INVITED LECTURES

PIONEER MEMORIAL THEATRE, UNIVERSITY OF UTAH

Monday, 9 July

9:00 OPENING CEREMONY

9:30 HANS WYNBERG (NETHERLANDS)

L-1 The Chemistry and Chiroptical Properties of Helicenes and Circulenes

Chairman: A. R. Katritzky

10:45 INTERMISSION

11:00 EDWARD F. ELSLAGER (U.S.A.)

L-2 Synthesis of Fused Pyrimidines as Folate Antagonists

Chairman: W. Pfleiderer

Tuesday, 10 July

9:00 HENK C. VAN DER PLAS (NETHERLANDS)

L-3 Ring Transformations of Azines: A Mechanistic Study of the Ring Transformations of ¹⁴C- and ¹⁵N-Labeled Azines

Chairman: R. G. Shepherd

10:15 INTERMISSION

10:45 A. J. BOULTON (ENGLAND)

L-4 Concerted Ring Interconversions of 1,2-Oxazoles and Related Compounds

Chairman: J-L. Imbach

Wednesday, 11 July

9:00 CHARLES W. REES (ENGLAND)

L-5 Interconversion of Nitrogen Heterocyclic Rings

Chairman: N. H. Cromwell

10:30 CONGRESS EXCURSION

Thursday, 12 July

9:00 JACK J. FOX (U.S.A.)

L-6 Nucleoside Transformations

Chairman: R. K. Robins

10:15 INTERMISSION

10:45 TETSUJI KAMETANI (JAPAN)

L-7 The Total Synthesis of Natural Products by the Intramolecular Coupling Reaction

Chairman: C. C. Cheng

Friday, 13 July

9:00 JACQUES STREITH (FRANCE)

L-8 Photochemical Synthesis and Reactivity of 1,2-Diazepines

Chairman: R. Jacquier

10:15 INTERMISSION

10:45 BRANKO STANOVNIK (YUGOSLAVIA)

L-9 Transformations of Azolopyridazines, Azinopyridazines and Related Systems

Chairman: W. W. Paudler

CONTRIBUTED PAPERS

MONDAY, 9 JULY

SESSION A	Chairman: John A. Montgomery	Page
2:00	Stereochemistry and Kinetics of Guanosine-Epoxide Reactions	1
A-1	R. Roe, Jr., J. S. Paul and P. O'B. Montgomery (Univ. of Texas, U.S.A.)

2:20	Synthesis of Some Tricyclic Nucleosides Related to the "Y" Bases of t-RNA	3
A-2	G. L. Anderson, B. H. Rizkalla and A. D. Broom (Univ. of Utah, U.S.A.)

2:40	Synthesis of 8-Amino-6-thioinosine, 8-Amino-6-thioguanosine and Related Nucleoside Derivatives	5
A-3	G. L. Szekeres, R. A. Long and R. K. Robins (ICN Pharmaceuticals, Inc., U.S.A.)

3:00	Synthesis of 5-Fluoropyrimidines and Their Nucleosides by Direct Fluorination Using Trifluoromethyl Hypofluorite	7
A-4	M. J. Robins, S. R. Naik and G. Ramani (Univ. of Alberta, CANADA)

3:20	Studies in Nucleoside Syntheses. I - Ribosides of s-Triazolopyrimidines -	9
A-5	J. L. Barascut and J. L. Imbach (Univ. des Sciences et Techniques du Languedoc, FRANCE)

3:40	INTERMISSION

4:00	Glycosylation Studies of Related N-Bridgehead Heterocyclic Systems: Pyrazolo[1,5-a]pyrimidine, Pyrazolo[1,5-a]-s-triazine, and s-Triazolo[1,5-a]pyrimidine	11
A-6	G. R. Revankar, R. K. Robins and R. L. Tolman (ICN Pharmaceuticals, Inc., U.S.A.)

4:20	Successful Functionalization of the 6-Position of Purine-2'-deoxynueleosides	13
A-7	M. J. Robins and G. L. Basom (Univ. of Alberta, CANADA)

4:40	Intra- and Intermolecular Alkylation of Formycin	15
A-8	J. Zemlieka (Michigan Cancer Foundation, U.S.A.)

5:00	Some Transformations of Adenine Cyclonucleosides	17
A-9	M. Ikehara and Y. Ogiso (Osaka Univ., JAPAN)

5:20	Synthesis of 2-Substituted Adenosine 3',5'-Cyclic Phosphates From Ribofuranosylimidazole 3',5'-Cyclic Phosphates -	19
A-10	R. B. Meyer, Jr., D. A. Shuman and R. K. Robins (ICN Pharmaceuticals, Inc., U.S.A.)

SESSION B	Chairman: Miha Tišler	Page
2:00	New Reactions of Heterocyclic, β-Enamino-esters	77
B-1	H. Wamhoff, C. Materne, J. Lehmann, J. Hartlapp and C. von Waldow (Univ. of Bonn, W. GERMANY)

2:20	Heterocycles by Ring Closure of Some N,N-Dimethyl-N'-azinyl-formamidines	78
B-2	M. Tišler, B. Stanovnik, B. Verček and S. Polanc (Univ. of Ljubljana, YUGOSLAVIA)

2:40	The Synthesis and Reactivity of Pyrrolo[2,3-d]pyridazine, Pyrrolo[3,2-e]pyridazine, and Pyrrolo[2,3-e]pyridazine	80
B-3	P. D. Cook and R. N. Castle (Brigham Young Univ., U.S.A.)

