SCIENTIFIC PROGRAM

J. H. C. NayIer, N. F. Osborne, M. J. Pearson, T. C. Smale, and R. Southagate (Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Brockham Park, Betchworth, Surrey, England)

15.00 On the Partial Asymmetric Synthesis of b-Lactams via b-Aminoesters

E. Simova, S. Khristoskova and B. Kurtev (Department of Chemistry, University of Sofia, Sofia, Bulgaria)

15.15 New Syntheses of Ampicillin and Some Related Investigation

V. Šunjič, F. Kaifež, V. Čaplar, and T. Kovač (CRC, Compagnia di Ricerca Chimica, Chiasso, Switzerland and Institute of Organic Chemistry and Biochemistry, University of Zagreb, Zagreb, Croatia, Yugoslavia)

15.30 Total Synthesis of Cephalosporin Analogues

R. Heymes, J. Martel, and G. Nomine (Centre de Recherches ROUSSEL UCLAF, Romainville, France)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: B. Gašpert

16.15 3-Heterosubstituted Cephems

R. Scartazzini, P. Schneider, and H. Bickel (Research Department, Pharmaceuticals Division, CIBA-GEIGY LTD., Basel, Switzerland)

16.30 Preparation of b-Thionolactam Analogs of Cepholosporins and Penicillins

P.W. Woitkowski, J.E. Dolfini, and C.M. Cimarusti (The Squibb Institute for Medical Research, Princeton, New Jersey, USA)

16.45 Effects of Neighboring Groups on the Rearrangement of Penicillin-S-oxides

T. Tsushima and H. Tanida (Shionogi Research Laboratory, Shionogi & Co., Ltd., Fukushima-ku, Osaka, Japan)

17.00 Inter- and Intramolecular Nucleophilic Displacement of 2-b-Halo methylpenicillin

T. Kamiya, T. Teraji, M. Hashimoto, O. Nakuquchi, and T. Oku (Research Laboratories, Fujisawa Pharmaceutical Co. Ltd., Kashima Yodogawa-ku, Osaka, Japan)

17.15 On the Degradation of Penicillin Sulphoxides

E.T. Gunda, J. Cs. Jászberényi, E. R. Farkas, and R. Bognár (Institute of Organic Chemistry, L. Kossuth., University, Debrecen, Hungary)

17.30 Direct Breaking of Benzylpenicillin Amide Bond

S. Petrhyić (Faculty of Technology and Metallurgy, Beograd), N. Kobilarov (Faculty of Natural Sciences, Novi Sad), and Ostoja Stojanović (Faculty of Technology and Mettalurgy, Beograd, Yugoslavia)

17.45 Intramolecular Cyclization of Azetidinone Diazosulfoxides to 2,3-Methylene-Cephams. A New Method for Dephthaloylation of Azetidinone Antibiotics

S.R. Lammert and S. Kukolia (The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA)

A-1 COMMUNICATIONS

14.00-15.45 Chairman: R. A. Abramovitch

14.00 Chemistry of Some 1-Methyl-3-alkoxy-5-arylpyrrolecarboxylic Acids and Derivatives

E. Campaigne and G.M. Shutske (Department of Chemistry, Indiana University, Bloomington, Indiana, USA)

14.15 Nucleophilic Substitution at the Pyrrole Ring

G. Doddi, G. Illuminati, P. Mencarelli, and F. Stegel (Centro di Studio sui Meccanismi di Reazione del Consiglio Nazionale delle Ricerche, c/o Istituto Chimico dell'Università, Roma, Italy)

14.30 New Route to Pyrroles and 1-Vinyl Pyrroles

B.A. Trofimov, A.I. Mikhaleva, S.E. Korostova, and L.N. Balabanova (Irkutsk Institute of Organic Chemistry, Siberian Division of Acad. Sci., Irkutsk, USSR)

14.45 Synthesis and Study of Some Metallo‑Porphyrins

B. Fliniaux, R. Guilard, and P. Fournari (Laboratoire de Polarographie Organique, associé au C.N.R.S., Université de Dijon, France)

15.00 Dihydropyridines and Pyrroles from α-Nitroolefins

F. Boberg, K.-H. Garburg, E. Pipeteit, and K.-J. Görlich (Organisch-Chemisches Institut, Techn. Universität, Clausthal, Germany)

15.15 Reactions of Methylenecyclopropenes with Azirines as Nitrile Ylids Precursors. Synthesis of Substituted Pyridines

L. Toupet and R. Carrié (Group de Recherches de Physicochimie Structurale, Université de Rennes, Rennes, France)

15.30 Rearrangements of 2-Aminoazirines to 1-Amino-2-azabutadienes. New Reagent for the Construction of Pyridines and Dihydropyridines

L. Ghosez, A. Demoulin, H. Gorissen, A.-M. Hesbain-Frisque, P. Hoet, and M. Rens (Laboratoire de Chemie Organique de Synthese, Université Catolique de Louvain, Batiment Lavoisier, Louvain-la-Neuve, Belgium)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: H.C. van der Plas

16.15 The Synthesis of Halogenated Pyridines from Acrylonitrile

H. Fritz, C.D. Weis, and T. Winkler (CIBA-GEIGY Corp., Basel, Switzerland)

16.30 Decomposition of 2-Azidoheteroaromatic N-Oxides

R.A. Abramovitch, I. Shinkai, J. Troinar, and K. Okaniwa (Department of Chemistry, University of Alabama, University, Alabama, USA)

16.45 New Reaction Paths in the Fischer Indole Synthesis

R. Fusco and F. Sannicolo (Istituto di Chimica industriale dell'Università, Milano, Italy)

17.00 A Novel Reaction Involving 2-Formyl Azine N-Oxides with Cyclohexylisocyanide

Y. Mizuno and J. Kobayashi (Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan)

17.15 Reactions of α-Substituted Isopropylpyridines with Nucleophiles

H. Feuer, J. Doty, and N. Kornblum (Department of Chemistry, Purdue University, West Lafayette, Indiana, USA)

17.30 Reactions of N-Alkoxyquinolinium Salts with Enamines

M. Harnana, H. Noda, K. Narimatsu, and I. Ueda (Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan)

17.45 New Conversion of Quinoline Cycle into Indole

K.M. Dyumaev and E.P. Popova (Organic Intermediates and Dyes Institute, Moscow, USSR)

B-1

14.00-15.45 Chairman: J. Streith

14.00 New Approaches to the Synthesis of the Azabicyclobutane and Azabicyclopentane Fused Ring Systems

D. Swern, J.N. Labows, M.J. O’Hare, and A. Wambsgans (Fels Research Institute and Department of Chemistry, Temple University, Philadelphia, Pennsylvania, USA)

14.15. The Reaction of Cyclic Nitrones with Phosphono Ylids

E. Breuer, I. Ronen-Braunstein, J. Pesso, S. Levi, H. Sofer, and S. Zbaida (Department of Pharmaceutical Chemistry, The Hebrew University, School of Pharmacy, Jerusalem, Israel)

14.30 Narcotic Antagonists and Analgesics in the Morphinan and Benzomorphan Series

I. Monkovic, Y. Lambert, and M. Saucier (Bristol Laboratories of Canada, Candiac, P.Q., Canada)

14.45 Functionalization of the Tropane Cyclic Systems via 3α-Oxytropine Radical. Conversion of Tropine into a Precursor of Scopolamine

S. Sarel and E. Dykman (Department of Pharmaceutical Chemistry, The Hebrew University, School of Pharmacy, Jerusalem, Israel)

15.00 Syntheses of Metabolites of Estazolam

Y. Kuwada, K. Meguro, T. Sohda, H. Natsugari, and H. Tawada (Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd., Juso-honmachi, Yodogawa-ku, Osaka, Japan)

15.15 Mechanism and Stereochemistry of Cyclization of 2-(N-β-haloalkyl)- aminobenzophenones into 2H-1,4-Benzodiazepines

M. Mihalić, N. Blažević, V. Šunjić, F. Kajfež, and D. Kolbah (CRC, Compagnia di Ricerca Chimica, Chiasso, Switzerland and Institute of Organic Chemistry and Biochemistry, University of Zagreb, Croatia, Yugoslavia)

