Systems Pathology and Cancer

Group leader: Paul Reynolds

Lecturer and Director of Postgraduate Studies

Research overview

Systems Pathology and Cancer

Why do some patients respond to therapy and some don’t? There is a growing need to personalise therapeutic treatments because human diseases are somewhat unique to the individual patient. Diagnostic assays detecting specific features (biomarkers) of a disease provide a framework to classify diseases according to their underlying molecular defects. In turn, the patient-specific molecular profile guides the clinician’s choice for therapy. Cancer is a remarkably heterogenous disease and the increasing complexity of molecular changes that occur during tumour evolution highlights the importance of identifying events that drive this process. Renal podocytes are essential for the normal filtration function of our kidneys.  With the increasing use of molecularly targeted cancer therapies, the toxic side-effects of targeted agents are increasingly being recognized and the renal safety of these drugs is becoming an important health issue.

The Reynolds lab is interested in identifying those molecular changes which drive disease with particular emphasis on 1) cancer resistance mechanisms to therapeutic drugs and 2) the mechanobiology of kidney podocytes in health and disease. We are employing biochemistry, molecular biology and cell biology approaches to investigate the nature and context of these factors and how they impact upon human health.

 

Publications

Tilston-Lunel, AM, Haley, K, Schlecht, N, Wang, Y, Chatterton, ALD, Moleirinho, SL, Watson, A, Hundal, H, Prystowsky, M, Gunn-Moore, FJ & Reynolds, PA 2016, 'Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells' Journal of Molecular Cell Biology, vol. 8, no. 5, pp. 439-455. DOI: 10.1093/jmcb/MJW020
Caie, PD, Schuur, K, Oniscu, A, Mullen, P, Reynolds, PA & Harrison, DJ 2013, 'Human tissue in systems medicine' FEBS Journal, vol. 280, no. 23, pp. 5949–5956. DOI: 10.1111/febs.12550

Overview

Overview header image

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences. The BSRC is grateful for funding from all funding agencies including the Institutional Strategic Support Fund from the Wellcome Trust.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research areas

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research by academic schools

Research in the BSRC is conducted by thirty-two independent research groups based in the Schools of Biology, Chemistry, Physics and Astronomy, and Medicine. Follow the links on the left to view groups associated with each school.