3:00	A Novel Route to Fluoro-1,2,4-triazoles and 8-Fluoropurines	82
B-4	S. R. Naik, J. T. Witkowski and R. K. Robins (ICN Pharmaceuticals, Inc., U.S.A.)

3:20	Synthesis of Poly 2-Uracil-4-aminobutyric Acid	83
B-5	J. Hes and M. Mertes (Univ. of Kansas, U.S.A.)

3:40	INTERMISSION

4:00	Formation of 5-Aryl-1,2,4-thiadiazine 1,1-Dioxides and N-Styrylamidines From Styrylsulfonylamidines	85
B-6	W. L. Matier and W. T. Comer (Mead Johnson and Co., U.S.A.)

4:20	Reaction of Pyrimidine Derivatives with Carbenes	87
B-7	U. K. Pandit, H. P. M. Thiellier and G. J. Koomen (Univ. of Amsterdam, NETHERLANDS)

4:40	Selective Attack by Hard and Soft Nucleophiles on Amino-pteridines: 6-Methylthio-, 6-Methylsulfinyl-, or 6-Methylsulfonyl-	89
B-8	W. D. Johnston, H. S. Broadbent and W. W. Parish (Brigham Young Univ., U.S.A.)

5:00	Some Experiments with Dihydroxypyrazines	91
B-9	G. W. H. Cheeseman and P. Sharma (Queen Elizabeth College, ENGLAND)

SESSION C	Chairman: Frank D. Popp	Page
2:00	The Synthesis and Reactions of the Inner Salt of 5,11-Dihydro-11-oxopyrido[1,2-b]cinnolin-6-ium Hydroxide	149
C-1	R. Y. Ning, W. Y. Chen and L. H. Sternbach (Hoffmann-La Roche, Inc., U.S.A.)

2:20	3,4-Dihydroquinazolines Through the Dimerization of Certain Ketenimines	151
C-2	M. W. Barker and J. D. Rosamond (Mississippi State Univ., U.S.A.)

2:40	Cycloaddition Reactions of Some Isoquinolinium Salts	153
C-3	C. K. Bradsher and F. H. Day (Duke Univ., U.S.A.)

3:00	Preparation and Reactions of Some 4-Substituted-1,3(2H,4H)-isoquinolinedones	155
C-4	I. W. Elliott, Y. Takekoshi and J. R. Green (Fisk Univ., U.S.A.)

3:20	Investigation on the Cyclization Mechanism of α-Phenyl-benzylideneacetone Oxime Benzoate to 1-Phenyl-3-methyl-isoquinoline	157
C-5	S. Goszczyński and M. Łoźyński (Poznań Technical Univ., POLAND)

3:40	INTERMISSION

4:00	Mannich Type Reactions with an Isobasic Isoquinoline	159
C-6	K. Harsányi, P. Kiss and D. Korbonits (Chinoin Pharmaceutical and Chemical Works, HUNGARY)

4:20	Isoquinoline Structures from N-Benzoates of 1‑Alkyl-3,4-dihydroisoquinolines	161
C-7	I. Ninomiya, T. Naito and H. Takasugi (Kobe Women's College of Pharmacy, JAPAN)

4:40	Novel Topochemical Behavior of 2H-Benz[de]isoquinoline-1,3-diones and 2,7-Dihydrobenzo[1mn]-3,8-phenanthroline-1,3,6,8-tetraones	163
C-8	J. J. Jordan and F. J. Goetz (Seton Hall Univ., U.S.A.)

5:00	Trans- and cis-Isoquino1ine-and Isochromane Type Heterocycles from erythro- and threo-3-Amino- and 3-Hydroxy-methyl-propionates	165
C-9	B. Kurtev, M. Haimova, S. Spassov, M. Palamareva and E. Stanoeva (Univ. of Sofia, BULGARIA)

SESSION D	Chairman: Dov Ben-Ishai	Page
2:00	Bromination of Some 1,X-Naphthyridine N-Oxides	227
D-1	W. Paudler, R. Van Dahm and J. Wang (Ohio Univ., U.S.A.)

2:20	Sodium Borohydride Reduction of N-Benzyloxpyridinium Salts	229
D-2	R. E. Manning and F. Schaefer (Sandoz-Wander, Inc., U.S.A.)

2:40	1-(Adamantanethio)pyridines	230
D-3	L. Bauer, B. A. Mikrut, K. K. Khullar, P. Y-P. Chan and R. S. Egan (Univ. of Illinois, U.S.A.)

3:00	Intramolecular Nucleophilic Cyclization of 3-Substituted Pyridines onto the 2-Position of the Pyridine Ring	232
D-4	H. L. Davis and E. M. Hawes (Univ. of Saskatchewan, CANADA)

3:20	An Unequivocol Synthesis of N-Substituted-1,4-dihydropyridines	234
D-5	A. I. Meyers and D.M. Stout (Colorado State Univ., U.S.A.)

