydrazones of Benzaldehyde and Benzophenone with Cyano-alkenes in Two-phase Basic Medium
P1-18	M. Los, R.K. Russell, J.J. Hand, P.C. Lauro, B.L. Lences, T.A Lies, EM. Parker, and P.J. Wepplo, American Cyanamid, Princeton, NJ, USA
	Metalation of Imidazolinylbenzenes in the Synthesis of Novel Herbicides
P1-19	M. Los, R.K. Russell, P.C. Lauro, B.L. Lences, S.K. Hadden, T.E. Brady, and P.J. Wepplo, American Cyanamid, Princeton, NJ, USA
	Metalation of 2-(2-pyridyl)-imidazolinones in the Synthesis of Novel Herbicides
P1-20	P.K. Kadaba and S.B. Edelstein, University of Kentucky, USA
	Nickel Peroxide Oxidation of Δ²-1,2,3-Triazolines: A Versatile General Synthetic Route for 1H-1,2,3-Triazoles
P1-21	T. Ueda and J. Sakakibara, Nagoya City University, Japan
	Utilization of Organic Selenium Compounds: Nucleophilic Reaction on Some Condensed Isoselenazoles
P1-22	C.W. Holzapfel, J. Koekemoer, and M. van Dyk, Rand Afrikaans University, Johannesburg, S. Africa
	The Synthesis and Ring Opening of Substituted 3-Cyanohexahydronaphth[2,3e]-1,2-oxazines
P1-23	J.-W. Chern, D.S. Wise, Jr. and L.B. Townsend, University of Michigan, USA
	A Novel Method for the Conversion of a N,N'-Disubstituted Thiourea into an O-Methyl-N,N'-Disubstituted Pseudourea
P1-24	S. Zen, E Kaji, and K. Takahashi, Kitasato University, Tokyo, Japan
	A Novel Ring Transformation of 4-Substituted-3,5-Bis(Methoxycarbonyl)-2-isoxazoline 2-Oxides by Lewis Acids
P1-25	J.-M. Fang, L-F. Liao, and B.-C. Hong, National Taiwan University, China
	Regio- and Diastereo-Selective Reactions of Dithio-Substituted Crotyllithium with . Carbonyl Compounds
P1-26	M. Garrossian, University of Mazandaran, Iran
	New Developments for the Preparation of α-Alko Thio Wittig Reagents
P1-27	S. Forsey, D. Rajapaksa, and R. Rodrigo, University of Waterloo, Canada
	Isobenzofurans in Organic Synthesis: The Synthesis of (±) Podophyllotoxin and Five Stereoisomeric Podophl/lum Lignans from a Common Intermediate
P1-28	G. Weeratunga, D. Rajapaksa, and R Rodrigo, University of Waterloo, Canada
	Isobenzofurans in the Synthesis of Natural Products: The Synthesis and Revision of the Relative Stereoehemistry of (±) Lirionol
P1-29	K. Ito, K. Nagasawa, and J. Maruyama, Hokkaido Institute of Pharmaceutical Sciences, Japan
	Selenium Dioxide Oxidation of Methyl-Substituted Coumarins, Chromones and Analogous Heterocycles
Poster Session P2			Physical and Spectral Properties of Heterocycles
P2-30	A.L. Baumstark, D.W. Boykin, and P.C. Vasquez, Georgia State University, USA
	¹⁷O NMR Spectroscopy (Natural Abundance) of Heterocycles: Anhydrides
P2-31	E. Aiello, G. Dattolo, G. Cirrincione, A.M. Almerico, R.A. Jones, and W. Hinz, Università di Palermo, Italy
	C-13 NMR Studies in Pyrrole Series
P2-32	K. Matsumoto, T. Uchida, Y. Ikemi, K. Aoyama, and H. Fujita, Kyoto University, Japan
	Carbon and Nitrogen Nuclear Magnetic Resonance Spectra of Cycloimmonium Ylids
P2-33	R.S. Salman, A.H. Hassan, University of Baghdad, Iraq
	Carbon-13 Chemical Shift of 1-R-2,4,6-Trimethyl Pyridinium Salts
P2-34	D.R. Adams, T. Coleman, C. Longo, N. Morante, and V. Lo Russo, Universidad Central de Venezuela, Caracas, Venezuela
	Synthesis of Substituted Aminoquinolines
P2-35	A.-T. Hansson, Pharmacia AB, Uppsala, Sweden
	New 2-Carboxypropyl-Substituted 1,10-Phenanthrolines
P2-36	M. Kuroki, Y.Tsunashima, and T. Takido, Nihon University, Tokyo, Japan
	Ring Strain of 4,5-Dimethylated Carbazoles
P2-37	C.A. Lipinski, RH. Craig, and R.B. Wright, Pfizer Inc., Groton, CN, USA
	2-Amino- and 2-Guanidino-4- Thiazolylpyrimidines
P2-38	Z.S. Salih and D.A. Al-Sammerrai, University of Baghdad, Iraq
	Study of the Thermal Stability of 6-Substituted-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrrolo[2,3-d] pyrimidines
P2-39	J.N. Vallat, G. Barthelemy, E Roussey, and Y. Rouzier, Sanofi Recherche, Toulouse, France
	N-Substituted-s-triazolo[4,3-a]pyrimidin-5-ones: Synthesis, Structure Elucidation and Pharmacological Properties
P2-40	M. Raban, L. Craine, H. Chang, and E. Hortelano, Wayne State University, MI, USA
	Chemistry and Stereochemistry of N-Arenesulfenylbenzimidazoles
P2-41	R. Chênevert, A. Rodrigue, D. Chamberland, J. Ouellet, and R. Savoie, Laval University, Québec, Canada
	Complexation of Inorganic and Organic Acids by Crown Ethers
P2-42	P. Tarburton, Tung Sun M.L. Gross, and N.H.Cromwell,Univcrsity of Nebraska USA
	The Mass Spectra of Small Ring Heterocycles
P2-43	M.B. Hocking, University of Victoria, Canada
	Mass Spectral Studies of the Electron Impact Stabilities of Phospholes and Related Compounds
P2-44	EC. Alyea, R. Rice, and J. Malito , University of Guelph, Canada
	Phosphole Systems: Comparison of Triphenylphosphine and 5-Phenyldibenzophosphole
P2-45	V.P. Mamaev, S.G. Baram, and O.P. Shkurko, Institute of Organic Chemistry, Novosibirsk, USSR
	Electronic Effects of Substituted Heteroaryl Groups
P2-46	E.G. Janzen, D.L. Haire, G.A. Coulter, and J.W. Hilborn, University of Guelph, Canada
	Heterocyclic Compounds as Detectors of Free Radicals. Pyrroline-N-Oxides as Spin Traps
P2-47	R.E. Kohrman, J.W. Bunce, R. Beyersdorf, and T.J. Beck, Central Michigan University, USA
	The Scope of Photochromism Observed in Sulfonate Esters of 3-Flavonol
Poster Session P3		Mechanism and Reactivity in Heterocyclic Chemistry
P3-48	J. Pielichowski and R. Popielarz, Politechnika Krakowska, Poland
	Reactivity of Some Heterocycles in Phase- Transfer Catalyzed Rections with Trichloroethylene
P3-49	C-S. Chien, T. Kawaski, and M. Sakamoto, Meiji College of Pharmacy, Tokyo, Japan
	Oxidation of Furan, Pyrrole, Thiophene, Benzo[b]furan, and Benzo[b]thiophene with Oxodiperoxomolybdenum(VI), MoO5.HMPA
P3-50	V.K. Ahluwalia, K.K. Arora, G. Kaur, and B. Mehta, University of Delhi, India
	An Unusual Observation in the Synthesis of Thiazoles
P3-51	F. Fülöp, G. Csirinyi, G. Bernàth, and P. Sohár, University Medical School, Szeged, Hungary
	Synthesis of cis- and trans-Trimethylene-1 ,3-Oxazine and Thiazine Derivatives
P3-52	S.J. Hodson and K. Turnbull, Wright State University, OH, USA
	Bromination of Sydnones
P3-53	G. Zvilichovsky and M. David, The Hebrew University of Jerusalem, Israel
	The Effect of C-H^.^{. .}O Hydrogen Bonds on the Formation and Reactivity of Isoxazolium Enolates
P3-54	K. Konuma, H. Hasegawa, and K. Itabashi, Nihon University, Japan
	Hydrogenolyses of Benzothiazole and Benzoxazole with MoS3 Catalyst
P3-55	P.W. Jennings, S.B. Gingerich, and K.P. Manfredi, Northern State College, Aberdeen, SD,USA
	Mechanism of the Peracid Oxidation of Trialkylated Furans
P3-56	U. Rao, G. Ariamala, and K.K. Balasubramanian, Indian Institute of Technology, Madras, India
	Novel Transformations of Bromophenyl Propargyl Ethers, Bromonaphthyl Propargyl Ethers and ω-Bromophenyl Propargyl Ether
P3-57	B.D. Beaver, J.V. Cooney, and J.M. Watkins, Jr., Naval Research Laboratory, Washington, DC, USA
	Autoxidation of Alkylpyrroles
P3-58	W.J. Houlihan, Y. Uike, and V.A. Parrino, Sandoz, East Hanover, NJ, USA
	An Unexpected Mono- or Di-Arylsulfenylation of N-Methylindoles by Arylsulfonyl Chlorides
P3-59	T.M. Schultz, K. Brown, and L.J. Wolfram, Clairol Research Laboratories, Stamford, CT, USA
	Metal Ion-Catalyzed Reactions of 5,6-Dihydroxyindoles
P3-60	S.F. Vice, H.N. deCarvalho, F. Lu, and G.I. Dmitrienko, University of Waterloo, Canada
	Generation, Spectroscopic Detection and Reactions of Indole-2,3-Quinodimethanes: 1,3-Dihydrothieno[3,4-b]indole-2,2-dioxides
P3-61	S.F. Vice, R.W. Friesen, G. MacKinnon, A.D.C. Chan, N.J. Taylor, and G.I. Dmitrienko, University of Waterloo, Canada
	N1 versus C3 Sulfenylation of Indoles: Synthesis and Properties of N-Sulfenylindoles
P3-62	R.A.Jones, and J.S. Arques, University of East Anglia, Norwich, England
	Reactivity of Vinylazoles with Acetylenic Esters and Ethyl Azodicarboxylate
P3-63	T. Kurihara, M. Hanakawa, S. Harusawa, Osaka College of Pharmacy, Japan
	A Novel Synthesis of 1-Aminocarbazoles
P3-64	M. Bruix, M.L Castellanos, M.A. Martin, and J. de Mendoza, Universidad Autonoma de Madrid, Spain
	Regioselective Nucleophilic Substitution in Activated 1-Aminopyrazolium Cations: A Facile Synthesis of 5-Substituted 1-Methylpyrazoles
P3-65	G. Szilágyi and P. Dvortsák, Institute for Drug Research, Budapest, Hungary
	Acylation of 1,3-Disubstituted-5-Aminopyrazoles
P3-66	F.I. Carroll and A. Philip, Research Triangle Institute, NC, USA
	Synthesis and Thermal Rearrangement of Spiro[2-Methyl-3-Phenylcyclopropane-1,5']-2',4',6'-Pyrimidinetrione. Novel Synthesis of 5-Methyl-6-Phenyl-5, 6-Dihydrofuro [2,3d]-2,4-(3H)-Pyrimidinedione
P3-67	D.A. de Bie, G. Geurtsen, and H.C. van der Plas, Agricultural University Wageningen, The Netherlands
	Ring Transformations of 5-Nitropyrimidine into 2-Substituted 5-Nitropyrimidine with Amidines
P3-68	A.F.M. Fahmy, J. Sauer, M.S.K. Yousef, M.S. Abd-El-Halim, and M.A. Hassan, Ain Shams University, Cairo, Egypt
	Novel Synthesis of Pyridopyrimidine Diones
P3-69	I.Hermecz, B. Podányi, J. Sipos, and Z. Mészáros, Chinoin Pharmaceutical and Chemical Works Ltd., Budapest, Hungary
	An Unusual Reaction Between Chloral and 4-Oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2‑a]pyrimidines
P3- 70	S.H. Krawczyk, O.L. Acevedo, and L.B. Townsend, University of Michigan, USA
	Synthesis of Some Azolopyrimidines
P3-71	A.L. Weis, A. Vishkautsan, and F. Frolow, The Weizmann Institute, Israel
	Synthesis, Structure, and Imine-Enamine Tautomerism of 1,2- and 2,5-Di-hydropyrimidines
P3-72	O.A. Zagulayeva and V.P. Mamaev, Institute of Organic Chemistry, Novosibirsk,USSR
	Synthesis and Properties of Pyrimidinylidene Derivatives
P3-73	P. Victory and M. Garriga, Instituto Quimico de Sarria, Barcelona, Spain
	Cyclization of Dinitriles by Hydrogen Halides. A Case in which the Tautomerism, the Thermic Level and even the Nature of the Halide Direct the Cyclization
P3-74	W.M. Stalick, G.W. Mushrush, J.V. Cooney, and J. Hohman, George Mason University, Fairfax, VA, USA
	Structure vs Reactivity of Model Long Chain Alkylpyridines at 450˚
P3-75	S.N. Balasubrahmanyam, and B. Jeyashri, Indian Institute of Science, Bangalore, India
	Formation of 2,6-Diarylpyridines from 2-Aryl-1,5-Diazapentadieniums: Intermediacy of α-Aryl Enamines
P3-76	S. Avramovici-Grisaru and S. Sarel, Hebrew University, Jerusalem, Israel
	Metal-Induced Nitrogen-Centered Metathesis of Aroyl Hydrazones into Corresponding Azines and Di-Aroyl Hydrazides
P3-77	H. Nagano, I. Matsunaga, and M. Hamana, Chugai Pharmaceutical Co., Tokyo, Japan
	Some Reactions of Nicotinic Acid 1-Oxide Derivatives
P3-78	J.W. Bunting and D. Stefanidis, University of Toronto, Canada
	Rates of Ferricyanide Oxidation of Heteroaromatic Cations
P3-79	H. Kawachi, K. Isomura, and H. Taniguchi, Kyushu University, Japan
	The Reaction Mechanism Forming Nitrogen Containing Heterocycles via Vinyl Nitrene
P3-80	Isao Takeuchi, Y. Shibata, and Y. Hamada, Meijo University, Nagoya, Japan
	Reaction of N-Alkylheteroaromatic Cation with Phosphite
P3-81	W. Dostal and G. Heinisch, University of Vienna, Austria
	Reissert Type Reactions on Simple Pyridazines
P3-82	M.P. Groziak, J-W. Chern, and L.B. Townsend, University of Michigan, USA
	Heterocyclic Synthesis via a 1,3-Dicyclohexylcarbodiimide-Mediated Cyclo-desulfurative Annulation Reaction. New Methodology for the Preparation of Guanosine and Guanosine- Type Nucleoside Analogs
P3-83	D.T. Hurst, U.B. Lakhani, P.M. Winter, and J. Wyer, Kingston Polytechnic, Kingston-upon-Thames, England
	Charge Transfer Interactions Between Nucleosides and Some Related Compounds and Catechol in Aqueous Solution
P3-84	D.T. Hurst, M. Johnson, M. Momin, and J.R. Seymour-Shove, Kingston Polytechnic, Kingston-upon- Thames, England
	The Nitration of Some Phenyl-Substituted N-Heterocycles
P3-85	P-O. Andersson, J. Bergman, and P. Sand, Royal Institute of Technology, Stockholm, Sweden
	Alkyl Oxalates as General Alkylating Agents
P3-86	T-s. Chou and L-J. Chang, Academia Sinica, Taiwan, China
	Ring-opening of Norbornadiene Sulfone by Nucleophilic Attack
P3-87	M. Daneshtalab and S.F. Golaziz, Tehran University, Iran
	Reaction of Methylketene Dimer with α-Amino-N-Heterocyclic Compounds
P3-88	L. Fodor, J. Szabó, G. Bernáth, P. Sohár, and J. Tamás, University Medical School, Szeged, and Hungarian Academy of Sciences, Budapest, Hungary
	Ring Transformations of Linearly and Angularly Condensed 1,3-Benzothiazine-chloro- β-lactams
P3-89	S.N. Eğe, T.M. Dewey, L Moore, and G.E. Ghastin, University of Michigan, USA
	Preparation of a Pyrazolinone Spirooxirane by Electron Transfer Reactions
P3-90	P.R. Iyer, C.S.R. Iyer and K.S.R. Mohan Rao, Indian Institute of Technology, Bombay, India
	Thermal Rearrangement of Angular Dihydropyranoisoflavone Carboxylic Acids to Linear Dihydropyranoisoflavones
P3-91	W. Löwe, P. Jeske, A. Kietzmann, and C. Műller-Menke, Freie Universitat Berlin, Germany
	Novel Ring Transformations of Chromone and 1,2-Benzoxathiine Derivatives
P3-92	M.M. Kayser and L. Breau, Mount Allison University, Canada
	Regioselectivity Patterns in Nucleophilic Additions to Unsymmetrically Substituted Cyclic Anhydrides
P3-93	K.C. Khemani and J.F. King, The University of Western Ontario, Canada
	1,2-Oxathietane 2,2-Dioxide (β-Sulfone) as a Short-Lived Intermediate in the Hydrolysis of 2-Hydroxyethanesulfonyl Chloride
P3-94	L. Lopez, Università di Bari, Italy
	Synthesis of 4a,8a-Diphenyl-2,3,4a,6,7 ,8a-hexahydro-p-dioxino-[2,3-b]-p-dioxin
P3-95	Y.-F. Zhao, S.J. Van, M.-C. Ye, and C. Zhai, Academia Sinica, Beijing, China
	Mechanism on Iodine-Induced Cyclization Reaction of Unsaturated Dialkyl-phosphonates
P3-96	F.A. Neugebauer and S. Kuhnhäuser, Max-Planck-Institut, Heidelberg, Germany
	A Double-Layered Triphenylamine
P3-97	K.-L. Mok and M.J. Nye, University of Guelph, Canada
	Tautomerism of Xanthine