15.30 The Synthesis of 2,4-Benzodiazepine-1-one, a New Potent C.N.S. Agent

U. Golik (Department of Chemistry, The Weizmann Institute of Science, Rehovot, Israel)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: G. Garcia-Muñoz

16.15 Synthesis of 6H-Thieno/3,2-f/ /1,2,4/triazolo/4,3‑a/ /1,4/diazepine derivatives

V. Gómez-Parra and R. Mandroñero (Institute of Medicinal Chemistry, Madrid, Spain)

16.30 Synthesis of Some Pyrido/1,5/diazocine and Pyridopyrimidine Derivatives

D. Korunčev, A. Deljac, and D. Cvek (PLIVA, Pharmaceutical and Chemical Works, Zagreb, University of Zagreb, Faculty of Natural Sciences and Mathematics, Laboratory of Organic Chemistry, Zagreb, Yugoslavia)

16.45 Hydrogenation of Nitrogen-Containing Heteroycles

I. Butula, M. Antunović, and N. Bevetek (Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia)

17.00 A New Synthesis of Alloxazines by the Reaction of Diethyl Azodicarboxylate with 6-Anilinopyrimidines

F. Yoneda, S. Matsumoto, and Y. Sakuma (Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi, Kumamoto, Japan)

17.15 New Method for the Preparation of 2,3-Dihydrobenzo/h/ /1,6/ naphthyridin-4(1H)-ones. Synthesis of Novel Naphthyridine Containing Heterocyclic Systems

F.S. Mikhailitsyn and A.F. Bekhli (Martsinovski Institute of Medical Parasitology and Tropical Medicine, Moscow, USSR)

17.30 Structure and Some Reactions of 1-Hydrazinophthalazines

B.I. Buzykin, N.N. Bystrych, and Yu.P. Kitaev (The A.E. Arbuzov Institute of Organic and Physical Chemistry, Academy of Sciences of USSR, Kazan, USSR)

17.45 The Reaction of b-Electrophilic Ketones with Dinucleophiles

K. Hideg and O.H. Hankovszky (Central Laboratory of Chemistry, University of Pécs, Hungary)

C-1

14.00-15.45 Chairman: M.G. Reinecke

14.00 Nitration of Furans with Acetyl Nitrate

K.K. Venters, D.O. Lola, M.A. Trushule, and S.A. Hillers (Institute of Organic Synthesis, Latvian Academy of Sciences, Riga, USSR)

14.15 Addition Compounds in the Halogenation of Heteroaromatics

E. Baciocchi, S. Clementi, and G.V. Sebastiani (Dipartimento di Chimica, Università di Perugia, Perugia, Italy)

14.30 Reactions of Furylethylene Derivatives

J. Kováč and D. Vegh (Department of Organic Chemistry, Slovak Technical University, Bratislava, Czechoslovakia)

14.45 The Chemistry of the Furopyridines

J.W. McFarland, W. Essory, L. Cilenti, W. Cozart, A. Kaylo, and P. McFarland (Department of Chemistry, DePauw University, Greencastle, Indiana, USA)

15.00 A New Synthesis of Pyrocin

A. Takeda, S. Tsuboi, T. Sakai, and S. Shinohara (Department of Synthetic Chemistry, School of Engineering, Okayama University, Tsushima, Okayama, Japan)

15.15 New Syntheses of O-Heterocycles from α, γ, δ, ξ -Tetraketones

M. Poje and K. Balenovič (Institute for Organic Chemistry and Biochemistry, University of Zagreb, Zagreb, Yugoslavia)

15.30 The Synthesis of Heterocyclic Compounds from Keto and Enol Tautomers of 3,4-Diaroyl-2,5-hexandione

M. Laćan and M. Vukićević (Department of Biochemistry, University of Zagreb, Zagreb), and D. Stefanović ("Rudjer Bošković Institute, Zagreb, Yugoslavia)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: C. Kashima

16.15 Interaction of Furan Derivatives with Carbenes and Transformation of Products

O.M. Nefedov, V.M. Shostakovsky, and M.I. Kravchenko (N.D. Zelinsky Institute of Organic Chemistry, Academy of Sciences of the USSR, Moscow)

16.30 Synthesis of Oxygen Heterocycles by Oxidation of ortho-Alkenyl-phenols

M. Cornia. L. Merlini, and A. Zanarotti (Politecnico, Istituto di Chimica, Milano, Italy)

16.45 A New Method of Synthesis of Six-Membered Heterocyclic Aldehydes Containing Oxygen, Sulphur and Nitrogen

S.H. Vartanian, A.S. Noravian, L.H. Avetian, and Sh.P. Mambreyan (Mnjoyan Institute of Fine Organic Chemistry, Academy of Sciences of the Armenian SSR, USSR)

17.00 Synthesis and Thermolysis of 1,5-Dihydro-2-benzoxepins

G. Descotes and F. Collonges (Université Lyon I, Lyon, France)

17.15 Amidines and Imidates in Furanic, Thiophenic, Selenophenic Series; First Synthesis of 3-Hydroxy-2-imidate Thiophen

B. Decroix, J. Pankiewicz, and J. Morel (Institut Scientifique de Haute-Normandie, Mont-Saint-Aignan, France)

17.30 Thermolysis of Heterocyclic Anhydrides as a Route to Five-Membered Hetarynes

M.G. Reinecke and J.G. Newsom (Department of Chemistry, Texas Christian University, Fort Worth, Texas, USA)

17.45 Stability of Thiphenium Ions and Some Transformations of 2,5-Bis-alkylmercaptothiophenes under the Action of Protonic Acids

L. Belenkii, A.P. Yokubov, N.V. Efimova, and Ya.L. GoI'dfarb (N.D. Zelinsky Institute, of Organic Chemistry, Academy of Sciences, Moscow, USSR)

D-1

14.00-15.45 Chairman: Y. Takeuchi

14.00 A Graphical Study of Positional Isomers

J.V. Knop, N. Trinajstić, and T. Živković (Rechenzentrum der Universität. Düsseldorf, Germany, and The Rudjer Bošković Institute, Zagreb, Croatia, Yugoslavia)

14.15 Semiempirical SCF-LCAO-MO Calculations as an Aid for the Assignment of ¹³C-Chemical Shifts

H. Sterk, H. Junek, and H.W. Schmidt (Institut für Organische Chemie Universität Graz, Graz, Austria)

14.30 The Tetraphenylborate Anion as a Nuclear Magnetic Resonance Shift Reagent for Heterocyclic Onium Cations

G.P. Schiemenz and M. Begtrup (Institutes of Organic Chemistry of the University of Kiel, Germany, and of Denmarks Tekniske Højskole, Lyngby, Denmark)

14.45 Stereodynamics at Two Nitrogen Centers in Bicyclic Hydrazines and Bicyclic Biurethanes. A C-13 NMR Study

Y. Nomura, N. Masai, and Y. Takeuchi (Department of Chemistry, College of General Education, University of Tokyo, Komaba, Meguro-ku, Tokyo, Japan)

15.00 The Conformational Study of Optical Active (9S,10S)-trans-Decahydroquinolin-4-one and Related Compounds

V.M. Potapov and G.V. Grishina (Moscow University, Department of Chemistry, Moscow, USSR)

15.15 Some Peculiarities in the Conformation of Quinuclidine Compounds

L.N. Yakhontoy, E.E. Mikhlina, K.F. Turchin, and Yu.N. Sheinker (S. Ordzhonikidze All-Union Chemical-Pharmaceutical Research Institute, Moscow, USSR)

15.30 Investigation of the cis-trans Isomers and the Conformation of an Eight-Membered Ring-System: Dibenzo/d,g/ /1,3/dioxocin

J. Fischer, G. Tóth, and J. Rákóczi (EGYT Pharmacochemical Works, Research Laboratory, Budapest, and Organic Chemical Institute of Semmelweis Medical School, Budapest, Hungary)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: A.J. Boulton

16.15 Stereospecific Rearrangements of Thiane- and 1,3-Dithiane-1-N-arylimides

P.K. Claus, W. Rieder, and F.W. Vierhapper (Organisch-Chemisches Institut der Universität Wien, Wien, Austria)

16.30 Allylic Strain and Conformational Distribution in Phenyl-Substituted 2-Oxotetra-hydrooxazines and 2-Oxo- and 2,4-Dioxohexahydropyrimidines