3:40	INTERMISSION

4:00	Reactions of 1,2-Dihydro-2-substituted Pyridyllithium Compounds. New Ambident Nucleophiles	236
D-6	C. S. Giam, E. E. Knaus, R. A. Lockhart, I. G. Keener and G. S. Neff (Texas A&M Univ., U.S.A.)

4:20	Reaction of Diketene With Some Enamine To Give Heterocyclic Compounds	238
D-7	T. Kato, T. Chiba, T. Sakamoto and T. Hozumi (Tohoku Univ., JAPAN)

4:40	Substituent Effects in Intramolecular 1,5-Cyclization of Allyl Pyridinium Ylides	240
D-8	E. K. Pohjala (Helsinki Univ. of Technology, FINLAND)

5:00	The Reactions of Pyridyl- and Arylhydrazones with Bases. A New Type of N-N-Bond Cleavage	242
D-9	L. N. Yakhontov, M. F. Marshalkin and E. V. Pronina (S. Ordzhonikidze All-Union Chemical-Pharmaceutical Research Institute, USSR)

TUESDAY, 10 JULY

SESSION A	Chairman: Gordon W. H. Cheeseman	Page
2:00	Mechanisms of Ring Interconversions and Factors Affecting Their Occurrence	21
A-11	R. G. Shepherd (American Cyanamid Co., U.S.A.)

2:20	A-11 continued
A-12

2:40	Dimroth Rearrangements in the Imidazo[1,2-a]pyridine Series	23
A-13	R. Jacquier, H. Lopez and G. Maury (Univ. des Sciences et Techniques du Languedoc, FRANCE)

3:00	Rearranging Cycloadditions to Five Membered S-Heterocycles	24
A-14	J. Goerdeler, J. Ulmen, R. Büchler and J. Haag (Univ. Bonn, GERMANY)

3:20	An Unusual Photoaddition of Alkenes to s-Triazolo[4,3-b]pyridazine	25
A-15	J. S. Bradshaw, B. Stanovnik and M. Tišler (Univ. of Ljubljana, YUGOSLAVIA)

3:40	INTERMISSION

4:00	A Novel Ring Contraction of O^5’-6(S)-Cyclo-5-diazouridine Elimination of a Ring Carbonyl Group in Preference to Diatomic Nitrogen	27
A-16	T. C. Thurber and L. B. Townsend (Univ. of Utah, U.S.A.)

4:20	Heat Induced Transformation of 1,2,3-Selenadiazoles to Disubstituted Selenophenes	29
A-17	I. Lalezari (Univ. of Tehran, IRAN)

4:40	The Synthesis of 4-Amino-8-(b-D-ribofuranosyl)aminopyrimido[5,4-d]pyrimidine: A Novel Rearrangement of the Purine Ring	31
A-18	H. M. Berman, R. J. Rousseau, R. W. Mancuso, G. P. Kreishman and R. K. Robins (ICN Pharmaceuticals, Inc., U.S.A.)

5:00	The Chemistry of 1,2,3-Triazines	33
A-19	H. Neunhoeffer, H-D. Votter and M. Ohl (Technische Hochschule Darmstadt, GERMANY)

5:20	Photochemistry of Nitrophenylpyrazoles	35
A-20	R. Jacquier, J. Elguero, P. Bouchet and C. Coquelet (Univ. des Sciences et Techniques du Languedoc, FRANCE)

SESSION B	Chairman: E. Campaigne	Page
2:00	Synthesis of New Pharmacologically Active Pyrrolidines	93
B-10	S. Ohki, N. Ozawa and H. Matsuda (Tokyo College of Pharmacy, JAPAN)

2:20	Potential Antitumor Agents. Analogs of Ergot Alkaloids and Related Compounds	95
B-11	A. C. Ghosh, R. R. Kurtz, H. Dalzell and R. K. Razdan (Sheehan Institute and Sharps Associates, U.S.A.)

2:40	A Novel Conversion of Penicillins into Cephalosporins	97
B-12	T. Kamiya, T. Teraji, Y. Saito, M. Hashimoto, O. Nakaguchi and T. Oku (Fujisawa Pharmaceutical Cc. Ltd., JAPAN)

3:00	2,5-Diazabicyclo[2.2.2]octanes, 3,8-Diazabicyclo[3.2.1]octanes, and 2,5-Diazabicyclo[2.2.1]heptanes as Bridged Analogs of the Antifilarial Drug, Diethylcarbamazine	99
B-13	P. A. Sturm and D. W. Henry (Stanford Research Institute, U.S.A.)

3:20	The Synthesis and Chemical Properties of 5,7-Dialkylpyrazolo[1,5a]1,3,5-triazines	101
B-14	K. Senga, T. Novinson, R. K. Robins and D. E. O'Brien(ICN Pharmaceuticals, Inc., U.S.A.)

3:40	INTERMISSION

4:00	Photochemical Transformations of Drugs Related to Pyrazoline	103
B-15	J. Reisch (Westfalien Wilhems Univ., FRG)

4:20	Synthesis of 5,5'-{[3-(Dimethylamino)propyl]Imino}bis[3-(trichloromethyl)1,2,4-thiadiazole] and Related Compounds As Antimalarial Agents	105
B-16	E. F. Elslager, J. Johnson and L. M. Werbel (Parke, Davis and Co., U.S.A.)