August 12 (Monday) Federation Hall 11:30 a.m. - 1:30 p.m

5:30 p.m. - 7:00 p.m.

Poster Session P4		Sterochemistry of Heterocycles
P4-98	M.R. Ibrahim, Z.A. Fatafta, and N.H. AI-Said, Yarmouk University, Irbid, Jordan
	Conformational Analysis of 1,4-Diacyl- and 1,4-Diaroyl-6,7-Dimethyl-1,2,3,4-tetrahydroquinoxalines
P4-99	G. Bernáth, G. Stájer, A.E. Szabó, G. Argay, and A Kálmám , University Medical School, Szeged, Hungary
	Synthesis and Steric Structure of Partially Saturated 3,1-benzoxazines and Related Compounds
P4-100	J. Fischer and W. Steglich, Gedeon Richter Works, Budapest, Hungary
	Investigation of the Claisen Rearrangements of Chiral Propargyl Groups on Azlactones
P4-101	I.Yavari,University of Mazandaran, Iran
	A Dynamic Nuclear Magnetic Resonance Spectroscopic Study of Conformational Properties of 1H-Octahydroazonine (Azacyclononane)
P4-102	J. Bergman and U. Tilstam, Royal Institute of Technology, Stockholm, Sweden
	A Sterochemical Study of 2,3-Dihydroindoles
P4-103	J.M. McIntosh and P. Mishra, University of Windsor, Canada
	Steroselectivity in the Alkylation of lithiated Imines of Glycinates

August 12 (Monday) Village 2, South 102 Lounge

5:30 p.m. General Meeting of the International Society of Heterocyclic Chemistry

August 13 - Tuesday

PLENARY LECTURES

August 13 (Tuesday) Humanities Theatre, J.G. Hagey Hall (HH)

8:30 a.m.	PL-3	A. Dondoni, Università di Ferrara, Italy
		Synthetic Aspects of the Chemistry of Silylthiazoles and Silyloxazoles
		(Chairman: D.J. Chadwick)
9:45 a.m.	PL-4	E. Fujita,Osaka College of Pharmacy, Japan
		Recent Progress on Asymmetric Synthesis Utilizing C-4 Chiral Thiazolidine-2-thione
		(Chairman: P. Yates)
10:45 a.m.	PL-5	V. Jäger, Universität Wűrzburg, Germany
		Synthesis via Isoxazolines: Old Concepts and Recent Results on Stereoselection at Isoxazoline Ring and Adjacent Centres
		(Chairman: S.M. Weinreb)

SPECIAL SYMPOSIA

August 13 (Tuesday) Room: AL 113 2:00 - 5:00 p.m.

Special Symposium S5			Heterocyclic Agrochemicals Il
			(K. Potts, Organizer and Chairman)
2:00 p.m.	S5-26	H. Wamhoff, A. Böhle, M. Ertas, G. Haffmanns, G. Hendrikx, W. Schupp and M. Zahran, Universität Bonn, Germany (Invited Contributed Paper)
		Dihalogentriphenylphosphoranes, Versatile Reagents in the Synthesis of Novel Heterocyclic Systems of Agrochemical Importance

2:30 p.m.	S5-27	A.G. Schultz, P. Sundararaman, M. Macielag, F. Lavieri and M.Welch, Rensselaer Polytechnic Institute, NY, USA (Invited Contributed Paper)
		Enantioselective Control in the Reductive Alkylation of Aromatic and Heteroaromatic Ring Systems

3:00 p.m.	S5-28	B.L. Chenard, DuPont, Wilmington, DE, USA (Invited Contributed Paper)
		The Chemistry of Pentathiepins

3:30 p.m.	S5-29	A.D. Brewer, Uniroyal Ltd., Guelph, Canada (Invited Contributed Paper)
		Synthesis and Agricultural Activity of Dihydro-1,4-Dithiin Tetraoxides
4:00 p.m.	S5-30	L.F.Lee, R.K. Howe, M.G. Dolson and B.R. Stults, Monsanto, St. Louis, MO, USA (Invited Contributed Paper)
		Synthesis of Heterocycles from 3-Aminoacrylates

4:30 p.m.	S5-31	R.F. Doehner, American Cyanamid, Princeton, NJ, USA (Invited Contributed Paper)
		Oxidation of Dihydropyridones to Polyfunctional Pyridines in POCl3

August 13 (Tuesday) Room: PAS 2083 1:30 -4:30 p.m.

Special Symposium S6		Bioorganic Chemistry of Heterocyclic Systems
		(G.I. Dmitrienko, Organizer and Chairman)
1:30 p.m.	S6-32	T.C. Bruice, University of California, Santa Barbara, USA (Invited Lecturer)
		Monooxygen Transfer Reactions Dependent Upon Flavins and Metalloporphyrins
2:30 p.m.	S6-33	N.J. Leonard, University of Illinois, USA (Invited Contributed Paper)
		Spatial Tolerance of Watson-Crick DNA, RNA Cross Sections
3:00 p.m.	S6-34	J.W. Bunting, University of Toronto, Canada (Invited Contributed Paper)
		Relative Reactivities of Heteroaromatic Cations Towards Reduction by 1,4‑Dihydronicotinamides
3:30 p.m.	S6-35	R. Kluger, M. Brandl, G. Thatcher and G. Gish, University of Toronto, Canada (Invited Contributed Paper)
		Heterocyclic Catalysis of Biological CO2 Transfer
4:00 p.m.	S6-36	A. Krantz, Syntex, Canada (Invited Contributed Paper)
		New Heterocyclic Inhibitors of Clinically Relevant Enzymes

August 13 (Tuesday) Theatre of the Arts, ML 2:30 - 5:00 p.m.

