Structural biology of enzymes and membrane proteins

Group leader: Jim Naismith

Research overview

The application of protein structure determination (by X-ray crystallography) coupled to molecular biology and biochemistry to probe biological mechanisms and to target specific disease pathways. We have on going research in 1) signal transduction 2) physical basis of protein carbohydrate interactions 3) pathogenic bacteria glycan assembly, we have cloned and crystallised a number of the enzymes involved in key steps of glycan synthesis in pathogenic bacteria. 4) viral replication, we are purifying and crystallising a hetero dimer crucial to replication of viruses in vivo (5) the biosynthesis of unusual natural products

Related links

Research group website

Publications

Koehnke, JAJG , Bent, AF, Zollman, D, Smith, K, Houssen, WE, Zhu, X, Mann, G , Lebl, T , Scharff, R , Shirran, SL , Botting, CH , Jaspers, M , Schwarz-Linek, U & Naismith, J 2013, ' The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction ' Angewandte Chemie International Edition , vol 52, no. 52, pp. 13991-13996.
Reeks, J, Sokolowski, RD, Graham, S, Liu, H , Naismith, JH & White, MF 2013, ' Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing ' Biochemical Journal , vol 452, no. 2, pp. 223-230.

Overview

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research areas

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research by academic schools

Research in the BSRC is conducted by thirty-two independent research groups based in the Schools of Biology, Chemistry, Physics and Astronomy, and Medicine. Follow the links on the left to view groups associated with each school.