4:40	The Synthesis of Novel Aryl Substituted Hexahydro-1,3 and 1,4-Diazocinones	107
B-17	R. Sarges and J. R. Tretter (Pfizer Inc., U.S.A.)

5:00	Reaction of Alkylhydrazines II. Synthesis of Heterocyclic Compounds of Biological Interest	109
B-18	J. Nematollahi, S. Kasina and D. Maness (Univ. of Texas, U.S.A.)

5:20	The Synthesis of Imidazo[1,5a]pyrimidines From 4(5)-Amino-5(4)-imidazolecarboxamide (AICA)	111
B-19	T. Novinson, R. K. Robins and D. E. O'Brien (ICN Pharmaceuticals, Inc., U.S.A.)

5:40	The Synthesis and Properties of the Pyrimido(4,5-b)(1,4)thiazines -- New Type of Folic Acid Antagonists	113
B-20	T. S. Safonova and M. P. Nemerjuk (S. Ordzhonikidze All-Union Chemical Pharmaceutical Research Institute, USSR)

SESSION C	Chairman: Yoshio Ban	Page
2:00	The Reaction of 4-Nitroquinoline 1-Oxide With Enamines	167
C-10	M. Hamana, H. Noda and T. Yamamori (Kyushu Univ., JAPAN)

2:20	Cyclization of b-Phenylbenzylideneacetone Oxime Esters to 2‑Methyl-4-phenylquinoline	169
C-11	S. Goszczyński and E. Salwińska (Pozńan Technical Univ., POLAND)

2:40	Comparative Hydrogenation of a Number of Quinoline Carbonyl Derivatives	171
C-12	E. V. Brown, H. H. Bauer, D. N. Schluter and T. Biegler (Univ. of Kentucky, U.S.A.)

3:00	Some Reactions of 2-Methyl-4(1H)-quinolone With N-Aliphatic and Aromatic Adlehydes	173
C-13	A. C. Casey and J. T. Marone (New England Institute, U.S.A.)

3:20	Intramolecular Nitrene Insertions into Aromatic and Heteroaromatic Ring Systems	174
C-14	R. N. Carde, G. R. Cliff, G. Jones and J. McK. Woollard (Univ. of Keele, ENGLAND)

3:40	INTERMISSION

4:00	Quinoxaline Derivatives. XII. A Study of the Reaction of Quinoxaline-1,4-dioxide and Its Derivatives With Acetic Anhydride	176
C-15	M. S. Habib, M. A. Farooqi, Y. Ahmad and M. I. Qureshi (Burroughs Wellcome & Co., Ltd., PAKISTAN)

4:20	2,4,6-Trialkyl-1,3,5-hexahydrotriazines. Synthesis, Stereochemistry and Chemical Behavior	178
C-16	A. T. Nielsen, R. L. Atkins, D. W. Moore, R. Scott, D. Mallory and J. M. LaBerge (Naval Weapons Center, U.S.A.)

4:40	Pyrazolo[5,1-c]benzo-1,2,4-triazine. A New Ring System by the Intramolecular Condensation of Aromatic Nitro-group with Amino-group	180
C-17	Y. Ahmad, M. I. Qureshi and S. S. Anwar (Pakistan Council of Sci. and Ind. Res. Lab., PAKISTAN)

5:00	Structures of Murrayacinine and Heptazolidine: Two Carbazole Alkaloids of Rutaceae	182
C-18	D. P. Chakraborty, P. Bhattacharyya, A. Islam and S. Roy (Bose Institute, INDIA)

5:20	A New Synthesis of 4-Keto-1,2,3,4-tetrahydroquinolines	184
C-19	G. Dienys, J. Gurevičienē, M. Kažemekaitē and L. Čekuolienē (Vilnius State Univ., USSR)

SESSION D	Chairman: Salo Gronowitz	Page
2:00	The Synthesis and Transformations of Some 3-Chloro-and 3-Nitroindolenines	243
D-10	A. Walser, J. Blount and R. I. Fryer (Hoffmann-La Roche, Inc., U.S.A.)

2:20	A Study of the α-Substituted 2'-Arylideneaminotoluene: 3-Substituted 2-Arylindoline Tautomerism	245
D-11	F. J. Goetz (Seton Hall Univ., U.S.A.)

2:40	Synthesis of 4-Keto-4,5,6,7-tetrahydroindoles via Munchnone Intermediates	247
D-12	F. M. Hershenson (Searle Laboratories, U.S.A.)

3:00	Reaction of 3-[2'-Tetrahydrofuranyl(pyranyl)thio]indole With Silver Ion	249
D-13	M. Pickering, T. D. Lee and G. D. Daves, Jr., (Oregon Graduate Center, U.S.A.)

3:20	Some New Chemistry of Isatin	251
D-14	F. D. Popp and R. M. Piccirilli (Clarkson College of Technology, U.S.A.)

3:40	INTERMISSION

4:00	The Reaction of Phenyl Isocyanate With N-Methyl-2-pyrrolidinone	253
D-15	R. Richter and H. Ulrich (The Upjohn Co., U.S.A.)

