Mass spectrometry and proteomics

Group leader: Catherine Botting

Lecturer

Research overview

Mass spectrometry can be used to study a wide range of biological problems.  We use both MALDI and ESI ionization techniques and apply them to a broad spectrum of sample types. However, the main focus of our work is on using proteomics-type analysis techniques to identify the proteins present in a sample. This can range from relatively routine analysis of simple samples, through to the quantitative analysis of complex mixtures of proteins, looking for those proteins whose expression levels have been altered by the experimental conditions.  Another important area of our work is in mapping sites of modification by interpretation of peptide fragmentation patterns. We collaborate with researchers both internal and external to St Andrews, working closely with them to use our methods to answer their scientific questions.

Publications

Overview

Overview header image

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences. The BSRC is grateful for funding from all funding agencies including the Institutional Strategic Support Fund from the Wellcome Trust.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research areas

Scientists associated with the thirty-two research groups that are affiliated with the Biomedical Sciences Research Complex perform highly innovative, multi-disciplinary research in eleven broad areas of biomedical research, employing state-of-the-art techniques to address key questions at the leading edge of the biomedical and biological sciences.

Follow the links on the left to view individual research groups associated with one or more of the eleven BSRC research areas.

Research by academic schools

Research in the BSRC is conducted by thirty-two independent research groups based in the Schools of Biology, Chemistry, Physics and Astronomy, and Medicine. Follow the links on the left to view groups associated with each school.