Special Symposium S7 Current Trends in Natural Product Chemistry I

(Syn) (R.H.F. Manske Symposium)

(R. Rodrigo and V. Snieckus, Organizers and Chairmen)

C. Burgener, Computer Science, University of Waterloo, Canada Introductory Remarks

2:30 p.m.	S7-37	P.D. Magnus, Indiana University, USA (Invited Contributed Paper)
		Recent Progress Towards the Synthesis of Complex Alkaloids
3:00 p.m.	S7-38	T.R. Kelly, R.J. Armstrong-Chong and N. Ohashi, Boston College, MA, USA (Invited Contributed Paper)
		Studies Directed Toward the Synthesis of Fredericamycin
3:30 p.m.	S7-39	T. Hino, H. Fukushima, L.J. Jun, T. Kawate, M. Ito, Y. Hasegawa, M. Taniguchi and M. Nakagawa, Chiba University, Japan (Invited Contributed Paper)
		Synthesis of Micotoxins Derived from Tryptophan
4:00 p.m.	S7-40	E. Benkert, S. Bienz, A. Guggisberg, J. Hajicek, A. Lorenzi-Riatsch, K. Kostova, B. Milenkov, Y. Nakashita, M. Süsse, R. Wälchli and M. Hesse, Universität Zürich, Switzerland (Invited Contributed Paper)
		Medium and Large Ring Heterocycles by Ring Enlargement Reactions
4:30 p.m.	S7-41	S.F. Martin,University of Texas, USA (Invited Contributed Paper)
		Recent Applications of Intramolecular Diels-Alder Reactions to Alkaloid Synthesis

August 13 (Tuesday) Room: AL 116 1:30 - 5:00 p.m.

Special Symposium S8 Metalation of Heterocycles Il

(G. Gribble, Organizer and Chairman)

1:30 p.m.	S8-42	G. Queguiner, Université de Rouen, France (Invited Lecturer)
		New Functionalization Method for Pyridines and Quinolines. Application to Synthesis
2:30 p.m.	S8-43	J. Epsztajn, University of Lodz, Poland (Invited Contributed Paper)
		New Synthetic Method for 2,3- and 3,4-Disubstituted Pyridine Derivatives
3:00 p.m.	S8-44	J.A. Turner, Dow Chemical, CA, USA (Invited Contributed Paper)
		An Ortho Metalation Approach to the Synthesis of 1,X-Naphthyridines
3:30 p.m.	S8-45	G.R. Newkome, Louisiana State University, USA (Invited Contributed Paper)
		Stable Organometallics via Cyclometallation. Syntheses, Structure, and Chemistry
4:00 p.m.	S8-46	N.S. Narasimhan and R. Ammanamanchi, University of Poona, India (Invited Contributed Paper)
		An Unusual Observation on the Lithiation of 2-Iodo-3-hydroxymethylquinoline
4:30 p.m.	S8-47	F. Effenberger and A. Krebs, Universität Stuttgart, Germany (Invited Contributed Paper)
		Regioselective Substitution of Heterocycles by Desilylation Reactions

GENERAL SESSIONS - ORAL PRESENTATIONS

August 13 (Tuesday) Room: AL 124 2:30 - 4:50 p.m.

General Session G4 Synthesis of Simple Heterocycles I

(Co-Chaired by: J. McIntosh and N. De Kimpe)

2:30 p.m.	G4-28	E.C. Taylor and J.E. Macor (Princeton University, NJ, USA)
		Diels-Alder Reactions with 1,2,4-Triazines: Novel Routes to Thieno(2,3‑c)Pyridines and Thieno(2,3-b)pyridines
2:50 p.m.	G4-29	C. Stropnik, L. Golic, B. Husu, B. Stanovnik and M. Tisler (University of Ljubljana, Yugoslavia)
		New Synthetic Approach for Pyrimidines or Pyridines from Enamines
3:10 p.m.	G4-30	P. Kaiser, T. Kappe, C. Kos, G. Megyeri, P.H. Olesen, W. Stadlbauer and S. Zengerer (Universität Graz, Austria)
		Synthesis and Reactions of 3,5-Substituted Pyridazines
3:30 p.m.	G4-31	H. Ulrich, R. Richter and B. Tucker (Upjohn, North Haven, CT, USA)
		Novel Carbodiimide Cycloaddition Reactions
3:50 p.m.	G4-32	R.M. Cory, B.M. Ritchie and A.M. Shrier (University of Western Ontario, Canada)
		Synthesis of α,β-Butenolides
4:10p.m.	G4-33	B. Stanovnik, B. Furlan, B. Huc, B. Koren, M. Merslavic, A. Stimac, M. Tisler and M. Zlicar (University of Ljubljana, Yugoslavia)
		1,3-Dipolar Cycloaddition of Diazoalkanes to Heteroaromatic 6π,10π, and 14π-Electron Systems. The Syntheses and Transformation of Fused Pyrazoles, Derivatives of Novel Heterocyclic Systems
4:30 p.m.	G4-34	K.-y. Akiba (Hiroshima University, Japan)
		Synthesis and Some Conversion of 3-Substituted 4-(2-oxoalkyl)-1,4-Dihydropyridines and Extension of the Method to Pyrimidine

August 13 (Tuesday) Room: AL 105 2:30 - 4:50 p.m

General Session G5 Synthesis of Multiring Heterocycles I

(Co-Chaired by: K. Steliou and W. Houlihan)

2:30 p.m.	G5-35	R. Neidlein, V. Poignée and U. Jäschke (Universität Heidelberg, Germany)
		Syntheses of New Heterocyclic Systems Starting From Benzocyclopropene and Alkoxy-1,6-Methano-(10)-Annulenes
2:50 p.m.	G5-36	D. Seebach and M.A. Brook (ETH Zürich, Switzerland)
		Stabilized Cyclic Nitronates: Intermediates for More Complex Heterocycles
3:10 p.m.	G5-37	G. Kollenz, R. Theuer and W. Ott (University of Graz, Austria)
		Cycloadducts of Isocyanides and Cyclic Vicinal Triones Via Non-Stabilized 1,3-Dipoles
3:30 p.m.	G5-38	D.B. Grotjahn and K.P.C. Vollhardt (University of California, Berkeley, USA)
		Cobalt-Mediated 2+2+2 Cycloaddition Involving Two Alkynes and the C-2,C-3 Bond of Indole Derivatives and Its Application to the Synthesis of Strychnine
3:50 p.m.	G5-39	D.J. Le Count and A.P. Marson (Imperial Chemical Industries, England)
		Cycloaddition Reactions of 3,3-Dialkyl-3H-Indoles with Heterocumulenes
4:10 p.m.	G5-40	V. Nair, D.A Young and S.D. Chamberlain (University of lowa, USA)
		Novel Functionalized C-Alkylated Purine Systems
4:30 p.m.	G5-41	T. Sheradsky and N. Itzhak (Hebrew University of Jerusalem, Israel)
		Reaction of Carbanions with N-Tosyloxyphthalimide. A New Route to Quinoline-2,4-diones

August 13 (Tuesday) Room: ML 354 2:30 - 4:50 p.m.

General Session G6 Physical and Spectral Properties of Heterocycles

(Co-Chaired by: M.M. Kayser and A. Weis)

2:30 p.m.	G6-42	C.R. Petrie, N.K. Dalley, G.R. Revankar and R.K. Robins (Brigham Young University, UT, USA)
		Relationship Between Intramolecular Hydrogen Bonding and Biological Activity of Certain Heterocyclic Nucleosides
2:50 p.m.	G6-43	C. Lohse and C.T. Pedersen (Odense University, Denmark)
		Photoisomerization of Cycloalkano-1 ,6,6αλ⁴-Trithiapentalenes
3:10 p.m.	G6-44	M. Raban, J. Quin III and E. Hortelano (Wayne State University, MI, USA)
		Flipped Out Ionophores
3:30 p.m.	G6-45	W. Kaim, C. Bessenbacher (Universität Frankfurt, Germany)
		Structural and Chemical Properties of Small 1,4-Diaza-1,4-Dihydroheteroaromatics
3:50 p.m.	G6-46	RT. Gampe, Jr., M.J. Musmar, G.E. Martin, M.L.Tedjamulia, R.N. Castle, M.L.Lee and R.E. Hurd (University of Houston, TX, USA)
		Combined Utilization of Heteronuclear Relay and ¹³C-¹³C Double Quantum Two-Dimensional NMR Experiments in the Assignment of the ¹³C-NMR Spectrum of Benzo[b]phenanthro[4,3-d]Thiophene
4:10p.m.	G6-47	D.W. Boykin, P. Balakrishnan and A.L. Baumstark (Georgia State University, USA)
		¹⁷O NMR Spectroscopy of Heterocyclic N-Oxides. Steric and Structural Effects
4:30 p.m.	G6-48	M.S. Morales-Rios and P. Joseph-Nathan (Instituto Polytécnico Nacional, Mexico)
		Carbon-13 NMR Assignment of Indole Signals with the Aid of 4-Deuterated Molecules

POSTER SESSIONS

August 13 (Tuesday) Federation Hall 11:30 a.m. - 1:30 p.m.

5:30 p.m. - 7:00 p.m.