4:20	Aryl Aroyl- and Aryl Aroyl Amino Pyrroles	255
D-16	N. H. Cromwell and D. E. Weiss (Univ. of Nebraska, U.S.A.)

4:40	Synthesis of Pyrrolic Condensed Systems	257
D-17	M. Farnier, S. Samreth and P. Fournari (Laboratoire de Polarographie Organique, FRANCE)

5:00	N,N-Diacylimidazolium Ions in Organic Synthesis	259
D-18	J. Bergman and L. Renström (Royal Inst. of Technology, SWEDEN)

5:20	A Solution to the Dicarbazylmethane Controversy, A Study of Photobromination of 9-Substituted-3-Methylcarbazole	261
D-19	M. T. Goetz (Seton Hall Univ., U.S.A.)

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WEDNESDAY, 11 JULY Congress Excursion

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THURSDAY, 12 JULY

SESSION A	Chairman: Morio Ikehara	Page
2:00	Synthesis of Nucleosides from Nitro-Sugars	36
A-21	R. E. Harmon, T-S. Lin and S. K. Gupta (Western Michigan Univ., U.S.A.)

2:20	Studies in Nucleoside Syntheses: IV, Obtention of New Ribosides of Benzoazoles	37
A-22	B. Kam, C. Tapiero and J-L. Imbach (Univ. des Sciences et Techniques du Languedoc, FRANCE)

2:40	Fluorescent 1,N⁶-Ethenoadenine Coenzymes and Dinucleoside Phosphates	39
A-23	G. L. Tolman, J. R. Barrio, N. J. Leonard, R. D. Spencer and G. Weber (Univ. of Illinois, U.S.A.)

3:00	The Investigation of Tautomerism in Certain Nucleosides by Carbon-13 Magnetic Resonance Spectroscopy	41
A-24	M-T. Chenon, R. J. Pugmire, D. M. Grant, R. P. Panzica and L. B. Townsend (Univ. of Utah, U.S.A.)

3:20	Chemical Ionization Mass Spectrometry of Nucleosides	43
A-25	M. S. Wilson and J. A. McCloskey (Baylor College of Medicine, U.S.A.)

3:40	INTERMISSION

4:00	Syntheses and Properties of Pteridine Cyclonucleosides	45
A-26	W. Pfleiderer and K. Kobayashi (Univ. of Konstanz, WEST GERMANY)

4:20	Reaction of 2,2'-Anhydro Pyrimidine Nucleosides with Amine Nucleophiles	47
A-27	T. J. Delia and J. Beranek (Central Michigan Univ., U.S.A.)

4:40	The Use of the Wittig Reaction in the Preparation of Purine Nucleosides	49
A-28	J. A. Montgomery, A. G. Laseter and K. Hewson (Southern Research Institute, U.S.A.)

5:00	Some Transformations of 5-Thioribosyluracil and Analogs	51
A-29	E. J. Eustace, T. E. Stone, C. Bachman and G. D. Daves, Jr., (Oregon Graduate Center, U.S.A.)

5:20	Studies in Nucleoside Syntheses: III, A Criterion for Determining Anomeric Configuration of Ribonucleosides	53
A-30	J-L. Imbach, J-L. Barascut, B. Kam, B. Rayner and C. Tapiero (Univ. des Sciences et Techniques du Languedoc, FRANCE)

5:40	Synthesis and Reactions of 1-Oxido-2-pyridylmethyl Protected Nucleosides and Nucleotides	55
A-31	Y. Mizuno, T. Endo, T. Miyaoka and K. Ikeda (Hokkaido Univ., JAPAN)

SESSION B	Chairman: Irwin J. Pachter	Page
2:00	Selenium Heterocycles. XI Reaction of 2-Aminoselenazoles and 2-Amino-1,3,4-selenadiazoles with Acetylenic Compounds	115
B-21	A. Shafiee and I. Lalezari (Univ. of Tehran, IRAN)

2:20	1,2,3-Selenadiazol-4-yl Derivatives of Steroids and Aromatic Polycyclic Compounds	117
B-22	H. Golgolab and I. Lalezari (Univ. of Tehran, IRAN)

2:40	Meisenheimer-Type Compounds from Heteroaromatic Substrates: The Reaction of CH₃O^- and H^- Ions with some 2,4-Disubstituted Thiophenes and Selenophenes	119
B-23	F. Terrier, A. P. Chatrousse, M. P. Simonnin and C. Paulmier (Ecole Nationale Supèrieure de Chimie, FRANCE)

3:00	Some Aspects of the Chemistry of Phosphorins	121
B-24	K. Dimroth (Philipps-Univ., GERMANY)

3:20	Substitution Reactions of 3,2-Borazaropyridines	123
B-25	S. Gronowitz and A. Maltesson (Univ. of Lund, SWEDEN)

3:40	INTERMISSION

4:00	Interconversion of Some Pentaatomic Heterocyclic Rings	124
B-26	V. Bertini (Univ. Via Risorgimento, ITALY)

4:20	Synthesis and Reactions of Methyl 2-Cyano-3-(2-substituted-indol-3-yl)thio-3-methylthioacrylates	126
B-27	S. Kisaki, Y. Tominaga, R. Natsuki, Y. Matsuda and G. Kobayashi (Nagasaki Univ. JAPAN)

4:40	Synthesis of Partially Hydrogenated 1H-Indeno[1,2-b]pyridin-2-ones	128
B-28	R. Kunstmann (Farbwerke Hoechst AG, WEST GERMANY)

5:00	New Synthesis of Methyl 5-Vinylquinuclidine-2-carboxylate	130
B-29	L. N. Yakhontov, L. I. Mastafanova (S. Ordzhonikidze All- Union Chemical-Pharmaceutical Research Institute, USSR)

SESSION C	Chairman: Charles K. Bradsher	Page
2:00	The Conversion of Azlactones into Unsaturated Azlactones	186
C-20	C. H. Stammer, J. Riordan, E. Breitholle and J. Hines(Univ. of Georgia, U.S.A.)

