Scientific Programs

 

Plenary Lectures, Award Address, and Honorary Invited Lecture

 

Room A

 

August 22 (Mon)                                                                                               9:00-11:15

PL-1

Chemistry of N-Oxides:  Further Developments

 

9:00

P. Potier (ICSN, CNRS, France)

1

 

Chairman H. Rapoport (M. Hamana)

 

PL-2

Development of Microbial Secondary Metabolites with Potential Usefulness

 

10:15

H. Umezawa (Inst. Microbial Chem., Japan)

2

 

Chairman P. Potier (Y. Ban)

 

 

August 23 (Tue)                                                                                                9:00-11:15

PL-3

New Approaches to the Synthesis of Carbohydrates

 

9:00

T. Mukaiyama (Univ. Tokyo, Japan)

 3

 

Chairman A. I. Meyers (Y. Tamura)

 

PL-4

Probing Receptors with Natural and Synthetic Alkaloids

 

10:15

A. Brossi (NIH, USA)

4

 

Chairman E. Wenkert (M. Hori)

 

 

August 24 (Wed)                                                                                               9:00-11:15

PL-5

Synthesis of Unusual Molecules by Flash Vacuum Pyrolysis of Heterocyclic Compounds

 

9:00

C. Wentrup (Univ. Marburg, W. Gerrnany)

 5

 

Chairman A. Neunhoffer (T. Sasaki)

 

PL-6

The Synthesis and Properties of Polycyclic Aromatic Thiophenes and Related Heterocycles Occurring in Coal-Derived Products (Award Address)

 

10:15

R. N. Castle (Univ. South Florida, USA)

 6

 

Chairman W. Pfleiderer (Y. Mizuno)

 

 

August 25 (Thu)                                                                                                9:00-11:15

PL-7

New Directions in Heterocyclic Synthesis Using Metalated Amides

 

9:00

V. Snieckus (Univ. Waterloo, Canada)

 7

 

Chairman S. W. Schneller (N. Inamoto)

 

PL-8

Six-Membered Zwitterionic Malonyl heterocycles

 

10:15

T. Kappe (Univ. Graz, Austria)

 8

 

Chairman H. Junek (T. Kato)

 

 

 

August 26 (Fri)                                                                                                  9:00-12:30

PL-9

Chemical and Biological Reactions of Reduced Pterins

 

9:00

W. L. F. Armarego (Australian Nat. Univ., Australia)

 9

 

Chairman L. B. Townsend (F. Yoneda)

 

PL-10

Alkylation of N-Heterocycles via Their α-Amino Carbanion

 

10:15

A. I. Meyers (Colorado State Univ., USA)

  10

 

Chairman H. Wasserman (S. Sakai)

 

H. Inv

Some Recent Progress in Natural Product Chemistry

 

11:30

D. H. R. Barton and W. B. Motherweil (ICSN, CNRS, France)

  11

 

Chairman T. Kametani (H. Yamanaka)

 

 

Session Programs

 

August 22 (Mon) Room A

Symposium V. Heterocycles in Anticancer and Antiviral Research (1)

Chairman J. A. Montgomery (Y Hashimoto)                                                        12:45-14:15

S. Inv-17    Synthesis and Ring A Conformations of New Anthracyclines (Special Invited Lecture)

 

12:45

S. Penco, F. Angelucci, M. Ballabio, G. Barchielli, A. Suarato, E. Vanotti, A. Vigevani, and F. Arcamone (Farmitalia, Ricerca Chimica, Italy)

  13

S-V-1

Condensed Pyrazoles. Synthesis of Pyrazolo[3,4-d]pyrimidin-4-ones and Pyrazolo[3,4-b] quinolin-4-amines

 

13:15

E.B. Pedersen, S.V. Nielsen, and P. Finlander (Odense Univ., Denmark)

  14

S-V-2

A Synthetic Method for Pyrrolo[1,4]benzodiazepine Antitumor Antibiotics

 

13:30

T. Kaneko, H. Wong, and T.W. Doyle (Bristol-Myers Co., Ltd., USA)

  15

S-V-3

1,3-Dienamines Reacting as 1,5-Dipoles in the Synthesis of N-Heterocycles

 

13:45

D.N. Reinhoudt, G.W. Visser, and W. Verboom (Twente Univ. Tech., Netherlands)

  16

S-V-4

Antitumor Activity of Acodazole and Related Anilinoimidazo[4,5-f]quinolines

 

14:00

F.F. Ebetino (Norwich Eaton Pharm., Inc., USA)

  17

 

Chairman F. F. Ebetino (N. Katagiri)                                                                   14:45-16:15

S-V-5

Interaction of 2-Aminodipyrido[1,2-a:3',2',d]imidazole with DNA. I. Structure of the Modified Nucleic Acid Base and Initial Chemical Event Caused by the Mutagen

 

14:45

Y. Hashimoto, K. Shudo, and T. Okamoto (Univ. Tokyo, Japan)

  18

S-V-6

Interaction of 2-Aminodipyrido[1,2-a:3',2'-d]imidazole with DNA. I. Synthesis of New Intercalative Analogs

 

15:00

C.-S. Lee, T. Ohta, Y. Hashimoto, K. Shudo, and T. Okamoto (Univ. Tokyo, Japan)

  19

S-V-7

Synthesis of Dihydro Diols as Potential Proximate Carcinogens of Benzo[c]acridines

 

15:15

J.K. Ray, G.K. Kar, and B.G. Chatterjee (Indian Inst. Tech., India)

  20

S-V-8

Bond Alternation and Mutagenicity of Azulenoquinolines and Diazulenopyridines

 

15:30

T. Morita, Y. Takizawa, S. Okita, K. Takase, A. Tajiri, K. Wakabayashi, and T. Sugimura (Tohoku Univ. and Nat. Cancer Center Res. Inst., Japan)

  21

S. Inv-18

Novel Ring Transformation Reactions and Their Application to the Syntheses of Potential Anticancer Heterocyclic Compounds (Special Invited Lecture)

 

15:45

K. A. Watanabe and T.-L. Su (Sloan-Kettering Inst., USA)

  22

 

Chairman K. A. Watanabe (K. Senga)                                                                16:30-18:00

S-V-9

Synthesis of Potential Anti-Cancer Agents

 

16:30

N.N. Singh, B. Singh, G.P. Singh, and P.N. Singh (Patna Univ., India)

  23

S-V-10

Synthesis and Antitumor Activity of N1-(4-Fluorobenzoyl)-3,5-diphenyl-4-sulfamoyl-phenylazo)-1,2-diazoles

 

16:45

C.P. Singh and Km. A. Chauhan (Sahu Jain Coll., India)

  24

S-V-11

Design, Synthesis, and Potent Chemotherapeutic Activity of Certain Azole Nucleosides

 

17:00

P.C. Srivastava, S.G. Harris, G.R. Revankar, and R.K. Robins (Brigham Young Univ., USA)

  25

S-V-12

Computer-Assisted Structure Antiturnor Activity Analysis of Purines, Purine Nucleosides and Their Aza and Deaza Analogs

 

17.15

M. Nasr, K.D. Paull, and V.L. Narayanan (Starks C.P., Inc. and NIH, USA)

  26

S. Inv-19

Purines, Pyrimidines, Pteridines, and Cancer (Special Invited Lecture)

 

17:30

J.A. Montgomery (Southern Res. Inst., USA)

  27

 

August 22 (Mon) Room B

 

Symposium III. Synthesis of Natural Heterocycles (1)

Chairman W N. Speckarnp (C. Kaneko)                                                             12:45-14:15

S-III-1

Heterocyclic Systems via Functionally Substituted Vinyl Carbanions

 

12:45

R.R. Schmidt, R. Betz, O. Miyata, and J. Kast (Univ. Konstanz, W. Germany)

  28

S-III-2

Studies in the Synthesis of Lorostemin and Related Pyranoxanthones

 

13:00

C.S. Rukmani Iyer and P.R. Iyer (Indian Inst. Tech. Bombay, India)

  29

S. Inv-9

Synthesis of Bioactive Natural Heterocycles with Polyfunctional Groups (Special Invited Lecture)

 

13:15

T. Goto and S. Nakatsuka (Nagoya Univ., Japan)

  30

S-III-3

Alkaloid Synthesis through Electron Transfer Mediated Cyclisation of o-Halogenated N-Acylbenzylamines

 

13:45

S.V. Kessar, P. Singh, R. Kaur, and P. Singla (Panjab Univ., India)

  31

S-III-4

Synthetic Approach toward Naphthyridinomycin

 

14:00

T. Fukuyama, R.K. Frank, A.A. Laird, and G.A. Krudy (Rice Univ., USA)

  32

 

Chairman A. S. Kende (S. Nakatsuka)                                                                14:45-16:15

S. Inv-10

Heterocyclic Diels-Alder Reactions for the Synthesis of Natural Products (Special Invited Lecture)

 

14:45

S. M. Weinreb (Pennsylvania State Univ., USA)

  33

S-III-5

Synthesis of Nitrogen-containing Polycycles Based upon New Generation of o-Quinone Methide Imine

 

15:15

Y. Ito, E. Nakajo, M. Nakatsuka, and T. Saegusa (Kyoto Univ., Japan)

  34

S-III-6

Synthesis of (±)-Lasubine-I and (±)-Subcosine-II

 

15:30

H. Iida, M. Tanaka, and C. Kibayashi (Tokyo Coll. Pharm., Japan)

  35

S-III-7

Synthetic Studies on Necine Bases of Pyrrolizidine Alkaloids

 

15:45

H. Niwa, A. Kuroda, Y. Uosaki, and K. Yamada (Nagoya Univ., Japan)

  36

S-III-8

A Novel Cyclization for the Synthesis of Nitrogen-containing Heterocycles: The Synthesis of (±)-Heliotridane, (±)-Nuphar Indolizidine, and (±)-Dihydrodeoxyotonecine

 

16:00

T. Ohnuma, K. Shiiya, M. Tabe, M. Nagasaki, and Y. Ban (Hokkaido Univ., Japan)

  37

 

Chairman S. M. Weinreb (C. Kibayashi)                                                             16:30-18:00

S-III-9

A Stereoselective Synthesis of the Compound Having Palustrine Structure

 

16:30

M. Ogawa, I. Yoda, M. Natsume, and M. Shiro (Itsuu Lab. and Shionogi & Co., Ltd., Japan)

  38

S-III-10

Synthesis of Quinazolinocarboline Alkaloids

 

16:45

J. Bergman (Royal Inst. Tech., Sweden)

  39

S. Inv-11

New Tactics in Heterocyclic Synthesis (Special Invited Lecture)

 

17:00

A.S. Kende (Univ. Rochester, USA)

  40

S-III-11

Alkaloid Syntheses Using Photochemical Reactions

 

17:30

C. Kaneko, T. Naito, C. Miwa, and T. Ohashi (Kanazawa Univ., Japan)

  41

S-III-12

Total Synthesis of (+)- and (-)- Tryptoquivaline G and L by Biomimetic Double Cyclization

 

17:45

M. Nakagawa, M. Taniguchi, M. Sodeoka, M. Ito, K. Yamaguchi, and T. Hino (Chiba Univ., Japan)

  42

 

August 22 (Mon) Room C

 

Symposium II. Heterocycles with Novel Functions (1)

Chairman D. N. Reinhoudt (E. Kimura)                                                               12:45-15:30

S. Inv-5

Macropolycyclic Compounds as Host Molecules (Special Invited Lecture)

 

12:45

I. O. Sutherland (Univ. Liverpool, UK)

  43

S-II-1

Crown Ethers of Low Symmetry. 14- to 17-Crown 5 and 17- to 22-Crown-6

 

13:15

M. Ouchi, Y. Inoue, and T. Hakushi (Himeji Inst. Tech., Japan)

  44

S-II-2

Synergistic Solvent Extraction of Crown Ether Complexes with Alkali Metal Picrates by Neutral Donor Solvents

 

13:30

Y. Takeda (Chiba Univ., Japan)

  45

S-II-3

Metal Ion Uptake and Release with 2,2'-Bipyridine Derivatives by pH Switching

 

13:45

S. Shiraishi, N. Kishii, and K. Araki (Univ. Tokyo, Japan)

  46

S-II-4

Active Transport of Alkali Metal Cations Using Crown Ethers Having an Amino Group

 

14:00

Y. Nakatsuji and M. Okahara (Osaka Univ., Japan)

  47

S-II-5

Thiol-bearing Crown Ethers as Enzyme Models for the Synthesis of Peptides

 

14:45

S. Sasaki, M. Shionoya, and K. Koga (Univ. Tokyo, Japan)

  48

S-II-6

Is  3-Methyl[15]annulenone-Hydroxy-3-methyl[15]annulenylium Ion Cycle Mimic to Bacteriorhodopsin Cycle?

 

15:00

H. Ogawa, M. Kuribayashi, H. Morita, T. Imoto, I. Miyamoto, H. Kato, and Y. Taniguchi(Kyushu Univ. and Kurume Tech. Coll., Japan)

  49

S-II-7

18<(2,6)Pyridino6coronand-6>:  "Sexipyridine"

 

15:15

G.R. Newkome and H.-W. Lee (Louisiana State Univ., USA)

  50

 

Chairman G. R. Newkome (M. Hirobe)                                                               15:30-17:30

S. Inv-6

Metal Porphyrin Complexes with Novel Functions (Special Invited Lecture)

 

15:30

Z. Yoshida (Kyoto Univ., Japan)

  51

S-II-8

Asymmetric Charge Distribution in Metallochlorins

 

16:00

A. Ulman (Weizmann Inst. Sci., Israel)

  52

S-II-9

Picket-gable Porphyrin as a New Hb Model

 

16:30

I. Tabushi, T. Sasaki, and T. Kondo (Kyoto Univ., Japan)

  53

S-II-10

Electron-Deficient Porphyrins. 1. Perfluoroalkylporphyrins

 

16:45

H. Ogoshi, M. Homma, Y. Aoyama, and K. Aoyagi (Tech. Univ. Nagaoka, Japan)

  54

S-Inv-7

Synthesis and Properties of Novel Porphyrins for Use as Oxygen-Reduction Catalysts (Special Invited Lecture)

 

17:00

T.G. Traylor, T.A. Evans, R. Hildreth, and K.B. Nolan (Univ. California-San Diego, USA)

  55

 

August 22 (Mon) Room D

 

General Sessions (Oral) (G) (1)

Chairman A. Dondoni (Y. Nagao)                                                                       12:45-14:15

G-1

Heterocycles as Masked Functional Monomers

 

12:45

H. Ulrich, S.-H. Dai, and F.A. Stuber (Upjohn Co., USA)

  56

G-2

Reactions of Vinimidinium Salts of Furan Derivatives

 

13:00

J. Kovác, T. Gracza, and Z. Arnold (Univ. Bratislava and Czech. Akad. Sci., Czechoslovakia)

  57

G-3

A New Synthetic Method of b-Substituted Furans

 

13:15

K. Itoh and H. Nishiyama (Toyohashi Univ. Tech., Japan)

  58

G-4

2-Cyanotetrahydrofurans via Cyano-oxyselenenylation

 

13:30

S. Tomoda, Y. Takeuchi, and Y. Nomura (Univ. Tokyo, Japan)

  59

G-5

Cyclization of Some Heterocyclic Dialdehydes with Nitromethane

 

13:45

M.El Borai (Tanta Univ., Egypt)

  60

G-6

The Claisen Rearrangement of Aryl Propargyl Ethers in Poly(ethylene glycol). An Improved Method for the Synthesis of (2H)Benzopyrans and 2-Methylbenzofurans

 

14:00

U. Rao and K.K. Balasubramanian (Indian Inst. Tech. Madras, India)

  61

 

 

 

 

Chairman G. Bernath (Y. Takeuchi)                                                                     14:45-16:15

G-7

Indenoisocoumarins: Synthesis of Indenoisocoumarins

 

14:45

G. Jha and J.N. Srivastava (Bhagalpur Univ., India)

  62

G-8

Synthesis and Reactions of Some 1,3-Oxazolium-4-olate

 

15:00

M.J. Haddadin and H. Tanous (American Univ. Beirut, Lebanon)

  63

G-9

Autocatalyzed Additions and Cycloadditions of Ketenes to Thiazoles

 

15:15

A. Dondoni, G. Fantin, M. Fogagnolo, A. Medici, and P. Pedrini (Univ. Ferrara, Italy)

  64

G-10

A New Nonenzymatic Chiral Induction into Cyclic meso-Compounds

 

15:30

Y. Nagao, T. Inoue, and E. Fujita (Kyoto Univ., Japan)

  65

G-11

Facile One-pot Synthesis of Benzothiazolones from 2-Halonitrobenzenes

 

15:45

I. Nishiguchi, K. Konishi, and T. Hirashima (Osaka Municipal Tech. Res. Inst., Japan)

  66

G-12

Syntheses of Thiazoles and Thiazines from Allenes

 

16:00

S.R. Landor, P.D. Landor, Z.T. Fomum, J.T. Mbafor, and J. Silike-Muruumu (Univ. West Indies, Jamaica)

  67

 

Chairman A. K. S. Gupta (Y. Oshiro)                                                                  16:30-18:00

G-13

Lithiation of Five-membered Heteroaromatic Compounds. The 5-Alkoxymethyl- and 5-Alkylthiomethylisoxazoles

 