B.J. Kurtev, M.Y. Lyapova, S.M. Mishev, O. Nakova, A.S. Orahovats, and I.G. Pojarliev (Institute of Organic Chemistry, Bulgarian Academy of Science, Sofia, Bulgaria)

16.45 Absolute Configuration of Cyclic Amino Compounds

G. Bettoni, C. Franchini, F. Morlacchi, V. Tortorella, and C. Vetuschi (Istituto di Chimica Farmaceutica, Bari, Italy)

17.00 Chiral Aziridines and Diaziridines

R.G. Kostyanovsky, A.V. Prosyanik, A.E. Polyakov, and G.V. Shustov (Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow, USSR)

17.15 1,3-Aroyl Migration in 1,2,3-Triazolyl-isoimides

N.E. Alexandrou and C. Hadjiantoniou-Louizou (Laboratory of Organic Chemistry, University of Thessaloniki, Thessaloniki, Greece)

17.30 Kinetic Evidence for Intermolecular Gear Effect: Alkylation of Methyl Pyridines by Methyl Iodide

J. Pierrot, C. Roussel, M. Chanon, and J. Metzger (I.P.S.O.I., Centre universitaire St. Jerome, Marseille, France)

17.45 Further Investigation into the Cyclization Mechanism of α-Phenyl- benzylidene-acetone Oxime Benzoate to 1-Phenyl-3-methylisoquinoline

S. Goszczyński and M. Lozyński (Poznań Technical University, Chemistry Department, Poznań, Poland)

Tuesday, 15 July

L PLENARY LECTURES

9.00 S. Gronowitz (University of Lund, Lund, Sweden)

Recent Work on Aromatic Boron-Containing Heterocycles

Chairman: A.R. Katritzky

10.15 INTERMISSION

10.45 A. Marxer (CIBA-GEIGY, Basel, Switzerland)

Reactions of Organometallic Compounds in the Heterocyclic Field

Chairman: I. Laiezari

S-2 SYMPOSIUM

14.00-15.45 Chairman: V. Škarić

14.00 Interaction of Benzylmagnesium Chloride with β ‑Lactams

AI. Spasov, B. Panajotova, and M. Arnaudov (Bulgarian Academy of Sciences, Institute of Biochemistry, Sofia, Academy of Medicine, Department of Chemistry, Sofia, and Bulgarian Academy of Sciences, Institute of Organic Chemistry)

14.15 Azetidinone-Sulphenimides. Versatile Intermediates in Penicillin-Cephalosporin Chemistry

J. Verwey and H.S. Tan (Gist-Brocades N.V., Research and Development, Delft, the Netherlands)

14.30 Trimethylsilyl 6-Isocyanato-penicillanate and Related Compounds

P.W. Henniger, P.M. Smid, and J. Kalter (Gist-Brocades N.V., Research and Development, Delft, The Netherlands)

14.45 Formation of D-Penicillamine in the Reactions of Penicillines with Hydrazines

J. Herak, M. Kovačević, and B. Gašpert (PLIVA, Pharmaceutical and Chemical Works, Zagreb, Yugoslavia)

15.00 New Reagents for the Synthesis of Functional b-Lactams and Their Iminium Salts

L. Ghosez, E. Deffense, A. Van Camp, M. De Poortere, H. Vanlierde, and F. Gaillez (Laboratoire de Chimie Organique de Synthese, Université Catolique de Louvain, Bâtiment Lavoisier, Louvain-la-Neuve, Belgium)

15.15 Synthesis of Potential L-Asparagine Synthetase Antagonists

G.T. Furst and E.J. Moriconi (SANDOZ A.G., Research Division, Dyestuffs Department, Basel, Switzerland, and Fordham University, Department of Chemistry, New York, USA)

15.30 Derivation of cis-3-Acylamino-4-thioazetidin-2-ones

D.F. Corbett, C.D. Maycock, and R.J. Stoodley (University of Newcastle upon Tyne, Newcastle upon Tyne, England)

15.45-16.15 INTERMISSION

16.15-17.15 Chairman: T. Kamiya

16.15 Reaction of Ketene-acetals with Isocyanates and Isothiocyanates

F. Effenberger, P. Fischer, and E. Schneider (Institut für Organische Chemie, Biochemie und Isotopenforschung, Stuttgart, Germany)

16.30 Synthesis of 9-Aza-5,7-nonamedienes

J. Streith and G. WoIff (Laboratoire Associé au CNRS; Ecole Supérieure de Chimie, Mulhouse, France)

16.45 A Novel Tricyclic b-Lactam Containing Ring System

J. Reiter, P. Sohár, M. Kiss. and L. Toldy (Research Institute for Pharmaceutical Chemistry, Budapest, Hungary)

17.00 Total Synthesis of b-Lactam Antibiotics. IX. Sodium Methyl (±)-7b-(2-Thienyl)- acetamido-3-methyl-ceph-3-em-4-phosphonate

N.G. Steinberg, R.W. Ratcliffe, and B.G. Christensen (Merck Sharp & Dohme Research Laboratories, Division of Merck Co., Inc., Rahway, New Jersey, USA)

17.15-18.00 PANEL DISCUSSION

Discussion leader: J. Sheehan

A-2 COMMUNICATIONS

14.00-15.45 Chairman: K. Lempert

14.00 The Meisenheimer Reaction Orientation by Substituents

E.V. Brown and A.C. Plasz (Department of Chemistry, University of Kentucky, Lexington, Kentucky, USA)

14.15 Synthesis and Reactions of 1,4-Dihydro-3(2H)-isoquinolines

Gy. Deák, K. Gall-Istók, L. Hazai, L. Sterk, and E. Zára-Kaczián (Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary)

14.30 Direction of Cyclization in the Reaction of 2-Hydroxymethylenecyclohexanone and Cyanoacetamide: Chemical Proof for the lsoquinoline Structure

A. Rosowsky (Sidney Farber Cancer Center and Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts, USA)

14.45 Stereoselective Synthesis of 3,4-Dihydro-1(2H)-isoquinolones from Homophthalic Anhydrides and Azamethines

M.A. Haimova, N.M. Mollov, S.Z. Ivanova, and V.I. Ognyanov (Department of Chemistry, University of Sofia, Sofia, Bulgaria)

15.00 Reissert Compounds in the Synthesis of Alkaloid Analogs

F.D. Popp, D.C. Smith, and R.M. Piccirilli (Department of Chemistry, Clarkson College of Technology, Potsdam, New York, USA)

15.15 Chemical and Anodic Oxidation of 1-Benzyl-3-isochromanone and -3-isoquinolone Derivatives

I.W. Elliott (Fisk University, Nashville, Tennessee, USA)

15.30 Versatile, New Preparations of Pyridines and Thiazoles

P. Dubs (Givaudon Ltd. Research Company, Dübendorf-Zürich, Switzerland)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: U.K. Pandit

16.15 Preparation and Chemistry of Pyridine-Containing Heteromacrocycles

G.R. Newkome, J.D. Sauer, G.L. McClure, J. Broussard-Simpson, and F. Donash-Koshboo (Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana, USA)

16.30 Synthesis of Amines Deriving from Nitrogen-Containing Analouges of Chrysene, Triphenylene and Benzophenanthrene

P. Jacquignon and Do Coo Thong (Institut de Chimie des Substances Naturelles. - C.N.R.S. Gif/s/Yvette, France)

16.45 Ring Transformations in Reactions of Pyrimidine, Pyrimidine Derivatives and N-Alkylpyrimidinium Salts with Nucleophiles

E.A. Oostveen, H.C. van der Plas, H. Jongeian, and K. Koudijs (Laboratory of Organic Chemistry, Agricultural University, Wageningen, The Netherlands)

17.00 Thermolysis of 5-Diazo-1-Methyluracils

T.C. Thurber and L.B. Townsend (Department of Chemistry and Department of Bipharmaceutical Sciences, University of Utah, Salt Lake City, Utah, USA)