2:20	Research in the Chemistry of Cyclic Ketals: Synthesis of 5,7-Dioxa-2-aza-bicyclo(2.2.2)octanes	187
C-21	P. Calinaud, J. Gelas and D. Petrequin (Univ. de Clermont-Ferrand, FRANCE)

2:40	Synthesis of Isomeric N-Substituted 5-Methyl-2H-1,2,6-thiadiazin-3(6H)-one 1,1-Dioxides	189
C-22	J. Díez, G. García-Munoz, R. Madroñero and M. Stud (Instituto de Química Orgánica General, SPAIN)

3:00	Synthesis of Novel Spiroheterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro[5.5]undec-1-enes and Related Compounds	191
C-23	N. Cohen, B. L. Banner, J. F. Blount, R. J. Lopresti, M. Tsai and G. Saucy (Hoffmann-La Roche Inc., U.S.A.)

3:20	Synthesis and Reactions of Non-Classical Thiophenes	193
C-24	K. T. Potts and D. McKeough (Rensselaer Polytechnic Inst., U.S.A.)

3:40	INTERMISSION

4:00	The Reactions of 2-Ethoxy-2,3-dihydrobenzoxazinone and 4,4-Diphenyl-2-ethoxyoxazolidinone with Olefins	195
C-25	D. Ben-Ishai and I. Gillon (Israel Inst. of Tech., ISRAEL)

4:20	Interconversion of 3-Acylaminobenzisoxazoles and 3-(2-hydroxyphenvl)-1,2,4-oxadiazoles	197
C-26	K. Harsányi (Chinoin Pharm. and Chem. Works, HUNGARY)

4:40	Mechanism of 1,2,4-Oxadiazole Synthesis from Amidoximes and Esters on the Basis of Anomalous Reaction of Salicyclic Acid Amidoxime	199
C-27	K. Harsányi (Chinoin Pharm. and Chem. Works, HUNGARY)

5:00	Reactions of Flavin-analogous Pyrimido[5,4-b][1,4]benzothiazines	203
C-28	H. H. Rössler and H. Fenner (Freien Univ.Berlin, GERMANY)

5:20	Novel Heterocycles from Dialkyl Sulfone Diimines	207
C-29	M. Haake, B. Eichenauer, H. Fode (Institute für Pharmazeutische Chemie der Univ. Marburg, WEST GERMANY)

SESSION D	Chairman: Ludwig Bauer	Page
2:00	Mesoionic Purinone Analogs. Synthesis and Properties of Several Mesoionic Xanthine Analogs	263
D-20	R. A. Coburn, R. A. Carapellotti and R. A. Glennon (State Univ. of New York at Buffalo, U.S.A.)

2:20	Reaction Between Dienes and Mesoionic Compounds - A New Type of Cycloaddition	264
D-21	K-L. Mok and M. J. Nye (Univ. of Guelph, CANADA)

2:40	Kinetics and Equilibria of Pseudobase Formation by Quaternary Nitrogen Heterocycles	266
D-22	J. W. Bunting and W. G. Meathrel (Univ. of Toronto, CANADA)

3:00	Polarization Directions of Electronic Transitions in Aza Analogs of Pyrene	268
D-23	J. W. Downing and J. Michl (Univ. of Utah, U.S.A.)

3:20	Physico Chemical Properties of First Singlet Excited State for Some Dibenzacridines and Pyridobenzocarbazoles	269
D-24	M. Deumie, P. Jacquignon, B. Saperas and P. Viallet (Centre Univ., FRANCE)

3:40	INTERMISSION

4:00	N.M.R. Conformational Studies of Formylpyrroles C-Substituted	271
D-25	T. Drakenberg and M. Farnier (Laboratoire de Polarographie Organique, FRANCE)

4:20	Use of Nuclear Overhauser Effect in the Elucidation of Structures: Determination of the Substitution sites in Heteroaromatic Systems	273
D-26	B. Roques, S. Combrissan and R. Oberlin (Ecole Polytechnique, FRANCE)

4:40	Biogenetic Type Synthesis of Branched and Extended Chain Carbohydrate Derivatives	275
D-27	A. M. Sepulchre, G. Lukacs, A. Gateau-Olesker, G. Vass and S. D. Gero (Institut de Chimie des Substances Naturelles, FRANCE)

5:00	Photo- and Electronolysis of 2-(3,5-Diphenyl-1-Phenylsulfonyl-2-Pyrazolin-5-yl)acetophenone	277
D-28	K. Lempert, M. Lempert-Sreter and J. Tamas (Techn. Univ., HUNGARY)

5:20	The Photochemistry of Tetrazines	278
D-29	M. Druelinger, H-F Chang and J. Gallagher (Indiana State Univ., U.S.A.)