16:30

R.G. Micetich, C.C. Shaw, P. Spevak, and P. Wolfert (Univ. Alberta, Ayerst Lab., and Chembiomed Ltd., Canada)

  68

G-14

A Synthesis of Geminally Functionalized Cyclic Aminocarboxylic Acids by Diels-Alder Reaction and 1,3-Dipolar Cycloaddition Using α,b-Dehydroalaninates

 

16:45

H. Horikawa, T. Nisbitani, T. Iwasaki, and I. Inoue (Tanabe Seiyaku Co., Ltd., Japan)

  69

G-15

Newer Heterocycles from Fluorochalcones

 

17-00

N. Latif, N. Mishriky, and W. Basyouni (Nat. Res. Centre, Cairo, Egypt)

  70

G-16

Ring Transformation Reaction of Heterocyclic Sulfoxides

 

17:15

N. Ueda, H. Shimizu, T. Kataoka, and M. Hori (Gifu Coll. Pharm., Japan)

  71

G-17

Some Unexpected Oxidation Reactions of 1,3-Benzothiazines. A New Isoquinoline Synthesis by Ring Transformation of 1,3-Benzothiazinc-b-lactams

 

17:30

J. Szabó, L. Fodor, E. Szücs, G. Bernáth, and P. Sohár (Univ. Med. School Szeged and EGYT Pharm. Works, Hungary)

  72

G-18

Studies on Phenothiazines, 4H[1,4]-Benzothiazines and Their Sulphones

 

17:45

R.R. Gupta, G.S. Kalwania, M. Kumar, and R. Kumar (Univ. Rajasthan, India)

  73

 

August 22 (Mon) Room E

 

General Sessions (Oral) (G) (2)

Chairman M. S. R. Naidu (M. Takeda)                                                               12:45-14:15

G-19

Transannular Interactions in the Reactions of Sulfilimines of Cyclic Polythiaethers with Strong Bases

 

12:45

N. Furukawa, K. Imaoka, A. Kawada, and S. Oae (Univ. Tsukuba, Japan)

  74

G-20

Facile Reduction of Sulfoxides and Sulfilimines to Sulfides by Using Metal/Chloromethylsilanes

 

13:00

K. Nagasawa, T. Umezawa, and K. Itoh (Hokkaido Coll. Pharm., Japan)

  75

G-21

New Mode of Thermal Reactions of Cyclic Sulfur Ylides. Solvent Uptake and Spiro-compound Formation

 

13:15

M. Kataoka, T. Kataoka, H. Shimizu, and M. Hori (Gifu Coll. Pharm., Japan)

  76

G-22

Synthesis and Properties of Bridged Thionin

 

13:30

R. Okazaki, T. Hasegawa, Y. Shishido, and N. Inamoto (Univ. Tokyo, Japan)

  77

G-23

Bridged Heteronins, Thiecinone, and Related Systems from Mesoionic Compounds

 

13:45

H. Kato, M. Hashimoto, and K. Ikoma (Shinshu Univ., Japan)

  78

G-24

1,2-Dithiolylium Salts in the Synthesis of 1,2-Tetrathiafulvalenes

 

14:00

C. Th. Pedersen and O. Hammerich (Odense Univ. and Univ. Copenhagen, Denmark)

  79

 

Chairman C. T. Pedersen (N. Furukawa)                                                             14:45-16:15

G-25

1-Methyl-2-azathiabenzene 1-Oxide: Synthesis and Some Properties

 

14:45

M. Ikeda, Y. Tamura, H. Tsubouchi, and M. Tsunekawa (Kyoto Coll. Pharm. and Osaka Univ., Japan)

  80

G-26

The Homothiopyrylium Ions

 

15:00

K. Yamamoto, S. Yamazaki, A, Matsukawa, and I. Murata (Osaka Univ., Japan)

  81

G-27

New Purple Pigment Produced by Brevibacterium fluvum

 

15:15

C. Eguchi and Y. Yokokawa (Ajinomoto Co., Inc., Japan)

  82

G-28

Synthesis and Structure of Novel Halosulfuranes, 5-Chloro- and 5-Bromo-5,11-dihydrodibenzo[b,e]thiepins

 

15:30

K. Onogi, M. Hori, T. Kataoka, H. Shirnizu, and M. Kido (Kowa Co., Ltd., Gifu Coll. Pharm., and Otsuka Pharm. Co., Ltd., Japan)

  83

G-29

Synthesis of 2-Substituted imino-1,3-dithioles, 2-Substituted imino-1,3-thiaselenoles and 2-Substituted imino-1,3-diselenoles

 

15:45

A. Shafiee and G. Fanaii (Tehran Univ., Iran)

  84

G-30

Novel Bicyclic σ-Selenuranes: Syntheses and Reactions of 9-Alkyl (or Aryl)-10-chloro-10,9-epoxyethanoselenoxanthenes and Their Related Compounds

 

16:00

K. Tomimatsu, T. Kataoka, H. Shimizu, and M. Hori (Gifu Coll. Pharm., Japan)

  85

 

Chairman P. Tovivich (M. Ikeda)                                                                         16:30-17:30

G-31

Insecticidal Cyclic Phosphorus Compounds

 

16:30

S. Tawata and N. Kobamoto (Univ. Ryukyus, Japan)

  86

G-32

Synthesis of 2,3-Dihydro-2-phenoxy-1H-1,3,2-benzodiazaphosphole 2-Sulphides

 

16:45

M.S.R. Naidu and R.L. Dannley (Sri Venkateswara Univ., India and Case Western Reserve Univ., USA)

  87

G-33

Isolation and Characterization of a Thiadiphosphirane

 

17:00

M. Yoshifuji, K. Shibayama, K. Ando, and N. Inamoto (Univ. Tokyo, Japan)

  88

G-34

New Developments for the Preparation of Allylic Monophosphates

 

17:15

M. Garrossian (Nat. Iranian Ind. Org., Iran)

  89

 

August 22 (Mon) Room F

 

General Sessions (Oral) (G) (3)

Chairman H. Suschitzky (H. Ishii)                                                                        12:45-14:15

G-35

Advances in Reissert Compound Chemistry

 

12:45

F.D. Popp and J. Kant (Univ. Missouri-Kansas City, USA)

  90

G-36

The Tetrahydroisoquinoline Oxidative Rearrangement

 

13:00

H. Hara, H. Shinoki, O. Hoshino; and B. Umezawa (Sci. Univ. Tokyo, Japan)

  91

G-37

Mechanism of the Condensation Reaction between 1-Aryl- and Heteroaryl-1,4-dihydro3(2H)-isoquinolinones and Aldehydes

 

13:15

L. Hazai, Gy. Deák, J. Tamás, G. Doleschall, and G. Tóth (Hungarian Acad. Sci. and Tech. Univ. Budapest, Hungary)

  92

G-38

A Synthetic Methodology for the Synthesis of Optically Active Heterocycles by Enamide Photocyclization

 

13:30

T. Naito, Y. Tada, and I. Ninomiya (Kobe Women's Coll. Pharm., Japan)

  93

G-39

Syntheses of Despyrrole Analogs of Ergoline Group of Alkaloids

 

13:45

I. Ninomiya, T. Kiguchi, C. Hashimoto, and T. Naito (Kobe Women's Coll. Pharm., Japan)

  94

G-40

Syntheses of Coumarinoxy Benzylisoquinolines

 

14:00

D. Ramesh and M. Srinivasan (Indian Inst. Tech. Madras, India)

  95

 

Chairman F. D. Popp (I. Ninomiya)                                                                     14:45-16:15

G-41

Ring Transformations of 1-Aza-dibenzo[c,f]bicyclo[3.3.1]nona-3,6-dienes

 

14:45

H. Takayama, T. Nomoto and N. Nasui (Teikyo Univ., Japan)

  96

G-42

Preparation of Nitrones from Secondary Amines. Tungstate Catalyzed Oxidation of Secondary Amines with Hydrogen Peroxide

 

15:00

S. Murahashi, H. Mitsui, and S. Zenki (Osaka Univ., Japan)

  97

G-43

Acyliminium Salts: Synthesis and Properties

 

15:15

J. Dusemund and E. Kröger (Freie Univ. Berlin, W. Germany)

  98

G-44

Photo-Ring Expansion of Azidomethoxyquinolines to Methoxypyridoazepines

 

15:30

R.K. Smalley, E.F.V. Scriven, and H. Suschitzky (Univ. Salford, UK)

  99

G-45

Intramolecular Aminopalladation Reaction of 1-Aminohexatriene

 

15:45

H. Taniguchi, H. Yamasaki, N. Okada, K. Isomura, and S. Kobayashi (Kyushu Univ., Japan)

100

G-46

Reissert Type's Reaction by Use of Phosphite

 

16:00

Y. Hamada, I. Takeuchi, and Y. Shibata (Meijo Univ., Japan)

101

 

Chairman T. Fukuyama (H. Takayama)                                                               16:30-17.30

G-47

Stereocontrolled Synthesis of Withaferin A and Withanolide D

 

16:30

K. Gamoh, M. Hirayama, and N. Ikekawa (Tokyo Inst. Tech., Japan)

102

G-48

Isolation and Structure of New Alkaloids from Buxus Papilosa

 

16:45

Atta-ur-Rahman, Mehrun Nisa, S. Farhi, and T.Z. Ismail (Univ. Karachi, Pakistan)

103

G-49

Novel 2'-Substituted Amino-3-methoxy-16α-bromo-17-oxoestra-1,3,5(10)-trieno[1,2-d]thiazoles

 

17:00

A.-M.M.E. Omar and O.M. Aboulwafa (Univ. Alexandria, Egypt)

104

G-50

Investigations Concerning the Total Synthesis of B-Nor-6,12-bisthiaestra-1,3,5(10),8,14- pentaen-17-one

 

17:15

S. R. Ramadas and J. Appa Rao (Indian Inst. Tech. Madras, India)

105

 

August 23 (Tue) Room A

 

Symposium IV. New b-Lactams and Other Heterocyclic Antibiotics (1)

Chairman B. G. Christensen (S. Kobayashi)                                                         12:45-14:15

S. Inv-13

Advances in Stereochemical Control (Special Invited Lecture)

 

12:45

S. Masamune (MIT., USA)

107

S-IV-1

New Synthesis of 1,4-Benzodiazepine Derivatives via Palladium Catalyzed Carbonylation

 

13:15

M. Mori, M. Ishikura, M. Terashima, M. Kimura, and Y. Ban (Hokkaido Univ. and Higashi-Nippon-Gakuen Univ., Japan)

108

S-IV-2

A Synthetic Approach to the Mechanism of DNA-Cleavage by Bleomycin-Fe(II)-O2 Complex

 

13:30

M. Otsuka, A. Kittaka, Y. Sugano, S. Kobayashi, Y. Sugiura, T. Takita, H. Umezawa, and M. Ohno (Univ. Tokyo, Kyoto Univ., and Inst. Microbial Chem., Japan)

109

S-IV-3

Synthesis of b-Lactam Antibiotics via the Sulfeno-cycloamination

 

13:45

M. Ihara, Y. Haga, M. Yonekura, K. Fukumoto, and T. Kametani (Tohoku Univ. and Hoshi Univ., Japan)

110

S-IV-4

7α-Hydroxycephaiosporin C, an Intermediate in the Methoxylation of Cephalosporin C by a Cell-Free Extract of S. Clavuligerus

 

14:00

J.D. Hood, A. Elson, M.L. Gilpin, and A.G. Brown (Beecham Pharm. Res. Div., UK)

111

 

Chairman W. A. Slusarchyk (I. Kawamoto)                                                         14:45-16:15

S. Inv-14

Highly Stereoselective Synthesis of Antitumor Antibiotics, (+)-Actinobolin and Bactobolin, by Asymmetric Cyclization (Special Invited Lccture)

 

14:45

M. Yoshioka, H. Nakai, and M. Ohno (Univ. Tokyo, Japan)

112

S-IV-5

Syntheses of Althiomycin and Its Analogs in Relation to Their Antibacterial Activities

 

15:15

T. Shiba, K. Inami, and H. Imanaka (Osaka Univ., Japan)

113

S-IV-6

The Structure of Medermycin

 

15:30

H. Ogura and K. Furuhata (Kitasato Univ., Japan)

114

S-IV-7

Synthetic Study of Carbapenems Utilizing D-Glucosamine

 

15:45

N. Chida, M. Miyashita, and A. Yoshikoshi (Tohoku Univ., Japan)

115

S-IV-8

Synthesis of Some 1-Aza/Oxa-Analogs of Cepham

 

16:00

S.D. Sharma and U. Mehra (Panjab Univ., India)

116

 

August 23 (Tue) Room B

 

Symposium V. Heterocycles in Anticancer and Antiviral Research (2)

Chairman V. L. Narayanan (T. Shimidzu)                                                             12:45-14:15

S-V-13

The Binding Sites in Xanthine and Methyl Substituted Xanthines with Some Group VIII Transition Metals

 

12:45

J.R. Lusty and J. Peeling (Nat. Univ. Singapore, Singapore and Univ. Petroleum Minerals, Saudi Arabia)

117

S-V-14

Circular Dichroism and Fluorescence Studies on the Interactions of Vincristine to Homopolyribonucleotides

 

13:00

H.N. Borazan and M.E. Zia (Univ. Baghdad, Iraq)

118

S-V-15

Chemical Synthesis and Biological Activity of 5'-"Capped" 2',5'-Oligoadenylates

 

13:15

J. Imai and P.F. Torrence (NIH, USA)

119

S-V-16

Synthesis and Biological Activity of a Tubercidin Analog of 2-5A

 

13:30

J.-C. Jamoulle, J. Imai, and P.F. Torrence (NIH, USA)

120

S. Inv-20

2'-Substituted 2'-Deoxypurinenucleotides - Their Conformation and Properties (Special Invited Lecture)

 

13:45

M. Ikehara (Osaka Univ., Japan)

121

 

Symposium III. Synthesis of Natural Heterocycles (2)

Chairman V. Snieckus (N. Aimi)                                                                          14:45-16:15

S-III-13

Total Synthesis of (±)-Clavicipitic Acid

 

14:45

S. Nakatsuka, T. Masuda, K. Yamada, and T. Goto (Nagoya Univ., Japan)

122

S-III-14

Synthesis of Active Fragments of Teleocidins and Lyngbyatoxins

 

15:00

Y. Endo, K. Shudo, and T. Okamoto (Univ. Tokyo, Japan)

123

S. Inv-12

Imines and Iminium Ions in Stereoselective Natural Product Synthesis (Special Invited Lecture)

 

15:15

W.N. Speckamp (Univ. Amsterdam, Netherlands)

124

S-III-15

A Synthetic Pathway to Strychnos, Aspidosperma, Schizozygane and Eburnamonine Alkaloids by Way of the Novel Photoisomerization

 

15:45

Y. Ban, K. Yoshida, S. Nomura, J. Goto, and T. Oishi (Hokkaido Univ., Japan)

125

S-III-16

Synthetic Approach toward Mitomycins. New Facile Synthesis of 3H-Pyrrolo [1,2-a]indol-5,8-diones

 

16:00

Y. Naruta, N. Nagai, and K. Maruyama (Kyoto Univ., Japan)

126

 

August 23 (Tue) Room C

 

Symposium II. Heterocycles with Novel Functions (2)

Chairman I. O. Sutherland (M. Okahara)                                                             12:45-14:15

S-II-11

New Type of ipso-Substitution in Pyridine Ring and Its Application for the Synthesis of Macrocycles Containing Both Oxa- and Thia-bridges

 

12:45

N. Furukawa, T. Kawai, S. Ogawa, and S. Oae (Univ. Tsukuba, Japan)

127

S-II-12

The Preparation of Macrocyclic Polyether-Diester Ligands Containing the Pyridine Subcyclic Unit, Their Complexes and Their Reductive Desulfurization to the Pyridino-Crown Ethers

 

13:00

B.A. Jones, J.S. Bradshaw, P.R. Brown, R.B. Davidson, J.J. Christensen, and R.M. Izatt(Brigham Young Univ., USA)

128

S-II-13

Synthesis of Multifunctional Macrocyclic Polyamines from Natural Amino Acids

 

13:15

T. Yatsunami, E. Kimura, and M. Kodama (Hiroshima Univ., Japan)

129

S-II-14

Selection of Guest Inclusion Geometry by a Series of Water-soluble Paracyclophanes Having Well-defined Hydrophobic Cavities

 

13:30

K. Mori, K. Odashima, A. Itai, Y. Iitaka, and K. Koga (Univ. Tokyo, Japan)

130

S-II-15

Host-Guest Complex Formation by an Optically Active Paracyclophane in Water

 

13:45

I. Takahashi, K. Odashima, and K. Koga (Univ. Tokyo, Japan)

131

S-II-16

Lipophilic and Amphiphilic Cyclodextrin Derivatives as the New Class of Host Compounds

 

14:00

W. Tagaki, Y. Irinatsu, H. Takahashi, and S. Kozuka (Osaka City Univ., Japan)

132

 

Chairman J. S. Bradshaw (S. Shiraishi)                                                                14:45-16:15

S-II-17

Flavin Catalysts Bearing Sulfur Functional Groups

 

14:45

K. Fujimori, T. Nagata, and S. Oae (Univ. Tsukuba, Japan)

133

S-II-18

Novel Function of the Pyrroloquinoline Quinone, PQQ, Enhanced by Micelle

 

15:00

Y. Ohshiro, T. Hirao, and T. Agawa (Osaka Univ., Japan)

134

S-Inv-8

Dyestuff Lasers and Light Collectors - Two New Fields of Application for Fluorescent Heterocyclic Compounds (Special Invited Lecture)

 

15:15

R. Raue, K.H. Drexhage, and H. Harnisch (Bayer AG and Univ. Siegen. W. Germany)

135

S-II-19

Syntheses of a New Class of Dyes - Coupling Reactions of Diazonium Salts with Bridged Annulenes - Syntheses of New Bridged Heterocycles

 

 15:45

R. Neidlein, C.M. Radke, R. Gottfried, Gg. Hartz, and V. Poignée (Univ. Heidelberg, W. Germany)

136

S-II-20

Electrical and Optical Properties of Heterocyclic Polymers and Their Application as Opto-Electronics Devices

 

16:00

K. Kaneto, K. Yoshino and Y. Inuishi (Osaka Univ., Japan)

137

 

August 23 (Tue) Room D

 

General Sessions (Oral) (G) (4)

Chairman K. C. Joshi (T Shioiri)                                                                          12:45-14:15

G-51

Synthesis of Aziridine Derivatives from a-Silyl Carbanion and Oxime Ethers

 

12:45

T. Konakahara, K. Sato, and M. Matsuki (Sci. Univ. Tokyo, Japan)

138

G-52

A Novel Ring Transformation of Imidazoles to Pyrimidines

 

13:00

S. Furuya and Y. Furukawa (Takeda Chem. Ind., Ltd., Japan)

139

G-53

Syntheses of Phenyltrifluoromethylacetylenes and Their 1,3-Dipolar Reaction

 

13:15

Y. Kobayashi, T. Yamashita, and I. Kumadaki (Tokyo Coll. Pharm., Japan)

140

G-54

Synthesis and Reactions of 5(3)-Methylpyrazole-3(5)-aldehyde Thiosemicarbazone, a Potential Antiviral Agent

 

13:30

N. Saha and N. Mukherjee (Univ. Coll. Sci. Calcutta, India)

141

G-55

Novel Cycloaddition Reactions of Nitroimidazole Derivatives with Diazomethane to Form Imidazopyrazoles

 

13:45

K. Nagarajan, V. Sudarsanam, S.J. Shenoy, and K. Rama Rao (Hindustan Ciba-Geigy Ltd., India)

142

G-56

Synthesis and Biological Activity of N1-Salicyloyl-3-methyl-4-(substituted phenylazo)-2-pyrazolin-5-ones.