Poster Session P5		Synthesis of Multiring Heterocycles
P5-104	C. Parkanyi, A.O. Abdelhamid, J.C.S. Cheng, W.D. Lloyd, S.M.K. Rashid, and A.S. Shawali, University of Texas at El Paso, USA
	New Azaheterocycles from Arylhydrazidoyl Halides and Arylhydroximoyl Chlorides
P5-105	Z.-t. Huang, L.-h. Tzai, Z.-r. Liu, Academia Sinica, Beijing, China
	Synthesis of Heterocyclic Ketene Aminals and Their Nucleophilic Addition Reactions
P5-106	B.P. Murphy, Clairol Research Laboratories, Stamford, CT, USA
	Synthesis of 5,6-Dihydroxy- and Diacetoxyindoles and Their ¹³C-2-¹³C-3-Labelled Derivatives
P5-107	F.F. Abdel-Latif and Y.S. Mohamed, El-Minia University, Egypt
	Reaction of Diazo Compounds and Hydrazines on Indolin-2-one Derivatives
P5-108	W.O. Lin and M.AG. Teixeira, Instituto Militar de Engenharia, Rio de Janeiro, Brazil
	5,6-Methylenedioxy-1H-Indazoles and Related Derivatives
P5-109	W. Wendelin and U. Radner, Universität Graz, Austria
	Synthesis of Hexahydroindazoles, Carbazoles, and Dibenzodiazepines by Reaction of Hydrazines with Arylmethylenecyclohexanones
P5-110	T.N. Gerasimova, N.I. Petrenko, T.V. Mikhalina, E.P. Fokin, Institute of Organic Chemistry, Novosibirsk, USSR
	A Novel Photocyclization of Polyfluorinated Aromatic Compounds for the Synthesis of Some N-Heterocycles
P5-111	M.J. Tanga and E.J. Reist, SRI International, CA, USA
	Synthesis of Some Aza-Aromatic Hydrocarbons
P5-112	C.-K. Sha, K.-S. Chuang, J.-J. Young, J.-M. Liu, and S.-J. Wey, National Tsing Hua University, Taiwan, China
	A Stable Analogue of Indole-2,3-Quinodimethane: Synthesis and Reactions of 2,4-Dihydropyrrolo[3,4-b ]indole
P5-113	J.P. Freeman and M.K. Fettes-Fields, University of Notre Dame, IN, USA
	Acid-Catalyzed Cyclization of 2-Hydroxy-3-Pyrrolone Derivatives
P5-114	J. Dusemund and T. Hardt, Freien Universität Berlin, Germany
	Reactions of Deoxy- and Homodeoxybenzoin-Dicarboxylic Acid with Nucleophiles
P5-115	B. Alo and A. Ode, University of Lagos, Nigeria
	Heterotricyclic Quinoxalinones: Some Reactions of 7,8,9,10-Tetrahydropyrido[1,2-a]quinoxalin-6-one
P5-116	F.D. Bellamy, P. Renaut, and Ph. Ratel, Laboratoires Fournier, France
	Synthesis of 2,3-Diamino-3,4-Dihydroquinazoline as a Building Block for New Condensed Heterocycles
P5-117	K.-C. Liu and M.-K. Hu, National Defence Medical Center, Taipei, China
	Synthesis of Novel Condensed Quinazolinone Derivatives from Isatoic Anhydride
P5-118	L.L. Martin, S.J. Scott, and L.L.Setescak, Hoechst-Roussel, Somerville, NJ, USA
	Synthesis of Novel Benzo[c]-1,5-naphthyridines from Pyrrolo[1,2-b]isoquinolines
P5-119	R.N. Radinov, M.A. Haimova, and E.M. Simova, University of Sofia, Bulgaria
	Synthesis of Heterocycles from C-3 Metallated 4-Chloropyridine
P5-120	J.J. Wade, Riker Labs/3M Company, St. Paul, MN, USA
	Synthesis of Imadazo[1,5-c]pyrimidine Derivatives
P5-121	N. Haider and G.Heinisch, University of Vienna, Austria
	Aryl-(5-Amino-4-Pyridazinyl) Ketones as Key Intermediates in Synthesis of Fused Pyridazines
P5-122	A. Jorgensen, N.S. Girgis, K.A.M. El-Bayouki, and E.B. Pedersen, Odense University, Denmark
	Some Uses of P₂O₅/Amine Reagents in the Synthesis of Heterocyclic Compounds
P5-123	H. Oda, H. Nagashima, and K. Kaji, Gifu Pharmaceutical University, Japan
	Synthesis of Pyrazolo[3,4-d]pyridazines by the Vilsmeier Reaction
P5-124	J.F. Gerster and C.D. Huber, Riker Laboratories, St. Paul, MN, USA
	A Synthesis of Pyrazolo[1,5-a]pyrazines
P5-125	A.F.M. Fahmy, J. Sauer, M.S.K. Yousef, M.S. Abd-EI-Halim, and M.A. Hassan, Ain Shams University, Cairo, Eygpt
	New Synthesis of Pyrido[2,3-d] and [3,2-d]Oxazines
P5-126	R.K. Bansal and J.K. Jain, University of Rajasthan, India
	A Facile Synthesis of Oxazolo[5,4-b]Pyridine Derivatives
P5-127	K. Saigo, R.-J. Lin, M. Kubo, A. Youda, and M. Hasegawa, University of Tokyo, Japan
	Synthesis and Complexation of a Novel Macrotricycle
P5-128	O. Juanes, J. de Mendoza, and J-C. Rodriguez-Ubis, Universidad Autonoma de Madrid, Spain
	Synthesis of Macrobicyclic Ligands Containing Pyrazole Subunits: The N,N'-Bipyrazolyl Cryptand
P5-129	G.R. Newkome, G.E. Kiefer, and N. Matsumara, Louisiana State University, USA
	Synthesis of Vinyl Derivatives of Phenanthroline and Dipyridine
P5-130	G.R. Newkome, Y.J. Joo, and F.R. Fronczek, Louisiana State University, USA
	Pyridine Xanthoporphinogenes: "Heterocalixarenes"
P5-131	O. Cox, H. Jackson, L.A. Rivera, and L. Ramirez, University of Puerto Rico, Puerto Rico
	Photo-Induced Cyclisation of Selected 2-Styrylbenzoheterazoles
P5-132	P. Molina, M. Alajarin, J.R. Saez, R.M. Claramunt, and J. Elguero, University of Murcia, Spain
	Iminophosphorane-Mediated Synthesis of 1,2,4-Triazolo[5,1-c][1,2,4]-Triazines
P5-133	C.E Smith and J.T. Sharp, University of Edinburgh, Scotland
	Generation and Reactions of C,N-Dianions of the Tosylhydrazones of Aromatic Ketones
P5-134	J. Reiter, L. Pongó, and P. Dvortsák, Egis Pharmaceuticals, Budapest, Hungary
	The Reaction of 5-Amino-1,2,4-Triazoles with Ethoxymethylene-Malonitrile and -Cyanoacetic Acid Esters
P5-135	K. Esses-Reiter and J. Reiter, Egis Pharmaceuticals, Budapest, Hungary
	Synthesis of Novel Condensed Ring Systems
P5-136	E.B. Pedersen and F.E. Nielsen, Odense University, Denmark
	Synthesis of 1,2,3-Triazolo[4,5-b][1,5]Benzoxazepines
P5-137	E.C. Taylor and J.E. Macor, Princeton University, NJ, USA
	Diels-Alder Reactions with 1,2,4- Triazines: An Efficient Synthesis of Furo[2,3‑b]pyridines
P5-138	C.P. Sloan, K. Shankaran, and V. Snieckus, University of Waterloo, Canada
	Synthetic Connections to the Aromatic Directed Metalation Reaction. Regioselective Synthesis of Benzofurans and Benzyopyrans by Radical-Induced Cyclizations
P5-139	M. Iwao and T. Kuraishi, Nagasaki University, Japan
	Novel Annulation of Aromatic Tertiary Amides into Naphthoquinones via Tandem Directed Lithiations
P5-140	Y. Tamura, M. Sasho, T. Tsugoshi, S.-i. Mohri, S. Akai, and Y. Kita, Osaka University, Japan
	Synthesis of Heteroanthracyclinones: A Strong Base-Induced Cycloaddition of Heterohomophthalic Anhydrides and Their Derivatives
P5-141	Y. Ahmad, M.I. Qureshi, and S.S. Anwar, Pakistan Council of Scientific and Industrial Research Laboratories, Pakistan
	Pyrazolo[5,1-c]pyrido[3,4-e][1,2,4]triazines. Synthesis of Penta-aza-tricyclic New Heterocycles
P5-142	F.F.A El-Latif, A.K.M.N. Gohar, A.M. Fahmy, and M.Z.A. Badr, El-Minia University, Egypt
	Novel Synthesis of Furo[2,3-b]indole Derivatives
P5-143	S.V. Eswaran and S.K. Sajadian, St. Stephen's College, Delhi, India
	Attempted Synthesis of Dimethylfuroxanobenzofuroxans
P5-144	V. Cantani, J.T.B. Ferreira, and J.V. Comasseto, Universidade Federal de Sao Carlos, Brasil
	Synthesis of 2,2-Thiadimethylchromenes, the Sulphur Analogues of Precocenes
P5-145	G.A. Poulton and C.A. Boulet, University of Victoria, Canada
	Synthesis and Properties of Benz-fused Lactones: 3-Methylphthalides and 3-Methylisochroman-3-ones
P5-146	O.H. Hishmat, A.K.M.N. Gohar, and F.F. Abdel-Latif, EI-Minia University, Egypt
	Synthesis of Benzo[1,2-b:5,4-b'] Dipyran Derivatives
P5-147	T.R. Kasturi and G.M. Reddy, Indian Institute of Science, Bangalore, India
	Spirocyclic Oxygen Heterocycles
P5-148	P. de March, M. Moreno-Manas, A. Pleixats, and I. Ripoll, Universidad Autonoma de Barcelona, Spain
	Approaches to Natural 4-Hydroxy-2-Pyrones by Functionalization at C-3 and C-5
P5-149	A Cantos, P. de March, M. Moreno-Manas, A. Pla, J. Ribas, and A. Virgili, Universidad Autonoma de Barcelona, Spain
	Heterocyclic Ring Systems from 4-Hydroxy-2-Pyrones
P5-150	O.R. Martin and R.M. Mahnken, State University of New York, Binghampton, NY, USA
	Synthesis of Polycyclic Oxygen Heterocycles from Benzylated Sugars
P5-151	S. Bhatnagar and S.C. Mehra, Bareilly College, India
	Synthesis of Some New Hydantoin Derivatives with Possible Antiepileptic Activity
P5-152	D.M. McKinnon and K.A. Duncan, University of Manitoba, Canada
	The Synthesis and Properties of Some Fused Isothiazoles
P5-153	R.N. Castle and S.Khora, University of South Florida, USA
	The Synthesis of Phenanthrothiazoles
P5-154	A Shafiee, H. Ghazar, and M. Nayebpour, University of Tehran, Iran
	Synthesis of 2-Aryl-6-carbethoxythiazolo[4,5-c]pyridine and 7-Chloro-2-phenylthiazolo[5,4-c]pyridine (1)
P5-155	D.K. Bates and R.T. Winters, Michigan Technological University, USA
	Synthesis of Pyrrolo[2,1-b]benzothiazoles and Pyrrolo[2,1-c]benzothiazines from a Common Precursor
P5-156	I. Lalezari, Montefiore Medical Center and Albert Einstein College of Medicine, NY, USA
	Dimethyl 2H,3H-Pyrrolo[2,1-b]thiazole-6,7-dicarboxylates their 1,1-Dioxides and Dimethyl 1 H,3H-Pyrrolo[1 ,2-c]thiazole-6,7-dicarboxylates and their 2,2-Dioxides
P5-157	L.H. Klemm, L. Cousins, S. Pou, R. Tsuchiya, and J. McConnell, University of Oregon, USA
	Isolation and Transformation of Some Condensed Thiophenes from Sulfur-Bridging Reactions
P5-158	V. Cody, P.A. Sutton, R.J. Kempton, C. McCarthy, S.A. Fletcher, and E.C. Taylor, Medical Foundation of Buffalo, NY, USA
	Crystal Structure and Chemistry of an Unusual Tetrahydrothieno[2,3-b]pyrrole
P5-159	H. Link, Hoffmann-La Roche, Basel, Switzerland
	2,4-Diamino-6-(arylthio)-thieno[2,3-d]pyrimidines and 2,4-Diamino-6-(arylthio)-thieno[3,2-d]pyrimidines
P5-160	D. Armstrong, Olivet Nazarene College, IL, USA
	Continued Progress Toward the Synthesis of 1,2,4-Oxathiazole Derivatives
P5-161	J. Bergman and B. Egestad, Royal Institute of Technology, Stockholm, Sweden
	Heterocyclopolyaromatic Compounds Formed from 3(2H)-Benzo[b]Furanone, 3(2H)-Benzo[b]Thiophenone and 3[2H]-Benzo[b ]Selenophenone
P5-162	M.S. Sardessai, M.J. Brander, K.K. Midha, and E.M. Hawes, University of Saskatchewan, Canada
	Synthesis of Phenothiazine Type Antipsychotic Agents Utilising Borane Reduction
P5-163	L. Hevesi and M. Renard, Universitaires Notre-Dame de la Paix, Bruxelles, Belgium
	Regiochemistry and Solvent Effect on the Reaction of 1-Selenoallyl Cations on Pyrroles: New Route to Porphyrins
P5-164	T.D. Lash, Illinois State University, USA
	Synthesis of a Novel Porphyrin with Four Exocyclic Rings from a Tetrahydroindole
P5-165	M.-K. Fan, Z. Yalin, and F. Ping, Academia Sinica, Beijing, China
	Photochemistry of Heterocycles II Photocycloadditions of Acetylenic Bond with Nucleic Acid Bases and Their Derivatives
P5-166	B. Kokel, G. Menichi, and M. Hubert-Habart, Institut Curie, Paris, France
	Transformation of Some Aminouracils and Related Compounds Into Heterocyclic Systems of Biological Interest
P5-167	R.S. Hosmane, F.N. Burnett, M.E. Rauser, C.S. Son, and B.B. Lim, University of Maryland, USA
	"Fat" Nucleosides and Nucleotides. I
P5-168	J. Fischer and I. Matus, Gedeon Richter Works Ltd., Budapest, Hungary
	A New Simple Synthesis far Canthin-Alkaloids

August 13 (Tuesday) Federation Hall 11:30 a.m. - 1:30 p.m.