FRIDAY, 13 July

SESSION A	Chairman: I. Lalezari	Page
2:00	The Reaction of Heteroaromatic N-Oxides with Acetylenes	57
A-32	R. A. Abramovitch and I. Shinkai (Univ. of Alabama, U.S.A.)

2:20	Degradative Ring Opening of Condensed 3-Benzenesulfonyloxy-uracils with Sodium Methoxide	59
A-33	L. Bauer and K-Y. Tserng (Univ. of Illinois, U.S.A.)

2:40	Cycloaddition of 1-Azirines with Cyclopentadienones. Formation of 2H- and 3H-Azepines and Mechanistic Interpretation	61
A-34	D. J. Anderson and A. Hassner (Univ. of Colorado, U.S.A.)

3:00	Synthesis and Rearrangements of 1,2,3,4,5,6-Hexahydro-3-benzazocin-6-ones	63
A-35	W. T. Comer, J. D. Catt, W. L. Matier and H. Scarborough (Mead Johnson and Company, U.S.A.)

3:20	A New Type of Heterocyclization Proceeding Through a Multicenter Rearrangement: Preparation of 5-aryl-6,6a-dialkyl-2,3-dioxo-2,2a,4a,6b-tetrahydro-1,4-dioxa-cyclopenta(c,d)pentalene	65
A-36	A. Valla, M. ,Giraud and D. Molho (Muséum National d'Histoire Naturelle, FRANCE)

3:40	INTERMISSION

4:00	Synthesis of Four Isomeric 1,2,3-Thiadiazolopyridines and Some 4-(x-Pyridyl)-1,2,3-thiadiazoles	67
A-37	A. Taurins and D. Eugène (McGill Univ., CANADA)

4:20	The Photochemistry of Five Membered Hydroheteroaromatics: 2-Thiazolines and 2-Isoxazolines	69
A-38	T. Matsuura and Y. Ito (Kyoto Univ., JAPAN)

4:40	Photochemical and Thermal Behaviours of Heterocycles Involving Azido-ketone Moiety	71
A-39	T. Sasaki, K. Kanematsu and M. Murata (Nagoya Univ., JAPAN)

5:00	Chemical Behaviors of Pyridinium N-Allylides	73
A-40	T. Sasaki, K. Kanematsu, A. Kakehi and G. Ito (Nagoya Univ., JAPAN)

5:20	A 5-Methylthiopenicillin Analog and its Transformation to Novel Bicyclic b-Lactams	75
A-41	A. K. Bose, J. L. Fahey and M. S. Manhas (Stevens Institute of Technology, U.S.A.)

SESSION B	Chairman: Bernard Loev	Page
2:00	Chiral 1,4-Benzodiazepines. Synthesis and Properties of 1,4-Benzodiazepin-2-ones Containing α-Amino Acids as a part of the 1,4-Benzodiazepine Ring	131
B-30	N. Blazevic, V. Sunjic, F. Kajfez, I. Stremar and D. Kolbah (Compagnia di Ricerca Chimica SA., SWITZERLAND)

2:20	Azaphenanthrenophenes and Their Metal Complexes	133
B-31	S. Ogawa and N. Gotoh (Univ. of Tokyo, JAPAN)

2:40	The Chemistry of 2-Tetrahydropyranthiol, A Reagent for Direct Introduction of Protected Thiols	135
B-32	R. Ketcham, M. Missakian and A. Martin (Univ. of California, U.S.A.)

3:00	Reactions of 1,2-Dimethyl-5-nitroimidazole. A Novel General Method for Conversion of Methyl Groups to Nitriles	137
B-33	J. D. Albright and R. G. Shepherd (American Cyanamid Co., U.S.A.)

3:20	Synthesis and Reactivity of 1,2-Tetrahydrodiazepinones and 1,2-Tetrahydrodiazepines	139
B-34	C-G. Wermuth and J-J. Koenig (Laboratoire de Chimie Organique, FRANCE)

3:40	INTERMISSION

4:00	Nitro Derivatives of N-Picrylbenzotriazoles and N-Picrylpyridotriazoles	141
B-35	M. D. Coburn (Univ. of California, U.S.A.)

4:20	Benzotriazoles from o-Azidoazobenzenes	142
B-36	J. H. Hall and F. W. Dolan (Southern Illinois Univ., U.S.A.)

