Chemical biology and medicinal chemistry

Group leader: Nick Westwood

Research overview

Organic synthesis (solution/solid phase); Chemistry/Biology interface

Related links

Research group website

Publications

Zhou, L, Stewart, G, Rideau, E , Westwood, NJ & Smith, TK 2013, ' A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro ' Journal of Medicinal Chemistry , vol 56, no. 3, pp. 796–806.
Alphey, MS , Pirrie, L, Torrie, LS, Abdelli Boulkeroua, W, Gardiner, M, Sarkar, A, Maringer, M, Oehlmann, W, Brenk, R, Scherman, MS, McNeil, M, Rejzek, M , Field, RA , Singh, M, Gray, D , Westwood, NJ & Naismith, J 2013, ' Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa ' ACS Chemical Biology , vol 8, no. 2, pp. 387-396.
Lancefield, CS, Zhou, L , Lebl, T , Slawin, AMZ & Westwood, NJ 2012, ' The Synthesis of Melohenine B and a Related Natural Product ' Organic Letters , vol 14, no. 24, pp. 6166-6169.
Zhou, L, Ishizaki, H, Spitzer, M, Taylor, K, Temperley, N, Johnson, S, Brear, P, Gautier, P, Zeng, Z, Mitchell, A, Narayan, V, McNeil, E, Melton, D , Smith, TK , Tyers, M , Westwood, NJ & Patton, E 2012, ' ALDH2 mediates 5-nitrofuran activity in multiple species ' Chemistry and Biology , vol 19, no. 7, pp. 883-892.

Overview

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research areas

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research by academic schools

Research in the BSRC is conducted by thirty-two independent research groups based in the Schools of Biology, Chemistry, Physics and Astronomy, and Medicine. Follow the links on the left to view groups associated with each school.