 

14:00

Km. Archana Chauhan and C.P. Singh (Sahu Jain Coll., India)

143

 

 

Chairman J. Becher (T. Koizumi)                                                                         14:45-16:15

G-57

Reaction of 1,2,3-Triazole N-Oxides with Acylating Agents and Nucleophiles

 

14:45

M. Begtrup (Tech. Univ. Denmark, Denmark)

144

G-58

Trimethylsilyldiazomethane: A New Synthon for the Preparation of 2-Amino-1,3,4-thiadiazoles

 

15:00

T. Aoyama, A. Fukushima, and T. Shioiri (Nagoya City Univ., Japan)

145

G-59

A Novel Synthesis of Heterocycles by Use of Trithiocyclopropenium Ion

 

15:15

Z. Yoshida, T. Sugimoto, H. Hirai, E. Seki, N. Nakayama, and S. Yoneda (Kyoto Univ., Japan)

146

G-60

Formation of 2-Alkylthio-substituted 2H-Pyrans in the Reaction of Cyclic 1,3-Diketones with Alkylthiodiphenylcyclopropenium Ions

 

15:30

H. Yoshida, M. Nakajima, T. Ogata, and K. Matsumoto (Shizuoka Univ. and Kyoto Univ., Japan)

147

G-61

Enhanced Reactivity of Fused Thiirene Sulfoxide in Cycloadditions with Enophiles

 

15:45

T. Takata, Y. Hanyu, and W. Ando (Univ. Tsukuba, Japan)

148

G-62

A Novel Synthesis of 5-Aryl-3-oxo-2-phenyl-2H,3H-1,2,4-thiadiazoles

 

16:00

V.K. Verma, Mohd. Ramzan Ali, and R. Singh (Banaras Hindu Univ., India)

149

 

August 23 (Tue) Room E

 

General Sessions (Oral) (G) (5)

Chairman S. C. Pakrashi (O. Hoshino)                                                                12:45-14:15

G-63

Synthesis of Some Triazine Derivatives and Their Biological Activity

 

12:45

A.K.S. Gupta, T. Bhattacharya, and K. Hajela (Lucknow Univ., India)

150

G-64

Synthesis of Novel Sulfur-containing Strong Analgesic (S-Etorphine)

 

13:00

T. Iwamura, E. Imai, H. Shimizu. T. Kataoka, M. Hori, M. Niwa, M. Nozaki, and H. Fujimura (Gifu Coll. Pharm., Gifu Univ., and Kyoto Coll. Pharm., Japan)

151

G-65

Benzo-separated Xanthines as Phosphodiesterase Inhibitors

 

13:15

S.W. Schneller and A.C. Ibay (Univ. South Florida, USA)

152

G-66

Naturally Occurring Bioactive Benzo [d e]-1,6-naphthyridines from the Sea Sponge Aaptos aaptos

 

13:30

H. Nakamura, J. Kobayashi, R. Abe, Y. Ohizumi, and Y. Hirata (Mitsubishi-Kasei Inst. Life Sci. and Meijo Univ., Japan)

153

G-67

Synthesis and Antihypertensive Activity of Some Fused Quinazoline Derivatives

 

13:45

K.-C. Liu and J.-W. Chern (Nat. Defense Med. Center, Taipei, China)

154

G-68

Synthesis of New Benzopyrano-/4,3-b/-pyridine Ring Systems

 

14:00

J. Bálint, M. Rákosi, Zs. Szegény, and R. Bognár (BIOGAL Pharm. Works and Hungarian Acad. Sci., Hungary)

155

 

 

Chairman J. Chattopadhyaya (T. Itaya)                                                                14:45-16:15

G-69

Synthesis of 4-Deoxy-4-C-ethylphosphinyl-D-ribo- and -L-lyxo-furanoses

 

14:45

Y. Nakamura, H. Yamamoto, S. Inokawa, and M. Yamashita (Okayama Univ. and Shizuoka Univ., Japan)

156

G-70

Synthesis of L-Idopyranose Derivatives Having a Phosphorus Atom in the Hemiacetal Ring

 

15:00

M. Yamashita, M. Yamada, K. Tsunekawa, T. Oshikawa, and S. Inokawa (Shizuoka Univ. and Okayama Univ., Japan)

157

G-71

Synthesis of Tunicaminyl Uracil

 

15:15

T. Suami, H. Sasai, and K. Matsuno (Keio Univ., Japan)

158

G-72

Nin-Mesitylene-2-sulfonyltryptophan, a New Tryptophan Derivative, and Its Application for Peptide Synthesis

 

15:30

N. Fujii, S. Futaki, K. Yasumura, K. Akaji, and H. Yajima (Kyoto Univ., Japan)

159

G-73

Chemistry of Nucleoside-Amino Acid Adducts and Its Relevance to Photoinduced Lesions

 

15:45

I. Saito, H. Sugiyama, M.B. Gupta, and T. Matsuura (Kyoto Univ., Japan)

160

G-74

Unconventional Toxic Heterocycles of Clitocybe acromelalga

 

16:00

K. Konno, H. Shirahama, and T. Matsumoto (Hokkaido Univ., Japan)

161

 

August 23 (Tue) Room F

 

General Sessions (Oral) (G) (6)

Chairman A. K. Ganguly (T. Sakamoto)                                                              12:45-14:15

G-75

Synthesis of Quinazolines and 1,4-Benzodiazepines

 

12:45

J. Bergman, A. Brynolf, and B. Elman (Royal Inst. Tech., Sweden)

162

G-76

Preparation and Reactions of 3-Benzoyl-3,4-dihydro-4-quinazolinecarbonitrile (Quinazoline Reissert Compound)

 

13:00

T. Higashino, H. Kokubo, and E. Hayashi (Shizuoka Coll. Pharm., Japan)

163

G-77

Novel Mesoionic Heterocycles

 

13:15

W. Friedrichsen, A. Böttcher, T. Debaerdemacker, G. Möckel, and M. Schildberg (Univ. Kiel and Univ. Ulm, W. Germany)

164

G-78

The Reaction of 5-Benzalimino-1,2,4-triazoles with Substituted Acetyl Chlorides

 

13:30

J. Reiter, L. Pongó, P. Sohár, and P. Dvortsák (EGYT Pharm. Works and Inst. Drug Res., Hungary)

165

G-79

Palladium Catalyzed Polyhetero-Claisen Rearrangement of 3-Allylthio-1,2,4-triazin-5(2H)-ones

 

13:45

M. Mizutani, Y. Sanemitsu, Y. Tamaru, and Z. Yoshida (Sumitomo Chem. Co., Ltd., Japan)

166

G-80

Synthesis of Some 3-Hydroxy Metabolites of Psychotropic Trifluoromethyl Analogs of Chlorpromazine. 3-Hydroxy and 3-Methoxy-trifluoroperazine and Their Sulphoxides

 

14:00

R.L. Mital, M. Anand, H.L. Sharma, A.R. Goyal, A.P. Shukla, and S.B. Gupta (Univ. Rajasthan, India)

167

 

Chairman R. L. Mital (R. Okazaki)                                                                      14:45-16:15

G-81

Synthesis of a Few Novel Purine Analogue Heterocycles (1,9-Dideaza-5-aza-9-thiapurines)

 

14:45

A. Nayak, S.N. Dehuri, and J.K. Sahu (Sambalpur Univ., India)

168

G-82

A New, Synchronous Construction of Some Fused Pyrimidines by the Reaction of 6‑Arylidenehydrazino-1,3-dimethyluracils with Thionyl Chloride

 

15:00

M. Ichiba, S. Nishigaki, and K. Senga (Keio Univ., Japan)

169

G-83

1,3-Dipolar Cycloaddition Reactions of Thiazolo[5,4-d]pyrimidine 1-Oxides and Thiazolo [4,5-g]quinazoline 1-Oxides with Acetylenic Esters

 

15:15

K. Senga, M. Ichiba, H. Kanazawa, and S. Nishigaki (Keio Univ., Japan)

170

G-84

4-Dicyanomethylene-1,4-dihydropyrimidines and Pyrido [4,3-d] pyrimidine-8-carbonitriles from Enaminonitriles

 

15:30

H. Junek and M. Mittelbach (Karl-Franzens-Univ., Austria)

171

G-85

Heterocyclic Syntheses with Brominated Malononitriles

 

15:45

R.W. Morrison, Jr. and W.R. Mallory (Burroughs Wellcome Co., USA)

172

G-86

Synthesis of 1,2,4-Triazino[6,5-e]-1,2,4-triazines, 1,2,4-Triazino [6,5-e]-1,2,4-thiadiazines and 1,2,4-Triazino [5,6-e]-1,2,4-thiadiazines

 

16:00

H. Neunhoeffer and H. Hammann (Tech. Hoch. Darmstadt, W. Germany)

173

 

August 23 (Tue) Room G

 

Poster Sessions (P) (1)                                                                                     16:15-18:00

P-1

A Novel Alkynylation Reaction of Epoxyalcohols

 

 

M. Yamaguchi and I. Hirao (Kyushu Inst. Tech., Japan)

174

P-2

Synthesis of Some Thiaziridine 1,1-Dioxide

 

 

M.M. Kidwai and J. Iqbal (Aligarh Muslim Univ., India)

175

P-3

Synthesis of 1-Benzazocin-5-one Derivative Having Aziridine Ring

 

 

K. Nomura, M. Takeuchi, and K. Masuda (Toyama Med. Pharm. Univ., Japan)

176

P-4

Effective Route to Azetidines from Azetidin-2-ones with the Use of Hydroalanes as Specific Reducing Agents

 

 

M. Yamashita and I. Ojima (Sagami Chem. Res. Center, Japan)

177

P-5

Aluminum Chloride-catalyzed Reactions of 4-Aryl-2-chloro- and 3-Aryl-2-chloro-thiophenes with Some Aromatic Compounds

 

 

T. Sone, K. Sato, and Y. Umetsu (Yamagata Univ., Japan)

178

P-6

An Investigation into the Chlorosulfonation of Acetophenone and Some Derivatives

 

 

D.D. Chapman (Eastman Kodak Co., USA)

179

P-7

Novel Sigmatropic Reactions and Particular Reactivities in the Field of 2-Oxatricyclo[3,3,0,04,6]oct-7-ene-3-ones

 

 

A. Valla, M. Giraud, C. Brassy, and B. Bachet (MNHN and CNRS, France)

180

P-8

New Methods for Syntheses of Furanone Derivatives Using Dianions

 

 

K. Tanaka, Y. Isobe, H. Yoda, and A. Kaji (Kyoto Univ., Japan)

181

P-9

Highly Efficient Synthesis of γ-Lactones with Titanium Homoenolates

 

 

E. Nakamura, H. Oshino, and I. Kuwajima (Tokyo Inst. Tech., Japan)

182

P-10

New Methods for the Synthesis of 3(2H)-Furanones and 2(5H)-Furanones

 

 

H. Saimoto, S. Matsubara, K. Oshima, T. Hiyama, and H. Nozaki (Kyoto Univ., Japan)

183

P-11

A New Method for the Synthesis of Functionalized Tetrahydrofurans and Tetrahydropyrans Directed toward the Total Synthesis of Polyether Antibiotics

 

 

Y. Oikawa, K. Horita, I. Noda, and O. Yonemitsu (Hokkaido Univ., Japan)

184

P-12

Silica Gel-promoted γ-Lactonization of γ-Halo Esters

 

 

S. Tsuboi, K. Muranaka, H. Fujita, K. Seko, and A. Takeda (Okayama Univ., Japan)

185

P-13

Facile Preparation of, 2,6-Dimethyl-2,6-tetrahydropyrancarbolactone, a Versatile Intermediate for the Syntheses of (±)-Frontalin, (±)-Cinenic Acid, and (±)-Linaloyl Oxide

 

 

M. Utaka, S. Tsuboi, H. Makino, Y. Oota, and A. Takeda (Okayama Univ., Japan)

186

P-14

Novel Synthetic Methods of Dihydro-4-pyrone, γ-Butyrolactone, and 3(2H)-Furanone by Using α,α'-Dihalo Ketone or α-Monohalo Ketone

 

 

T. Sakai, M. Ishikawa, A. Yamawaki, H. Ito, E. Amano, and A. Takeda (Okayama Univ., Japan)

187

P-15

Reaction of Methyl 12-Hydroxyabietan-8,11,,13-triene-19-oate with Thallium(III) Perchlorate. Formation of a Lactone with a New Rearranged Skeleton

 

 

T. Nakano, M.I. Hernández, and A.T. McPhail (IVIC, Venezuela and Duke Univ., USA)

188

P-16

Reactions of 5-Arylfurfurals and Dialkylphosphonates

 

 

C.-H. Wang, P.-L. Hsiao, Z.-S. Chuang (Northwest Teacher's Coll., China)

189

P-17

New Synthetic Intermediates for Heterocyclic Syntheses from Furfurylidenes

 

 

R. El Gharbi, Y. Le Bigot, M. Delmas, and A. Gaset (Ecole Nat. Sup. Chim., France)

190

P-18

Oxidation Reactions of Bicyclic Pyrrole Derivatives

 

 

Y. Otsuji, N. Ohmura, S. Nakanishi, and K. Mizuno (Univ. Osaka Prefecture, Japan)

191

P-19

Novel Base-catalyzed 1,3-Dipolar Cycloaddition Leading to Pyrrolidines from N-(Phenylthiomethyl) amino Acids

 

 

N. Imai, Y. Terao, K. Achiwa, and M. Sekiya (Shizuoka Coll. Pharm., Japan)

192

P-20

Preparation of Optically Active Phosphonic Acid Derivatives Using Ethyl L-Prolinate and Their Application to Asymmetric Organic Synthesis

 

 

T. Koizumi, M. Iwata, N. Tanaka, K. Hirutani, and E. Yoshii (Toyama Med. Pharm. Univ., Japan)

193

P-21

Stereospecific Synthesis of Nucleoside Cyclic P-Chiral 3',5'-Phosphates and -Phosphoro-thioates

 

 

W. J. Stec (Polish Acad. Sci., Poland)

194

P-22

Syntheses of Five-membered Heterocycles Containing Both Ring and Side-chain Phosphorus Atoms

 

 

Md. Amin, D.G. Holah, A.N. Hughes, and T. Rukachaisirikul (Lakehead Univ., Canada)

195

P-23

Stereoselective Total Synthesis of Pyrrolizidine Alkaloid Bases, (-)-Rosmarinecine and(-)-Isoretronecanol

 

 

K. Tatsuta, H. Takahashi, Y. Amemiya, and M. Kinoshita (Keio Univ., Japan)

196

P-24

Reactions of Trifluoroacetonitrile Ylides with Electron-deficient Olefins and Acetylenes

 

 

K. Tanaka, H. Daikaku, and K. Mitsuhashi (Seikei Univ., Japan)

197

P-25

Reactivity of Isoselenazole Derivatives

 

 