5:30 p.m. - 7:00 p.m.

Poster Session P6		Structural Elucidation of Natural Heterocycles
P6-169	Atta-ur-Rahman, University of Karachi, Pakistan
	Some Recent Isolation, Structural and Synthetic Studies on the Constituents of Indigenous Medicinal Plants
P6-170	K.A.Woode, Hampton University, VA, USA
	X-ray Crystallographic Studies of Heterocycles from Medicinal Plants
P6-171	P.Bhattacharyya, Bose Institute, Calcutta, India
	Structures of Two New Carbazole Alkaloids, Glycosal and Clausenapol of Rutaceae
P6-172	T.M. Schultz, M.R. Chedekel and K. Subbarao, Clairol Research Laboratories, Stamford, CT, USA
	¹³C-NMR Spectroscopy of Phaeomelanins
P6-173	T.M. Schultz, B.P. Murphy, M.R. Chedekel, and K. Subbarao, Clairol Research Laboratories, Stamford, CT, USA
	Structure Elucidation of 5,6-Dihydroxyindole Eumelanin
P6-174	Y. Nakamura and T. Tashiro, Josai University, Saitama, Japan
	A New Chemical Approach to Double Strand-Cleavage of DNA. Synthesis and Reactivity of Psoralen-EDTA-Fe"

August 13 (Tuesday) Federation Hall 11:30 a.m. - 1:30 p.m.

5:30 p.m. - 7:00 p.m.

	Poster Session P7		Synthesis of Naturally Occurring Heterocycles
P7-175		J. Balint, M. Szarvas, R. Bognar, and M. Rakosi, BIOGAL Pharmaceutical Works, Debrecen, Hungary
		New Methods for the Process of Hydrochloric Salts in Heterocyclic Compounds
P7-176		H.A. Bates, S. Rosenblum, and L. Smilowitz, State University of New York at Stony Brook, NY, USA
		A Novel Stereospecific Approach to the Synthesis of Biotin
P7-177		A. MacEachern, P. Morand, J.T. Arnason, J. Kaminski, L.C. Leitch, and B. Philogène, University of Ottawa, Canada
		Synthesis and Biological Activity of a Heterocyclic Plant Phototoxin
P7-178		K. Drauz, Degussa Wolfgang, Hanau, Germany
		A New Synthesis of L-Proline, Starting from L-Pyroglutamic Acid
P7-179		D.S. Grierson, J.-C. Quirion, and H.-P. Husson, Institut de Chimie des Substances Naturelles C.N.R.S., Gif sur Yvette, France
		Towards a General Approach to Piperidine Alkaloid Synthesis
P7-180		M.P. Sibi, S. Chattopadhyay, J.W. Dankwardt, and V. Snieckus, University of Waterloo, Canada
		Combinational O-Aryl Carbamate and Benzamide Directed Ortho Metalation Reactions. Synthesis of Ochratoxin A and Ochratoxin B'
P7-181		Y. Sakito and G. Suzukamo, Sumitomo Chemical Co. Ltd., Osaka, Japan
		Asymmetric Synthesis of a Chroman Derivative (Vitamin E Precursor)
P7-182		P.R. Iyer, C.S.R. Iyer, and K.S.R. Mohan Rao, Indian Institute of Technology, Bombay, India
		Synthesis of Alpinum Isoflavone, 4'-O-Methyl Alpinum Isoflavone and Their Angular Isomers
P7-183		G.N. Patel and K.N. Trivedi, University of Baroda, India
		Synthesis of Naturally Occurring Xanthones and Furanoxanthones
P7-184		M. Watanabe, M. Iwao, and S. Furukawa, Nagasaki University, Japan
		Regiospecific Total Synthesis of Bostrycoidin via Directed Lithiation of Tertiary Nicotinamide
P7-185		P.D. Cook, Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, MI, USA
		Synthesis of Thioanhydroimidazole Nucleosides and Their Conversion to Imidazole Deoxynucleosides and Deoxysugars
P7-186		J. Kjellberg, N.G. Johansson, and J. Kobe, Royal Institute of Technology, Stockholm, Sweden
		Regioselective Alkylation of Guanine via Diacyloxy-Glyoxal-N²-Acetylguanine Adduct to obtain 7-Alkylguanine Derivatives
P7-187		S. Kovacs-Gheczy, K. Eklind, C.-E. Hagberg, N.G. Johansson, and B Lindborg, Astra Läkemedel AB, Sweden
		The Synthesis and Antiviral Activity of HBG, DHBG, and THBG
P7-188		K. Tanaka, M. Kawase, T. Kimachi, and F. Yoneda, Kyoto University, Japan
		Studies Directed Toward the Total Synthesis of Coenzyme Factor 420 (5 Deazaflavin Cofactor)
P7-189		K. Matsumoto, S. Hashimoto, Y. Okamato, and H.S. Lee, Kyoto University, Japan
		Cycloaddition Reactions of Furan with Strained Compounds
P7-190		L.M.Fuentes, Merck Sharp & Dohme, Rahway, NJ, USA
		Enantioselective Synthesis of 1-β-Methyl Carbapenem Antibiotics Intermediates
P7-191		Y.S. Mohammed and F.F. Abdel-Latif, El-Minia University, Egypt
		Penicillium Metabolites, Synthesis of Viridicatin and Viridicatol Analogues
P7-192		H. Ishibashi, K. Sato, M. Ikeda, H. Maeda, and Y. Tamura, Kyoto Pharmaceutical University, Japan
		One-Step Synthesis of Erythrinane Skeleton
P7-193		H. Tanaka, Y. Takamura, K. Ito, K. Ohira, and M. Shibata, Meijo University, Nagoya, Japan
		Synthesis of (+) Dysazecine
P7-194		K. Ito, M. Shibata, and H. Tanaka, Meijo University, Nagoya, Japan
		Synthesis of 3-Demethoxyerythratidinone via Formation of a Dibenzazonine Alkaloid
P7-195		T. Sano, R. Yamamoto, J. Toda, K. Isobe, and Y. Tsuda, Showa College, Tokyo, Japan
		Approaches to the Synthesis of β-Erythroidine
P7-196		R.J. Sundberg, J.P. Laurino, B.C. Pearce, and V. Srinivasan, University of Virginia, USA
		Synthesis of Benzo[1,2-b;4,3-b']dipyrroles
P7-197		M. Nakagawa, S. Kato, Y. Yokoyama, and T. Hino, Chiba University, Japan
		Oxidation and Reaction of Indoline and Related Compounds
P7-198		Y. Naruta, N. Nagai, and K. Maruyama, Kyoto University, Japan
		Synthetic Approach Toward Mitomycins
P7-199		J. Bergman and B. Pelcman, Royal Institute of Technology, Stockholm, Sweden
		A New Route to Carbazole Alkaloid

August 14 - Wednesday

PLENARY LECTURES

August 14 (Wednesday) Humanities Theatre, J.G. Hagey Hall (HH)

9:00 a.m.	PL-6	R.M.Kellogg, University of Groningen, The Netherlands
		Macroheterocycles Designed for Catalysis
		(Chairman: P. Deslongchamps)
10:15 a.m.	PL-7	R.J. Stoodley, U.M.I.S.T., Manchester, England
		Synthetic Endeavours Involving β-Lactam Derivatives
		(Chairman: S. Wolfe)

August 15 - Thursday

PLENARY LECTURES

August 15 (Thursday) Humanities Theatre, J.G. Hagey Hall (HH)

8:30a.m.	PL-8	H.W. Gschwend, CIBA-GEIGY, Summit, NJ, USA
		Heterocycles as Building Blocks and Auxiliaries
		(Chairman: P. Beak)
9:45 a.m.	PL-9	A. Padwa, Emory University, Atlanta, GA, USA
		New Applications of Dipolar Cycloaddition Chemistry Toward the Synthesis of Heterocycles
		(Chairman: T.L. Gilchrist)
10:45 a.m.	PL-10	T. Kametani, Hoshi University, Japan, Recipient of 3rd Intemational Award in Heterocyclic Chemistry
		Total Syntheses of Heterocyclic Natural Products by Development of New Methodologies
		(Chairman: S. Schneller)

SPECIAL SYMPOSIA

August 15 (Thursday) Room: PA5 2083 1:30 -5:30 p.m.

Special Symposium S9 Novel Heterocyclic Pharmaceuticals

(M. Ménard, Organizer and Chairman)

1:30 p.m.	S9-48	H. Meyer, Bayer AG, Germany (Invited Lecturer)
		Bioactive Molecules by Cyclising Michael Addition
2:30 p.m.	S9-49	D.E. Bays, Glaxo Ltd., England (Invited Lecturer)
		Heterocycles As Inhibitors of Gastric Acid Secretion
3:30 p.m.	S9-50	S. Goldmann, F. Bossert, M. Schramm and G. Thomas, Bayer AG, Germany (Invited Contributed Paper)
		Synthesis and Pharmacological Activity of Novel 1,3,4,7- Tetrahydrobenzo[c]furanones
4:00 p.m.	S9-51	J.J. Baldwin, W.A. Bolhofer, S.F. Britcher, B.V. Clineschmidt, N.P. Gould, C.N. Habecker, J.M. Hoffman, W.C. Lumma, Jr., R.G. Pendleton, B.T. Phillips, K.M.Strohmaier and M.L.Torchiana, Merck, Sharp & Dohme, PA, USA (Invited Contributed Paper)
		Inhibitors of Gastric Acid Secretion: 3,4-Diaminoisothiazole-1,1-dioxides as Urea Equivalents in a Series of Histamine H₂-Receptor Antagonists
4:30 p.m.	S9-52	K.D. Berlin, M.D. Thompson, E.M. Holt, B.J. Scherlag and C.-Y. Hung, Oklahoma State University, USA (Invited Contributed Paper)
		Selenium Members of 3,7-Diheterabicyclo[3.3.1]nonanes and Derivatives with Anti-arrhythmic Properties
5:00 p.m.	S9-53	G. Fodor, K. Sussangkarn, H. Mathelier and R. Arnold, West Virginia University, USA (Invited Contributed Paper)
		A New Route to Furans with Immunological Activity

August 15 (Thursday) Room: AL 113 1:30 - 5:30 p.m.