17.15 Substitued 5-Benzylpyrimidines and 5-Benzylbarbituric Acids

B. Glunčić, K. Kovačević, and N. Kujundžić (PLIVA, Pharmaceutical and Chemistry Works, Zagreb, Yugoslavia)

17.30 Cyclization of Amino-dicyano-allylidene-imines, a Simple Route to Pyridazine Derivatives

H. Junek and G. Zacharias (Institute of Organic Chemistry, University of Graz, Austria)

17.45 New Synthesis of Acetylene Analogs of Piperazine

M.V. Mavrov and V.F. Kucherov (N.D. Zelinsky Institute of of Organic Chemistry, USSR Academy of Sciences, Moscow, USSR)

B-2

14.00-15.45 Chairman. K.T. Potts

14.00 Biomimetic Heterocyclizations of Cyclic Acylimmoniumions

J. Dijkink and W.N. Speckamp (Laboratorium voor Organische Scheikunde der Universiteit van Amsterdam, Amsterdam, The Netherlands)

14.15 Synthesis of Indolizine and Azaindolizine Derivatives Using N-Ylides and Diketenes

T. Kato, T. Chiba, S. Masuda, and S. Tanaka (Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan)

14.30 Total Synthesis of (±) Mappicine

T. Kametani (Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, Japan)

14.45 Synthesis and Properties of 6(H)-Pyrrolo/3,2-f/indolysines

R.P. Evstigneeva and A.F. Mironov (The Lomonosov Institute of Fine Chemical Technology, Moscow, USSR)

15.00 Total Synthesis of Emetine Analogues

A. Buzas, F. Cossais, J.P. Finet, J.P. Jacquet, and G. Lavielle (Université d'Orleans, Faculté de Technologie, Laboratoire de Synthese Organique, Orleans-La Source, France)

15.15 Structural Ambiguity Resolved: s-Triazolo/4,3-a/pyrimidines vs s-Triazolo/1,5-a/pyrimidines

T. Novinson, T. Okabe, R.K. Robins, and P. Dea (ICN Pharmaceuticals, Inc., Nucleic Acid Research Institute, Irvine, California, USA

15.30 Synthesis of N- and O-Containing Heterocycles on the Basis of Benzylidene Monoketones and Their Derivatives

Yu. Pelcher, Z. Bomika, M. Andaburska, and G. Duburs (Institute of Organic Synthesis, Academy of Sciences Latvian SSR, Riga, USSR)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: H.S. Broadbent

16.15 The Formation of Non-Classical "Tetravalent Sulfur" Heterocycles Using Nitrene Intermediates

K.T. Potts and J.L. Marshall (Department of Chemistry, Rensselaer Polytechnic Institute, Troy, N.Y., USA)

16.30 Regioselective Ring Opening of Fused Tetrazolium Salts and Their Benzologues

A. Messmer, A. Gelléri, and G. Hajos (Central Research Institute for Chemistry of the Hungarian Academy of Sciences, Budapest, Hungary)

16.45 Synthesis in the Pyrazine Series

M. Maeck and R. Promel (Service de Chimie Organique, Faculté des Sciences, Université Libre de Bruxelles, Brussels, Belgium)

17.00 Pyrrolo/1,2-b/1,2,4,5-tetrazines and 1,2,4,5-Tetrazino/3,2-a/isoindoles

H. Neunhoeffer and H.-J. Degen (Technische Hochschule Dormstodt, Darmstadt, Germany)

17.15 New Methods for the Synthesis of lmidazo/5,1-a/isoquinolines

K. Harsányi (Chinoin Pharmaceutical and Chemical Works, Budapest, Hungary)

17.30 Synthesis and Properties of s-Triazolo-barbituric Acids

B.V. Chemishey, Z.D. Raikov, and E.T. Bogdanova (Medical Academy-Chair of Chemistry and Biochemistry, Sofia, Bulgaria)

17.45 Reaction of 2,2',3,3'-Tetrachloro-6,6'-biquinoxaline with Nucleophilic Reagents

V.V. Titov and L.F. Kozhokina (Organic Intermediates and Dyes Institute, Moscow, USSR)

D-2

14.00-15.45 Chairman: F.D. Popp

14.00 Hydrogen-Deuterium Exchange Reaction of 3,5-Dimethylisoxazole,

C. Kashima, Y. Tsuda, and Y. Omote (Department of Chemistry, University of Tsukuba, Ibaraki-ken, Japan)

14.15 Ethyl Vinyl Ether in Cationic Polar Cycloaddition: Further Evidence Concerning the Reaction Mechanism

T.G. Wallis, N.A. Porter, and C.K. Brodsher (Department of Chemistry, Duke University, Durham, N.C., USA)

14.30 Kinetics of the Cycloaddition of Arylidene-pyrazolones with Vinylethers

G. Desimoni, M. Nicola, and G. Tacconi (Istituto di Chimica Organica dell'Università, Pavia, Italy)

14.45 Prediction of Equilibrium Constants of Zwitterionic Systems

M.J. Nye, M.J. O'Hare, and Wah-piu, Tong (Department of Chemistry, University of Guelph, Guelph, Ontario, Canada)

15.00 Electronic Structure of Substituted Thiophenes

Z. Božić, T. Cvitaš, K. Humski, and L. Klasinc (Faculty of Technology, University of Zagreb, Sisak; Institute "Rudjer Bošković", Zagreb, and Faculty of Sciences and Mathematics, University of Zagreb, Zagreb, Yugoslavia)

15.15 The Transmission of the Electronic Effects of Substituents in Pyrimidine Ring

O.P. Shkurko and V.P. Mamaev (Institute of Organic Chemistry, Siberian Division of the Academy of Sciences, Novosibirsk, USSR)

15.30 Transmission of Substituents Effects in Pyridine and Pyridine N-Oxide Ring. Reaction of Pyridine and Pyridine N-Oxide Carboxylic Acids with Diazophenylmethane

Dj.M. Dimitrijević, Ž.D. Tadić, M. Mišić-Vuković, M. Muškatirović, and M. Radojković-Veličković (Department of Organic Chemistry, Faculty of Technology and Metallurgy, University of Beograd, Beograd, Yugoslavia)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: A. Mangini

16.15 Electron Spin Resonance Study of Pyridinyl Radicals

A. Mangini and G.F. Pedulli (Istituto di Chimica Organica, Bologna, and Laboratorio dei composti del carbonio del CNR, Ozzano Emilia, Italy)

16.30 N-1,N-1'-Linked Bisverdazyls

R. Bernhardt and F.A. Neugebauer (Max-Planck-lnstitut für Medizinische Forschung, Heidelberg, Germany)

16.45 Decomposition of Amino-Indole Radical Cations

P. Bruni and G. Fava (Istituto Chimico della Facoltà di Ingegneria, Università di Ancona, Ancona Italy)

17.00 Synthesis of New Arylated and Hetero-Arylated Heterocyclic Compounds by Free Radical Substitution Methods

G. Vernin, H.J.-M. Dou, and J. Metzger (Laboratoire de Chimie Organique A, Centre de St. Jerome, Marseille, France)

17.15 The Reactions of 4-Brommethyl-, 4-(1-Bromethyl)- and 4-Dibrommethyl-2,2,5,5-tetramethyl-Δ³-imidazoline-3-oxide-1-oxides with Amines. The Syntheses of the Nitroxides Radicals of Imidazoline

L. B. Volodarsky and I.A. Grigoriev (Institute of Organic Chemistry, Siberian Division of the Academy of Sciences USSR, Novosibirsk, USSR)

17.30 Heterocyclic Compounds as Organic Metals: Synthesis and Properties of Salts of Tetrathio- and Tetraselenotetracene with Tetracyanoquinodimethane

O.W. Yeremenko, M.L. Khidekel, and E.B. Yogubskii (Institute of Chemical Physics of Academy of Sciences, Moscow, USSR)

17.45 Isomeric N-Aryltetrazoles: Chemical and Spectroscopical Behaviour

E. Lippmann and A. Könnecke (Sektion Chemie der Karl-Marx-Universität Leipzig, Leipzig, GDR)

P POSTER SESSION

P-1

14.30-15.30

Practical Method about Synthesis of Dibenzacridines meso Alkyl-Substituted

J. Andre and P. Jacquignon (Institut de Chimie des Substances

Naturelles, C.N.R.S., Gif/s/Yvette, France)

lodobenzene Dichloride as a Selective Agent in Pyrrole Chemistry. Preparation of Ethyl 4-Chloro-3,5-dimethyl-pyrrole-2-carboxylate