F. Lucchesini, V. Bertini, and A. De Munno (Univ. Calabria and Inst. Chim. Org. Pisa, Italy)

198

P-26

Synthesis of Thiazoline, Thiophene, and 1,3-Dithiolane Using Ethyl 4-Haloacetoacetate

 

 

T. Chiba, H. Sato, and T. Kato (Tohoku Univ., Japan)

199

P-27

C-Alkylation, Alkenylation, and Arylation of 1,2,5-Thiadiazoles

 

 

V. Bertini, A. De Munno, and N. Picci (Univ. Calabria and Inst. Chim. Org. Pisa, Italy)

200

P-28

A New Aromatic Annelation Reaction Utilizing Reaction of Isoxazole with Diiron-nonacarbonyl

 

 

N. Takeuchi, K. Okazaki, J. Ohki, and S. Tobinaga (Showa Coll. Pharm. Sci., Japan)

201

P-29

The Mechanism of Asymmetric Transformation of 2-Substituted Alkanoic Acids

 

 

S. Shibata, H. Matsushita, H. Kaneko, M. Noguchi, M. Saburi, and S. Yoshikawa (Japan Tabacco Salt Public Corp. and Univ. Tokyo, Japan)

202

P-30

Diels-Alder Reaction of Oxazoles

 

 

T. Ibata and S. Nakano (Osaka Univ., Japan)

203

P-31

4,7-Dihydroisoxazolo [5,4-b] pyridines

 

 

T. Yamamori, Y. Hiramatsu, K. Sakai, and I. Adachi (Shionogi & Co., Ltd., Japan)

204

P-32

Air Oxidation Reaction of Diazoalkenes. Efficient Oxygen-transfer Reaction to Give Epoxyketones

 

 

T. Miyashi, M. Kamata, Y. Nishizawa, and T. Mukai (Tohoku Univ., Japan)

205

P-33

Trimethylsilyldiazomethane: A New Synthon for the Preparation of Pyrazoles

 

 

S. Inoue, K. Sudo, T. Aoyama, and T. Shioiri (Nagoya City Univ., Japan)

206

P-34

The Selective Synthesis of Pyrazoles

 

 

C. Kashima and N. Yoshiwara (Univ. Tsukuba and Tokyo Gakugei Univ., Japan)

207

P-36

Photochemistry of the Nitrogen-containing Thiocarbonyl System

 

 

K. Oda, M. Machida, and Y. Kanaoka (Higashi-Nippon-Gakuen Univ. and Hokkaido Univ., Japan)

208

P-37

Sulfur Dichloride as a Sulfur Transfer Reagent in Heterocyclic Synthesis

 

 

M. Komatsu, Y. Ohshiro, and T. Agawa (Osaka Univ., Japan)

209

P-38

Diphenyl Phosphorazidate (DPPA) as a 1,3-Dipole. Formation and Decomposition of Labile 1,2,3-Triazoline Derivatives

 

 

N. Kato, Y. Hamada, and T. Shioiri (Nagoya City Univ., Japan)

210

P-39

Trimethylsilyldiazomethane: A New Synthon for the Preparation of 5-Hydroxy-1,2,3-triazoles

 

 

T. Aoyama, A. Fukushima, and T. Shioiri (Nagoya City Univ., Japan)

211

P-40

Oxidation of 4-Acetyl-2-methylthio-Δ2-1,3,4-thiadiazolines with m-Chloroperbenzoic Acid and Reaction of the Oxidation Products

 

 

S. Kubota, K. Toyooka, M. Shibuya, and Z. Taira (Univ. Tokushima and Tokushima Bunri Univ., Japan)

212

P-41

Heterocyclic Conversion from 5-Amino-1-vinyl-4,5-dihydro-1H-1,2,3-triazoles

 

 

M.M. Ito, Y. Nomura, Y. Takeuchi, and S. Tomoda (Aoyama Gakuin Univ. and Univ. Tokyo, Japan)

213

P-42

Behavior of the Active Aldehyde Generated from Thiamine and Its Derivatives

 

 

K. Hirai and H Sugimoto (Shionogi & Co., Ltd., Japan)

214

P-43

The Oxidation and Reduction of 4-Formyl- and 4-Acetyl-3-arylsydnones

 

 

H.-J. Tien (Nat. Cheng Kung Univ., China)

215

P-44

Synthesis of Sydnone Compounds with Heterocyclic Substituents

 

 

H.-J. Tien, M.-Y. Yeh, T. Goto, T. Fuchigami, and T. Nonaka (Nat. Cheng Kung Univ., China and Tokyo Inst. Tech., Japan)

216

P-45

Reactions of 6-Bromoacetyl-2,3-diphenyl-5-methoxybenzofuran

 

 

A.H.Abd-El-Rahman and M.A. Hanna (Univ. Mansoura, Egypt)

217

P-46

Synthesis and Biological Activities of Some Naphthofurans as Analogues of 7,8‑Benzoflavones

 

 

G. Bastian and R. Royer (Inst. Curie, France)

218

P-47

A New Synthesis of Substituted 2(1H)Pyridinethiones from Enolates of 1,5-Enediones Obtained via Pyrylium Salts.

 

 

J. Becher, F.M. Asaad, and H. Nissen (Odense Univ., Denmark)

219

P-48

Reaction de Kostanecki Appliquee aux Cynnamoyl-pyrones-2

 

 

M. Hamdi, D. Chergui, and Y. Rachedi (Univ. Sci. Tech., Algeria)

220

P-49

Synthesis of Terpenoids from Coumarins

 

 

K.J. Divakar, Y.S. Sanghvi, D.G. Talekar, and A.S. Rao (Nat. Chem. Lab. Pune, India)

221

P-50

A Study on the Oxidative Degradation of Dibenz[b,f]oxepin-11(10H)-one by Field Desorption Mass Spectrometry

 

 

K. Yoshida, S. Arakawa, K. Hino, T. Irie, and H. Uno (Dainippon Pharm. Co., Ltd., Japan)

222

 

August 23 (Tue) Room H

 

Poster Sessions (P) (2)                                                                                     16:15-18:00

P-51

Heterocycles from Photolysis of b-(o-Heteroatom-substituted-phenyl)vinyl Bromides

 

 

T. Kitamura, H. Kawasato, S. Kobayashi, and H. Taniguchi (Kyushu Univ., Japan)

223

P-52

Synthesis of 2-Pyrone Derivatives Using Ketenethioacetal (3)

 

 

Y. Tominaga, A. Ushirogochi, Y. Matsuda, and G. Kobayashi (Nagasaki Univ., Japan)

224

P-53

Structures of Natural Diels-Alder Adducts from the Root Barks of the Mulberry Tree

 

 

T. Fukai, Y. Hano, J. Matsumoto, T. Fujimoto, K. Hirakura, and T. Nomura (Toho Univ., Japan)

225

P-54

Total Synthesis of D-Homoesterone Using Pyran Annelation

 

 

M. Yamamoto, S. Iwasa, K. Suzuki, and K. Yamada (Chiba Univ., Japan)

226

P-55

The Synthesis of Dimeric Macrolides, (±)-Pyrenophorin and (±)-Colletallol

 

 

T. Wakamatsu, S. Yamada, Y. Ohseko, and Y. Ban (Hokkaido Univ., Japan)

227

P-56

New Annelation Methods for Heteroaromatics

 

 

C. Kaneko, T. Naito, N. Shimomura, and Y. Momose (Kanazawa Univ., Japan)

228

P-57

Synthesis of Pyridines and Pyridones

 

 

O.H. Hishmat, M.M.Y. Zohair, and J.A.A. Micky (Nat. Res. Centre and El-Azhar Univ., Egypt)

229

P-58

Acylation of Some Furocoumarin Derivatives

 

 

O. H. Hishmat, and S.S.E.-D. El-Nakkady (Nat. Res. Centre, Egypt)

230

P-59

New Synthesis of Polyheteroarenes via Palladium-Phosphine Complex Catalyzed Cross-coupling

 

 

A. Minato, K. Suzuki, K. Tamao, and M. Kumada (Kyoto Coll. Pharm. and Kyoto Univ., Japan)

231

P-60

Ethyl 2-Cyano-3-ethoxycrotonate in the Gould-Jacobs Reaction

 

 

M.A. Khan and P.G.P. de Oliviera (Inst. Militar Eng., Brasil)

232

P-61

Synthesis of Pyranobenzimidazoles and Pyranoquinoxalines

 

 

M.A. Khan and E.C. Caldas (Inst. Militar Eng., Brasil)

233

P-62

Synthesis of Cycloalkenopyridine by Thermal Rearrangement of Cycloalkanone Oxime O‑Allyl Ether and Synthesis of Alkaloids by Its Application

 

 

H. Irie, J. Koyama, T. Sugita, and Y. Suzuta (Nagasaki Univ. and Kobe Women's Coll. Pharm., Japan)

234

P-63

Photochemistry of 2-Pyridones. Photoaddition with Conjugated Dienes

 

 

Y. Kanaoka, Y. Ikeda, and E. Sato (Hokkaido Univ., Japan)

235

P-64

Dealkylation of Tertiary Amines Using TMS Reagents

 

 

N. Tokitoh, R. Okazaki, and N. Inamoto (Univ. Tokyo, Japan)

236

P-65

Thermal cis-trans Isomerization of 5-Ethyl-2-oxo-4-piperidineacetic Acid and Related Compounds

 

 

T. Fujii, M. Ohba, S. Yoshifuji, and S. Akiyama (Kanazawa Univ., Japan)

237

P-66

Photo-arylation: Synthesis of Aryl- and Heteroarylpyridines by Photolysis of 2‑Halopyridines

 

 

K. Seki, K. Ohkura, C. Yoshida, M. Terashima, and Y. Kanaoka (Higashi-Nippon-Gakuen Univ. and Hokkaido Univ., Japan)

238

P-67

Syntheses and Reactions of Heteroarylorganoboranes

 

 

M. Terashima, M. Ishikura, and M. Kamada (Higashi-Nippon-Gakuen Univ., Japan)

239

P-68

Preparation of Arylamines Using Diphenyl Phosphorazidate (DPPA)

 

 

S. Mori, T. Aoyama, and T. Shioiri (Nagoya City Univ., Japan)

240

P-69

Intramolecular Cyclization Reactions of Cyclic Amine N-Imides Having Unsaturated Substituents

 

 

H. Sashida, M. Hasebe, M. Kato, J. Kurita, and T. Tsuchiya (Hokuriku Univ., Japan)

241

P-70

Indirect Electrooxidation of tert-Amines with RuO4

 

 

S. Torii, T. Inokuchi, and T. Yukawa (Okayama Univ., Japan)

242

P-71

Oxidation of Heterocyclic b-Dicarbonyl Compounds

 

 

W. Stadlbauer and T. Kappe (Univ. Graz, Austria)

243

P-72

Reaction of Dihydropyrimidine with p-Benzoquinone

 

 

C. Kashima, M. Shimizu, A. Katoh, and Y. Omote (Univ. Tsukuba, Japan)

244

P-73

A New Condensation of Enol Silyl Ethers with Oxime Sulfonates

 

 

K. Maruoka, Y. Matsumura, J. Fujiwara, and H. Ywnainoto (Nagoya Univ., Japan)

245

P-74

A Synthetic Route to the Morphan Ring System from Norbonadiene. The synthesis of the 6,7-Pyridazinoannelated Morphan

 

 

H. Inoue, T. Origuchi, and K. Umano (Univ. Osaka Prefecture, Japan)

246

P-75

Novel Formation of [5]Para-1-azacyclophanes

 

 

H. Takeuchi and Y. Okazaki (Shinshu Univ., Japan)

247

P-76

Double Intramolecular Cycloaddition of 3,6-Bis(2-allylphenoxy)pyridazines

 

 

H. Takeshiba, T. Kinoto, and T. Jojima (Sankyo Co., Ltd., Japan)

248

P-77

Synthesis of Pyrimidine "Analogs" of Natural Polyamines

 

 

G. Menichi, J. Naciri, K. Takagi, and M. Hubert-Habart (Inst. Curie, France)

249

P-78

Photochemical Ring Opening of Pyrimidin-2(1H)-ones

 

 

T. Nishio and Y. Omote (Univ. Tsukuba, Japan)

250

P-79

New Synthetic Methods of Pyrazinoisoquinolines by Simultaneous C-N and C-C Bond Formation

 

 

C.S. Kim, J.H. Kim, and N.J. Lee (Korea Ady. Inst. Sci. Tech., Korea)

251

P-80

A Metal Mediated Synthesis of Chelate Reagent: 2,3,5,6-Tetra(α-pyridyl)pyrazine

 

 

Y. Okamoto, K. Ogura, and T. Kinoshita (Kitasato Univ., Japan)

252

P-81

Abnormal Formation of Pyrazolo[1,5-a]alpyridines via the Desulfurization of Pyrido[1,2-b]-4,1,2-thiadiazine Intermediates

 

 

A. Kakehi, S. Ito, and M. Ito (Shinshu Univ., Japan)

253

P-82

Reactions of Isoquinoline N-Oxide with Cyanoacetic Acid and Related Compounds

 

 

K. Funakoshi, H. Inada, and M. Hamana (Kyushu Univ., Japan)

254

P-83

Syntheses of α,b-Conjugated Carbodiimides and Ketenimines and Their Conversion to Some Heterocycles

 

 

S. Motoki, T. Saito, and M. Nakane (Sci. Univ. Tokyo, Japan)

255

P-84

Synthesis of Pyrimidin-4-ones from Diphenylcyclopropenone and Amidoximes

 

 

M. Takahashi, T. Nogami, and K. Nidaira (Ibaraki Univ., Japan)

256

P-85

Synthesis and Property of 5-(2,2-Difluorovinyl)uracil Derivatives

 

 

K. Hirota, F. Iwami, Y. Kitade, S. Senda, and Y. Maki (Gifu Coll. Pharm., Japan)

257

P-86

Synthesis of Pyrimidines from Perfluoro-2-methyl-2-pentene and Amidines

 

 

I. Ikeda, T. Ineyama, and M. Okahara (Osaka Univ., Japan)

258

P-87

Reaction of Trichloromethyl-N-heteroaromatics with Triphenylphosphine

 

 

S. Konno, E. Takaharu, Y. Sato, S. Fujimura, T. Sakamoto, and H. Yamanaka (Tohoku Univ., Japan)

259

P-88

A Novel Photochemical Ring Transformation of 4-Pyrimidinones. Formation of 5‑Carboxypyrimidinium Betaines

 

 

T. Takahashi, S. Hirokami, M. Nagata, and T. Yamazaki (Toyama Med. Pharm. Univ., Japan)

260

P-89

Pyrazinols and Pyrazinethiols as Acyl Carriers

 

 

A. Ohta, M. Shimazaki, M. Inoue, and Y. Inagawa (Tokyo Coll. Pharm., Japan)

261

P-90

Palladium Catalyzed Reactions of Pyrazines

 

 

A. Ohta, A. Inoue, and Y. Akita (Tokyo Coll. Pharm., Japan)

262

P-91

Regioselective Syntheses of Monosubstituted 2(1H)-Quinoxalinone Derivatives

 

 

G. Sakata, K. Makino, K. Morimoto, and I. Hashiba (Nissan Chem. Ind., Ltd., Japan)

263

P-92

Synthesis and Reactions of 1,2,3-Triazines

 

 

A. Ohsawa, K. Yamaguchi, T. Kaihoh, H. Arai, H. Ohnishi, H. Igeta, and Y. Iitaka (Showa Univ. and Univ. Tokyo, Japan)

264

P-93

Heterocyclic Synthesis via Cu(I)-promoted Arylation of Anionic Species

 

 

H. Suzuki, S.V. Thiruvikraman, and A. Osuka (Ehime Univ., Japan)

265

P-94

Ring Transformation of 1,3-Thiazinones with Hydrazines

 

 

Y. Yamamoto, Y. Azuma, Y. Morita, and S. Ohnishi (Tohoku Coll. Pharm., Japan)

266

P-95

New Synthesis of Cephems

 

 

G. Duguay, J.P. Pradčre, H. Quiniou, and A. Reliquet (Lab. Chim. Org. Nantes, France)

267

P-96

Synthesis of Stereoisomeric 2-Imino-1,3-oxazine and 2-Imino-1,3-thiazine Derivatives with Condensed Skeleton

 

 

G. Bernáth, F. Fülöp, and G. Csirinyi (Univ. Med. School Szeged, Hungary)

268

P-97

Synthesis and Stereochemical Studies of Pyrido[2,1-b]quinazolin-11-ones

 

 

F. Fülöp, I. Huber, G. Bernáth, G. Tóth, K. Simon, I. Hermecz, and Z. Mészáros (Univ. Med. School Szeged and CHINOIN Pharm. Chem. Works, Hungary)

269

P-98

Synthesis of Methylene-bridged Saturated 1,3-Benzoxazines

 

 

G. Stájer, E.A. Szabó, G. Bernáth, and P. Sohár (Univ. Med. School Szeged and EGYT Pharm. Works, Hungary)

270

P-99

Reactions of 1,3-Benzothiazine Derivatives with Aroyl Cyanides

 

 

J. Szabó, L. Fodor, E. Szücs, G. Bernáth, and P. Sohár (Univ. Med. School Szeged and EGYT Pharm. Works, Hungary)

271

P-100

Syntheses of Monocyclic 1,4-Diheteroepines from Pyridines via 3‑Azatricyclo[4.1.0.0]heptanes

