Molecular parasitology

Group leader: Terry Smith

Professor

Research overview

 

1) Biosynthesis and uptake of phospholipids in protozoan parasites.

 

2) The enzymology of biosynthetic enzymes in parasites.

 

3) Lipidomics and focussed metabolomics of pathogens.

 

4) Carbohydrate synthesis and “simple” chemistry towards drugs for neglected disease.

 

5) Structure, function & biosynthesis of parasite glycoconjugates including GPI anchors.

 

Publications

Loureiro, I, Faria, J, Santarem, N, Smith, TK, Tavares, J & Cordeiro-da-Silva, A 2018, 'Potential drug targets in the pentose phosphate pathway of trypanosomatids' Current Medicinal Chemistry, vol. 25, no. 39, pp. 5239-5265. https://doi.org/10.2174/0929867325666171206094752
Rojas, F, Silvester, E, Young, J, Milne, R, Tettey, M, Houston, DR, Walkinshaw, MD, Pérez-Pi, I, Auer, M, Denton, H, Smith, TK, Thompson, J & Matthews, KR 2018, 'Oligopeptide signaling through TbGPR89 drives trypanosome quorum sensing' Cell, vol. 176, no. 1-2, e16, pp. 306-317. https://doi.org/10.1016/j.cell.2018.10.041

Overview

Overview header image

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences. The BSRC is grateful for funding from all funding agencies including the Institutional Strategic Support Fund from the Wellcome Trust.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research areas

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research by academic schools

Research in the BSRC is conducted by thirty-two independent research groups based in the Schools of Biology, Chemistry, Physics and Astronomy, and Medicine. Follow the links on the left to view groups associated with each school.