G. Angelini and G. Sleiter (Centro di Studio sui Meccanismi di Reazione del Consiglio Nazionale delle Ricerche, c/o Istituto Chimico dell'Università, Roma, Italy)

Synthesis of Methyl-Substituted Spiro-1,5-Dioxa-8,9,10-trithia- and Spiro-2,4-dioxa-/5,5/undecanes. The Effect of the Substituents on the Rate of Ring Reversal

M. Anteunis and D. Tavernier (Department of Organic Chemistry, Gent, Belgium)

Interaction of N-Heterocyclic Compounds with 7,7,8,8-Tetracyanoquino-dimethan

B.P. Bespalov, E.V. Ghetmanova, and V.V. Titov (Organic Intermediates and Dyes Institute, Moscow, USSR)

Oxidation of Cyclic Aminocompounds by Ruthenium Tetroxide

G. Bettoni, C. Franchini, F. Morlacchi, N. Tangari, and V. Tortorella (Istituto di Chimica Farmaceutica, Bari, Italy)

2-Aryl-3,3a-dihydro-8a-pyrazolo/5,1-a/isoindol-8-ones and -8H-pyrazolo/5,1-a/isoindol-8-ones

E.W. Bousquet, M.D. Moran, J. Harmon, A.L. Johnson and J.C. Summers (Central Research and Developoment and Biochemicals Departments, E. I. du Pont de Nemours and Company, Experimental Station, Wilmington, Delaware, USA)

The Synthesis and Properties of Macrocyclic Polyether Sulfides

J.S. Bradshaw, R.A. Reeder, B.L. Haymore, R.M. Izatt, and J.J. Christensen (Department of Chemistry and Chemical Engineering and The Center for Thermochemical Studies, Brigham Young University, Provo, Utah, USA)

Synthesis of cis and trans lndole/2,3-a/quinolizidine-2-ones; Formation of Related aza-D-homo-octahydroindolo/2,3-a/quinolizines

A. Buzas, J.P. Jacquet and A. Merour (Université d'Orleans, Faculte de Technologie, Laboratoire de Synthese Organique, Orleans-La Source, France)

The Synthesis and Reactions of Some Azaphenothiazines

S.D. Carter and G.W.H. Cheeseman (Chemistry Department, Queen Elizabeth College, London, England)

Iodine Promoted Thermal Synthesis of Carbazole from Aniline

D.P. Chakraborty, A. Islam, and M. Sarker (Base Institute, Calcutta, India)

Syntheses of 5-Amino- and 5-Hydrazino-2,3-dihydro-1H-1,4-benzodiazepine Derivatives

C. Corral, C. Gómez, R. Madroñero, and S. Vega (Institute of Medicinal Chemistry, Madrid, Spain)

Aryl-2-thienyl Sulphides and Aryl-2-thienyl Sulphones

E.N. Deryagina, L.G. Klochkova, and M.G. Voronkov (Institute of Organic Chemistry, Siberian Division Acad. Sci. USSR, Irkutsk, USSR)

High Temperature Synthesis of Thianthrene and its Derivatives

E.N. Deryagina, L.G. Klochkova, G.M. Ivanova, T.I. Vakulskaya, and M.G. Voronkov (Institute of Organic Chemistry, Siberian Divison Acad. Sci. USSR, Irkutsk, USSR)

Dimerisation of Aromatic Nitrile Oxides under Nucleophilic Catalysis

F. De Sarlo, and A. Guarna (Centro di Studio sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni, C.N.R., Istituto di Chimica Organica, Università di Firenze, Italy)

Reaction of Diazoaminobenzenes with Furan or Thiophene and Isopentyl Nitrite or Lewis Acid

L. Fišera and J. Kovač (Department of Organic Chemistry, Slovak Technical University, Bratislava, Czechoslovakia)

Synthesis and Reactions of 3(5)-Halogeno-1,2,4-triazole Nucleoside

M. Fuertes, S.R. Naik, R.K. Robins, and I.T. Witkowski (ICN Pharmaceuticals, Inc., Nucleic Acid Research Institute, Irvine, California, USA)

2-(m-Trifluoromethylphenyl)-Pyrimidines

A. Ghanborpour and I. Lalezari (College of Pharmacy, Tehran University, Tehran, Iran)

Synthesis of 6-Substituted-2-carboxymethylene-3,4-dihydro-3-oxo-2H-s-triazolo/3,4-b/-1,3,4-thiadiazines

H. Golgolab, I. Lalezari, and A. Shaflee (Department of Chemistry, College of Pharmacy, University of Tehran, Tehran, Iran)

Heterocycles from Thioamides and Activated Acetylenes

C.M. Hall (The Upjohn Company, Kalamazoo, Michigan, USA)

Condensation of Ethyl Ester of 2-Methyl-5,6-dihydro-4H-pyran-3-carboxylic Acid with Aromatic Aldehydes and Ketones

Chr. lvanov, Y. Anghelova, and St. Metsov (Department of Chemistry, University of Sofia, Sofia, Bulgaria)

Wolff's Rearrangement of Some 2-Aryl-quinolyl-4-diazomethyl Ketones

M. Jančevska and M. Lazarević (Institute of Chemistry, University of Skopje, Skopje, Yugoslavia)

A New Synthesis of Trisubstituted Ethylenes

A. Jurašek and J. Kovač (Department of Organic Chemistry, Slovak Technical University, Bratislava, Czechoslovakia)

Ring Transformation Reactions of 4,5-Diacyl-1,2,3-triazolines

P.K. Kadaba (Division of Medicinal Chemistry, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA)

Photochemistry of 1,2-Diphenylindazolone

S.K. Kapoor and J. Reisch (Institute for Pharmaceutical Chemistry, Westfalian Wilhelms-University, Münster, Germany)

The Reactions of 3-Oxidopyridiniums with 2π-, 4π- and 6π-Electron Addends

A.R. Katritzky in collaboration with N. Dennis, B. Iberaim, Y. Takeuchi, and G. Sabounji (School of Chemical Sciences, University of East Anglia, England)

Synthesis and Reactivity of 2-Formyl-2,5-dialkoxy-(alkylthio)-2,3-dihydro-γ-pyranes

N.A. Keiko, L.G. Stepanova, I.D. Kalikhman, G.I. Kirillova, and M.G. Voronkov (Institute of Organic Chemistry, Siberian Division of the USSR Academy of Sciences, Irkutsk, USSR)

The Synthesis and Structure of Bithienyl

V.V. Keiko, E.N. Deryagina, E.N. Sukhomazova, O.I. Randin, and M.G. Voronkov (Institute of Organic Chemistry, Siberian Division Acad. Sci., USSR., Irkutsk, USSR)

Photoelectron Spectroscopy of Heterocycles. V. Azaindenes and Aza-indolizines

L. Klasinc, B. Stanovnik, and M. Tišler (Institut "Rudier Bošković”, Zagreb, and Department of Chemistry, University of Ljubljana, Ljubljana, Yugoslavia)

The Synthesis and Properties of Sulfides and Sulphones of 5-Nitrofuran Series

V. Knoppová, R. Kada, and J. Kovač (Department of Organic Chemistry, Slovak Technical University, Bratislava, Czechoslovakia)

P-2

16.15-17.15

Some Novel Reactions of Diazo- and Azido-heterocycles

M. Kočevar, B. Koren, S. Polanc, B. Verček, B. Stanovnik, and M. Tišler (Department of Chemistry, University of Ljubljana, Ljubljana, Yugoslavia).