 

 

J. Kurita, M. Hasebe, K. Iwata, and T. Tsuchiya (Hokuriku Univ., Japan)

272

P-101

Thermal Cycloaddition Reactivity and Regioselectivity of Adamantanethione

 

 

T. Sasaki, S. Eguchi, and T. Katada (Nagoya Univ., Japan)

273

P-102

Synthesis of Some Novel Homoadamantano[4,5]fused Azaheterocycles

 

 

T. Sasaki, S. Eguchi, and Y. Wakata (Nagoya Univ., Japan)

274

P-103

A Novel Synthesis of Benzothiazocines and Their Homologues

 

 

S. Sato, K. Tomita, S. Kobayashi, H. Fujita, and Y. Sato (Sankyo Co., Ltd. and Sankyo Chem. Ind., Japan)

275

P-104

Synthesis of the Cyclobutane Derivatives by Photochemical Cycloaddition of 1,2- or1,4-Benzopyrones to Acetylene

 

 

T. Matsui and M. Nakayama (Miyazaki Univ. and Hiroshima Univ., Japan)

276

P-105

Regioselective Syntheses of 2-Methyl-4H,5H-pyrano[3,2-e][1]benzopyran-4-one and 4,10‑Dihydro-3-hydroxy-3-methyl-1H,3H-pyrano[4,3-b][1]benzopyran-10-one

 

 

M. Yamauchi, S. Katayama, Y. Nakashita, and T. Watanabe (Josai Univ., Japan)

277

P-106

Distribution of Some Coumarins in Different Plants Families Grown in Saudi Arabia

 

 

B.A.H. El-Tawil and F.K.A. El-Beih (King Abdulaziz Univ., Saudi Arabia)

278

P-107

Reactions of Pyridone Derivatives with Isocyanates: Preparation of 1,3,5-Triazine-2,4-dione Derivatives

 

 

Y. Furukawa, M. Sawada, and T. Hanafusa (Osaka Univ., Japan)

279

P-108

Ring-Opening of Methylenedioxyquinolones

 

 

J. Frank and B. Podányi (CHINOIN Pham. Chem. Works, Hungary)

280

P-109

Synthesis and Some Reactions of 2,4-Benzodiazepines

 

 

H. Sawanishi and T. Tsuchiya (Hokuriku Univ., Japan)

281

P-110

Regio- and Stereo-selective Synthesis of Amido-lactones by Anodic Oxidation. The Application for the Synthesis of Eburnamonine and Vincamine

 

 

K. Irie, M. Okita, T. Wakamatsu, Y. Ban, Y. Nishibata, K. Aoe, and K. Kodera (Hokkaido Univ. and Tanabe Seiyaku Co., Ltd., Japan)

282

P-111

The Synthesis and Study of Some Condensed and Uncondensed Bisindoles

 

 

Sh. A. Samsonia (Tbilisi State Univ., USSR)

283

P-112

Synthetic Approach to the Antitumor Antibiotic Labendamycin

 

 

S. Hibino, M. Okazaki, K. Sato, I. Morita, and M. Ichikawa (Fukuyama Univ., Japan)

284

P-113

Synthesis of 6-Thio-L-sorbopyranose

 

 

G. E. M. Moussa, M. N. Basyouni, and A. Saad (Ain Shams Univ., Egypt)

285

P-114

Himalayamin and Limogine. Alkaloids of a New Skeletal Type

 

 

S. K. Talapatra (Univ. Calcutta, India)

286

P-115

The Photochemical Reaction of N-Alkyl-7-azabenzonorbornadienes

 

 

S. Yamada, S. Sato, and M. Ohashi (Univ. Electro-Commun., Japan)

287

P-116

Photo-dearomatization of N-Methylphthalimides

 

 

Y. Kanaoka and Y. Hatanaka (Hokkaido Univ., Japan)

288

P-117

Cyclic Peptides. Syntheses and Properties of Cyclic Hexa- and Octa-peptides Containing Lysine or Aspartic Acid

 

 

Y. Kanaoka, K. Okumura, H. Itoh, Y. Hatanaka, and K. Tanizawa (Hokkaido Univ., Japan)

289

P-118

Reactions of Vinylogous Acyl Cyanides with Enamines

 

 

M. Sakamoto, Y. Akiyama, J. Abe, T. Takano, and T. Kawasaki (Meiji Coll. Pharm., Japan)

290

P-119

A Practical Synthesis of 4-Aryl-1,2,3,4-tetrahydroisoquinolines

 

 

H. Hara, R. Shirai, O. Hoshino, and B. Umezawa (Sci. Univ. Tokyo, Japan)

291

P-120

A Synthesis of Mixed Tetrahydroisoquinoline Dimers via p-Quinol Acetate

 

 

H. Hara, M. Murakata, O. Hoshino, and B. Umezawa (Sci. Univ. Tokyo, Japan)

292

 

August 24 (Wed) Room A

 

Symposium IV. New b-Lactams and Other Heterocyclic Antibiotics (2)

Chairman R. G. Micetich (M. Otsuka)                                                                 12:45-14:00

S. Inv-15

Monobactams: Ring Activating N-1-Substituents in Monocyclic b-Lactam Antibiotics (Special Invited Lecture)

 

12:45

W.A. Slusarchyk, T. Dejneka, E.M. Gordon, W.H. Koster, and E.R. Weaver (Squibb Inst., USA)

293

S-IV-9

Asymmetric Synthesis of b-Lactams Using Chiral Five-membered Heterocyclic Compounds Derived from (+)-Tartaric Acid and L-Amino Acids

 

13:15

N. Ikota and A. Hanaki (Nat. Inst. Radiol. Sci., Japan)

294

S-IV-10

Asymmetric Synthesis of b-Lactam Antibiotics

 

13:30

A. Nishida, M. Shibasaki, and S. Ikegami (Teikyo Univ., Japan)

295

S-IV-11

Synthesis and Antibacterial Activity of 2-Fluoroalkylthiopenems

 

13:45

I. Kawamoto, R. Endo, K. Suzuki, and S. Sugawara (Sankyo Co., Ltd., Japan)

296

 

Chairman C. Hubschwerlen (S. Ikegami)                                                             14:45-16:00

S-IV-12

Synthesis of Penem Antibiotics

 

14:45

A.K. Ganguly, A. Afonso, V. Girijavallabhan, and S. McCombie (Schering-Plough Corp., USA)

297

S-IV-13

Chemistry of 3-H-1-Carbacephem Compounds

 

15:00

T. Hirata, A. Sato, and S. Kobayashi (Kyowa Hakko Kogyo Co., Ltd., Japan)

298

S-IV-14

Synthesis of Penem and Cephem Antibiotics Employing Carbene Reaction

 

15:15

T. Kametani, N. Kanaya, and T. Honda (Hoshi Univ., Japan)

299

S-IV-15

Penicillin-Cephalosporin Conversion with Complete Utilization of All the Framework Elements

 

15:30

S. Torii, H. Tanaka, T. Siroi, and M. Sasaoka (Okayama Univ., Japan)

300

S-IV-16

A New Method for the Synthesis of 7α-Methoxycephalosporins

 

15:45

K. Katano, K. Atsumi, K. Nishihata, F. Kai, E. Akita, S. Inoue, and T. Niida (Meiji Seika

Kaisha, Ltd., Japan)

301

 

 

August 24 (Wed) Room B

 

Symposium I. Organic Synthesis Utilizing Heterocycles (1)

Chairman J. W. Lown (M. Yokoyama)                                                                12:45-14:15

S-I-1

2-Lithio-2-trimethylsilyl-1,3-oxathiane: A Possible Acyl Dianion Equivalent

 

12:45

K. Fuji, M. Ueda, and E. Fujita (Kyoto Univ., Japan)

302

S-I-2

Nucleophilic Acylation of Heteroaromatics with Aromatic Aldehydes in the Presence of Benzimidazolium Salt

 

13:00

A. Miyashita and E. Hayashi (Shizuoka Coll. Pharm., Japan)

303

S-I-3

Synthesis and Properties of Pyrrolo[2,3-d]pyrimidine Derivative and Related Compounds

 

13:15

Z.S. Salih and W. Pfleiderer (Univ. Baghdad, Iraq and Univ. Konstanz, W. Germany)

304

S-I-4

Reactivity of b-(1-Imidazolyl)enones with Nucleophile

 

13:30

C. Kashima and T. Tajima (Univ. Tsukuba, Japan)

305

S-Inv-1

Organic Synthesis Utilizing Thiazolidine and the Related Heterocycles (Special Invited Lecture)

 

13:45

E. Fujita (Kyoto Univ., Japan)

306

 

Chairman P. K. Kadaba (M. Isobe)                                                                    14:45-16:15

S-I-5

Formation of Novel 1-,2-Oxathietanes and Their Chemical Reactivity Including Formal [σ2s + σ2a] Cycloreversions and Rearrangement

 

14:45

J.W. Lown and R.R. Koganty (Univ. Alberta, Canada)

307

S-I-6

Thermal and Photochemical Rearrangements of S-Substituted 2,5-Diphenyl-1,4-dithiins

 

15:00

K. Kobayashi and K. Mutai (Univ. Tokyo, Japan)

308

S-I-7

Reaction Mechanism of S,N-Double Rearrangement

 

15:15

M. Yokoyama, M. Kodera, M. Nakamura, and T. Imamoto (Chiba Univ., Japan)

309

S-I-8

Synthesis of N-Heterocycles Using 1,3-Dioxin-4-ones

 

15:30

M. Sato, H. Ogasawara, S. Komatsu, and T. Kato (Tohoku Univ., Japan)

310

S.Inv-2

New Methods and Reagents for the Synthesis of Heterocyclic Natural Products (Special Invited Lecture)

 

15:45

I. Ugi, J. Geller, and J. Götz (Tech. Univ. München, W. Germany)

311

 

August 24 (Wed) Room C

 

General Sessions (Oral) (G) (7)

Chairman J. Bergman (M. Somei)                                                                        12:45-14:15

G-87

Synthesis of 6-Hydroxy-4-(2'-di-n-propylaminoethyl)indole

 

12:45

T. Lee and J.G. Cannon (Univ. Iowa, USA)

312

G-88

Regioselective Vinylation of Indoles with Olefins and PdCl2

 

13:00

Y. Murakami, Y. Yokoyama, and T. Aoki (Toho Univ., Japan)

313

G-89

A New Versatile Synthesis of 4-Nitroindoles

 

13:15

J. Bergman, P.J.O. Sand, and U. Tilstam (Royal Inst. Tech., Sweden)

314

G-90

Reactions of Ethyl Phenylpropiolate with Indole Derivatives

 

13:30

M.Y. Shandala, H.A. Khatab, and N.Y. Yahya (Univ. Mosul, Iraq)

315

G-91

A Novel Spiro System: 2-Oxo-1',2',4',5'-tetrahydro-spiro[3H-indole-3,3'-1,2,4,5-tetrazine]-6'-thione

 

13:45

K.C. Joshi, P. Chand, and A. Dandia (Univ. Rajasthan, India)

316

G-92

A Novel Spiro System: 4',7'-Dihydro-8'-phenyl-spiro[3H-indole-3,6'-[pyrazolo(3,2-d)-1,3,5-thiadiazepine] ]-2,3'(1H)-dione

 

14:00

K.C. Joshi, P. Chand, and A. Dandia (Univ. Rajasthan, India)

317

 

Chairman R. Neidlein (Y. Murakami)                                                                   14:45-16:15

G-93

Some Reactions and Antibacterial Activities of Some Sulfonylimino-indoline Derivatives

 

14:45

C.A. Obafemi and D.C. Kolawole (Univ. Ife, Nigeria)

318

G-94

Reaction of 4,6-Dibromo-2-mercaptobenzimidazole with α,b-Bifunctional Compounds

 

15:00

H.K. Pujari and Brij Raj Sharma (Kurukshetra Univ., India)

319

G-95

Tetrahydro-b-carboline- and b-Carboline-3-carboxamides

 

15:15

R.T. Coutts, R.G. Micetich, R.A. Locock, G.B. Baker, A. Benderley, J. Pyrozko, T.W. Hall, and T. Dewhurst (Univ. Alberta, Canada)

 320

G-96

Synthesis and Chemical Reactivity of Some Benzimidazol-2-yl Hydrazonyl Chlorides

 

15:30

E.M. Kandeel, H. H. Alnima, and M.H. Elnagdi (Mansoura Univ., Egypt)

321

G-97

Reactions of Haloketenes with Ethyl N-(2-Pyridyl)formimidates and 2‑Arylideneaminopyridines

 

15:45

N. Katagiri, R. Niwa, and T. Kato (Tohoku Univ., Japan)

322

G-98

Photochemical Formation and Transannular Reactions of Medium-sized Nitrogen Heterocycles

 

16:00

T. Sheradsky and R. Moshenberg (Hebrew Univ., Israel)

323

 

August 24 (Wed) Room D

 

General Sessions (Oral) (G) (8)

Chairman W. Lowe (K. Akiba)                                                                           12:45-14:15

G-99

4-Diazomethylcoumarins as Stable Diazoalkanes. Their Facile Isomerization into Benzopyrano[3,4-c]pyrazol-4(3H)-ones

 

12:45

K. Ito, K. Nagasawa, and J. Maruyama (Hokkaido Inst. Pharm. Sci., Japan)

324

G-100

Triethylamine Mediated Transformation of 3-Formylchromone

 

13:00

C.K. Ghosh, C. Bandyopadhyay, and N. Tewari (Calcutta Univ., India)

325

G-101

Synthetic and Spectral Investigation on Some Coumarin Derivatives

 

13:15

D. Ramash, B.M. Sivaram, and M. Srinivasan (Indian Inst. Tech. Madras, India)

326

G-102

5-(2-Nitroethenyl)salicylandides, 6-(2-Nitroethenyl)-3-alkyl-2H-1,3-benzoxazine-2,4-dione, and Related Compounds and Their Antimicrobial and Molluscicidal Activity

 

13:30

N. Latif, N.S. Girgis, and F.M. Assad (Nat. Res. Centre, Cairo, Egypt)

327

G-103

Photo- and Radiation-induced Alkylation, Hydroxyalkylation, and Alkoxylation of Pyridinecarboxamides in Alcohol

 

13:45

A. Sugimori, H. Itoh, M. Kanai, N. Kuniyoshi, and M. Nishijima (Sophia Univ., Japan)

328

G-104

Stereoselective Condensation Reactions of 3-Formyl-2(1H)pyridones and Thiones

 

14:00

J. Becher, T. Johansen, I. Winckelmann, and M.A. Michael (Odense Univ., Denmark)

329

 

Chairman H. -H. Otto (A. Kubo)                                                                        14:45-16:15

G-105

Stereo- and Regioscicctive Aldol-type Reaction of Active Methylene Groups of Nitrogen-containing Heteroaromatic Compounds

 

14:45

H. Hamana and T. Sugasawa (Shionogi & Co., Ltd., Japan)

330

G-106

On the Facile and Convenient Synthesis of Substituted Pyridylglycols

 

15:00

A. Clerici and O. Porta (Politec. Milano, Italy)

331

G-107

Introduction of b-Ketoalkyl Groups at 4-Position of Pyridine Using Silyl Enol Ethers

 

15:15

K. Akiba, Y. Nishihara, and M. Wada (Hiroshima Univ., Japan)

332

G-108

The Pseudo-Gomberg Reaction of 4-Aminopyridine N-Oxide

 

15:30

S. Saeki, S. Kondo, T. Hayashi, and M. Hamana (Kyushu Univ., Japan)

333

G-109

The Reformatsky Reactions of N-Aryl-2(1H)-pyrimidinones

 

15:45

A. Katoh, Y. Omote, and C. Kashima (Univ. Tsukuba, Japan)

334

G-110

Vilsmeyer-Haack Reaction on Tetrahydroisoquinolines

 

16:00

T.R. Kasturi and H.R.Y. Jois (Indian Inst. Sci. Bangalore, India)

335

 

August 24 (Wed) Room E

 

General Sessions (Oral) (G) (9)

Chairman G. R. Revankar (I. Saito)                                                                     12:45-14:15

G-111

Synthesis of 6,2'-Methylene-cyclouridines

 

12:45

H. Inoue, T. Sano, S. Shuto, and T. Ueda (Hokkaido Univ., Japan)

336

G-112

Structure of a C-Cyclopyrimidine Nucleoside Derived from a 2'-C-Nitromethyluridine

 

13:00

T. Ueda, S. Sbuto, and H. Inoue (Hokkaido Univ., Japan)

337

G-113

A Ring Expansion Approach to 1,3-Diazepin-2-one Nucleosides

 

13:15

V.E. Marquez, K.V.B. Rao, J.V. Silverton, and J.A. Kelley (NIH, USA)

338

G-114

3-N-Acyl Uridines: Preparation and Properties of a New Class of Uracil Protecting Groups

 

13:30

C.J. Welch and J. Chattopadhyaya (Univ. Uppsala, Sweden)

339

G-115

The 9-Fluorenylmethoxycarbonyl-(FMOC) and 2-Nitrophenylsulfenyl-(NPS) Groups for the Protection of the Base Residues for the Chemical Syntheses of DNA and RNA Fragments

 

13:45

J. Heikkilä and J. Chattopadhyaya (Univ. Uppsala, Sweden)

340

G-116

Synthesis and Chemistry of Psicofuranosyl and Fructofuranosyl Nucleosides

 