Special Symposium S10 Novel Heterocyclic 5tructure and Reactivity

(E.G. Janzen, Organizer and Chairman)

1:30 p.m.	S10-54	A.R. Katritzky, University of Florida, USA (Invited Contributed Paper)
		The Reactivity of Substituents Attached to Heterocyclic Nitrogen Atoms
2:00 p.m.	S10-55	L.D. Quin, Duke University, NC, USA (Invited Contributed Paper)
		Building Complex Phosphorus and Sulfur Heterocycles from Phospholenes and Sulfolenes
2:30 p.m.	S10-56	M.G. Reinecke, Texas Christian University, USA (Invited Contributed Paper)
		Five-Membered Heterocyclic Analogues of Benzyne and Benzcyclopropenone
3:00 p.m.	S10-57	R.T. Oakley, University of Guelph, Canada (Invited Contributed Paper)
		Heterocyclic Thiazenes - Crossing the Inorganic/Organic Frontier
3:30 p.m.	S10-58	T.J. Barton, Iowa State University, USA (Invited Contributed Paper)
		Reactive Intermediates in the Synthesis of Unsaturated Organosilacycles
4:00 p.m.	S10-59	J.F.W. Keana, G.S. Heo, G.T. Gaughan, V.S. Prabhu and S. Ohmiya, University of Oregon, USA (Invited Contributed Paper)
		Synthesis and Applications of Novel Nitroxide Heterocycles
4:30 p.m.	S10-60	A.P. Schaap, B. Giri, E. Palomino, M. Sandison and Y. Takahashi, Wayne State University, MI, USA (Invited Contributed Paper)
		Electron-Transfer Photooxygenation of Epoxides, Cyclopropanes and Aziridines
5:00 p.m.	S10-61	W. Pfleiderer, Universität Konstanz, Germany (Invited Contributed Paper)
		A New Pteridine → Purine Rearrangement

August 15 (Thursday)

Room: Theatre of the Arts, ML 2:30 - 5:30 p.m.

Special Symposium S11 Current Trends in Natural Product Chemistry II

(Biosyn-Struct) (R.H.F. Manske Symposium)

(A. Rodrigo and V. Snieckus, Organizers)

2:30 p.m.	S11-62	I.D. Spenser, McMaster University, Canada (Invited Contributed Paper)
		Biogenetic Hypothesis Versus Biosynthetic Reality: The Origin of the Pyrrolizidine and of the Quinolizidine Alkaloids
3:00 p.m.	S11-63	S.J. Gould, LR. Hillis and Y. Sato, Oregon State University, USA (Invited Contributed Paper)
		The Biosynthesis of the Quinoid Antibiotics Sarubicin A and Kinamycin D
3:30 p.m.	S11-64	R.J. Parry, Rice University, TX, USA (Invited Contributed Paper)
		Recent Investigations of the Biosynthesis of Nitrogen-Containing Natural Products
4:00 p.m.	S11-65	W.A. Ayer, J.D. Figueroa and B. Migaj, University of Alberta, Canada (Invited Contributed Paper)
		Lachnelluloic Acid and Lachnellulone Acid, Antifungal Metabolites of Lachnellula Fuscosanguinea
4:20 p.m.	S11-66	S.W. Pelletier, B.S. Joshi, J. Glinski, H.K. Desai and S.K. Srivastava, John D. Olsen, University of Georgia, USA (Invited Contributed Paper)
		CMR Spectroscopy of Some New C₁₉-Diterpenoid Alkaloids
5:00 p.m.	S11-67	J.P. Kutney, University of British Columbia, Canada (Invited Contributed Paper)
		Studies in Plant Tissue Cultures. Synthesis and Biosynthesis of Biologically Active Heterocyclic Systems

August 15 (Thursday) Room: AL 116 1:30 - 5:30 p.m.

Special Symposium S12 Cycloadditions in Heterocyclic Chemistry

(D. Mackay and M.J. Nye, Organizers)

1:30 p.m.	S12-68	T.L. Gilchrist, University of Liverpool, England (Invited Lecturer)
		The Construction of Heterocycles by Cycloaddition
2:30 p.m.	S12-69	D.L. Boger, A.S. Coleman, S.R. Duff, J.S. Panek, M. Yasuda and D. Yohannes, University of Kansas, USA (Invited Contributed Paper)
		Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes: Scope and Applications
3:00 p.m.	S12-70	A.P. Kozikowski and C.-S. Li, University of Pittsburgh, PA, USA (Invited Contributed Paper)
		The Isoxazoline Route to 1,3-Dienes and Dihydropyranones - A Total Synthesis of Compactin
3:30 p.m.	S12-71	P. DeShong, J.M. Leginus and S.W. Lander, Jr., Pennsylvania State University, USA (Invited Contributed Paper)
		Nitrone Cycloadditions with Vinyl and AllylSilanes. A Stereoselective Approach to the Synthesis of Allylic Amines and Heterocyclic Systems
4:00 p.m.	S12-72	W. Friedrichsen, B.-M. König and T. Debaerdemaeker, Universität Kiel, Germany (Invited Contributed Paper)
		Thermal[π₄ + π₄]Cycloadditions of Bicyclic Mesoionic Imidazo[1,2‑c]Thiazoles with O-Quinoid Compounds
4:30 p.m.	S12-73	S. Evans, J.E. Hayes, S.N. Hirwe, W.L. Hsue, K.J. Lee and E.E. Schweizer, University of Delaware, USA (Invited Contributed Paper)
		Alkenyl and Cumulated Azines as Synthons for a Variety of Fused Pyrazolo Heterocycles
5:00 p.m.	S12-74	S.M. Weinreb, Pennsylvania State University, USA (Invited Contributed Paper)
		Synthetic Methodology Based Upon Diels-Alder Adducts of N-Sulfinyl Dienophiles

GENERAL SESSIONS - ORAL PRESENTATIONS

August 15 (Thursday) Room: AL 124 2:30 -5:30 p.m.

	General Session G7			Synthesis of Simple Heterocycles II
2:30 p.m.		G7-49	H. Ishibashi, M. Okada, M. Ikeda and Y. Tamura (Kyoto Pharmaceutical University, Japan)
			[4⁺+2],and [2⁺+4]Cycloadditions of Thionium Ions: Syntheses of Thiochromans and Vinylcyclopropanes
2:50 p.m.		G7-50	G.V. Boyd and G.A. Nicolaou (Queen Elizabeth College, London, England)
			Old and New Heterocycles from 1-Chloro-1-Dimethylamino-2-Azapropenylium Salts
3:10 p.m.		G7-51	P. Patel and J.A. Joule (University of Manchester, England)
			Lithiation of Pyridones
3:30 p.m.		G7-52	J. Bergman, A. Brynolf and E Vuorinen (Royal Institute of Technology, Stockholm, Sweden)
			Synthesis of Quinazolinones and Quinolinones
3:50 p.m.		G7-53	R. Richter, F.A. Stuber, B. Tucker and E.A. Barsa (Upjohn, North Haven, CT, USA)
			Reactions of Oxalyl Chloride and Alkyloxalyl Chlorides with Heterocumulenes

4:10 p.m.		G7-54	J. Kovác, P. Cepec, M. Kriz (Slovac Technical University, Bratislava, Czechoslovakia)
			New Synthetic Routes to 2-Aminofuran Derivatives
4:30 p.m.		G7-55	K. Vaughan, R.J. LaFrance, H.W. Manning (St. Mary's University, Canada)
			Heterocyclic Synthesis via 1-(o-Acetylphenyl)-3-Alkyltriazenes with Reactive α-Substituents in the Alkyl Group
4:50 p.m.		G7-56	L.M. Codacovi and R.T. LaLonde (SUNY College of Environmental Science and Forestry, Syracuse, NY, USA)
			Polysulfide Conversions of Michael Acceptors to Thiophenes: Studies Directed Toward the Carbon-Sulfur and Carbon-Carbon Bond- Forming Steps
5:10 p.m.		G7-57	G. Stájer, A.E. Szabó, G. Bernáth and P. Sohár (University Medical School, Szeged, Hungary)
			Cycloaddition Reactions and Retrodiene Decomposition of Norbornene- Condensed 1,3-Oxazines

August 15 (Thursday) Room: AL 105 2:30 - 5:30 p.m.

General Session G8			Synthesis of Multiring Heterocycles II
2:30 p.m.	G8-58	R.A. Abramovitch, B. Mavunkel, S. O'Oconnor, J.R. Stowers and M.M. Wegrzyn (Clemson University, SC, USA)
		Azepine Formation by Ring-Expansion of Five-Membered N-Acylimines: Possible Mechanism
2:50 p.m.	G8-59	M.P. Sibi and V. Snieckus (University of Waterloo, Canada)
		A Directed Ortho Metalation Approach Towards Antitumor Anthracyclines Involving Phthalide Intermediates
3:10 p.m.	G8-60	P.W. Groundwater, K.R. Motion, I.R.. Robertson and J.T. Sharp(University of Edinburgh, Scotland)
		Diene-Conjugated 1,3-Dipolar Intermediates: Synthetic and Mechanistic Studies on the Conversion of Nitrile Ylides into Azepines, and Diazo-Compounds into 1,2-Diazepines
3:30 p.m.	G8-61	G.A. Newkome, K.J. Theriot and F.R. Fronczek (Louisiana State University, USA)
		Palladium(II) Assisted Synthesis of 3-Substituted 4-Quinolizones
3:50 p.m.	G8-62	T. Zaima and K. Mitsuhashi (Seikei University, Japan)
		Novel Syntheses of 1,2,3,4-Tetrasubstituted 7-Azanorbornenes and Norbornanes
4:10 p.m.	G8-63	P.A. Brownsort and R.M. Paton (University of Edinburgh, Scotland)
		Intramolecular Reactions of Nitrile Sulphides
4:30 p.m.	G8-64	E. LeGoff, R.A. Berger and O.G. Weaver (Michigan State University, USA)
		The Synthesis and Properties of the Platyrins (Polyazaannulenes)
4:50 p.m.	G8-65	B. Abarca, R. Ballesteros, E. Gomez-Aldaravi, G. Jones and D.J. Mouat (University of Keele, England)
		Triazolopyridines as Synthons for Pyridines, Quinolines and Isoquinolines
5:10 p.m.	G8-66	R.E. Banks and J. Thomson (U.M.I.S.T., Manchester, England)
		Reaction of Pyridinium Methylides with Perfluoroalkylnitriles

August 15 (Thursday) Room: ML 354 2:30 - 5:30 p.m.

General Session G9		Synthesis of Naturally Occurring Heterocycles
2:30 p.m.	G9-67	M. Natsume, I. Utsunomiya and Y. Kitagawa (Research Foundation Itsuu Laboratory, Tokyo, Japan)
		Synthetic Studies on the Aspidosperma and Related Alkaloids
2:50 p.m.	G9-68	R.S. Ward and A. Pelter (University College of Swansea, Wales)
		Some New Approaches to the Synthesis of Lignans
3:10 p.m.	G9-69	N. Katagiri, M. Sato, T. Haneda, N. Yoneda, M. Muto and C. Kaneko (Tohoku University, Japan)
		Synthesis of β-Lactams via Photopyridones
3:30 p.m.	G9-70	R.J. Sundberg, E. Baxter and T. Nishiguchi (University of Virginia, USA)
		The Intramolecular Carbene Addition Route to CC-1065
3:50 p.m.	G9-71	G.J. Koomen, M.J. Wanner, N.P. Willard and U.K. Pandit (University of Amsterdam, The Netherlands)
		Studies in the Synthesis of Sesbanimides
4:10 p.m.	G9-72	P. Lavallee, R. Ruel and M. Bissonnette (University of Sherbrooke, Canada)
		Natural Products Containing Quaternary Gem-Dimethyl Centers: The Elaboration of a Unified and Versatile Strategy
4:30 p.m.	G9-73	T. Naito, T. Kiguchi, C. Hashimoto, Q. Miyata and I. Ninomiya (Kobe Women's College of Pharmacy, Japan)
		The Use of Furan Ring in the Photochemical Synthesis of Alkaloids
4:50 p.m.	G9-74	R.R. Schmidt, M. Maier and B. Haag (Universität Konstanz, Germany)
		3,4-Dihydro-2H-Pyrans As Versatile Intermediates in Heterocycle and Natural Product Syntheses
5:10 p.m.	G9-75	M. Yamauchi, S. Katayama and T. Watanabe (Josai University, Japan)
		Total Synthesis of Fulvic Acid

POSTER SESSIONS

Authors will attend their posters for at least one hour during each of the 11:30 a.m. - 1:30 p.m. and 5:30 p.m. - 7:00 p.m. sessions, as indicated on their poster board. Posters will be mounted any time beginning Wednesday afternoon, but by 11:30 a.m. today at the latest. They may be viewed at any time until they are removed some time after 7:00 p.m.