4:40	Uses of γ-Piperidones for the Synthesis of Heterocyclic Compounds	143
B-37	N. S. Prostakov (Peoples Friendship Univ., USSR)

5:00	Synthesis of the 2,3,6,7-Dibenzo-9-azabicyclo(3,3,1)nonanediol-1,5-Type Heterocyclic Compounds on the Basis of 1,2,5,6-Dibenzo-3,3,7,7-tetramethylcyclo-octanedione-4,8 and Some Biogenic Amines.	145
B-38	R. M. Lagidze, N. K. Iremadze, D. R. Lagidze, and R. R. Devdariani (Academy of Sciences of the Georgian SSR, USSR)

5:20	Cycloaddition Reaction of Dibenzo[b,e]-1,3a,6a-triazapentalenes as New Cyclic Azomethine Imines	147
B-39	O. Tsuge and H. Samura (Kyushu Univ., JAPAN)

SESSION C	Chairman: B. S. Thyagarajan	Page
2:00	The Anomeric Effect in Sulfur-Containing Heterocycles	209
C-30	M. Ōki, T. Sugawara, K. Arai and M. Fukunaga (Univ. of Tokyo, JAPAN)

2:20	The Crystal Structure of the Heterocycle C₈H₁₆S₃0	211
C-31	N. K. Dalley, R. M. Izatt and J. J. Christensen (Brigham Young Univ., U.S.A.)

2:40	A New Synthesis of Bullatenone and Related Reactions	213
C-32	A. Takeda, S. Tsuboi and T. Sakai (Okayama Univ., JAPAN)

3:00	Recent Advances in Heterocyclic Ylidenemalononitrile Chemistry	215
C-33	S. W. Schneller, D. R. Moore, J. Hays and F. W. Clough(Univ. of South Florida, U.S.A.)

3:20	Preparation of 2,5-Dimethyl-4-hydroxy-3(2H)-furanone	217
C-34	K. K. Light, W. J. Evers and A. O. Pittet (International Flavors and Fragrances, Inc., U.S.A.)

3:40	INTERMISSION

4:00	Studies in the Synthesis of Furobenzopyrones: Synthesis of Psoralene and Psoralene Derivatives	218
C-35	N. H. Pardanani, Y. A. Shaikh and K. N. Trivedi (Univ. of Baroda, INDIA)

4:20	Studies in the Synthesis of Furocoumarins: Synthesis of 4-hydroxy-4',8-dimethylpsoralene and Psoralene Derivatives	220
C-36	Y. A. Shaikh, N. H. Pardanani and K. N. Trivedi (Univ. of Baroda, INDIA)

4:40	Syntheses and Properties of Pyranopyrandiones	222
C-37	S. F. Tan (Univ. of Singapore, SINGAPORE)

5:00	Unusual Nitration Reactions of Benzo-1,4-dioxane Derivatives	224
C-38	G. V. Purvaneckas, E. B. Udrėnaitė and V. K. Daukšas (Vilnius V. Kapsukas State Univ., USSR)

5:20	Use of 5-Nitrofurfury1nitrate in Organic Synthesis	226
C-39	J. Kováč and A. Jurášek (Slovak Technica1 Univ., ČSSR)

SESSION D	Chairman: Albert I. Meyers	Page
2:00	The C₆H₅N Energy Surface: Isomerization in Pyridylcarbenes	279
D-30	W. D. Crow, A. N. Khan, M. N. Paddon-Row and D. S. Sutherland(Australian National Univ., AUSTRALIA)

2:20	Metalation of 2-Methylthiazoles. Substituent, Steric and Isotope Effects	281
D-31	A. I. Meyers and G. Knaus (Colorado State Univ., U.S.A.)

2:40	Some Principles Governing Cation Selectivity by Macrocyclic Compounds	283
D-32	L. D. Hansen, J. J. Christensen, D. J. Eatough and R. M. Izatt (Brigham Young Univ., U.S.A.)

3:00	Formation and Reactions of Heterocyclic Free Radicals in the Gas Phase I. The Thienyl Radical	284
D-33	E. K. Fields and S. Meyerson (Amoco Chemicals Corp., U.S.A.)

3:20	Frontier Orbitab Method: Stereochemistry of the Approach of the Dipole by the Dipolarophile in the 1,3 Dipolar Addition of Nitrones and Nitronic Esters to Activated Olefins	286
D-34	R. Grée, M. Joucla, F. Tonnard, J. Hamelin, and R. Carrié (Groupe de Recherches de Physicochimie Structurale, FRANCE)

3:40	INTERMISSION

4:00	Heterocyclic 8π Systems as Reactive Intermediates	288
D-35	R. R. Schmidt (Institut für Organische Chemie, Biochemie und Isotopenforschung,GERMANY)

4:20	The Mechanism of Ring-opening of 3-Unsubstituted-3-isoxazolin-5-ones	290
D-36	D. J. Woodman and P. M. Stonebraker (Univ. of Washington, U.S.A.)

4:40	Spectroscopic Investigation of Cyclic Conjugated Enamines	291
D-37	H. W. Dürbeck and L. L. Duttka (Jülich Nuclear Research Center, FRG)

5:00	The Sulfonic Acids of Strychnine and Derivatives	293
D-38	G. A. Baramki, J. T. Edward, P. G. Farrell and G. Welch (McGill Univ. - CANADA)

5:20	Carbon-13 Studies of Neutral and Ionic Purines and Pyrimidines	294
D-39	G. D. Mateescu and G. Pouzard (Case Western Reserve Univ., U.S.A.)

5:40	Reaction of Substituted 1,3,5-Triazines under High Pressure. Rearrangement to 4-Aminapyrimidines and Replacement of the Substituents	296
D-40	M. Kurabayashi, K. Yanagiya and M. Yasumato (Nat. Chem. Lab. for Industry, JAPAN)