14:00

A. Grouiller and J. Chattopadhyaya (Inst. Sci. Appl. Lyon, France and Univ. Uppsala, Sweden)

341

 

Chairman P. C. Srivastava (J. Imai)                                                                     14:45-16:00

G-117

Synthesis of 3,4-Disubstituted-1-b-D-ribofuranosylpyrazolo[3,4-d]pyrimidines

 

14:45

H.B. Cottam, C.R. Petrie, G.R. Revankar, and R.K. Robins (Brigham Young Univ., USA)

342

G-118

Mitsunobu Reaction on Protected Deoxyguanosine and Guanosine

 

15:00

R. Charubala, T. Trichtinger, and W. Pfleiderer (Univ. Konstanz, W. Germany)

343

G-119

One-pot Synthesis of Oligoribonucleotide from Unblocked Nucleoside

 

15:15

T. Shimidzu, K. Yamana, A. Murakami, and S. Maikuma (Kyoto Univ., Japan)

344

G-120

Chemical Synthesis of an Undecaribonucleoside Decaphosphate Constituting the 3'‑Terminal Acceptor Stem Sequence of Yeast tRNAPhe

 

15:30

M. Kwiatkowski, J. Heikkilä, S. Björkman, H. Seliger, and J. Chattopadhyaya (Univ. Uppsala, Sweden and Univ. Ulm, W. Germany)

345

G-121

Preparation of Blocks for Oligonucleotide Synthesis: A New Approach

 

15:45

G. Kochak and K. Misra (Univ. Allababad, India)

346

 

August 24 (Wed) Room F

 

General Sessions (Oral) (G) (10)

Chairman S. K. Talapatra (K. Kanematsu)                                                          12:45-14:15

G-122

Catalytic Asymmetric Epoxidation by Means of Polyaminoacids in a Triphase System

 

12:45

S. Colonna, S. Julia, H. Molinari, and S. Banfi (Univ. Milano, Italy and Inst. Quim. Sarria, Spain)

347

G-123

Synthesis of (±)-1-Hydroxy-2,6-diaryl-3,7-dioxabicyclo[3,3,0]octane Lignans

 

13:00

E. Taniguchi, F. Ishibashi, and Y. Narutomi (Kyushu Univ., Japan)

348

G-124

Enantioselective Synthesis of (-)-Sarracenin Using D-Glucose as Chiral Template

 

13:15

S. Takano, K. Morikawa, and S. Hatakeyama (Tohoku Univ., Japan)

349

G-125

The Total Synthesis of (+)-Polyzonimine

 

13:30

T. Sugahara, Y. Komatsu, and S. Takano (Tohoku Univ., Japan)

350

G-126

Total Synthesis of (±)-Sarubicin A (U-58,431)

 

13:45

Y. Takeuchi, M. Sudani, and E. Yoshii (Toyama Med. Pharm. Univ., Japan)

351

G-127

Syntheses of Pyranoisoflavones from the Corresponding Chalcones with Thallium (III) Nitrate

 

14:00

M. Tsukayama, Y. Iguchi, T. Horie, M. Masumura, and M. Nakayama (Tokushima Univ. and Hiroshima Univ., Japan)

352

 

Chairman J. P. Kutney (E. Yoshii)                                                                       14:45-16:15

G-128

9,10-Dihydrophenanthropyrans and Pyrones: Novel Phenolic Oxygen Heterocycles of Himalayan Orchids

 

14:45

P.L. Majumder, S. Joardar, D. Bandyopadhyay, N. Datta, M. Joardar, A.K. Sarkar, and J. Chakraborti (Univ. Coll. Sci. Calcutta, India)

353

G-129

Synthetic Studies of Crowned Morphines: Synthesis and Chemical Transformations of Crowned Thebaine

 

15:00

I. Fujii, K. Hayakawa, and K. Kanematsu (Kyushu Univ., Japan)

354

G-130

Chemistry of Isoquinolinequinone Antibiotics

 

15:15

A. Kubo, Y. Kitahara, S. Nakahara, N. Saito, K. Takahashi, and T. Arai (Meiji Coll. Pharm., Chiba Cancer Center Res. Inst., and Chiba Univ., Japan)

355

G-131

Caesalpinine A - A New Skeleton Spermidine Alkaloid from Caesalpinia digyna Rottl.

 

15:30

S.B. Mahato, N.P. Sahu, and P. Luger (Indian Inst. Chem. Biol., India and Freie Univ. Berlin, W. Germany)

356

G-132

Introduction of a Hydroxyl Group at C-14 of Yohimbine Alkaloids

 

15:45

E. Yamanaka, S. Kasamatsu, N. Aimi, S. Sakai, D. Ponglux, and S. Wongseripipatana (Chiba Univ., Japan and Chulaiongkorn Univ., Thailand)

 357

G-133

Alamaridine, a Novel Isoquinoline Alkaloid from Alangium lamarckii Thw.

 

16:00

S.C. Pakrashi, R. R. Sinha, A. Bhattacharjya, R. Mukhopadhyay, and E. Ali (Indian Inst. Chem. Biol. Calcutta, India)

358

 

August 24 (Wed) Room G

 

Poster Sessions (P) (3)                                                                                     16:15-18:00

P-121

A Synthesis of (±)-3-Hydroxyhomoaporphines

 

 

O. Hoshino, A. Takahashi, and B. Umezawa (Sci. Univ. Tokyo, Japan)

359

P-122

A Synthesis of (±)-2-Hydroxyhomoaporphines Bearing a Hydroxyl Group on the D-Ring

 

 

O. Hoshino, H. Ogose, M. Inoue, and B. Umezawa (Sci. Univ. Tokyo, Japan)

360

P-123

A Study on the Cyclization of N-Phenylacetyliminium Ions

 

 

S. Kano, T. Yokomatsu, and Y. Yuasa (Tokyo Coll. Pharm., Japan)

361

P-124

Synthesis of N-Heterocycles through N-Oxa-acyliminium Ions

 

 

S. Kano, Y. Yuasa, T. Yokomatsu, and S. Shibuya (Tokyo Coll. Pharm., Japan)

362

P-125

Facile Oxy-Vinyl [1,3]-Shift Promoted by Tetrabutylammonium Fluoride

 

 

T. Sano, J. Toda, and Y. Tsuda (Showa Coll. Pharm. Sci. and Kanazawa Univ., Japan)

363

P-126

Synthesis and Rearrangement Reactions of 3-(1,2,3,4-Tetrahydro-1-isoquinoline-methylene)-Δ2-1,2,4-oxadiazolin-5-ones

 

 

K. Takács (CHINOIN Pharm. Chem. Works, Hungary)

364

P-127

Synthesis and Properties of New Heterotricyclic Quinoxalinones - 3,3a‑Dihydrothiazolo[3,4-a]quinoxalin-4-ones

 

 

E.A. Adegoke and B.I. Alo (Univ. Lagos, Nigeria)

365

P-128

New Ring Transformations of a Spiro[quinoxaline-3,4'-butene] into Novel Quinoxaline Derivatives

 

 

Y. Kurasawa and A. Takada (Kitasato Univ., Japan)

366

P-129

Biosynthesis and Biomimetic Synthesis of Heterocyclic b-Substituted Alanines in Higher Plants

 

 

I. Murakoshi, F. Ikegami, and C. Koide (Chiba Univ., Japan)

367

P-130

Syntheses and Reaction of 2-Chloroformyl-4H-3,1-benzoxazin-4-one

 

 

M. Tsubota and M. Hamashima (Utsunomiya Univ., Japan)

368

P-131

Novel Ring-Closure Reaction between Quinones and Diamines

 

 

M. Matsuoka, K. Takagi, K. Hamano, and T. Kitao (Univ. Osaka Prefecture, Japan)

369

P-132

A Novel and Convenient "One Pot" Synthesis of 5-Substituted Pyrimido(4,5-b)quinolines Including 5-Substituted 5-Deazaflavines

 

 

B. Kokel (Inst. Curie, France)

370

P-133

A Convenient Novel "One Pot" Synthesis of Quinazoline and Benzoxazine Derivatives from Corresponding 2-Amino and 2-Hydroxybenzonitriles via Phosgeniminium Salt Condensation

 

 

B. Kokel (Inst. Curie, France)

371

P-134

Synthetic Studies of the Lythraceae Alkaloids via [3+2]Cycloaddition Reaction

 

 

K. Shishido, K. Tanaka, K. Fukumoto, T. Kametani, and S. Takano (Tohoku Univ. and Hoshi Univ., Japan)

372

P-135

Photochemistry of Hemicyanines. Part II. Syntheses of New Nitrogen Heterocyclic Ring Systems

 

 

K.B. Soroka, A.R. Kósmider, and J.A. Soroka (Polytech. Univ. Szczecin, Poland)

373

P-136

New Syntheses of Antitumor Benzo[c]phenanthridine Alkaloids: Nitidine and Fagaronine

 

 

H. Ishii, T. Ishikawa, I.-S. Chen, and Y. Ichikawa (Chiba Univ., Japan)

374

P-137

Reactions and Properties of New Azonia Compounds Derived from 2‑Methylbenzo[a]quinolizinium Salt

 

 

S. Arai, K. Nagakura, M. Ishikawa, and M. Hida (Tokyo Metropolitan Univ., Japan)

375

P-138

Synthesis of Some b-D-Ribofuranosyl-4,7-methanoindazoles and Pyrazolo[1,5-a]azepines

 

 

S. Nagai and J. Sakakibara (Nagoya City Univ., Japan)

376

P-139

Reactivity of Oxygenated 5-Deazaflavins

 

 

F. Yoneda, Y. Sakuma. and M. Takamoto (Kumamoto Univ. and Takeda Chem. Ind., Ltd., Japan)

377

P-140

Synthesis and Desulfurization of Pyridazino[4,5-e][1,3,4]thiadiazines

 

 

K. Kaji and H. Oda (Gifu Coll. Pharm., Japan)

378

P-141

Some Anionic Reactions of Δ2-Pyrazolines

 

 

A. Jończyk, J. Włostowska, W. Woźniak, and M. Ludwikow (Tech. Univ. Warszawa, Poland)

379

P-142

Novel Aminomethynylation Reaction of Guanidine Heterocyclic System

 

 

S.M.M. Bayomi, A. Tantawy, and M. El-kerdawy (Mansoura Univ., Egypt)

380

P-143

Synthesis of 2-Bromo-2,3-dihydro-1H-pyrazolo[1,2-a]indazolium Bromides and Their Reactions with Alkaline Solations

 

 

Y. Fujimura, Y. Nawata, I. Matsunaga, and M. Hamana (Chugai Pharm. Co., Ltd., Japan)

381

P-144

Synthesis of Macrocyclic Polyethers Containing Cyclobutane Ring by Intramolecular Photocycloaddition

 

 

K. Mizuno, H. Kagano, T. Hashizume, and Y. Otsuji (Univ. Osaka Prefecture, Japan)

382

P-145

Methine Dyes from 1-Alkyl-3-[4-(dialkylamino)phenyl]-2,3-dihydro-2,2-dimethyl-1H- indole-5-carboxaldehydes

 

 

J.J. Krutak and H.M. Beard (Eastman Kodak Co., USA)

383

P-146

Electron Transfer Processes: Reaction of Indolizines with Diazonio Ions or Cripto-Ions

 

 

M. Colonna and M. Poloni (Univ. Bologna, Italy)

384

P-147

Introduction of a Methoxyl Group into the 6-Position of Indoles

 

 

Y. Miyake, M. Kawase, and Y. Kikugawa (Josai Univ., Japan)

385

P-148

Catalytic Transfer Hydrogenation (CTH) of Indoles with Palladium on Carbon in Formic Acid

 

 

M. Kashimura and Y. Kikugawa (Josai Univ., Japan)

386

P-149

Methyl Migration and Demethylation in the 4,5-Dimethylcarbazole Synthesis by Täuber Method

 

 

Y. Tsunashima and M. Kuroki (Shibaura Inst. Tech., Japan)

387

P-150

Synthesis and Characterization of 4,9-Dioxy-1H-benz[f]indoles

 

 

G. Malesani, M.G. Ferlin, G. Chiarelotto, and S. Masiero (Univ. Padova, Italy)

388

P-151

Strong Base Induced Cycloaddition of Homophthalic Anhydrides and Their Heteroaromatic Analogues Leading to Polycyclic Aromatic Compounds

 

 

Y. Tamura, M. Sasho, H. Maeda, T. Tsugoshi, and Y. Kita (Osaka Univ., Japan)

389

P-152

The Photochemistry of Keto-imine Compounds

 

 

Y. Hirai, H. Egawa, and T. Yamazaki (Toyama Med. Pharm. Univ., Japan)

390

P-153

A New Synthetic Method for the Framework of Aspidosperma Alkaloids

 

 

I. Utsunomiya and M. Natsume (Itsuu Lab., Japan)

391

P-154

1-Ethyl-octahydro-indoloquinolizine-1-pyruvic Acid Methyl Ester Oxime. A Key Intermediate for the Synthesis of Ebumane Alkaloids

 

 

A. Nemes, J. Kreidl, Gy. Kalaus, L. Szabó, Cs. Szántay (Chem. Works G. Richter Ltd. and Tech. Univ. Budapest, Hungary)

392

P-155

Syntheses and Reactions of Yohimban Derivatives

 

 

I. Ninomiya, O. Miyata, Y. Hirata, and T. Naito (Kobe Women's Coll. Pharm., Japan)

393

P-156

Total Synthesis of Surugatoxin

 

 

S. Inoue, K. Okada, H. Tanino, K. Hashizume, H. Kakoi, and M. Mizuno (Meijo Univ., Japan)

394

P-157

The Synthesis of Spiro-(cyclopentane-1,3'-oxindol)-derivatives

 

 

T. Kosuge, H. Ishida and Y. Katuyama (Shizuoka Coll. Pharm., Japan)

395

P-158

Studies Directed toward the Total Synthesis of (+)-Griseoviridin

 

 

S. Saito, K. Terao, T. Yamakawa, Y. Matsumoto, R. Nishida, M. Inaba, and T. Moriwake (Okayama Univ., Japan)

396

P-159

Synthesis of 2,3,4,9-Tetrahydrothiopyrano[2,3-b]indoles via a Novel Intramolecular Indole Grignard Reaction

 

 

N. Ishizuka and Y. Makisumi (Shionogi & Co., Ltd., Japan)

397

P-160

A Ring Destruction Approach to Novel Fused Azecine and Azonine Derivatives from Bridgehead Amines

 

 

J. B. Bremner and K.N. Winzenberg (Univ. Tasmania, Australia)

398

P-161

Syntheses and Reactions of 3-Cyanoindolizines

 

 

K. Matsumoto, Y. Ikemi, and T. Uchida (Kyoto Univ. and Fukui Univ., Japan)

399

P-162

Addition Reactions of Condensed Azole Derivatives with Dimethyl Acetylenedicarboxylate. II

 

 

N. Kawahara, T. Nakajima, T. Itoh, and H. Ogura (Hokkaido Inst. Pharm. Sci. and Kitasato Univ., Japan)

400

P-163

The Synthesis of Novel Heterocyclic Compounds. Derivatives of 3H-Indole and Benzofuro[3,3a-d]isoxazole

 

 

K. Takahashi, E. Kaji, and S. Zen (Kitasato Univ., Japan)

401

P-164

Novel Synthesis of Benzofuran and Chroman Derivatives

 

 

K. Matsukawa, T. Ueda, J. Setsune, and T. Kitao (Univ. Osaka Prefecture, Japan)

402

P-165

Typical Electrophilic Reactions of Furopyridines

 

 

S. Shiotani and H. Morita (Univ. Toyama, Japan)

403

P-166

Mechanisms of Photo-induced Isomerization of 4-Oxo-4H-benzisoxazolo[2,3-a]pyridine Derivatives

 

 

T. Yoshida, N. Nagamoto, H. Mizuta, S. Naruto, and H. Uno (Dainippon Pharm. CO., Ltd., Japan)

404

P-167

Steric Effects in the Ring Closure Reactions of 2-(2-Pyridylaminomethylene)succinates

 

 

L. Vasvári-Debreczy, I. Hermecz, and Z. Mészáros (CHINOIN Pharm. Chem. Works, Hungary)

405

P-168

One-Step Synthesis of Pyrrolo[2,3-d]pyrimidin-4-imines

 

 

N.S. Girgis, A. Jřrgensen, and E.B. Pedersen (Nat. Res. Centre, Egypt and Odense, Univ., Denmark)

406

P-169

The Reaction of 5-Amino-1,2,4-triazoles with Cyclic b-Keto Esters. A Novel Ring System

 

 

J. Reiter, L. Pongó, P. Sohár, and P. Dvortsák (EGYT Pharm. Works and Inst. Drug Res., Hungary)

407

P-170

Synthesis of Some New 2-Thiox-4-amino[1,2-d]pyrimidine Derivatives

 

 

E.M. Kandeel, S. Elmorsi, and M.T. Zimaity (Mansoura Univ., Egypt)

408

 

August 24 (Wed) Room H

 

Poster Sessions (P) (4)                                                                                     16:15-18:00

P-171

Synthesis of Furopyridine Derivatives for Biological Evaluation

 

 

A. Attia and M.M. Kamel (Nat. Res. Centre, Egypt)

409

P-172

Thia and Ring-opening Analogues of Isoalloxazines

 