Building hours are 6:30 to 11:00 p.m. Cash bar.

August 15 (Thursday) Federation Hall 11:30 a.m. - 1:30 p.m.

5:30 p.m. - 7:00 p.m.

Poster Session P8		Synthesis of Simple Heterocycles
P8-200	T. Kaneko, Bristol-Myers Company, Syracuse, NY, USA
	Possible Biomimetic Synthesis of β-Lactams
P8-201	R. Niwa, M. Itoh, Y. Shitori, N. Katagiri, and T. Kato, Kantoishi Pharmaceutical Co., Tokorozawa, Japan
	Cycloaddition of Ketenes with Imines
P8-202	Y. Ohshiro, M. Komatsu, and T. Agawa, Osaka University, Japan
	New Synthesis of Functionalized - β Lactams
P8-203	R.P. Gandhi and M.P. Singh, IIT-Delhi, India
	Regio- and Stereospecificity in Addition Reactions Involving Allenic Esters and Furan: Formation of 7-Oxa-2-Ethoxycarbonyl-3-Alkylidene(Arylidene)-Bicyclo[2.2.1]-Hept-5-Enes
P8-204	J.V. Cooney, B.D. Beaver, and W.E. McEwen, Naval Research Laboratory, Washington, DC, USA
	Synthesis of Pyrroles by Intramolecular Amide-Wittig Condensation
P8-205	T. Zaima, and K. Mitsuhashi, Kanagawa University, Yokohama, Japan
	Novel Synthesis of Substituted Pyrroles
P8-206	G. Szakal-Quin and D.G. Graham, Duke University, Durham, NC, USA
	Stereoisomer Effects on the Paal-Knorr Synthesis of Pyrroles
P8-207	K. Izawa, S. Nishi, and S. Asada, Ajinomoto Co. Kawasaki, Japan
	Synthesis of N-Acyl Cyclic Imino Acid Derivatives by Amidocarbonylation
P8-208	N. De Kimpe, M. Palamareva, P. Sulmon, L. De Buyck, R. Verhe, and N. Schamp, State University of Gent, Belgium
	Rearrangement of a-Chloroketimines Unusual Ring-opening of a Cyclopropylideneamine During a Favorskii-type
P8-209	N. De Kimpe, W. De Cock, R. Verhe, L. de Buyck, and N. Schamp, State University of Gent, Belgium
	Synthesis of Nitrogen Heterocycles from a-Halomethylketimines
P8-210	I. Ikeda, Y. Kogame, and M. Okahara, Osaka University, Japan
	Synthesis of Novel Pyrazoles Containing Perfluoroalkyl Groups by the Reactions of Perfluoro-2-methylpent-2-ene and Hydrazones
P8-211	M.A.J. Miah and V. Snieckus, University of Waterloo, Canada
	Directed Ortho Metalation of O-Pyridyl Carbamates. New Entries into Polysubstituted Pyridines
P8-212	M.J. Sharp and V. Snieckus, University of Waterloo, Canada
	Synthesis of Unsymmetrical Biaryls and Hetero Biaryls by Palladium-Catalyzed Cross Coupling of Directed Metalation-Derived Aryl Boronic Acids with Aryl Halides
P8-213	F.F. Abdel-Latif, A.K.M.N. Gohar and Y.S. Mohammed, EI-Minia University, Egypt
	A New Approach for the Synthesis of Some Dihydropyridine Derivatives
P8-214	E.E. Knaus, S.K. Dubey, and C.-S. Giam, University of Alberta, Canada
	The Regioselective Nucleophilic Addition of Organolithiums to 3-(4,4-Dimethyloxazoline-2-yl)Pyridine. Synthesis of 1,2,-, 1,4- and/or 1,6- Dihydropyridines
P8-215	S.K. Talapatra, D. Basu, T. Deb, S. Goswami, and B. Talapatra, University College of Science, Calcutta, India
	Structure and Absolute Stereochemistry of Four New 5,6-Dihydro-2-Pyrones from Goniothalamus Sesquipedalis and Goniothalamus Grifithii: Synthetic Studies on Goniothalamin
P8-216	M.-J. Shiao and W.-P. Fang, Academia Sinica, Taiwan, China
	Synthesis of 3-Substituted-5(4-Pyridinyl)-2(1H)-Pyridone Compounds
P8-217	A. Attia and O.A El-Fath, National Research Centre, Cairo, Egypt
	New Pyridine Derivatives for Biological Evaluation
P8-218	R.H. Prince, A.M. Coyle, G.J. Will,and P. Wyeth, University of Cambridge, England
	The Zinc-Catalysed Reduction of Heterocyclic Carbonyl Compounds Using an NADH Model: Mechanism and a Comparison with LADH and YADH Enzymic Reductions
P8-219	M. Sarkar and K.K. Mahalanabis, Jadavpur University, Calcutta, India
	Studies on β-Enaminonitriles: Regioselective Acylation of β-Aminocrotononitrile One Pot Synthesis of Highly Substituted Dihydro-2-Pyridones
P8-220	L. Simon, G.S. Talpas, G. Bernáth, and P. Sohár, University Medical School, Szeged, Hungary
	Preparation of Spiro-Oxazolines and Condensed-Skeleton Oxadiazepines from Cyclic Olefins
P8-221	G. Bernáth, J. Kóbor, and F. Fülöp, University Medical School, Szeged, Hungary
	A Simple Efficient Synthesis of a New, Versatile Isoquinoline1,3-Aminoalcohol Synthon
P8-222	K. Grohe, Bayer AG, Leverkusen, Germany
	A New Synthesis of Quinolone-3-Carboxylic Acids
P8-223	R. Lakhan, O.P. Singh, and B.J. Rai, Banaras Hindu University, India
	Novel Synthesis of 5/6-Membered Heterocycles from α-Ketonitriles
P8-224	H. Kristinsson and T. Winkler, CIBA-GEIGY, Basel, Switzerland
	New Synthetic Routes to Five and Six Membered Heterocycles from N-Cyanoazomethines
P8-225	M. Abou-Gharbia, D.M. Ketcha, D.E. Zachonias, and D. Swern, Tempie University, Philadelphia, PA, USA
	Reactions of Ketenes with Sulfilimines. Synthetic Routes to Oxazolinones and Indolinones
P8-226	M.A. Hassan, A.G. El-Shekeil, A. Babaqi, and S.A. Sheba, Sana's University, Yemen
	Some Addition Reactions with 3-(5-Chloro-1,3-diphenyl-1H-pyrazol-4-yl)-1-aryl-prop-2-en-3-ones
P8-227	M. El-Borai, M.A. Hassan, and M.M. Mohamed, Ain Shams and Tanta Universities, Egypt
	Synthesis of Some Substituted N-Methylimidazole Derivatives
P8-228	A. Khalaj and M. Ghaffari, Tehran University, Iran
	Synthesis of Imidazoles and Their Uses in Peptide Analysis
P8-229	M. Yoshizumi, K. Isomura, and H. Taniguchi, Kyushu University, Fukuoka, Japan
	Versatile Synthesis of Symmetrical and Asymmetrical 2,5-Diarylpyrazines
P8-230	A. Ohta, A Inoue, M. Ohta, and T. Watanabe, Tokyo College of Pharmacy, Japan
	Cross-Coupling Reaction of Chloropyrazines with Alkylmetals
P8-231	P.J. Warwick, A. Shaw, and M.J. Chapdelaine, Stuart Pharmaceuticals, Wilmington, DE, USA
	An Efficient Method for Preparation of 3,5-Diamino-6-Chloro-Pyrazinyl Alkyl Ketones
P8-232	H. Cho, M. Ueda, Y. Ohnaka, and M. Hayashimatsu, Suntory Institute for Biomedical Research, Osaka, Japan
	Synthesis of Novel 5-Alkoxycarbonyl-5,6-Dihydropyrimidin-4(3H)-ones
P8-233	T.J. Kress, Eli Lilly, Indianapolis, IN, USA
	Synthesis of Pyrimidine-N-Oxides and 4-Pyrimidones. Evidence for Covalent Hydrates as Reaction Intermediates
P8-234	T. Tsuchiya, H. Sawanishi, and M. Osada, Hokuriku University, Kanazawa, Japan
	Synthesis and Reactions of Monocyclic 1,3-Diazepines
P8-235	H. Sawanishi, K. Tajima, J. Kurita, and T. Tsuchiya, Hokuriku University, Kanazawa, Japan
	Synthesis and Reactions of Monocyclic 1,4-Diazepines
P8-236	L. Pongó, J. Reiter, and P. Dvortsák, Egis Pharmaceuticals, Budapest, Hungary
	Isothiocyanates
P8-237	G. Kollenz and R. Theuer, University of Graz, Austria
	Diaza-Propellanes via Fischer-Indolization - Scope and Limitations
P8-238	V.L. Garcia and E.J. Barreiro, Universidade Federal do Rio de Janeiro, Brazil
	Diastereoisomeric Selection in the Oxidative Cyclization of 2-Carboethoxy-2- Allylcyclopentanol
P8-239	T. Schurreit and J. Dusemund, Freie Universität Berlin, Germany
	Acid and Base Catalyzed Reactions of 2-Amino-4-Oxo-4H-[1]Benzopyran-3- Carbaldehyde with Sulfamide
P8-240	O.H. Hishmat, Kh.M.A. Khalil, A.H.A El-Rahman, and Sh.I. El-Naem, Mansoura University, Egypt
	Ring Opening of Benzopyrans and Benzodipyrans with Hydrazines
P8-241	O.H. Hishmat, Kh.M.A. Khalil, A.H.A El-Rahman, and Sh.I. El-Naem, Mansoura University, Egypt
	Synthesis of Benzodipyrans
P8-242	M. Mumtaz and V. Snieckus, University of Waterloo, Canada
	New Heterocyclic Ring Construction Using Dimetalated Heteroatom-containing Diamides
P8-243	H. Suginome and S. Yamada, Hokkaido University, Sapporo, Japan
	Replacement of a Carbonyl Group of Cyclic Ketones by a Hetero Atom: A New Method for the Synthesis of Cyclic Ethers, Cyclic Amines, and Cyclic Sulphides
P8-244	H. Yoshida, T. Ogata, and K. Matsumoto, Kyoto University, Japan
	Formation of Heterocycles via Cyclopropenium Salts
P8-245	H. Feuer and X. Lou, South-Central Institute, Hubei, China
	Preparation and Alkyl Nitrate Nitration of 2-tert-Alkyl-(alkaryl)-2-oxazolines
P8-246	M.J. Haddadin, R. Artinian, and C.H. Issidorides, American University of Beirut, Lebanon
	Reactions of Some Substituted Quinoxaline 1,4-Dioxides
P8-247	A.F.M. Fahmy, N.F. Aly, S.A. Essawy, and N.Y. Aly, Ain Shams University, Cairo, Egypt
	Synthesis and Mass Spectra of 5,8,9,10-Tetrahydrophthalazine-1,4-diones
P8-248	F.D. Bellamy, P. Renaut, and D. Thomas, Laboratoires Fournier, France
	Synthesis of N(2)-Alkylated 1,2,4-Oxadiazolidine-3,5-Diones Through an Improved Access to the Parent Heterocycle
P8-249	H.-J. Tien and M.-Y.Yeh, National Cheng Kung University, Taiwan, China
	Synthesis of 3-Aryl-4-Sydnonecarbonitrile Oxides and Their Derivatives
P8-250	M. El Borai, University of Tanta, Egypt
	Reaction of o-Thiophenedicarboxaldehyde and Thiol with Primary Amines. A New Fluorogenic Reagent for Detection of Amino Compounds
P8-251	E.G. Doadt and V. Snieckus, University of Waterloo, Canada
	Regioselective Synthesis of Polysubstituted Thiophenes via Lithiations of Thiophene-2-Carboxamide
P8-252	V.K.Verma, M. Ramzan Ali and R. Singh, Banaras Hindu University, India
	Oxidative Debenzylation and Cyclisation as a Route to the Synthesis of 5-(N-Cyclohexylidenehydrazono)-3-Arylimino-1,2,4-Dithiazolidines
P8-253	W.J. Houlihan and V.A. Parrino, Sandoz, East Hanover, NJ, USA
	Synthesis of 2-R-3-Arylbenzo[b]Thiopenes from 2-Methyl-3-Aryl-1,2-Benzothiazolines-1,1-Dioxides
P8-254	J.J. D'Amico, R.W. Fuhrhop, F.G. Bollinger, and W.E. Dahl, Monsanto, St. Louis, MO, USA
	Synthesis of Heterocyclic Compounds from o-Aminobenzenethiol and Ammonium Thiolcarbamate
P8-255	C.S. Rooney, B.K. Wasson, and J. Scheigetz, Merck Sharp & Dohme, West Point, PA,USA
	Formation and Stability of N-Acyl Derivatives of 3-(2-Hydroxyethytamino)-4- Substituted-1,2,5-Thiadiazole Derivatives
P8-256	A. Shafiee, M. Anaraki, and A. Bazzaz, Tehran University, Iran
	Synthesis of 5-Thiazolyl-1,2,3-Selenadiazoles and 5-Selenazolyl-1,2,3-Selenadiazoles. Selenium Heterocycles XXXVII
P8-257	K. Sunitha and K.K. Balasubramanian, Indian Institute of Technology, Madras, India
	A New Route to the Synthesis of 3-Substituted Coumarins via Sequential Pericyclic Transformations of α-Aryloxymethylacrylic Acids and Enophiles
P8-258	M.A. Metwally, F.A. Amer, and E.E.M. Kandel, University) of Mansoura, Egypt
	Synthesis of Some Ferrocenyl Pyrimidobenzimidazole, Triazolopyrimidine, Pyrazolopyridine and Pyrimidine as Antimicrobial Agents
P8-259	J.K. Luo, T.Y. Liu, C.L. Chung, and S.W. Schneller, Soochow University, Taiwan, China
	Synthesis of 4-Amino-1 H-Pyrrolo[2,3-b]pyridine-3-carbonitrile (3-deazatoyo-camyein aglycon)
P8-260	J.E. Toomey, Jr., G.A. Chaney, M. Wilcox, and D. Goss, Reilly Tar, Indianapolis, IN, USA
	Filter-Press Cell Design for Electroorganic Processing
P8-261	J.E. Toomey, Jr., G.A. Chaney, M. Wilcox, and D. Goss, Reilly Tar, Indianapolis, IN, USA
	Electroorganic Processing: Anodic Oxidation of 2-Picoline