Covalent Hydration of s-Triazines

B.A. Korolev and M.A. Maltseva (Organic Intermediates and Dyes Institute, Moscow, USSR)

The Synthesis and The Structure Determination of the Tetrasubstituted 4,4'-Diisoxazoles

M. Laćan and N. Filipović-Marinić (Institute of Food Science and Technology, Zagreb, Yugoslavia), and D. Stefanović (Institute "Rudjer Bošković", Zagreb, Yugoslavia)

Electrochemical Synthesis of Heterocyclic Compounds

M. Laćan, I. Tabaković, M. Trkovnik, V. Rogić, Z. Stunić, and C. Rogić (Faculty of Technology, University of Zagreb, Zagreb, Yugoslavia)

Synthesis of Substituted Aralkyl Analogues of Tetrahydronorharmane

J.R. Lagidze, L.I. Talakvadze, and R.M. Lagidze (Institute of Experimental and Clinical Surgery, Ministry of Health of the Georgian SSR, Tbilisi, USSR)

A Quantum-chemical Analysis of 1,2,4-Triazole, 3-Amino-1,2,4-triazole and 3,5-Diamino-1,2,4-triazole Tautomerism

V.A. Lopyrev, V.V. Makarsky, V.A. Zubkov, E.F. Shibanova, and M.G. Voronkov (Institute of Organic Chemistry, Siberian Division Acad. Sci. USSR, Irkutsk, USSR)

The Synthesis and Properties of Some Phthalocyanine Derivatives

B.A. Luk'yanets, S.A. Mikhalenko, and L.I. Solovyova (Organic Intermediates and Dyes Institute, Moscow, USSR)

On the Synthesis of Thienopyridines

J.P. Maffrand and F. Eloy (PARCOR, Départment Recherche et Développement, Toulouse, France)

Semiempirical Calculations of the Electric Field Gradients at Nitrogen in Some Small and Medium Size Molecules

Z.B. Maksić and J.E. Bloor (Institute "Rudjer Bošković”, Zagreb, Croatia, Yugoslavia, and Department of Chemistry, The University of Tennessee, Knoxville, Tennessee, USA)

Conformational Analysis and Electronic Structure of Thienylpyridines

M. Milun, N. Trinajstić, and I. Gutman (The Rudier Bošković Institut, Zagreb, Yugoslavia)

Thermal Dealkylation of 2-Chloro-4,6-bis(alkylamino)s-triazines. The Effect of Alkyl Group Structure on the Reaction of Dealkylation

D. M. Muškatirović, Ž.D. Tadić, J.A. Jovanović, B.Ž. Jovanović, and M.B. Pešić (Faculty of Technology and Metallurgy, University of Beograd, Beograd, Yugoslavia)

Photocyclization of N-Picolinoylenamines for the Preparation of Azaanalogs of Alkaloids

I. Ninomiya, T. Naito, and T. Kiquchi (Kobe Women's College of Pharmacy, Motoyamakita, Higahinada, Kobe, Japan)

Cycloaddition of Oxaziridine to Ketenimine

Y. Ohshiro, N. Murai, M. Komatsu, and T. Agawa (Department of Petroleum Chemistry, Faculty of Engineering, Osaka University,

Yamadakami, Suita, Osaka, Japan)

Degradation of a Steroidal Lactam to the nor-seco-Amino Aldehyde

K. Oka, K. Kato, and S. Hara (Tokyo College of Pharmacy, Uenosakuragi, Taito-ku, Tokyo, Japan)

Pyrrolo/2,1,5-cd/indolizines via the Perkin Reaction of 2-Pyridinecarbaldehyde. Evidence for a Disproportionation-Dehydrogenation Mechanism

E. Pohjala (Department of Chemistry, Helsinki University of Technology, Espoo, Finland)

Reduction of Some 2,5-Dihalogen Pyridine Derivatives

M.V. Proštenik and I. Butula (PLIVA Pharmaceutical and Chemical Works, Zagreb, Yugoslavia)

Chiral 1,4-Benzodiazepines. Syntheses and Structure Determinations of in vitro Metabolites of 3-(5)-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepine-2-one

S. Randić, V. Šunjić, P. Mildner, and F. Kajfež (CRC, Compagnia di Ricerca Chimica, Chiasso, Switzerland, and Institute of Organic Chernistry and Biochemistry, University of Zagreb, Zagreb, Croatia, Yugoslavia)

Synthesis of 1,2,3-Thiadiazolo/4,5-d/pyridazines, a New Heterocyclic Ring Systems

A. Shafiee, I. Laiezari, and H. Golgolab (Department of Chemistry, College of Pharmacy, University of Tehran, Tehran, Iran)

Synthesis and Certain Transformation of Silylisoxazolines

M.G.A. Shvechgeimer and E.V. Arslanov (Moscow Textile Institute, Moscow, USSR)

Syntheses and Investigation of Some Thiazolic Ketoximes

I. Simiti, Gh. Hintz, H. Demian, and A. Muresan (Institute of Medicine and Pharmacy, Department of Pharmacy, Laboratory of Organic Chemistry, Cluj-Napoca, Rumania)

Interaction of 3-BenzenesulphonyIbenzthiazolone with Amines

D. Simov and A. Antonova (University of Sofia, Faculty of Chemistry, Sofia, Bulgaria)

Synthesis and Some Properties of 2-Aminobenzoxazoles and 2-Amino-3-methylbenzoxazolines

D.A. Simov and K. Davidkov (University of Sofia, Department of Chemistry, Sofia, Bulgaria)

N-Quaternary Heterocyclics. Synthesis and Reactions with Nucleophiles

H. Singh, K.B. Lal, and K.S. Kumar (Deparment of Chemistry, Guru Nanak University, Amritsar, India)

Structure and Reactivity of Aryl-3-hydroxypyridines at Electrophilic Substitution

L.D. Smirnov, V.P. Lezina, and B.E. Zaitsev (Organic Intermediates and Dyes Institute, Moscow, USSR)

Asymmetric Induction During the Synthesis of Optically Active 1,3-Dioxolane-4-ones. Identification of Isomers by H and ¹³C NMR

J. Soulier, M. Farines, R. Soulier, M. Bercot, and A. Neszmelyi (Centre Universitaire, Perpignan, France, and Chemistry Institute of the Hungarian Academy of Sciences, Budapest, Hungary)

Configurations and Preferred Conformations of 1,3-Dioxepanic Systems with Partly Blocked Structure

J. Soulier, M. Farines, A. Loquerre, A. Bonafos-Bastouill, and J. Neszmelyi (Centre Universitaire, Perpignan, France and Chemistry Institute of Hungarian Academy of Sciences, Budapest, Hungary)

A New Method for the Synthesis of 3,4-Dihydro- and 1,2,3,4-Tetrohydro-quinazolines

G. Tóth, J. Fischer, and P. Vágó (Organic Chemical Institute of Semmelweis Medical School, Budapest; EGYT Pharmacochemical Works, Research Laboratory, Budapest, Hungary)

Spiro-substituted Heterocyclic Compounds Prepared by the Reaction of 3-Amino-2-aryI(alkyl)indene-1-thiones with 1,3-Dipolar Agents

V.A. Usov, N.A. Korchevin, A.F. Tokareva, Ya.S. Tsetlin, E.O. Tsetlina, V.A. Pestunovich, and M.G. Voronkov (Institute of Organic Chemistry, Siberian Division of the USSR Academy of Sciences, Irkutsk, USSR)

Conformational Studies by NMR Spectra in Nematic Phases: 3-Phenyl-1,2,5-oxa-thia- and –selenadiazole

C.A. Veracini, M. Longeri, G. Chidichimo, V. Bertini, and A. de Munno (Istituti di Chimica Fisica e di Chimica Organica dell'Università, Pisa, Italy, Dipartimento di Chimica dell'Università della Calabria, Arcavacata di Rende -Cosenza, Italy)

Synthesis of 2-Sulfo-2-Alkylthieno(2,3- and 3,2-d) thiazoliumbetaine and Some mezo- Substituted Trimethyncyanine Derivative of their Base

V.G. Zhiryak, N.I. Astrakantseva, and I.I. Levkoev (State Scientific Research Institute of Chemical-Photographic Industry, Moscow, USSR)

Novel Fissions of the Pyridine Ring in Basic Media

H.J. den Hertog, H.N.M. van der Lans, and J.W. Streef (Laboratory of Organic Chemistry, Agricultural University, Wageningen, The Netherlands)

Synthesis and conformation studies on 5,6,7,8,10,11,12,13-octahydro-13a H-pyrido/1,2-f/ phenanthridine derivatives

G. Laus, L. Cekuoltene, and G. Van Binst (Laboratorium voor Organische Chemie Vrije Universiteit Brussels., Belgium)

Wednesday, 16 July

L PLENARY LECTURES

9.00 A. Lattes (University of Toulouse, Toulouse, France)

Mechanism of Chemical and Photochemical Rearrangement of Unsaturated Amines and Related Heterocycles