 

M. Sako, Y. Kojima, K. Hirota, and Y. Maki (Gifu Coll. Pharm., Japan)

410

P-173

Studies on Reactive Intermediates.III.Reaction of Diketene with 3-Amino-1,2,4-triazines

 

 

M. Daneshtalab and M.H.H. Tehrani (Tehran Univ., Iran)

411

P-174

Synthesis of N6-Alkoxy-1,3-dialkyladeninium Salts and an Attempt to Synthesize 1,3‑Dimethyladenine

 

 

T. Fujii, T. Saito, and T. Nakasaka (Kanazawa Univ., Japan)

412

P-175

Synthesis of New Heterocyclic Compounds Containing 1,2,3,4-Tetrahydroisoquinoline or 3-Oxo-tetrahydroisoquinoline Ring

 

 

K. Gáll-Istók, Gy. Deák, and G. Tóth (Hungarian Acad. Sci. and Tech. Univ. Budapest,Hungary)

413

P-176

Reaction of 7-Methoxy-1-phenyl-1H-1,2,3-triazolo[4,5-d]pyridazine 5-Oxide with Nucleophiles

 

 

E. Oishi, Y. Asahina and E. Hayashi (Shizuoka Coll. Pharm., Japan)

414

P-177

Hydrolysis of Nucleosides Related to Fluorescent Minor Components of Phenylalanine Transfer Ribonucleic Acids

 

 

T. Itaya and T. Harada (Kanazawa Univ., Japan)

415

P-178

Synthesis of Phosphorylcholine-bearing Porphinato-Iron Complexes and Their Hemolytic Activities

 

 

E. Hasegawa, Y. Matsushita, K. Eshima, and E. Tsuchida (Taiho Pharm. Co., Ltd. and Waseda Univ., Japan)

416

P-179

Cationic Polar Cycloaddition with α-Chlorosulfides

 

 

Y. Tamura, S. Akai, H.-D. Choi, H. Nakagawa, and H. Ishibashi (Osaka Univ., Japan)

417

P-180

Preparation and Thermolysis of 1,2,3,6-Tetrahydro-1,2-diphenyl-1λ,2λ-diphosphorin-1,2-Disulfide

 

 

T. Kawashima, M. Shimamura, and N. Inamoto (Univ. Tokyo, Japan)

418

P-181

Diels-Alder Reaction of 1,4-Benzodithiin 1,1,4,4-Tetraoxide with a Variety of Dienophiles

 

 

J. Nakayama, Y. Nakamura, and M. Hoshino (Saitama Univ., Japan)

419

P-182

Syntheses of Biologically Active Organic Germanium Compounds

 

 

N. Kakimoto, M. Akiba, and T. Takada (Asai Germanium Res. Inst. and Tokyo Coll. Pharm., Japan)

420

P-183

Carbon-13 Chemical Shift of Some Substituted Tetrahydropyrazine

 

 

S.R. Salman, M. Khayate, and S.A. Kanber (Univ. Baghdad, Iraq)

421

P-184

An Account of the Selectivity in the Reactions of Nitrile Oxides with Substituted p‑Benzoquinones by FMO Theory

 

 

T. Hayakawa, K. Araki, and S. Shiraishi (Univ. Tokyo, Japan)

422

P-185

Azinyl-Ylidene Tautomerism of Acylmethyl Azines

 

 

S.A. Stekhova, V.V. Lapachov, O.P. Petrenko, and V.P. Mamaev (Inst. Org. Chem., Novosibirsk, USSR)

423

P-186

Prototropic Rearrangements in Some Aminopyrrolidinones

 

 

J. Lange, J. Rajewski, and W. Koberda (Warsaw Tech. Univ., Poland)

424

P-187

Covalent Hydration of 7,8-Dihydro(3H)pterin

 

 

W.L.F. Armarego, D. Randies, and H. Taguchi (Australian Nat. Univ., Australia, and Kyoto Women's Univ., Japan)

425

P-188

A New Heterocyclisation between Monosubstituted Amidines and α-Bromo-α,b- unsaturated Esters and Ketones

 

 

C. Luu-Duc, A. Marsura, and G. Gellon (UER Pharm. Grenoble, France)

426

P-189

Photochemical Aromatization of 9-Benzyl-1,6-dihydro-2-methyl-8-azapurine through Its Intermediate Intermolecular Photo Dimer ic. Bis-(9-benzyl-1,6-dihydro-2-methyl-8-azapurin-6-yl)

 

 

F. Kázmierczak (Adain Mickiewicz Univ., Poland)

427

P-190

Solution Form of Rubranine and Related Compounds from NMR and X-Ray Studies

 

 

S.K. Arora, V.V. Kane, A.R. Martin, and P. Crews (Univ. Arizona and Univ. California, USA)

428

P-191

Synthesis of Oxygen-bridged Aza[15]annulene Derivatives. Novel Cyclization Reaction Leading to Aza-annulene Frames

 

 

H. Ogawa, M. Kumemura, T. Imoto, I. Miyamoto, H. Kato, S. Takahashi, and Y. Taniguchi (Kyushu Univ. and Kurume Tech. Coll., Japan)

429

P-192

Amphiphilic Phthalocyanine

 

 

T. Kunitake, M. Shimomura, and H. Tsuruta (Kyushu Univ., Japan)

430

P-193

Generation of Chiral Cavity from Achiral Heterocyclophane Host and Achiral Guest

 

 

I. Tabushi, K. Yamamura, H. Nonoguchi, K. Hirotsu, and T. Higuchi (Kyoto Univ. and Osaka City Univ., Japan)

431

P-194

Structure and Cation Selectivity of Unsymmetrical Bis(Crown Ether)s

 

 

T. Ikeda, K. Kikukawa, and T. Matsuda (Kyushu Univ., Japan)

432

P-195

Crown Ether-based Extraction Photometric Reagents for Alkali Metals

 

 

H. Nakamura, K. Nita, M. Takagi, and K. Ueno (Kyushu Univ., Japan)

433

P-196

Synthesis and Property of Fluorescent Cyclic Polyether Dye Containing a Benzothiazole Unit

 

 

I. Tanigawa, T. Kaneda, and S. Misumi (Osaka Univ., Japan)

434

P-197

Total Synthesis of Jolkinolide A, B, and E

 

 

S. Katsumura and S. Isoe (Osaka City Univ., Japan)

435

P-198

An Application of the Angular Hydroxylation Using Benzeneseleninic Anhydride to the Synthesis of 10β-Hydroxyfuranocremophilanes and Related Compounds

 

 

K. Yamakawa, T. Satoh, S. Takita, T. Iida, and M. Iwasaki (Sci. Univ. Tokyo, Japan)

436

P-199

Alkylations at C-3 and C-5 of Triacetic Acid Lactone and Derivatives

 

 

P. de March, M. Moreno-Mańas, R. Pleixats, and I. Ripoll (Univ. Autónoma Barcelona, Spain)

437

P-200

Synthetic Studies on Antibiotic A23187 (Calcimycin)

 

 

Y. Nakahara, A. Fujita, and T. Ogawa (Inst. Phys. Chem. Res., Japan)

438

P-201

Total Synthesis of (±)-Sesbanine via Directed Metalation of Tertiary Nicotinamides

 

 

M. Iwao and T. Kuraishi (Nagasaki Univ., Japan)

439

P-202

Stereospecific Synthesis of Solenopsin A

 

 

M. Ogawa and M. Natume (Itsuu Lab., Japan)

440

P-203

Aziridine in Alkaloid Synthesis: Syntheses of γ-Lycorane and Erythrina Skeletons

 

 

K. Higashiyama, T. Honda, H. Otomasu, and T. Kametani (Hoshi Univ., Japan)

441

P-204

Conversion of the Protopine N-Oxides to the Benzo[c]phenanthridines and the Secoberbines

 

 

K. Iwasa and N. Takao (Kobe Women's Coll. Pharm., Japan)

442

P-205

Synthesis of Benzindenoazepine Alkaloids, Fumarofine and Fumaritrine

 

 

M. Hanaoka, C. Mukai, S. Sakurai, A. Ashimori, H. Yamagishi, M. Iwasaki, and S. Yasuda(Kanazawa Univ., Japan)

443

P-206

Synthetic Study Directed toward Cyclopiazonic Acid

 

 

M. Somei, S. Tokutake, and C. Kaneko (Kanazawa Univ., Japan)

444

P-207

Synthesis of Cardioactive Steroids. Modified Synthetic Route to Isocardenolide

 

 

M.-J. Shiao (Tunghai Univ., China)

445

P-208

Synthesis of Both the Enantiomers of 2,5-Dimethyl-2-isopropyl-2,3-dihydrofuran, the Sex Pheromone of Hylecoetus dennestoides L.

 

 

T. Ebata and K. Mori (Univ. Tokyo, Japan)

446

P-209

A Stereoselective Synthesis of Daunosamine Utilizing Oxazole Derivatives

 

 

A. Kawai, Y. Hamada, and T. Shioiri (Nagoya City Univ., Japan)

447

P-210

Synthesis and Antimicrobial Activity of Some Heterocycles

 

 

N.F. Eweiss, M.A. Ghannoum, A.A. Bahajaj, and E.A. Elsherbini (Univ. Kuwait, Kuwait)

448

P-211

Synthesis of Some New [1,2]Diazepino[4,5-b]indoles and [1,2]Diazepino[5,6-b] indoles

 

 

A. Monge J.A. Palop, T. Gońi, A. Martínez, and E. Femandez-Alvarez (Univ. Navarra, Spain)

449

P-212

Synthesis and Antibacterial Activity of 2-Phenyl-4H-benzo[b]thiopyran-4-ones (Thioflavones) and Related Compounds

 

 

H. Nakazumi, T. Ueyama, T. Kitaguchi, and T. Kitao (Univ. Osaka Prefecture, Japan)

450

P-213

Synthesis and Bioactivitics of Fused Perimidine Derivatives

 

 

K.-C. Liu and H.-H. Chen (Nat. Defense Med. Center, Taipei, China)

451

P-214

Synthesis and Antibacterial Activity of Thiazolo[5,4-b]pyridine Analogs of Pipemidic Acid

 

 

D.C. Leysen, A. Haemers, and A.J. Vlietinck (Univ. Antwerp, Belgium)

452

P-215

Synthesis and Chemotherapeutical Activity of 5-Cyano-6-aryluracil and 2-Thiouracil Derivatives

 

 

V.J. Ram, A.J. Vlietinck, and D.A.V. Berghe (S.C. Coll. Ballia, India and Univ. Antwerp, Belgium)

453

P-216

A Novel Fluorogenic Substrate for Chymotrypsin. 4-Amino-7-nitrobenzo-2-oxa-1,3-diazole Derivatives

 

 

E. Sato, M. Miyakawa, and Y. Kanaoka (Hokkaido Univ., Japan)

454

P-217

Synthetic Study on Dolastatin 3 Bearing Thiazole Ring

 

 

Y. Hamada, M. Kokuryu, and T. Shioiri (Nagoya City Univ., Japan)

455

P-218

Novel Functions of Porphyrin-Iron Complex as a Model of Cytochrome P-450: Deoxygenation and Reductive Dioxygen Activation

 

 

N. Miyata, T. Santa, and M. Hirobe (Univ. Tokyo, Japan)

456

P-219

Micro-computer-assisted Synthesis Design

 

 

S. Hara and T. Uchimaru (Tokyo Coll. Pharm., Japan)

457

P-220

Heterocycles from Carbohydrate Precursors. Studies on Dehydro-D-Erythro-ascorbic Acid 2-Arylhydrazone 3-Oximes: Conversion into Substituted Triazoles and Isoxazolines

 

 

M.A.El Sekily and S. Mancy (Alexandria Univ., Egypt)

458

P-221

Synthesis of the Phthalimide C-Nucleoside, a Benzologue of Showdomycin

 

 

I. Maeba, F. Usami, and H. Furukawa (Meijo Univ., Japan)

459

P-222

Some New Aspects in the Synthesis of Purine 8-N-Cyclonucleosides

 

 

T. Sasaki, K. Minamoto, Y. Fujiki, and H. Nakade (Nagoya Univ., Japan)

460

P-223

Benzodithiol-2-yl as a New Hydroxyl Protecting Group in Nucleosides

 

 

M. Sekine and T. Hata (Tokyo Inst. Tech., Japan)

461

P-224

Synthesis of Dinucleotide-like Compounds Containing a 5'-Deoxy-S'-adenosineacetic Acid

 

 

T. Kurihara, A. Ota, H. Urata, S. Harusawa, H. Hirano, M. Inoue, and T. Ishida (Osaka Coll. Pharm., Japan)

462

P-225

Synthesis and Attempted Polymerization of N-Arylmaleimides Substituted with Allylamino or Cyclopropylamino Groups at 2- Position

 

 

T.M. Pyriadi and H. Kaleefa (Univ. Baghdad, Iraq)

463

P-226

Synthesis of Some New Heterocyclic Systems of Biological Interest via Reactions with Isothiocyanates

 

 

H.H.S. Alnima (Univ. Salahaldin, Iraq)

464

P-227

Chemical Reactivity of 2-Amino-4-methyl-5-benzothiazole towards Isothiocyanates

 

 

H.H.S. Alnima (Univ. Salahaldin, Iraq)

465

P-228

Photochemical Decomposition of the Oxides of 2,5-Diphenyl-1,4-dithiin Systems in DMSO-A Novel Case of Ring Expansion

 

 

C. L. Gajurel and S. R. Vaidya (Tribhuvan Univ., Nepal)

466

P-229

A Novel Approach towards the Synthesis of the 3,4,5-Trihydro-1,3-diazepin-5-ol Ring Structure

 

 

L. B. Townsend, O.L. Acevedo, and S. Krawczyk (Univ. Michigan, USA)

467

P-230

Reactions of Scienonucleosides with Koshland's Reagents

 

 

A. Jankowsky (Adam Mickiewicz Univ., Poland)

468

P-231

The Synthesis of Glucopyranosylthioureas from Rhodanines

 

 

P. Tovivich and W. Pasakdee (Chulaiongkorn Univ. and Chiangmai Univ., Thailand)

469

P-232

NMR and IR Studies on Cyclic Formals

 

 

L. Arslan (Univ. Salahedeen, Iraq)

470

P-233

Synthesis of Phosphorylated 2,5-Dihydrothiophene 1,1-Dioxides

 

 

C.M. Angelov, D.D. Enchev, and M. Kirilov (Higher Pedagogical Inst., Bulgaria)

471

P-234

Synthesis of Ethynylselenocarboxylic Acids from 1,2,3-Selenadiazoles

 

 

I. Lalezari (Montefiore Med. Center, USA)

472

P-235

A New Synthesis of 4H-1,4-Thiazines and N-Alkyl-4H-1,4-benzothiazines

 

 

G. Liso, G. Trapani, A. Reho, A. Latrofa, and P. Marchini (Univ. Bari, Italy)

473

P-236

N-(2-Acylthio)phenylenamides from Benzothiazolines

 

 

G. Liso, G. Trapani, A. Reho, A. Latrofa, and F. Morlacchi (Univ. Bari, Italy)

474

P-237

Synthesis and Spectroscopic Data of Some Quinolinium Nucleosides

 

 

F. C. Alderweireldt, L. Kemps E. L. Esmans, R. A. Dommisse, and J. A. Lepoivre (Antwerp Univ., Belgium)

475

P-238

On the Synthesis, Reducing and Spectroscopic Properties of Methyl Substituted 1,4‑Dihydronicotinamides

 

 

J.D. Bossaerts, R. A. Dommisse, and F. C. Alderweireldt (Antwerp Univ., Belgium)

476

P-239

Thermal Rearrangement and in vitro Activity of Toromycin against Aerobic Anaerobic Bacteria. Significance of Rearrangement Studies on the Nature of Chrysomycin and the Structure of Gilvocarcin A

 

 

T. Jain, L. Jackman, G. Simolike, and I. Zajac (Smith Kline & French Labs., USA)

477

 

August 25 (Thu) Room

 

A Symposium IV. New β-Lactams and Other Heterocyclic Antibiotics (3)

Chairman S. Masamune (M. Sbibasaki)                                                               12:45-14:00

S. Inv-16

The Total Synthesis of Some Non-classical β-Lactams (Special Invited Lecture)

 

12:45

D.H. Shih, L.D. Cama, F. Baker, and B.G. Christensen (Merck Sharp & Dohme Res. Lab., USA)

479

S-IV-17

A Simple Enantioselective Synthesis of β-Lactams

 

13:15

C. Hubschwerlen and G. Schmid (F. Hoffmann-La Roche and Co., Ltd., Switzerland)

480

S-IV-18

Enantioscicetive Synthesis of Asparenomyein C by Chemicoenzymatic Approach

 

13:30

S. Kobayashi, K. Okano, and M. Ohno (Univ. Tokyo, Japan)

481

S-IV-19

Enantioselective Synthesis of Optically Active β-Lactams from D-Glyceraldehyde Acetonide

 

13:45

H. Matsunaga. T. Sakamaki, H. Nagaoka, and Y. Yamada (Tokyo Coll. Pharm., Japan)

482

 

Chairman A. G. Brown (M. Ihara)                                                                       14:45-15:45

S-IV-20

The Chlorinolysis of Sulfur Containing β-Lactams

 

