Chemical biology and medicinal chemistry

Group leader: Nick Westwood

Lecturer in Chemistry

Research overview

Organic synthesis (solution/solid phase); Chemistry/Biology interface

Publications

Ladds, MJGW, Pastor-Fernández, A, Popova, G, van Leeuwen, IMM, Eng, KE, Drummond, CJ, Johansson, L, Svensson, R, Westwood, NJ, McCarthy, AR, Tholander, F, Popa, M, Lane, DP, McCormack, E, McInerney, GM, Bhatia, R & Laín, S 2018, 'Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib' PLoS One, vol 13, no. 4, e0195956. DOI: 10.1371/journal.pone.0195956
Ladds, MJGW, van Leeuwen, IMM, Drummond, CJ, Chu, S, Healy, AR, Popova, G, Pastor-Fernández, A, Mollick, T, Darekar, S, Sedimbi, SK, Nekulova, M, Sachweh, MCC, Campbell, J, Higgins, M, Tuck, C, Popa, M, Safont, MM, Gelebart, P, Fandalyuk, Z, Thompson, AM, Svensson, R, Gustavsson, A-L, Johansson, L, Färnegårdh, K, Yngve, U, Saleh, A, Haraldsson, M, D'Hollander, ACA, Franco, M, Zhao, Y, Håkansson, M, Walse, B, Larsson, K, Peat, EM, Pelechano, V, Lunec, J, Vojtesek, B, Carmena, M, Earnshaw, WC, McCarthy, AR, Westwood, NJ, Arsenian-Henriksson, M, Lane, DP, Bhatia, R, McCormack, E & Laín, S 2018, 'A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage' Nature Communications, vol 9, 1107. DOI: 10.1038/s41467-018-03441-3
Ricci, F, Carrassa, L, Christodoulou, MS, Passarella, D, Michel, B, Benhida, B, Martinet , N, Hunyadi, A, Ioannou, E, Roussis, V, Musso, L, Dallavalle , S, Silvestri, R, Westwood, NJ, Mori, M, Ingallina, C, Botta, B, Kavetsou, E, Detsi, A, Majer, Z, Hudecz, F, Bősze, S, Kaminska, B, Hansen, TV, Bertrand, P, Athanassopoulos, CM & Damia, G 2018, 'A high-throughput screening of a chemical compound library in ovarian cancer stem cells' Combinatorial Chemistry and High Throughput Screening , vol 21. DOI: 10.2174/1386207321666180124093406

Overview

Overview header image

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences. The BSRC is grateful for funding from all funding agencies including the Institutional Strategic Support Fund from the Wellcome Trust.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research areas

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research by academic schools

Research in the BSRC is conducted by thirty-two independent research groups based in the Schools of Biology, Chemistry, Physics and Astronomy, and Medicine. Follow the links on the left to view groups associated with each school.