Chairman: J.L. Imbach

10.15 INTERMISSION

10.45 R.B. Moffett (Upjohn, Kalamazoo, Michigan, USA)

New Benzodiazepine Analogs. Synthesis and CNS Activity

Chairman: R.G. Shepherd

Thursday, 17 July

L PLENARY LECTURES

9.00 Y. Ban (Hokkaido University, Sapporo, Japan)

Synthetic Studies on Poly-Heterocyclic Ring Sistems

Chairman: S. Oae

10.15 INTERMISSION

10.45 J. Clark (University of Salford, Salford, England)

Ring-Cleavage, Tautomerism, and Ionization of Some Pyrimidines and Related Compounds

Chairman: W. Pfieiderer

A-3 COMMUNICATIONS

14.00-15.45 Chairman: L.B. Townsend

14.00 Synthesis of 5-Substitued Uracil Derivatives

E.C. Ressner, Ph. Fraher, and M.P. Mertes (Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas, USA)

14.15 A Selective Bromination of Thymidine

D. Bärwolff, P. Langen, and G. Kowollik (Akademie der Wissenschaften der DDR, Forschungszentrurn für Molekularbiologle und Medizin, ZIM-Abt. Zellkinetik, Berlin, GDR)

14.30 Synthesis of Some 1-D-Ribofuranosyl Purines

A. Dhainaut, J.-L. Montero and J.-L. Imbach (Université des Sciences et Techniques du Lanquedoc, Laboratoire de Chimie Bio-Organique, Montpellier, France)

14.45 Hydrazinoribose - An Intermediate for the Formation of Nucleosides

R.R. Schmidt, J. Karg, and W. Guilliard (Institut für Organische Chemie, Stuttgart, Germany)

15.00 Transformations of Uracil-Carbene Adducts. An Approach to Modified Nucleosides

U.K. Pandit, H.P.M. Thiellier, and G.J. Koomen (Organic Chemistry Laboratory, University of Amsterdam, Amsterdam, The Netherlands)

15.15 C-Nucleosides Possesing a Bridgehead Nitrogen. Synthesis and Rearrangement of 3-b-D-ribofuranosyl-s-triazolo/4,3-a/pyrimidines

J. Kobe, M. Jurjevčič, M. Hohnjec, M. Japelj, and A. Krbavčič (Pharmaceutical Works Krka, Novo mesto, Chemical Institute Boris Kidrič and Faculty of Natural Sciences and Technology, Ljubljana, Yugoslavia)

15.30 The Chemistry of 4,9-Dioxa- and 4-thia-9-oxa-2-azobicyclo/4,2,1/nonanes

V. Škarić and M. Hohnjec (Laboratory of Sterochemistry and Natural Products, Institute "Rudjer Bošković, Zagreb, Croatia, Yugoslavia)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: C.K. Bradsher

16.15 N-(3-Quinazolino)-amidates. Synthesis and Some Reactions

J. Fetter and K. Lempert (Department of Organic Chemistry, Technical University, Budapest, Hungary) and Jørgen Møller (The H.C. Ørsted Institute, University of Copenhagen, Denmark)

16.30 Selectivity of Substitution by Hard and Soft Nucleophiles on Amino-and Methylsufonyl-Azines

H.S. Broadbent, C.W. McCausland, and Wm.D. Johnston (Brigham Young University, Provo, Utah, USA)

16.45 Azlactone Oxidation

J.M. Riordan. E.G. Breitholle. M. Sato, and C.H. Stammer (Department of Chemistry, University of Georgia, Athens, Georgia, USA)

17.00 Transformation of the Ring in the Reaction of Nucleophilic Substitution of the Quinoxaline Derivatives

H. Poradowska (Institute of Organic Chemistry and Technology, Polytechnical University, Kraków, Poland)

17.15 The Reaction of Benzofurazan Oxide with Unsymmetrical 1,3-Diketones

MJ. Haddadin, M.U. Taha, and C.H. Issidorides (Department of Chemistry, American University of Beirut, Beirut, Lebanon)

17.30 The Reactions of Azine or Diazine with Aromatic Aldehydes in the Presence of Cyanide Ion

T. Higashino, M. Goi, and E. Hayashi (Shizuoka College of Pharmacy, Oshika, Shizuoka, Japan)

17.45 Reactivity Differences of the Nucleophilic Substitution of Halogenes in Naphthyridines

W. Czuba (Institute of Organic Chemistry and Technology, Polytechnical University, Kraków, Poland)

B-3

14.00-15.45 Chairman: P. Grünanger

14.00 An Intriguing Copper Salt Effect upon the Photochemistry of Pyridine N-Oxides. Specific Photoinduced Synthesis of 3-Substituted 2-Formyl-Pyrroles

J. Streith and F. Bellamy (Laboratoire Associé au CNRS; Ecole Supérieure de Chimie, Mulhouse, France)

14.15 Photoreactions of Halogenopyrimidines in liquid Ammonia

D.A. de Bie, H.C. van der Plas, and G. Geurtsen (Laboratory of Organic Chemistry, Agricultural University, Wageningen, The Netherlands)

14.30 The Photochemical Synthesis of Novel Heterocyclic System from s-Triazolo/4,3-b/pyridazine

J.T. Carlock, J.S. Bradshaw, G. Was, and W. Zmolek (Chemistry Department, Brigham Young University, Provo, Utah, USA)

14.45 Synthesis of Some N-Heterocycles via Photochemical Interaction between a Nitro Group and a Neighboring Unsaturated Bond

Y. Maki, T. Furuta, M. Kuzuya, and M. Suzuki (Gifu College of Pharmacy, Mitahora, Gifu, Japan)

15.00 Reductive Photocyclization of Benzo(b)furans and Their Analogs

A. Couture, A. Lablanche-Combier, and H. Ofenberg (Labo- ratoire de Chimie Organique Physique, Université des Sciences et Techniques de Lille, Villeneuve d’Ascq, France)

15.15 Regioselectivity of the Cycloadditions of Nitrile Oxides to Furan, Thiophen and Some of Their Derivatives

P. Caramella, G. Cellerino, and F.M. Albini (Istituto di Chimica Organica, Pavia, Italia)

15.30 Synthesis of Seven Membered Heterocycles by 1,5-Dipolar Cycloaddition

H. Griengl, and A. Bleikolm (Institut für Organische Chemie und Organisch-chemische Technologie der Technischen Hochschule in Graz, Austria)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: J.S. Bradshaw

16.15 Reaction of Vinylpyridines as Dienes

A. N. Kost, P.B. Terentjev, and V.G. Kartsev (Moscow State, University, Department of Chemistry, Moscow, USSR)

16.30 Cycloaddition Reactions of Sulfines

B. Zwanenburg, L. Thijs, H. Ambrosius, B.F. Bonini, G. Maccagnani, and G. Mazzanti (Department of Organic Chemistry, University of Nijmegen, Nijmegen, The Netherlands, and Istituto di Chimica Organica dell'Università, Bologna, Italy)

16.45 1,3-Dipolar Cycloaddition of "Hector's Base" to Arylcyanamides and Acetylenes: Role of Hypervalent Sulfur

K. Akiba, T. Tsuchiya, M. Ochiumi, und N. Inamoto (The University of Tokyo, Hongo, Tokyo, Japan)

17.00 Periselective Reactions of Fulvenes with Heterodienes and Heterodienophiles

T. Sasaki, K. Kanematsu, and T. Kataoka (Institute of Applied Organic Chemistry, Faculty of Engineering, Nagoya University, Chikusa, Nagoya, Japan)

17.15 Synthetic Applications of TosMIC and Analogues

A.M. van Leusen, J. Schut, H. Jeuring, R. Bouma, and H. Houwing (Groningen University, Groningen, The Netherlands)

17.30 Synthesis of Heterocyclic Compounds by Cycloaddition of Enamines

K. Grohe (Wissenschaftliches Hauptlaboratorium der Bayer AG, Leverkusen, Germany)

17.45 Interaction of Acyl Isocyanates with Azomethines

B.A. Arbuzov and N.N. Zobova (V.I. UI'yanov-Lenin University, Kazan, USSR)