14:45

R.G. Micetich, R.B. Morin, C.C. Shaw, and R. Singh (Univ. Alberta, Canada, Bristol-Meyers Co., USA, and Ayerst Lab., Canada)

483

S-IV-21

Synthesis of β-Lactams with Thienamycin-type Sidechain

 

15:00

M. Sunagawa, K. Goda, M. Enomoto, and A. Sasaki (Sumitomo Chem. Co., Ltd., Japan)

484

S-IV-22

Synthesis of Thienamycin and 2-Alkylthiomethyl-carbapenem (2-Homo-thienamycin) Analogues from 6-Aminopenicillanic Acid

 

15:15

T. Hiraoka, T. Kobayashi, N. Ishida, M. Shiozaki, K. Hirai, H. Maruyama, S. Sato, C. Tamura, and S. Sugawara (Sankyo Co., Ltd., Japan)

485

S-IV-23

A Chiral Synthesis of Carbapenem Antibiotics from Penicillins

 

15:30

M. Aratani, K. Sawada, H. Hirai, and M. Hashimoto (Fujisawa Pharm. Co., Ltd., Japan)

486

 

August 25 (Thu) Room B

 

Symposium I. Organic Synthesis Utilizing Heterocycles (2)

Chairman I. Ugi (K. Fuji)                                                                                     12:45-14:15

S-I-9

Quinone Diazide Cyclizations

 

12:45

G.A. Kraus and J.O. Nagy (Iowa State Univ., USA)

487

S-I-10

Darzens Condensation for Stereocontrol in Sugar Template

 

13:00

M. Isobe, N. Fukami, and T. Goto (Nagoya Univ., Japan)

488

S-I-11

Enantiocontrolled Synthesis of Natural Products Utilizing Heterocycles

 

13:15

S. Takano, K. Seya, H. Nuinata, E. Goto, M. Hirama, and K. Ogasawara (Tohoku Univ., Japan)

489

S-I-12

An Approach to Taxane Diterpenes. The Synthesis of the Bicyclo[5.3.1]undecan-4-one Derivatives

 

13:30

Y. Ohtsuka and T. Oishi (Inst. Phys. Chem. Res., Japan)

490

S. Inv-3

New Routes to Macrocyclic Lactones and Lactams (Special Invited Lecture)

 

13:45

H.H. Wasserman, R.P. Robinson, C.G. Carter, H. Matsuyama, G.D. Berger, and M.R. Leadbetter (Yale Univ., USA)

491

 

Chairman G. A. Kraus (K. Ogasawara)                                                               14:45-16:00

S-I-13

Conversion of Azidotriazolines to Tetrazoles via Diazo Transfer Reaction

 

14:45

P.K. Kadaba (Univ. Kentucky, USA)

492

S-I-14

Synthesis of Bridgehead Nitrogen Heterocycles Utilizing Intramolecular Ring Transformation

 

15:00

T. Sasaki, E. Ito, and K. Asai (Nagoya Univ., Japan)

493

S-I-15

Utilization of Optically Active 4-Trityloxymethyl-2-buten-4-olide in Photoinduced Asymmetric (2+2) Cycloaddition

 

15:15

M. Tanaka, K. Tomioka, and K. Koga (Univ. Tokyo, Japan)

494

S.Inv-4

Alkaloid Synthesis (Special Invited Lecture)

 

15:30

E. Wenkert (Univ. California-San Diego, USA)

495

 

August 25 (Thu) Room C

 

General Sessions (Oral) (G) (11)

Chairman F. A. Neugebauer (K. Matsumoto)                                                      12:45-14:15

G-134

Mechanistic and Synthetic Studies of Pyrimidine Ring Formation from α,β-Unsaturated Carbonyl Compounds and Amidines

 

12:45

A. Weis, M. Bernstein, and D. Zamir (Weizmann Inst. Sci., Israel)

496

G-135

Cyclic Amidines as Convenient Models for the Studies of Proton Transfer Reactions

 

13:00

A. Weis (Weizmann Inst. Sci., Israel)

497

G-136

Substituent Effect on the Site-selective Reaction of Pyrimidines

 

13:15

T. Sakamoto, H. Yoshizawa, S. Kaneda, and H. Yamanaka (Tohoku Univ., Japan)

498

G-137

Effect of Thymine Hydroperoxide on DNA Bases

 

13:30

T. Nagamatsu, F. Yoneda, and S.Y. Wang (Kumamoto Univ., Japan and Johns Hopkin’s Univ., USA)

499

G-138

One Stage Synthesis of Nitrogen-Heterocycles Using Nitriles under High Pressure

 

13:45

M. Kurabayashi, K. Yanagiya, and M. Yasumoto (Nat. Chem. Lab. Industry, Japan)

500

G-139

Synthesis and Stereochemical Studies of cis and trans Condensed-skeleton 5,6-Dihydro-2-phenyl-4H-1,3-thiazines. An Unexpected Spirocyclization

 

14:00

L. Simon, S.G. Talpas, F. Fülöp, G. Bernáth, and P. Sohár (Univ. Med. School Szeged and EGYT Pharm. Works, Hungary)

501

 

Chairman S. V. Kessar (T. Higashino)                                                                 14:45-16:15

G-140

Synthesis and Properties of Some New Sulfur Derivatives of Chromone and 4-Quinolone

 

14:45

W. Löwe, A. Kennemann, A. Kietzmann, and C. Müller-Menke (Free Univ. Berlin, W. Ger- many)

502

G-141

Novel Synthesis of Substituted Quinolines

 

15:00

M.Z.A. Badr, Y.S. Mobamed, and F.F. Abdel-Latif (Assiut Univ., Egypt)

503

G-142

Intramolecular Alkylazide 1,3-Dipolar Cycloadditon: Application to the Synthesis of Heterocyclic Systems

 

15: 15

C.-K. Sha, J.-J. Yuang, and S.-L. Ouyang (Nat. Tsing Hua Univ., China)

504

G-143

Transition Metal Catalyzed Novel Route to Quinoline Derivatives Using Alcohols

 

15:30

Y. Watanabe and Y. Tsuji (Kyoto Univ., Japan)

505

G-144

Studies on the Vilsmeier-Haack Reaction. Reaction of Substituted Acetophenone Oximes

 

15:45

R.A. Pawar (Sci. Coll., Dhule, India)

506

G-145

Curtius Rearrangement of 1(2H)-Isoquinoline- and 1H-2-Benzopyran-1-one Carboxylic Acids

 

16:00

I. Atanassova, M. Haimova, E. Stanoeva, and S. Spassov (Univ. Sofia and Bulgarian Acad. Sci., Bulgaria)

507

 

August 25 (Thu) Room D

 

General Sessions (Oral) (G) (12)

Chairman Atta-Ur-Rahman (T. Tsuchiya)                                                             12:45-14:15

G-146

Facile Syntheses of Spiro[cycloheptane-1,3'(4H)[2H]thiazolo[3,2-b]-s-tetrazine] and Spiro[cyclooctane-1,3'(4'H)[2H]thiazolo[3,2-b]-s-tetrazine] – Two New Novel Heterocyclic Systems

 

12:45

H.K. Pujari Sat Narayan, and V. Bindal (Kurukshetra Univ., India)

508

G-147

Cyclodehydration of Some Fused Triazolyl Malondialdehydes to Heteryl Quinolines

 

13:00

D.S. Deshpande, S.T. Jannawar, S.K. Deshmukh, and A.P. Kulkarni (Sci. Coll., Nanded, India)

509

G-148

Thermal and Photochemical Cyclisation of the Schiff’s Bases and Enamino-imines Derived from 4-Chloro-3-formyl(2H)benzopyrans and Benzothiopyrans

 

13:15

 

K.K. Balasubramanian, K.S. Swaminathan, R. Sai Ganesh, C.S. Venkatachalam, and G.V. Bindumadhavan (Indian Inst. Tech. Madras, India)

 510

G-149

Synthesis of Furo and Thieno Fused Phenanthridines

 

13:30

V. Arisvaran, R.D. Rajan, and P. Shanmugam (Bharathiar Univ., India)

511

G-150

Novel Heterocycles by the Malonic Ester Variation of the Japp-Klingemann Reaction

 

13:45

R. Heckendorn and A.R. Gagneux (Ciba-Geigy Ltd., Switzeriand)

512

G-151

Hypochromism Encountered in Dimerization of Porphyrin

 

14:00

H. Kamogawa, T. Nakamura, and S. Miyama (Yamanashi Univ., Japan)

513

 

Chairman W. Friedrichsen (S. Zen)                                                                      14:45-16:00

G-152

Synthesis and Cycloaddition Reaction of 1,2-Aromatic Ring Fused-3-Cyanoindolizines

 

14:45

K. Matsumoto, T. Uchida, T. Sugi, and T. Kobayashi (Kyoto Univ. and Fukui Univ., Japan)

514

G-153

Synthesis and Cycloaddition Reaction of a Nitrogen-bridged Tetravalent Sulfur Compound, 1,3,6-Triphenylimidazo [1,2-c] thiazole

 

15:00

O. Tsuge, S. Kanemasa, and T. Hamamoto (Kyushu Univ., Japan)

515

G-154

Synthesis and Structure of Purinophanes with Fully Overlapped Conformation

 

15:15

Y. Sakata, K. Akahori, F. Hama, and S. Misumi (Osaka Univ., Japan)

516

G-155

Novel Method for Preparation of 6H-1,3-Oxazin-6-ones by Retrodiene Reaction

 

15:30

G. Bernáth, G. Stájer, E.A. Szabó, and F. Fülöp (Univ. Med. School Szeged, Hungary)

517

G-156

A Novel Generation of Bridgehead Imines via Intramolecular Aza-Wittig Reactions. Synthesis and Reactions of 4-Azahomoadamant-3(4)-ene and 4-Aza-4-homobrend-3(4)‑enes

 

15:45

T. Sasaki, S. Eguchi, and T. Okano (Nagoya Univ., Japan)

518

 

August 25 (Thu) Room E

 

General Sessions (Oral) (G) (13)

Chairman J. Reiter (A. Obia)                                                                               12:45-14:15

G-157

The Topliss Manual Approach to the Hansch Design of Biologically Active Heterocycles

 

12:45

P.K. Kadaba (Univ. Kentucky, USA)

519

G-158

The Synthesis of Novel Tetrahydrofuran Analogs as Molecular Probes for Cholinergic Receptors

 

13:00

M.C. Lu and M.T. Flavin (Univ. Illinois-Chicago, USA)

520

G-159

Synthesis of Some New Potential Antithyroids

 

13:15

S.C. Mehra, R. Aron, and A. Saxena (Barcilly Coll., India)

521

G-160

Synthesis and Biological Activity of Some New Coumarin-6-sulphonylamino Acid and Dipeptide Derivatives

 

13:30

A.M. El-Naggar, A.M. Abd El-Saiam, F.S.M. Ahmed, and T.M. Ibrabim (Al-Azhar Univ.,Egypt)

522

G-161

Synthesis of New Radioiodinated Barbiturates as Potential Brain Imaging Agents

 

13:45

P.C. Srivastava and F.F. Knapp, Jr. (Oak Ridge Nat. Lab., USA)

523

G-162

Conformational and Chemical Indices Study of Some Biologically Active Compounds

 

14:00

P.G. Abdul-Ahad (Sci. Res. Council, Iraq)

524

 

Chairman R. R. Schmidt (T. Miyasaka)                                                                14:45-16:15

G-163

Synthesis and Elucidation of Structure of 1- or 2-R-3-R', R"-Amino-5-amino-1,2,4-triazoles

 

14:45

J. Reiter, L. Pongó, T. Somorai, and P. Dvortsák (EGYT Pharm. Works and Inst. Drug Res., Hungary)

525

G-164

Some Conversions of 1,2,4-Triazolyl-imino-dithiocarbonic Acid Dimethyl Esters

 

15: 00

J. Reiter, L. Pongó, and P. Dvortsák (EGYT Pharm. Works and Inst. Drug Res., Hungary)

526

G-165

Correlation of Substituent Constants in Heteroaromatic Esters Using the Lanthanide Shift Reagent Eu(fod)3

 

15:15

K. Ranganayakulu and K. Rajeswari (Reg. Eng. Coll., Waranpl, India)

527

C-166

Photochemistry of 1-Azatriptycene

 

15:30

T. Sugawara and H. Iwamura (Inst. Mol. Sci., Japan)

528

G-167

Synthesis of C 10213-GO, a Potent Antiprotozoal Nitroimidazole Derivative

 

15:45

K. Nagarajan, V.P. Arya, T. George, and V. Sudarsanam (Hindustan Ciba-Geigy Ltd., India)

529

G-168

Applications of 13C NMR Spectroscopy to Assignment of Structures of Isomeric imidazoles and Pyrazoles

 

16:00

K. Nagarajan, V.P. Arya, V. Sudarsanam, and S.J. Sbenoy (Hindustan Ciba-Geigy Ltd., India)

530

 

August 25 (Thu) Room F

 

General Sessions (Oral) (G) (14)

Chairman T. Jain (T. Shibata)                                                                              12:45-14:15

G-169

Heterocycles from p-Methoxyphenyl(3,4-xylyl)propen-1-one

 

12:45

H.H. Moussa and L.M. Chabaka (Nat. Res. Center, Cairo, Egypt)

531

G-170

Synthesis and Absolute Configuration of 2-Alkyl-chroman-4-spiro-hydantoin Derivatives

 

13:00

Y. Kawakami, Y. Nagai, H. Ono, K. Ueda, T. Sato, and S. Tanaka (Eisai Co., Ltd., Japan)

532

G-171

Base-induced Chemiluminescence of N-Methyl-9-(dicarboalkoxymethyl)acridanes

 

13:15

N. Suzuki, T. Tsukamoto, and Y. Izawa (Mie Univ., Japan)

533

G-172

Barriers to Rotation and Inversion in meso-1,1'-Bi(2-methylpiperidine)s

 

13:30

K. Ogawa, Y. Takeuchi, H. Suzuki, and Y. Nomura (Univ. Tokyo, Japan)

534

G-173

Oxidation and Reactivity of Thiopteridines

 

13:45

W. Pfleiderer, M. Bartke, and A. Heckel (Univ. Konstanz, W. Germany)

535

G-174

Reactions of Some Nitrogen Heterocyclics Containing Donor Functional Groups with Metal Ions

 

14:00

B. Singh (Patna Univ., India)

536

 

Chairman S. Colonna (N. Suzuki)                                                                        14:45-16:15

G-175

Dithiolane and Dithiane: New Chiroptical Group for Determination of Absolute Confíguration at α- and β-Positions to the Groups by CD

 

14:45

T. Shibata, T. Ohkura, T. Ohsaka, S. Nislúhara, M. Yanagita, and S. Inayama (Keio Univ., Japan)

537

G-176

1,5-Dialkyl Verdazyls and a New Betaine System

 

15:00

H. Fischer, F.A. Neugebauer, and R. Siegel (Max-Planck Inst., W. Germany)

538

G-177

Synthesis and Hydrolysis of a New Water Soluble Pyrylium Cation

 

15:15

A.R. Katritzky, M.De Rosa and N.E. Grzeskowiak (Univ. Florida, USA and Univ. Simón Bolivar, Venezuela)

539

G-178

Tautomeric Structure and Alkylation Products of 3,5-Dioxo-4-phenyl Derivatives of Isoxazole and Pyrazole

 

15:30

G. Zvilichovsky and M. David (Hebrew Univ., Israel)

540

G-179

Charge Density Activity Correlations in Nicotinoids

 

15:45

S. Natarajan, V. Kannappan, Sp. Shanmuganathan, and M.J. Nanjan (Presidency Coll., India)

541

G-180

Thermal Analysis of Some Pharmaceutical Compounds

 

16:00

U. Bhattacharyya, P.P. De, and K. Datta (Indian Inst. Tech., India)

542

 

Special Invited Lecturers

 

Special Topic I:  Organic Synthesis Utilizing Heterocycles

E. Fujita (Kyoto University, Japan)

306

I. Ugi (Technische Universität München, West Germany)

311

H. H. Wasserman (Yale University, USA)

491

E. Wenkert (University of California at San Diego, USA)

495

 

Special Topic II:  Heterocycles with Novel Functions

R. Raue (Bayer Werk, West Germany)

135

I. O. Sutherland (University of Liverpool, UK)

  43

T. G. Traylor (University of California at San Diego, USA)

  55

Z. Yoshida (Kyoto University, Japan)

  51

 

Special Topic III:  Synthesis of Natural Heterocycles

T. Goto (Nagoya University, Japan)

  30

A. S. Kende (University of Rochester, USA)

  40

W. N. Speckamp (University of Amsterdam, The Netherlands)

124

S. M. Weinreb (Pennsylvania State University, USA)

  33

 

Special Topic IV:  New β-Lactams and Other Heterocyclic Antibiotics

B. G. Christensen (Merck Sharp & Dohme Research Laboratories, USA)

479

S. Masamune (Massachusetts Institute of Technology, USA)

107

M. Ohno (University of Tokyo, Japan)

112

W. A. Slusarchyk (Squibb Institute, USA)

293

 

Special Topic V:  Heterocycles in Anticancer and Antiviral Research

F. Arcamone (Farmitalia, Ricerca Chimica, Italy)

  13

M. Ikehara (Osaka University, Japan)

121

J. A. Montgomery (Southern Research Institute, USA)

  27

K. A. Watanabe (Sloan-Kettering Institute for Cancer Research, USA)

  22