Synthesis of complex bioactive natural products and organic materials for biomedical applications

Group leader: Gordon Florence

Royal Society University Research Fellow

Research overview

1. Synthesis of Bioactive Natural Products

Our research focus is concerned with the development of new methods and strategies for the practical synthesis of bioactive natural products. The targets we select represent an exciting range of secondary metabolites that display startling bioactivity in preliminary biological screening, but due to their scarcity, require practical synthetic routes to enable structure determination and allow further biological evaluation of their properties in the quest for new therapeutic agents, while providing platforms for the development of new synthetic methodology. For example, we have recently completed the synthesis and structural assignment of the Annonaceous acetogenin chamuvarinin, a potent cytotoxic agent which contains a unique tricyclic THP-bis-THF ring system with undefined stereochemical arrays.  Palmerolide A and C are highly potent and selective cytotoxic marine macrolides, available in trace amounts from an Antarctic tunicate. These target compounds also provide the opportunity to generate novel structural analogues in order to probe the features responsible for their biological activity and mode of action, which in turn can aid future pharmaceutical design.

 

2. Novel Biomaterials for Medical Applications

As part of a collaborative project with Prof Sir Alfred Cuschieri (IMSAT, Dundee) and Dr Pascal Andre (St Andrews) we are preparing a unique range of hybrid biomaterials for application in minimal access surgery.

Publications

Overview

Overview header image

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences. The BSRC is grateful for funding from all funding agencies including the Institutional Strategic Support Fund from the Wellcome Trust.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research areas

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research by academic schools

Research in the BSRC is conducted by thirty-two independent research groups based in the Schools of Biology, Chemistry, Physics and Astronomy, and Medicine. Follow the links on the left to view groups associated with each school.