C-2

14.00-15.45 Chairman: D. Ben-Ishai

14.00 Tautomeric Properties of Potential Hydroxy-thienothiophenes

G. Martelli, L. Testaferri, M. Tiecco, and P. Zanirato (Istituto di Chimica Organica, Bari, Italy)

14.15 Chemistry of Trithione Ylides, Imines and Related Derivatives

S. Tamagaki, K. Sakai, and S. Oae (Osaka City University and University of Tsukuba, Department of Chemistry, Ibaraki-ken, Japan)

14.30 Syntheses with Azomethinimines-1-Substituted Pyrazolidine-3-ones by Nucleophilic Substitution

H. Dorn and H. Graubaum (Zentralinstitut für Organische Chemie der Akademie der Wissenschaften der DDR, Berlin, GDR)

14.45 The Preparation of Some New 3- and 5-Nitropyrazoles by N-Substitution of 3(5)-Nitropyrazoles

D. Dumanović, R. Maksimović, J. Ćirić, D. Jeremić, and A. Muk (Research Laboratory "GALENIKA", Zemun, Faculty of Science. University of Belgrade, and Boris Kidrič Institute of Nuclear Sciences, Vinča, Belgrade, Yugoslavia)

15.00 Reactions of Acetylenic Ketones with Nucleophilic Nitrogen Compounds

F.G. Baddar, F. El-Hajjar, and N.N. El-Rayyes (Department of Chemistry, Kuwait University, Kuwait)

15.15 Lactone-Substituted N-Heterocycles. Synthesis of 5-(2-Oxo- tetrahydro-3-furyl)- and 5-(2-Oxotetrahydro-4H-3-pyranyl)-hydantoins

J. Lehmann and F. Zymalkowski (Pharmazeutisches Institut der Universität Bonn, Bonn, Germany)

15.30 Novel Methods for the Synthesis of 1-Substituted 5,5-Dipheyl-hydantoins and ‑Glycocyamidines

G. Simig and K. Lempert (Research Group for Alkaloid Chemistry of the Hungarian Academy of Sciences, Budapest, Hungary)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: T. Kappe

16.15 2-Oxazolines as Stable or Transient Intermediates in the Reaction of α-Metalated lsocyanides with Carbonyl Compounds

U. Schöllkopf (University of Göttingen, Göttingen, Germany)

16.30 2-Thiazoline, 2-Pyrroline and lmidazolidine Derivatives from 2-Thioxooxazolidine-4-carboxylates via 2-Isothiocyanatoacrylates

D. Hoppe and M. Kloft (Organisch-Chemisches Institut der Universität Göttingen, Göttingen, Germany)

16.45 Interaction of Aryloxazolone-3-yl Propanones with Nucleophilic Agents

D.A. Simov, V.B. Kalcheva, and H.S. Boycheva (University of Sofia, Faculty of Chemistry, Sofia, Bulgaria)

17.00 Addition of 2-Benzylbenzoxazole to Aromatic Aldehydes in the Presence of Aqueous Sodium Hydroxide

C. Ivanov, V. Dryanska, and S.L. Spassov (Department of Chemistry, University of Sofia, Sofia, and Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria)

17.15 1-Substituted Benzotriazoles as Antiinflammatory and Antiviral Agents

A. Kreutzenberger, H. van der Goot, and H.-H. Schröders (Freie Universität Berlin, Institut für Pharmazie, Berlin, Germany)

17.30 The Synthesis of 1,2,3-Thiadiazoles and 1,2,3-Triazoles

A. Martvon and M. Uher (Department of Organic Chemistry, Slovak Technical University, Bratislava, Czechoslovakia)

17.45 The Synthesis of Some 4,4'-Diaryl-substituted /3,3'-bis-1(H)-1,2,4-triazole/-5,5'-dithione

M. Jančevska and B. Bogdanov (Institute of Chemistry, University of Skopje, Yugoslavia)

D-3

14.00-15.45 Chairman: B. Zwanenburg

14.00 Synthesis and Reactions of New Ylidic Thiabenzenes

M. Hori, T. Kataoka, H. Shimizu, S. Ohno, K. Narita, and H. Aoki (Gifu College of Pharmacy, Gifu, Japan)

14.15 Reactions of Heterocyclic Sulfur Cation Radicals with Alkyl-amines and Ketones

H.J. Shine, B.K. Bandlish, K. Kim, A.G. Padilla, and S.R. Mani (Chemistry Department, Texas Tech University Lubbock, Texas, USA)

14.30 6-Substituted 2H-1,3,3-Thiadiazine-2,4(3H)-diones

R.A. Coburn, Chuen-huei Ho, and M.A. Leavery (Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, New York, USA)

14.45 Synthesis and Chemistry of a Cyclic Sulfoximine

K. Schaffner, H. Tomaselli, B. Henrici, and H.B. Renfroe (Research Department, Pharmaceutical Division, CIBA-GEIGY Corporation, Ardsley, N.Y., USA, and CIBA-GEIGY Ltd., Basel, Switzerland)

15.00 Synthesis and Reactions of Thia(IV)triazines

E. Fischer, G. Rembarz, and G. Voss (Universität Rostock, Sektion Chemie, Rostock, GDR)

15.15 Synthesis of New Fused Heterocyclic Ring Systems Derived from 1,2,6-Thiadiazine

G. Garcia-Muñoz, C. Ochoa, R. Madroñero, and M. Stud (Institute of Medicinal Chemistry, Madrid, Spain)

15.30 Polycondensed Nitrogen Heterocycles. V. Two Novel Ring Systems: 1,1-Dioxypyrazolo/3,4-c/1,2,4-thiadiazines and 1,1-Dioxypyrazolo/3,4-c/1,2-thiazine

E. Aiello, S. Plescia, and G. Dattolo (Istituto di Chimica Farmaceutica, Palermo, Italy)

15.45-16.15 INTERMISSION

16.15-18.00 Chairman: M.J. Shine

16.15 Preparation of 2H-1,3-Benzthiazine Derivatives

J. Szabo, I. Varga, L. Fodor, and E. Vinkler (Department of Pharmaceutical Chemistry, The Medical University, Szeged, Hungary)

16.30 Sulfur, Sulfoxide and Sulfone Derivatives in the 2,8-Dioxa-6-thiabicyclo-(3,2,1)octane Series

P. Calinaud and J. Gelas (Université de Clermont-Ferrand, Ensemble Scientifique des Cézeaux, Aubiere, France)

16.45 Syntheses of Thioxanthene Derivatives as Models of Certain Sulfur Containing Coal Compounds

K.-D. Gundermann and H. Debrodt (Organisch-Chemisches Institut der Technischen Universität Clausthal, Clausthal-Zellerfeld, Germany)

17.00 Selenium Heterocycles. XVIII. Synthesis and Chemistry of 5-Arylsulfonyl and 4-Arylsulfonylmethylene-1,2,3-selenadiazoles. Preparation of Arylsulfonylacetylenes

I. Lalezari, A. Shafiee and H. Golgolab (Department of Chemistry, College of Pharmacy, University of Tehran, Tehran, Iran)

17.15 Thiazolidinedione Chemistry

M. Pergal, K. Popov-Pergal and N. Kobilarov (Faculty of Sciences and Institute of Chemistry, University of Novi Sad, Novi Sad, Yugoslavia)

17.30 Intramolecular Electrophilic Substitution of Aryl-Substituted Organophosphorus Compounds. New Routes to Bicyclic Carbon-Phosphorus Heterocycles

G.A. Dilbeck, M.M. El-Deek, G.D. Macdonell, and K.D. Berlin (Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma, USA)

17.45 Reactivity of Phosphortrihydrazides: Synthesis of New Bi- and Tricyclic Compounds

J.P. Majoral, R. Kraemer, J. Navech, and F. Mathis (Laboratoire des Hétérocycles du Phosphore et de I'Azote, Université Paul Sabatier. Toulouse, France)

Friday, 18 July

L PLENARY LECTURES

9.00 K. Hafner (University of Darmstadt, Darmstadt, Germany)

New Heterocyclic Conjugated π-Electron Systems, Synthesis and Properties

Chairman: U. SchZilikopf

10.15 INTERMISSION

10.45 M.L. Mihailović (University of Beograd, Beograd, Yugoslavia)

The Formation of Cyclic Ethers from Alcohols by Intramolecular Substitution and Addition Processes

Chairman: R. Fusco

CLOSING OF THE CONGRESS