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Prof Gareth Miles

gbm4

Professor of Neuroscience

tel +44 01334 462050
fax +44 01334 463042
email gbm4@st-andrews.ac.uk
Full research profile

Head of School
psyhos@st-andrews.ac.uk

Research overview

The primary goal of the research in my laboratory is to provide a better understanding of the neural control of movement with a focus on motor systems of the brainstem and spinal cord. A detailed knowledge of the normal physiology of these systems is required to enable us to understand and ultimately treat neurodegenerative diseases and injuries which can afflict them. My lab's interests extend from the level of ion channels on individual neurons up to entire neuronal networks involved in  motor behaviours. We study the physiology and anatomy of motor systems both in their normal 'healthy' state and when they are affected by conditions such as Motor Neuron Disease (MND). Lab website: http://ncm.wp.st-andrews.ac.uk/

Highlighted publications

Picton, LD, Nascimento, F, Broadhead, MJ, Sillar, KT & Miles, GB 2017, 'Sodium pumps mediate activity-dependent changes in mammalian motor networks' The Journal of Neuroscience, vol. 37, no. 4, pp. 906-921. DOI: 10.1523/JNEUROSCI.2005-16.2017
DOI: https://doi.org/10.1523/JNEUROSCI.2005-16.2017
Full text: http://research-repository.st-andrews.ac.uk/bitstream/10023/10286/1/Picton_2017_Sodium_JNeurosci_906_CC.pdf
2017

Acton, D & Miles, GB 2015, 'Stimulation of glia reveals modulation of mammalian spinal motor networks by adenosine' PLoS One, vol. 10, no. 8, e0134488. DOI: 10.1371%2Fjournal.pone.0134488
DOI: https://doi.org/10.1371%2Fjournal.pone.0134488
Full text: http://research-repository.st-andrews.ac.uk/bitstream/10023/7234/1/journal.pone.0134488.pdf
2015

Devlin, A-C, Burr, K, Borooah, S, Foster, JD, Cleary, EM, Geti, I, Vallier, L, Shaw, CE, Chandran, S & Miles, GB 2015, 'Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability' Nature Communications, vol. 6, 5999. DOI: 10.1038/ncomms6999
DOI: https://doi.org/10.1038/ncomms6999
Full text: http://research-repository.st-andrews.ac.uk/bitstream/10023/5992/1/Devlin_2015_NatComm_Human_CC.pdf
2015

Foster, JD, Dunford, C, Sillar, KT & Miles, GB 2014, 'Nitric oxide-mediated modulation of the murine locomotor network' Journal of Neurophysiology, vol. 111, no. 3, pp. 659-674. DOI: 10.1152/jn.00378.2013
DOI: https://doi.org/10.1152/jn.00378.2013
Full text: http://research-repository.st-andrews.ac.uk/bitstream/10023/4836/1/659.full.pdf
2014

Herron, LR & Miles, GB 2012, 'Gender-specific perturbations in modulatory inputs to motoneurons in a mouse model of Amyotrophic Lateral Sclerosis' Neuroscience, vol. 226, pp. 313-323. DOI: 10.1016/j.neuroscience.2012.09.031
DOI: https://doi.org/10.1016/j.neuroscience.2012.09.031
2012

Full research profile