August 15 (Thursday) Federation Hall 11:30 a.m. - 1:30 p.m.

5:30 p.m. - 7:00 p.m.

Poster Session P9		Novel Heterocyclic Pharmaceuticals
P9-262	L.W. Dudycz and G.E. Wright, University of Massachusetts Medical Centre, Worcester, MA, USA
	N²-(p-n-Butylphenyl)Guanine Isosteres as Mammalian DNA Polymerase-Specific Inhibitors and as Cytotoxic Agents
P9-263	J.-W. Chern, D.S. Wise, Jr., and L.B. Townsend, University of Michigan, MI, USA
	An Efficient Procedure for the Synthesis of a Potent Purine Nucleoside Phosphorylase Inhibitor: 8-Amino-9-Benzylguanine
P9-264	M.E. Rodriguez, J.-W. Chern, and L.B. Townsend, University of Michigan, MI, USA
	Synthesis of a Potential Purine Nucleoside Phosphorylase Inhibitor: 8-Amino-9-(β-D-Arabinofuranosyl)Guanine
P9-265	C.K. Chu, S.J. Cutler, and J.J. Suh, University of Georgia, USA
	Acyclopyrimidine C-Nucleosides: Synthesis of 5-(2,3-Dihydroxy-1-Propoxymethyl) Pyrimidines
P9-266	M. MacCoss, R.L. Tolman, J. Hannah, A.F. Wagner, and W.T. Ashton, Merck, Sharp& Dohme, Rahway, NJ, USA
	The Use of 2-Amino-6-Benzyloxypurine as a Synthon in the Preparation of Guanine- Containing Acyclonucleosides
P9-267	P.D. Cook, Warner-Lambert/Parke-Davis, Ann Arbor, MI, USA
	Synthesis of 8-Substituted 3-Deazaguanines and 3-Deazaguanosines via Imidazole Precursors
P9-268	P.K. Bridson, Memphis State University, TN, USA
	Synthesis of Imidazo[4,5-e]-1,4-Diazepine Nucleosides
P9-269	P.K. Gupta, G.R. Revankar, and R.K. Robins, Brigham Young University, Provo, UT USA
	Synthesis of Certain Substituted Imidazo[4,5-c]pyridine and Pyrazolo[4,3-c]pyridine Nucleosides Related to 3-Deazaguanosine
P9-270	K.G. Upadhya, B.G. Ugarkar, G.R. Revankar, and R.K. Robins, Brigham Young University, Provo, UT, USA
	Synthesis of 5-Substituted Derivatives of Formycin and Formycin B
P9-271	A. Monge, J.A. Palop, T. Goni, A Martinez, and E. Fernandez-Alvarez, Universidad de Navarra, Spain
	Synthesis of [1,2]Diazepino Indole Derivatives
P9-272	A. Monge, V. Martinez, and E. Fernandez-Alvarez, Universidad de Navarra, Spain
	Synthesis of 2-Substituted 3-Oxo-isothiazolo[5,4-b]pyridines
P9-273	T. Sugasawa, M. Adachi, K. Sasakura, A Matsushita, and M. Eigyo, Shionogi and Co., Osaka, Japan
	1-Azacycloalkyl-1,4-Benzod iazepi n-2-Ones with Antianxiety-Antidepressant Actions
P9-274	S.-i. Kodato, H. Wada, S. Saito, and H. Tamaki, Tanabe Seiyaku Co. Ltd., Saitama, Japan
	Synthesis of Novel Pyridotriazepinones as Antisecretory Agents
P9-275	F.M. Abdel-Galil, G.E.H. Elgemeie, S.M. Sherif, and M.H. Elnagdi, Cairo University, Egypt
	A Novel Synthesis of 4-H-Thiopyrans: Unexpected Products of Reaction of Cyanothioacetamide with Cinnamonitrile Derivatives
P9-276	H.J. Shue, M.J. Green, A.K. Saksena, W. Kreutner, and A.T. MePhail, Sehering-Plough, Bloomfield, NJ, USA
	Synthesis of Novel Forskolin Analogs and Tetrahydropyran Ring Contracted Rearrangement Products
P9-277	K. Steinbeck and J. Klein, RWTH Aachen, Germany
	The Reactivity of CH-Bonds in Substituted 1,3-Dioxans Towards Dichlorocarbene
P9-278	M.P. Hutt and J.P. Sanchez, Warner-Lambert/Parke-Davis, Ann Arbor, MI, USA
	Thiomorpholine and Thiazolidine Analogs of Enoxacin and Norfoxacin
P9-279	R.R. Wexler, D.J. Carini, W.A. Price, Jr., and J.G. Whitney, Du Pont, Wilmington, DL, USA
	Synthesis and Antihypertensive Activity of a Novel Series of Diaryl and Alkyl- Arylimidazoles, Thiazoles and Oxazoles
P9-280	H.O. Hankovszky, K. Hideg, I. Bódi, and L. Frank, University of Pécs, Hungary
	2,2,5,5-Tetramethyl-Δ³-Pyrroline-3-Carboxamides. A New Class of Antiarrhythmic Agents
P9-281	C. Kashima and Y. Ornate, University of Tsukuba, Ibaraki, Japan
	Reactivities of 2,5-Dimethylpyrroleacetic Acid and Their Derivatives
P9-282	P.K. Kadaba, University of Kentucky, USA
	1,2,3-Triazolines and Triazoles: Novel Anticonvulsants
P9-283	A. Kreutzberger, U. Rose, and K. Kolter, Universität Mainz, Germany
	Dehydro-C-Mannich-Bases and (Dihexylamino)-s-Triazines as Agents Against Protozoic Infections
P9-284	H. Singh, M.R. Yadav, and D. Paul, Panjab University, India
	Steroidal [3,4-c]-1',2',5'-Oxadiazoles as Potential Bioactive Molecules
P9-285	G. Dannhardt and L. Steindl, University of Regensburg, Germany
	Antiinflammatory 6,7-Diaryl-2,3-Dihydro-1H-Pyrrolizines
P9-286	J.C.S. Gonçalves, M.T.L. Lima, and A.C.C. Freitas, Universidad do Rio de Janeiro, Brazil
	New Antiinflammatory Agents from the Arylalkanoic Class
P9-287	N. Kakimoto, M. Akiba, and T. Takada, Tokyo College of Pharmacy, Japan
	Synthesis of Biologically Active Organogermanium Compounds
P9-288	R.R. Gupta and R. Kumar, University of Rajasthan, India
	Synthesis of 2-Amino-3-fluorobenzenethiol and its Conversion into Different Biologically Active Heterocycles
P9-289	L-Y. Hsu and K.-C. Liu, National Defense Medical Center, Taiwan, China
	Synthesis and Biological Evaluation of Some Thiazo- and 1,3-Thiazino[2,3-b]- Quinazoline Derivatives
P9-290	A. Nishida, T. Kasaka, M. Shibasaki, and S. Ikegami, Teikyo University, Kanagawa, Japan
	An Efficient Synthesis of Chiral Intermediates by Asymmetric Thiol Addition and Application to the Synthesis of SQ27860 Ester
P9-291	Y. Ueda and V. Vinet, Bristol-Myers, Ouebec, Canada
	Synthesis of New Carbapenem Antibiotics
P9-292	M.F. Harper, J.O. Morley, P.N. Preston, and S.M. Waddell, Heriot-Watt University, Edinburgh, Scotland
	Heterocycles in Anthracyclinone Analogue Synthesis
P9-293	J.N. Reed and V. Snieckus, Memorial University of Newfoundland, Canada
	Synthesis of Acridones and the Antibiotic Anthramycin via Amination of Ortho-Lithiated Benzene Derivatives

August 16 - Friday

PLENARY LECTURES

August 16 (Friday) Humanities Theatre, J.G. Hagey Hall (HH)

9:15 a.m.	PL-11	E. Vogel, Universität Köln,Germany
		The Heterocyclic Dimension of Bridged Annulene Chemistry
		(Chairman: N.J. Leonard)
10:30 a.m.	PL-12	L.E. Overman, University of California, Irvine, CA, USA
		New Strategies for Stereocontrolled Total Synthesis of Heterocyclic Natural Products
		(Chairman: D. Enders)

CLOSING CEREMONIES

11:30 a.m. Humanities Theatre, J.G. Hagey Hall